Opaleye boosts Alpha Cognition (ACOG) stake with open-market buys

Rhea-AI Filing Summary

Opaleye Management Inc., as investment manager and portfolio manager for related entities, reported indirect open-market purchases of Alpha Cognition common stock totaling 4,228 shares around $6 per share. Fund-related holdings rose to 2,288,638 shares, and a separately managed account is shown holding 80,000 shares.

Insider Trade Summary

Net Buyer: 4,228 shares ($25,328)

Net Buy 3 txns

Insider Opaleye Management Inc.

Role 10% Owner

Bought 4,228 shs ($25K)

Type	Security	Shares	Price	Value
Purchase	Common Stock, no par value	3,638	$5.9915	$22K
Purchase	Common Stock, no par value	590	$5.985	$4K
holding	Common Stock, no par value	--	--	--

Holdings After Transaction: Common Stock, no par value — 2,288,638 shares (Indirect, By Opaleye, L.P.)

Footnotes (1)

1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.975 to $6.00. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.975 to $6.00. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

Form 4 Insider Transactions: What Each Field Means →

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
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hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Opaleye Management Inc.

(Last) (First) (Middle)

ONE BOSTON PLACE, 26TH FLOOR

(Street)

BOSTON MA 02108

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Alpha Cognition Inc. [ ACOG ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

3. Date of Earliest Transaction (Month/Day/Year)
02/26/2026

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock, no par value	02/26/2026		P		590	A	$5.985	2,285,000	I	By Opaleye, L.P.(1)(3)(5)
Common Stock, no par value	02/27/2026		P		3,638	A	$5.9915	2,288,638	I	By Opaleye, L.P.(1)(4)(5)
Common Stock, no par value								80,000	I	By Managed Account(2)(5)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.

2. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.

3. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.975 to $6.00. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.

4. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.975 to $6.00. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.

5. Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

	Opaleye Management Inc., By: /s/ James Silverman, President	03/02/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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FAQ

What insider activity did Opaleye Management report for Alpha Cognition (ACOG)?

Opaleye Management reported indirect open-market purchases of Alpha Cognition common stock. The filing shows two buy transactions totaling 4,228 shares, plus an updated position for a separately managed account holding 80,000 shares of common stock.

How many Alpha Cognition (ACOG) shares did Opaleye-linked entities buy and at what prices?

Opaleye-linked entities bought 3,638 shares on February 27, 2026 at $5.9915 and 590 shares on February 26, 2026 at $5.985. Footnotes state these were weighted averages across trades from $5.975 to $6.00 per share.

What are Opaleye-related Alpha Cognition (ACOG) holdings after these transactions?

After the reported purchases, Opaleye, L.P. is shown holding 2,288,638 Alpha Cognition common shares, while a separately managed account holds 80,000 shares. Opaleye Management may be deemed to beneficially own these indirectly, subject to its pecuniary interest disclosure.

How is Opaleye Management’s ownership in Alpha Cognition (ACOG) structured?

Shares are owned directly by Opaleye, L.P. and a separately managed account. Opaleye Management acts as investment manager and portfolio manager and may be deemed a beneficial owner, but it disclaims beneficial ownership beyond its pecuniary interest in those securities.

Is Opaleye Management a ten percent owner of Alpha Cognition (ACOG)?

Yes. The filing designates Opaleye Management as a ten percent owner of Alpha Cognition. This status triggers detailed reporting of indirect holdings and transactions through Opaleye, L.P. and the separately managed account under Section 16 of the Exchange Act.

Were Opaleye’s Alpha Cognition (ACOG) trades direct or indirect holdings?

All reported Alpha Cognition transactions are indirect. The purchases are attributed to Opaleye, L.P., identified as the fund, and to a separately managed account. Opaleye Management reports these as indirect interests through its investment and portfolio management roles.