[10-Q] Alkermes Inc. plc Quarterly Earnings Report

Rhea-AI Filing Summary

Alkermes (ALKS) Q2-25 10-Q highlights: Net revenue slipped 2% YoY to $390.7 m as a 36% fall in manufacturing & royalty income (-$46.4 m) outweighed a 14% jump in proprietary product sales to $307.2 m. VIVITROL +9% to $121.7 m, ARISTADA franchise +18% to $101.3 m and LYBALVI +18% to $84.3 m.

Earnings & cash: Operating income from continuing ops declined 15% to $93.0 m; diluted EPS fell to $0.52 from $0.55. R&D spending rose 30% to $77.4 m while SG&A was flat. Lower royalties cut gross margin mix but cost-of-goods remained modest at 12.7% of sales. Operating cash flow rose 49% to $249.0 m, lifting cash & equivalents to $521.2 m (vs $291.1 m YE-24); no long-term debt remains, eliminating interest expense.

Balance sheet: Total assets grew to $2.25 bn; equity improved 11% to $1.62 bn. Share count fell 2% YoY to 165.1 m; $200 m of the $400 m buyback authorization is still available.

Key developments: • Royalty stream from long-acting INVEGA products continued to fade after August-24 U.S. expiry. • Medicaid rebate true-ups cut reserves by $30.1 m, aiding cash. • July-25 settlement with Zydus grants first generic VUMERITY entry only immediately prior to patent expiry. • New U.S. patent (12,311,027) extends ARISTADA protection to 2033.

Outlook: Management signals further revenue mix shift toward proprietary brands, higher R&D for pipeline assets (e.g., alixorexton), and materially higher operating cash following recent U.S. tax law changes.

Positive

• Proprietary product sales up 14 % YoY, driven by double-digit growth in VIVITROL, ARISTADA and LYBALVI.
• Operating cash flow surged 49 % to $249 m, boosting cash to $521 m and eliminating net debt.
• New U.S. patent extends ARISTADA exclusivity to 2033, strengthening long-term IP moat.
• VUMERITY generic settlement delays competitive entry until patent expiry, preserving royalty stream.

Negative

• Total revenue fell 2 % YoY as manufacturing & royalty income dropped 36 % following INVEGA patent expiry.
• Net income and diluted EPS declined 8 % and 5 % respectively versus Q2-24.
• R&D expenses jumped 30 %, pressuring operating margin and signaling higher future spend.
• Royalty concentration risk remains with further erosion expected in INVEGA franchise royalties.

Insights

Sell-Side Pharmaceutical Analyst

TL;DR – Solid brand growth offsets royalty cliff; overall neutral impact.

Product momentum is encouraging: LYBALVI and ARISTADA combined now exceed 50 % of sales and grew double-digits. However, legacy INVEGA royalties fell $48 m YoY and will keep compressing, capping top-line expansion. Operating margin held at 24 % despite a 30 % R&D step-up aimed at late-stage pipeline, indicating good cost discipline. Cash generation and a debt-free balance sheet give flexibility to fund R&D or resume buybacks (remaining $200 m). Net income down 8 % and diluted EPS down $0.03 tempers enthusiasm. On balance, filing is strategically positive long-term but near-term neutral for valuation.

Biotech Industry Specialist

TL;DR – Revenue mix shift highlights transition to self-owned assets.

Rapid erosion of INVEGA royalties post-patent loss was expected; Alkermes’ ability to grow proprietary brands 14 % YoY validates commercial execution. The July settlement delays VUMERITY generic pressure and ARISTADA patent issuance secures a key franchise to 2033, de-risking future cash flows. R&D ramp (now 19 % of revenue) signals management’s confidence in neuroscience pipeline but raises spend profile. With $521 m cash and no debt, Alkermes can absorb increased R&D while maintaining optionality on M&A or shareholder returns. Overall strategic trajectory positive though immediate earnings drag limits short-term upside.

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UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

Form 10-Q

(Mark One)

☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended June 30, 2025

OR

☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

Commission File Number 001-35299

ALKERMES PUBLIC LIMITED COMPANY

(Exact name of registrant as specified in its charter)

Ireland		98-1007018
(State or other jurisdiction of incorporation or organization)		(I.R.S. Employer Identification No.)

Connaught House

1 Burlington Road

Dublin 4, Ireland, D04 C5Y6

(Address of principal executive offices)

+ 353-1-772-8000

(Registrant’s telephone number, including area code)

Securities registered pursuant to Section 12(b) of the Act:

Title of each class		Trading Symbol(s)		Name of each exchange on which registered
Ordinary shares, $0.01 par value		ALKS		Nasdaq Global Select Market

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer ☒		Accelerated filer ☐
Non-accelerated filer ☐		Smaller reporting company ☐
		Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒

The number of the registrant’s ordinary shares, $0.01 par value, outstanding as of July 25, 2025 was 165,077,979 shares.

ALKERMES PLC AND SUBSIDIARIES

QUARTERLY REPORT ON FORM 10-Q

FOR THE QUARTERLY PERIOD ENDED JUNE 30, 2025

		Page No.
PART I - FINANCIAL INFORMATION
Item 1.	Condensed Consolidated Financial Statements (unaudited):
	Condensed Consolidated Balance Sheets — June 30, 2025 and December 31, 2024	5
	Condensed Consolidated Statements of Income and Comprehensive Income — For the Three and Six Months Ended June 30, 2025 and 2024	6
	Condensed Consolidated Statements of Cash Flows — For the Six Months Ended June 30, 2025 and 2024	7
	Condensed Consolidated Statements of Shareholders’ Equity — For the Three and Six Months Ended June 30, 2025 and 2024	8
	Notes to Condensed Consolidated Financial Statements	10
Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	24
Item 3.	Quantitative and Qualitative Disclosures about Market Risk	35
Item 4.	Controls and Procedures	35
PART II - OTHER INFORMATION
Item 1.	Legal Proceedings	36
Item 1A.	Risk Factors	36
Item 2.	Unregistered Sales of Equity Securities and Use of Proceeds	37
Item 5.	Other Information	37
Item 6.	Exhibits	38
Signatures		39

2

Cautionary Note Concerning Forward-Looking Statements

This document contains and incorporates by reference “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended (the “Securities Act”), and Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”). In some cases, these statements can be identified by the use of forward-looking terminology such as “may,” “will,” “could,” “should,” “would,” “expect,” “anticipate,” “continue,” “believe,” “plan,” “estimate,” “intend” or other similar words. These statements discuss future expectations and contain projections of results of operations or of financial condition, or state trends and known uncertainties or other forward-looking information. Forward-looking statements in this Quarterly Report on Form 10-Q (this “Form 10-Q”) may include, without limitation, statements regarding:

•our expectations regarding our financial performance, including revenues, expenses, liquidity, capital expenditures, income taxes and profitability;

•our expectations regarding our products, including expectations related to product development, regulatory filings, approvals and timelines; therapeutic and commercial value, scope and potential; and the costs and expenses related to such activities and expectations;

•our expectations regarding the timing, design and results of clinical trials of our products;

•our expectations regarding the competitive, payer, legislative, regulatory and policy landscape, and changes therein, related to our products, including competition from generic forms of our products or competitive products and development programs; barriers to access or coverage of our products and potential changes in reimbursement of our products; and legislation, regulations, executive orders, guidance or other measures that may impact pricing and reimbursement of, and access to, our products;

•our expectations regarding the financial impact of currency exchange rate fluctuations and valuations;

•our expectations regarding acquisitions, collaborations, licensing arrangements and other significant agreements with third parties, including those related to our products, development programs, and other business development opportunities;

•our expectations regarding the impacts of new legislation, rules and regulations, the adoption of new accounting pronouncements, potential government shutdowns, or other global, political or economic changes, instability or disruptions;

•our expectations regarding near-term changes in the nature of our market risk exposures or in our management’s objectives and strategies with respect to managing such exposures;

•our expectations regarding future capital requirements and expenditures for our operations and our ability to finance such capital requirements and expenditures;

•our expectations regarding the timing, outcome and impact of administrative, regulatory, legal and other proceedings related to our products and intellectual property (“IP”), including our patents, know-how, and related rights or obligations;

•our expectations regarding the tax treatment and other anticipated benefits of the completed separation of our oncology business; and

•other expectations discussed elsewhere in this Form 10-Q.

Actual results might differ materially from those expressed or implied by these forward-looking statements because these forward-looking statements are subject to risks, assumptions and uncertainties. In light of these risks, assumptions and uncertainties, the forward-looking expectations discussed in this Form 10-Q might not occur. You are cautioned not to place undue reliance on the forward-looking statements in this Form 10-Q, which speak only as of the date of this Form 10-Q. All subsequent written and oral forward-looking statements concerning the matters addressed in this Form 10-Q and attributable to us or any person acting on our behalf are expressly qualified in their entirety by the cautionary statements contained or referred to in this section. Except as required by applicable law or regulation, we do not undertake any obligation to update publicly or revise any forward-looking statements, whether as a result of new information, future events or otherwise. For information about the risks, assumptions and uncertainties of our business, see “Part I, Item 1A—Risk Factors” in our Annual Report on Form 10-K for the year ended December 31, 2024, filed with the United States (“U.S.”) Securities and Exchange Commission (the “SEC”) on February 12, 2025 (our “Annual Report”) and “Part II, Item 1A—Risk Factors” in this Form 10-Q.

3

This Form 10-Q may include data that we obtained from industry publications and third-party research, surveys and studies. Industry publications and third-party research, surveys and studies generally indicate that their information has been obtained from sources believed to be reliable, although they do not guarantee the accuracy or completeness of such information. While we believe that any industry publications and third-party research, surveys and studies from which data is included in this Form 10-Q are reliable, we have not independently verified any such data. This Form 10-Q may also include data based on our own internal estimates and research. Our internal estimates and research have not been verified by any independent source and are necessarily subject to a high degree of uncertainty and risk due to a variety of factors, including those described in “Part I, Item 1A—Risk Factors” in our Annual Report and “Part II, Item 1A—Risk Factors” in this Form 10-Q. These and other factors could cause our results to differ materially from those expressed or implied in this Form 10-Q.

Note Regarding Company and Product References

Alkermes plc is a global biopharmaceutical company that seeks to develop innovative medicines in the field of neuroscience. We have a portfolio of proprietary commercial products for the treatment of alcohol dependence, opioid dependence, schizophrenia and bipolar I disorder, and a pipeline of clinical and preclinical candidates in development for neurological disorders, including narcolepsy and idiopathic hypersomnia. Use of terms such as “us,” “we,” “our,” “Alkermes” or the “Company” in this Form 10-Q is meant to refer to Alkermes plc and its consolidated subsidiaries. Except as otherwise suggested by the context, (a) references to “products” or “our products” in this Form 10-Q include our marketed products, marketed products using our proprietary technologies, our licensed products, our product candidates and product candidates using our proprietary technologies, (b) references to the “biopharmaceutical industry” in this Form 10-Q are intended to include reference to the “biotechnology industry” and/or the “pharmaceutical industry” and (c) references to “licensees” in this Form 10-Q are used interchangeably with references to “partners.”

Note Regarding Trademarks

We are the owner of various U.S. federal trademark registrations (“®”) and other trademarks (“TM”), including ALKERMES®, ARISTADA®, ARISTADA INITIO®, LinkeRx®, LYBALVI®, NanoCrystal® and VIVITROL®.

The following are trademarks of the respective companies listed: BYANNLI®, INVEGA®, INVEGA HAFYERA®, INVEGA SUSTENNA®, INVEGA TRINZA®, RISPERDAL CONSTA®, TREVICTA®, and XEPLION®—Johnson & Johnson or its affiliated companies; FAMPYRATM—Merz Pharmaceuticals, LLC; and VUMERITY®—Biogen MA Inc. (together with its affiliates, “Biogen”). Other trademarks, trade names and service marks appearing in this Form 10-Q are the property of their respective owners. Solely for convenience, the trademarks and trade names in this Form 10-Q may be referred to without the ® or TM symbol, but such references should not be construed as any indicator that their respective owners will not assert, to the fullest extent under applicable law, their rights thereto.

4

PART I. FINANCIAL INFORMATION

Item 1. Condensed Consolidated Financial Statements:

ALKERMES PLC AND SUBSIDIARIES

CONDENSED CONSOLIDATED BALANCE SHEETS

(unaudited)

		June 30, 2025				December 31, 2024
		(In thousands, except share and per share amounts)
ASSETS
CURRENT ASSETS:
Cash and cash equivalents		$	521,199			$	291,146
Investments—short-term			494,540				460,522
Receivables, net			354,906				384,528
Inventory			191,924				182,887
Prepaid expenses and other current assets			71,295				91,282
Contract assets			1,424				4,990
Total current assets			1,635,288				1,415,355
PROPERTY, PLANT AND EQUIPMENT, NET			239,399				227,564
INVESTMENTS—LONG-TERM			38,269				73,148
RIGHT-OF-USE ASSETS			80,532				84,245
INTANGIBLE ASSETS, NET AND GOODWILL			83,880				83,917
DEFERRED TAX ASSETS			155,533				154,835
OTHER ASSETS			19,908				16,503
TOTAL ASSETS		$	2,252,809			$	2,055,567
LIABILITIES AND SHAREHOLDERS’ EQUITY
CURRENT LIABILITIES:
Accounts payable and accrued expenses		$	245,749			$	185,332
Accrued sales discounts, allowances and reserves			253,173				272,452
Operating lease liabilities—short-term			6,462				6,166
Contract liabilities—short-term			578				1,249
Total current liabilities			505,962				465,199
OPERATING LEASE LIABILITIES—LONG-TERM			66,216				69,372
OTHER LONG-TERM LIABILITIES			56,047				56,019
Total liabilities			628,225				590,590
COMMITMENTS AND CONTINGENT LIABILITIES (Note 16)
SHAREHOLDERS’ EQUITY:
Preferred shares, par value, $0.01 per share; 50,000,000 shares authorized; and zero issued and outstanding at June 30, 2025 and December 31, 2024			—				—
Ordinary shares, par value, $0.01 per share; 450,000,000 shares authorized; 180,439,750 and 176,670,785 shares issued; and 165,054,912 and 162,176,994 shares outstanding at June 30, 2025 and December 31, 2024, respectively			1,805				1,767
Treasury shares, at cost (15,384,838 and 14,493,791 shares at June 30, 2025 and December 31, 2024, respectively)			(449,714	)			(419,255	)
Additional paid-in capital			2,940,789				2,860,890
Accumulated other comprehensive loss			(1,400	)			(1,967	)
Accumulated deficit			(866,896	)			(976,458	)
Total shareholders’ equity			1,624,584				1,464,977
TOTAL LIABILITIES AND SHAREHOLDERS’ EQUITY		$	2,252,809			$	2,055,567

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

5

ALKERMES PLC AND SUBSIDIARIES

CONDENSED CONSOLIDATED STATEMENTS OF INCOME AND COMPREHENSIVE INCOME

(unaudited)

		Three Months Ended								Six Months Ended
		June 30,								June 30,
		2025				2024				2025				2024
		(In thousands, except per share amounts)
REVENUES:
Product sales, net		$	307,235			$	269,273			$	551,728			$	502,809
Manufacturing and royalty revenues			83,422				129,858				145,439				246,691
Research and development revenue			—				—				—				3
Total revenues			390,657				399,131				697,167				749,503
EXPENSES:
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below)			49,460				61,472				98,657				120,116
Research and development			77,370				59,649				149,187				127,260
Selling, general and administrative			170,849				168,113				342,553				347,862
Amortization of acquired intangible assets			—				14				—				1,073
Total expenses			297,679				289,248				590,397				596,311
OPERATING INCOME FROM CONTINUING OPERATIONS			92,978				109,883				106,770				153,192
OTHER INCOME, NET:
Interest income			11,090				10,735				21,231				20,134
Interest expense			—				(5,952	)			—				(11,930	)
Other income, net			771				2,053				2,327				2,235
Total other income, net			11,861				6,836				23,558				10,439
INCOME BEFORE INCOME TAXES			104,839				116,719				130,328				163,631
INCOME TAX PROVISION			17,741				22,061				20,766				30,025
NET INCOME FROM CONTINUING OPERATIONS			87,098				94,658				109,562				133,606
LOSS FROM DISCONTINUED OPERATIONS, NET OF TAX			—				(3,300	)			—				(5,420	)
NET INCOME		$	87,098			$	91,358			$	109,562			$	128,186
EARNINGS PER ORDINARY SHARE:
Earnings per ordinary share from continuing operations - basic		$	0.53			$	0.56			$	0.67			$	0.79
Loss per ordinary share from discontinued operations - basic		$	—			$	(0.02	)		$	—			$	(0.03	)
Earnings per ordinary share - basic		$	0.53			$	0.54			$	0.67			$	0.76
Earnings per ordinary share from continuing operations - diluted		$	0.52			$	0.55			$	0.65			$	0.78
Loss per ordinary share from discontinued operations - diluted		$	—			$	(0.02	)		$	—			$	(0.03	)
Earnings per ordinary share - diluted		$	0.52			$	0.53			$	0.65			$	0.75
WEIGHTED AVERAGE NUMBER OF ORDINARY SHARES OUTSTANDING:
Basic			164,959				168,321				164,188				168,152
Diluted			168,357				170,977				168,470				171,960
COMPREHENSIVE INCOME:
Net income		$	87,098			$	91,358			$	109,562			$	128,186
Holding gain (loss), net of a tax provision (benefit) of $16, $(8), $184 and $(83), respectively			55				11				567				(480	)
COMPREHENSIVE INCOME		$	87,153			$	91,369			$	110,129			$	127,706

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

6

ALKERMES PLC AND SUBSIDIARIES

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(unaudited)

		Six Months Ended
		June 30,
		2025				2024
		(In thousands)
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income		$	109,562			$	128,186
Adjustments to reconcile net income to cash flows from operating activities:
Depreciation and amortization			15,239				14,714
Share-based compensation expense			47,776				53,356
Deferred income taxes			(900	)			21,724
Gain on sale of the Athlone Facility			—				(1,462	)
Other non-cash charges			3,245				2,136
Changes in assets and liabilities:
Receivables			29,622				(33,939	)
Contract assets			3,566				(2,786	)
Inventory			(10,043	)			(9,538	)
Prepaid expenses and other assets			16,163				(1,206	)
Right-of-use assets			3,713				3,571
Accounts payable and accrued expenses			56,109				(1,930	)
Accrued sales discounts, allowances and reserves			(19,279	)			(185	)
Contract liabilities			(671	)			(1,463	)
Operating lease liabilities			(5,137	)			(5,049	)
Other long-term liabilities			48				1,009
Cash flows provided by operating activities			249,013				167,138
CASH FLOWS FROM INVESTING ACTIVITIES:
Additions of property, plant and equipment			(23,126	)			(15,453	)
Proceeds from the sale of property, plant and equipment			34				434
Proceeds from the sale of the Athlone Facility			1,708				97,933
Purchases of investments			(193,806	)			(209,962	)
Sales and maturities of investments			195,078				138,947
Cash flows (used in) provided by investing activities			(20,112	)			11,899
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from the issuance of ordinary shares under share-based compensation arrangements			31,611				13,833
Employee taxes paid related to net share settlement of equity awards			(30,459	)			(29,000	)
Payment for the repurchase of ordinary shares			—				(84,689	)
Principal payments of long-term debt			—				(1,500	)
Cash flows provided by (used in) financing activities			1,152				(101,356	)
NET INCREASE IN CASH AND CASH EQUIVALENTS			230,053				77,681
CASH AND CASH EQUIVALENTS—Beginning of period			291,146				457,469
CASH AND CASH EQUIVALENTS—End of period		$	521,199			$	535,150
SUPPLEMENTAL CASH FLOW DISCLOSURE:
Non-cash investing and financing activities:
Purchased capital expenditures included in accounts payable and accrued expenses		$	7,562			$	1,649

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

7

ALKERMES PLC AND SUBSIDIARIES

CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS’ EQUITY

(unaudited)

		Ordinary Shares								Additional Paid-In				Accumulated Other Comprehensive				Accumulated				Treasury Stock
		Shares				Amount				Capital				(Loss) Income				Deficit				Shares				Amount				Total
		(In thousands, except share data)
BALANCE — December 31, 2024			176,670,785			$	1,767			$	2,860,890			$	(1,967	)		$	(976,458	)			(14,493,791	)		$	(419,255	)		$	1,464,977
Issuance of ordinary shares under employee stock plans			3,510,611				35				29,493				—				—				—				—				29,528
Receipt of Alkermes' ordinary shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards			—				—				—				—				—				(834,590	)			(28,781	)			(28,781	)
Share-based compensation			—				—				22,883				—				—				—				—				22,883
Unrealized gain on marketable securities, net of tax provision of $168			—				—				—				512				—				—				—				512
Net income			—				—				—				—				22,464				—				—				22,464
BALANCE — March 31, 2025			180,181,396			$	1,802			$	2,913,266			$	(1,455	)		$	(953,994	)			(15,328,381	)		$	(448,036	)		$	1,511,583
Issuance of ordinary shares under employee stock plans			258,354				3				2,080				—				—				—				—				2,083
Receipt of Alkermes' ordinary shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards			—				—				—				—				—				(56,457	)			(1,678	)			(1,678	)
Share-based compensation			—				—				25,443				—				—				—				—				25,443
Unrealized gain on marketable securities, net of tax provision of $16			—				—				—				55				—				—				—				55
Net income			—				—				—				—				87,098				—				—				87,098
BALANCE — June 30, 2025			180,439,750			$	1,805			$	2,940,789			$	(1,400	)		$	(866,896	)		$	(15,384,838	)		$	(449,714	)		$	1,624,584

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

8

		Ordinary Shares								Additional Paid-In				Accumulated Other Comprehensive				Accumulated				Treasury Stock
		Shares				Amount				Capital				Loss				Deficit				Shares				Amount				Total
		(In thousands, except share data)
BALANCE — December 31, 2023			172,569,051			$	1,726			$	2,736,934			$	(3,110	)		$	(1,343,528	)			(5,589,218	)		$	(189,336	)		$	1,202,686
Issuance of ordinary shares under employee stock plans			3,165,169				31				11,195				—				—				—				—				11,226
Receipt of Alkermes' ordinary shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards			—				—				—				—				—				(960,486	)			(28,349	)			(28,349	)
Share-based compensation			—				—				32,863				—				—				—				—				32,863
Unrealized loss on marketable securities, net of tax benefit of $75			—				—				—				(491	)			—				—				—				(491	)
Net income			—				—				—				—				36,828				—				—				36,828
BALANCE — March 31, 2024			175,734,220			$	1,757			$	2,780,992			$	(3,601	)		$	(1,306,700	)			(6,549,704	)		$	(217,685	)		$	1,254,763
Issuance of ordinary shares under employee stock plans			225,052				3				2,604				—				—				—				—				2,607
Receipt of Alkermes' ordinary shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards			—				—				—				—				—				(26,692	)			(651	)			(651	)
Repurchase of Alkermes' ordinary shares			—				—				—				—				—				(3,496,187	)			(84,689	)			(84,689	)
Share-based compensation			—				—				20,606				—				—				—				—				20,606
Unrealized gain on marketable securities, net of tax benefit of $8			—				—				—				11				—				—				—				11
Net income			—				—				—				—				91,358				—				—				91,358
BALANCE — June 30, 2024			175,959,272			$	1,760			$	2,804,202			$	(3,590	)		$	(1,215,342	)			(10,072,583	)		$	(303,025	)		$	1,284,005

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

9

ALKERMES PLC AND SUBSIDIARIES

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS — (Unaudited)

1. THE COMPANY

Alkermes plc is a global biopharmaceutical company that seeks to develop innovative medicines in the field of neuroscience. Alkermes has a portfolio of proprietary commercial products for the treatment of alcohol dependence, opioid dependence, schizophrenia and bipolar I disorder and a pipeline of clinical and preclinical candidates in development for neurological disorders, including narcolepsy and idiopathic hypersomnia. Headquartered in Ireland, Alkermes also has a corporate office and research and development (“R&D”) center in Massachusetts and a manufacturing facility in Ohio.

In May 2024, the Company completed the sale of its research and development business and manufacturing facility in Athlone, Ireland (the “Athlone Facility”) to Novo Nordisk (“Novo”). The Company and Novo also entered into subcontracting arrangements to continue certain development and manufacturing activities performed at the Athlone Facility for a period of time after the closing of the transaction, which activities may continue through the end of 2025. In connection with the sale of the Athlone Facility, the Company received approximately $97.9 million from Novo, which included a payment of approximately $91.0 million for the facility and certain related assets, and recorded a gain of approximately $1.5 million within “Other income, net” in the accompanying condensed consolidated statements of income and comprehensive income for the three and six months ended June 30, 2024.

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Basis of Presentation

The accompanying condensed consolidated financial statements of the Company for the three and six months ended June 30, 2025 and 2024 are unaudited and have been prepared on a basis substantially consistent with the audited financial statements for the year ended December 31, 2024. The year-end consolidated balance sheet data, which is presented for comparative purposes, was derived from audited financial statements, but does not include all disclosures required by accounting principles generally accepted in the U.S. (commonly referred to as “GAAP”). In the opinion of management, the condensed consolidated financial statements include all adjustments of a normal recurring nature that are necessary to state fairly the results of operations for the reported periods.

The accompanying condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and notes thereto of the Company, which are contained in the Annual Report. The results of the Company’s operations for any interim period are not necessarily indicative of the results of the Company’s operations for any other interim period or for any full fiscal year.

Principles of Consolidation

The accompanying condensed consolidated financial statements include the accounts of Alkermes plc and its wholly-owned subsidiaries as disclosed in Note 2, Summary of Significant Accounting Policies in the “Notes to Consolidated Financial Statements” accompanying the Annual Report. Intercompany accounts and transactions have been eliminated. Columns and rows within tables may not sum due to rounding.

Discontinued Operations

The Company determined that the separation of its oncology business into Mural Oncology plc (“Mural”), a new, independent, publicly-traded company (the “Separation”), completed in November 2023, met the criteria for classification of the oncology business as discontinued operations in accordance with Financial Accounting Standards Board (“FASB”) Accounting Standards Codification (“ASC”) 205, Discontinued Operations (“Topic 205”).

Use of Estimates

The preparation of the Company’s condensed consolidated financial statements in accordance with GAAP requires that Company management make estimates, judgments and assumptions that may affect the reported amounts of assets, liabilities, revenues and expenses, and related disclosure of contingent assets and liabilities. On an ongoing basis, the Company evaluates its estimates, judgments and methodologies, including, but not limited to, those related to revenue from contracts with its customers and related allowances, impairment of long-lived assets, share-based compensation, income taxes including the valuation allowance for deferred tax assets, valuation of investments and litigation. The Company bases its estimates on historical experience and on various other assumptions that are believed to be reasonable, the results of which form the basis for making judgments about the carrying values of assets and liabilities. Actual results may differ from these estimates under different conditions or using different assumptions.

10

ALKERMES PLC AND SUBSIDIARIES

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS — (Unaudited) (Continued)

Segment Information

Operating segments are defined as components of an enterprise engaging in business activities for which separate financial information is available and regularly reviewed by the chief operating decision maker (“CODM”) in deciding how to allocate resources and in assessing performance. The Company has utilized the management approach to determine that the Company is managed as one segment on a consolidated basis and is in the business of developing, manufacturing and commercializing medicines designed to help people living with complex and difficult-to-treat psychiatric and neurological disorders. The Company’s CODM, the Chairman and Chief Executive Officer, reviews the Company’s operating results on an aggregate basis and manages the Company’s operations as a single operating unit. The Company’s CODM measures profitability on a reportable segment basis using net income and utilizes this information in allocating resources and in assessing performance by monitoring budget versus actual results. Please refer to Note 15, Segment Reporting, in these “Notes to Condensed Consolidated Financial Statements” in this Form 10-Q for further information.

New Accounting Pronouncements

From time to time, new accounting pronouncements are issued by the FASB or other standard-setting bodies that are adopted by the Company on or prior to the specified effective date. Unless otherwise described in this Form 10-Q, the Company believes that the impact of recently issued standards that are not yet effective will not have a material impact on its financial position or results of operations upon adoption.

In December 2023, the FASB issued Accounting Standards Update (“ASU”) 2023-09, Income Taxes (Topic 740): Improvements to Income Tax Disclosures, to enhance the transparency and decision usefulness of income tax disclosures in order to provide information to assist key stakeholders in better assessing how the Company’s operations and related tax risks and tax planning and operational opportunities affect the Company’s tax rate and prospects for future cash flows. This ASU becomes effective for public companies for annual periods beginning after December 15, 2024. This guidance will be applied on a prospective basis. The Company is currently evaluating the impact this ASU will have on its consolidated financial statements and related disclosures.

In November 2024, the FASB issued ASU 2024-03, Income Statement - Reporting Comprehensive Income-Expense Disaggregation Disclosures, to improve disclosures about public business entity expenses and address requests from investors for more detailed information about the types of expenses (including purchases of inventory, employee compensation, depreciation, amortization and depletion) in commonly-presented expense captions, such as cost of sales, selling, general and administrative expenses, and research and development. All disclosure requirements under this guidance are required for public business entities and will be effective for annual periods beginning after December 15, 2026 and interim periods beginning after December 15, 2027. Early adoption is permitted and the amendments in this guidance will be applied prospectively to financial statements for periods after the effective dates. The Company is currently evaluating the impact this ASU will have on its consolidated financial statements and related disclosures.

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3. DISCONTINUED OPERATIONS

Mural Oncology Separation

In connection with the Separation, the Company and Mural entered into, among other agreements: a separation agreement; a tax matters agreement; and an employee matters agreement, which are described in Note 3, Discontinued Operations in the “Notes to Consolidated Financial Statements” accompanying the Annual Report.

Discontinued Operations

The Company determined that the Separation met the criteria for classification of its former oncology business as discontinued operations in accordance with Topic 205. During the three and six months ended June 30, 2025, the Company recorded no losses from discontinued operations. The following summarizes the loss from discontinued operations for the three and six months ended June 30, 2024:

		Three Months Ended				Six Months Ended
(In thousands)		June 30, 2024				June 30, 2024
Operating expenses from discontinued operations
Cost of goods manufactured		$	—			$	—
Research and development			3,913				6,429
Selling, general and administrative			—				—
Total operating expenses from discontinued operations			3,913				6,429
Operating loss from discontinued operations			(3,913	)			(6,429	)
Income tax benefit from discontinued operations			(613	)			(1,009	)
Net loss and comprehensive loss from discontinued operations		$	(3,300	)		$	(5,420	)

4. REVENUE FROM CONTRACTS WITH CUSTOMERS

The Company recognizes revenue when its customer obtains control of promised goods or services, in an amount that reflects the consideration which it expects to receive in exchange for those goods or services. The Company recognizes revenue following the five-step model prescribed in accordance with FASB ASC 606, Revenue from Contracts with Customers, or Topic 606: (i) identify contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) the Company satisfies the performance obligations.

Product Sales, Net

The Company’s product sales, net consist of sales in the U.S. of VIVITROL, ARISTADA and ARISTADA INITIO, and LYBALVI, primarily to wholesalers, specialty distributors and pharmacies. Product sales, net are recognized when the customer obtains control of the product, which is when the product has been received by the customer.

During the three and six months ended June 30, 2025 and 2024, the Company recorded product sales, net, as follows:

		Three Months Ended June 30,								Six Months Ended June 30,
(In thousands)		2025				2024				2025				2024
VIVITROL		$	121,660			$	111,873			$	222,656			$	209,532
ARISTADA and ARISTADA INITIO			101,295				86,049				174,770				164,919
LYBALVI			84,280				71,351				154,302				128,358
Total product sales, net		$	307,235			$	269,273			$	551,728			$	502,809

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Revenues from product sales are recorded net of reserves established for applicable discounts and allowances that are offered within contracts with the Company’s customers, healthcare providers or payers. The Company’s process for estimating reserves established for these variable consideration components does not differ materially from historical practices. The transaction price, which includes variable consideration reflecting the impact of discounts and allowances, may be subject to constraint and is included in the net sales price only to the extent that it is probable that a significant reversal of the amount of the cumulative revenues recognized will not occur in a future period. Actual amounts may ultimately differ from the Company’s estimates. If actual results vary, the Company adjusts these estimates, which could have an effect on earnings in the period of adjustment. See the “Revenue from Contracts with Customers” section in Note 2, Summary of Significant Accounting Policies in the “Notes to Consolidated Financial Statements” in the Annual Report for information with respect to the Company’s significant categories of sales discounts and allowances.

Actual Medicaid rebates related to VIVITROL and ARISTADA/ARISTADA INITIO during the six months ended June 30, 2025 were lower than original estimates, and as a result the Company reduced its rebate reserve for each product by approximately $17.7 million and $7.2 million, respectively, during the period.

A rollforward of the Company’s provisions for sales discounts and allowances is as follows:

		Six Months Ended June 30, 2025
(In thousands)		Contractual Adjustments(1)				Discounts(2)				Product Returns				Other				Total
Beginning balance — December 31, 2024		$	228,978			$	43,645			$	50,507			$	13,297			$	336,427
Current provisions relating to sales in current year			263,018				196,845				13,049				43,096				516,008
Adjustments relating to prior years			(25,329	)			152				(4,601	)			(332	)			(30,110	)
Payments relating to sales in current year			(125,484	)			(182,256	)			—				(33,652	)			(341,392	)
Payments relating to sales in prior years			(128,250	)			(22,941	)			(5,503	)			(12,231	)			(168,925	)
Ending balance — June 30, 2025		$	212,933			$	35,445			$	53,452			$	10,178			$	312,008

1.“Contractual Adjustments” include “Medicaid Rebates” and “Medicare Part D” accruals

2.“Discounts” include “Chargebacks” and “Product Discounts”

Total revenue-related reserves as of June 30, 2025 and December 31, 2024 included in the accompanying consolidated balance sheets are summarized as follows:

		June 30,				December 31,
(In thousands)		2025				2024
Reduction of accounts receivable		$	16,658			$	22,031
Components of accrued sales discounts, allowances and reserves			253,173				272,452
Components of other long-term liabilities			42,177				41,944
Total revenue-related reserves		$	312,008			$	336,427

Manufacturing and Royalty Revenues

During the three and six months ended June 30, 2025 and 2024, the Company recorded manufacturing and royalty revenues from its collaboration arrangements as follows:

		Three Months Ended June 30, 2025												Six Months Ended June 30, 2025
(In thousands)		Manufacturing Revenue				Royalty Revenue				Total				Manufacturing Revenue				Royalty Revenue				Total
Long-acting INVEGA products(1)		$	—			$	30,315			$	30,315			$	—			$	48,060			$	48,060
VUMERITY			7,383				32,016				39,399				13,358				53,874				67,232
RISPERDAL CONSTA			3,812				8				3,820				12,927				22				12,949
Other			5,372				4,516				9,888				7,609				9,589				17,198
		$	16,567			$	66,855			$	83,422			$	33,894			$	111,545			$	145,439

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NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS — (Unaudited) (Continued)

		Three Months Ended June 30, 2024												Six Months Ended June 30, 2024
(In thousands)		Manufacturing Revenue				Royalty Revenue				Total				Manufacturing Revenue				Royalty Revenue				Total
Long-acting INVEGA products(1)		$	—			$	78,739			$	78,739			$	—			$	141,412			$	141,412
VUMERITY			9,863				25,371				35,234				21,987				44,501				66,488
RISPERDAL CONSTA			3,428				130				3,558				6,023				253				6,276
Other			6,989				5,338				12,327				22,300				10,215				32,515
		$	20,280			$	109,578			$	129,858			$	50,310			$	196,381			$	246,691

(1)“long-acting INVEGA products”: INVEGA SUSTENNA/XEPLION (paliperidone palmitate), INVEGA TRINZA/TREVICTA (paliperidone palmitate) and INVEGA HAFYERA/BYANNLI (paliperidone palmitate).

In August 2024, the Company’s royalty on U.S. net sales of INVEGA SUSTENNA expired. Accordingly, the Company expects royalty revenues from net sales of the long-acting INVEGA products to continue to be lower in 2025, as the royalty revenues related to U.S. net sales of INVEGA SUSTENNA comprised a significant portion of the overall royalty revenues from the long-acting INVEGA products.

Contract Assets

Contract assets include unbilled amounts related to the manufacture of a product that, once complete, will be sold under certain of the Company’s manufacturing contracts. The amounts included in the contract assets table below are classified as “Current assets” in the accompanying condensed consolidated balance sheets, as they relate to manufacturing processes that are completed in ten days to eight weeks.

Total contract assets at June 30, 2025 were as follows:

(In thousands)		Contract Assets
Contract assets at December 31, 2024		$	4,990
Additions			3,766
Transferred to receivables, net			(7,332	)
Contract assets at June 30, 2025		$	1,424

Contract Liabilities

Contract liabilities consist of contractual obligations related to deferred revenue. At June 30, 2025 and December 31, 2024, $0.6 million and $1.2 million of the contract liabilities, respectively, were classified as “Contract liabilities–short-term” in the accompanying condensed consolidated balance sheets and none of the contract liabilities in either period were classified as “Other long-term liabilities” in the accompanying condensed consolidated balance sheets.

Total contract liabilities at June 30, 2025 were as follows:

(In thousands)		Contract Liabilities
Contract liabilities at December 31, 2024		$	1,249
Additions			1,313
Amounts recognized into revenue			(1,984	)
Contract liabilities at June 30, 2025		$	578

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NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS — (Unaudited) (Continued)

5. INVESTMENTS

Investments consist of the following (in thousands):

						Gross Unrealized
										Losses
		Amortized								Less than				Greater than				Estimated
June 30, 2025		Cost				Gains				One Year				One Year				Fair Value
Short-term investments:
Available-for-sale securities:
U.S. government and agency debt securities		$	266,091			$	892			$	(5	)		$	(12	)		$	266,966
Corporate debt securities			226,554				1,027				(4	)			(3	)			227,574
Total short-term investments			492,645				1,919				(9	)			(15	)			494,540
Long-term investments:
Available-for-sale securities:
U.S. government and agency debt securities			29,580				—				—				(55	)			29,525
Corporate debt securities			8,627				—				—				(28	)			8,599
			38,207				—				—				(83	)			38,124
Held-to-maturity securities:
Certificates of deposit			145				—				—				—				145
Total long-term investments			38,352				—				—				(83	)			38,269
Total investments		$	530,997			$	1,919			$	(9	)		$	(98	)		$	532,809
December 31, 2024
Short-term investments:
Available-for-sale securities:
U.S. government and agency debt securities		$	266,506			$	763			$	(58	)		$	(6	)		$	267,205
Corporate debt securities			192,617				762				(58	)			(4	)			193,317
Total short-term investments			459,123				1,525				(116	)			(10	)			460,522
Long-term investments:
Available-for-sale securities:
U.S. government and agency debt securities			48,856				—				—				(179	)			48,677
Corporate debt securities			24,484				—				—				(158	)			24,326
			73,340				—				—				(337	)			73,003
Held-to-maturity securities:
Certificates of deposit			145				—				—				—				145
Total long-term investments			73,485				—				—				(337	)			73,148
Total investments		$	532,608			$	1,525			$	(116	)		$	(347	)		$	533,670

At June 30, 2025, the Company’s investments in corporate debt securities had a minimum rating of A2 (Moody’s)/A (Standard and Poor’s), and 52 of the Company’s 330 investment securities were in an unrealized loss position with an aggregate estimated fair value of $99.3 million. The primary reason these securities were in an unrealized loss position is that they are fixed-rate securities that were acquired in a rising interest rate environment. In making the determination whether the decline in fair value of these securities was temporary, the Company evaluated whether it intended to sell the security and whether it was more likely than not that the Company would be required to sell the security before recovering its amortized cost basis. The Company has the intent and ability to hold these investments until recovery, which may be at maturity.

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NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS — (Unaudited) (Continued)

Realized gains and losses on the sales and maturities of investments, which were identified using the specific identification method, were as follows:

		Six Months Ended June 30,
(In thousands)		2025				2024
Proceeds from the sales and maturities of investments		$	195,078			$	138,947
Realized gains		$	3			$	—
Realized losses		$	—			$	—

The Company’s available-for-sale and held-to-maturity securities at June 30, 2025 had contractual maturities in the following periods:

		Available-for-sale								Held-to-maturity
		Amortized				Estimated				Amortized				Estimated
(In thousands)		Cost				Fair Value				Cost				Fair Value
Within 1 year		$	283,975			$	284,485			$	145			$	145
After 1 year through 5 years			246,877				248,179				—				—
Total		$	530,852			$	532,664			$	145			$	145

In February 2025, the Company entered into an agreement whereby it is committed to provide up to €10.0 million to a partnership, Fountain Healthcare Partners Fund IV, L.P. (“Fountain”), which was created to carry on the business of investing exclusively in companies and businesses engaged in the healthcare, pharmaceutical and life sciences sectors. The Company’s commitment represents approximately 9.2% of the partnership’s total funding, and the Company is accounting for its investment in Fountain under the equity method. As of June 30, 2025, the Company had made payments of, and its investment is equal to, $0.6 million (€0.5 million), which is included within “Other assets” in the accompanying condensed consolidated balance sheets.

6. FAIR VALUE

The following table presents information about the Company’s assets and liabilities that are measured at fair value on a recurring basis and indicates the fair value hierarchy and the valuation techniques that the Company utilized to determine such fair value:

		June 30,
(In thousands)		2025				Level 1				Level 2				Level 3
Assets:
Cash equivalents		$	17,740			$	17,740			$	—			$	—
U.S. government and agency debt securities			296,491				250,211				46,280				—
Corporate debt securities			236,173				—				235,673				500
Total		$	550,404			$	267,951			$	281,953			$	500

		December 31,
		2024				Level 1				Level 2				Level 3
Assets:
Cash equivalents		$	8,388			$	8,388			$	—			$	—
U.S. government and agency debt securities			315,882				265,090				50,792				—
Corporate debt securities			217,643				—				217,643				—
Total		$	541,913			$	273,478			$	268,435			$	—

The Company transfers its financial assets and liabilities, measured at fair value on a recurring basis, between the fair value hierarchies at the end of each reporting period. There were no transfers of any securities between levels during the six months ended June 30, 2025.

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NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS — (Unaudited) (Continued)

The following table is a rollforward of the fair value of the Company’s assets with fair values that were determined using Level 3 inputs at June 30, 2025:

(In thousands)		Fair Value
Balance, January 1, 2025		$	—
Purchase of a corporate debt security			500
Balance, June 30, 2025		$	500

The Company’s investments classified as Level 2 within the fair value hierarchy were initially valued at the transaction price and subsequently valued, at the end of each reporting period, utilizing market-observable data. The market-observable data included reportable trades, benchmark yields, credit spreads, broker/dealer quotes, bids, offers, current spot rates and other industry and economic events. The Company validated the prices developed using the market-observable data by obtaining market values from other pricing sources, analyzing pricing data in certain instances and confirming that the relevant markets are active.

The carrying amounts reflected in the accompanying condensed consolidated balance sheets for cash and cash equivalents, accounts receivable, contract assets, other current assets, accounts payable and accrued expenses, sales discounts, allowances and reserves approximate fair value due to their short-term nature.

7. INVENTORY

Inventory is stated at the lower of cost and net realizable value. Cost is determined using the first-in, first-out method. Inventory consists of the following:

		June 30,				December 31,
(In thousands)		2025				2024
Raw materials		$	68,423			$	72,139
Work in process			81,390				79,871
Finished goods(1)			42,111				30,877
Total inventory		$	191,924			$	182,887

(1)At June 30, 2025 and December 31, 2024, the Company had $33.5 million and $22.7 million, respectively, of finished goods inventory located at its third-party warehouse and shipping service provider.

8. PROPERTY, PLANT AND EQUIPMENT

Property, plant and equipment consist of the following:

		June 30,				December 31,
(In thousands)		2025				2024
Land		$	957			$	957
Building and improvements			149,674				134,699
Furniture, fixtures and equipment			274,115				244,113
Leasehold improvements			42,535				42,416
Construction in progress			37,043				58,391
Subtotal			504,324				480,576
Less: accumulated depreciation			(264,925	)			(253,012	)
Total property, plant and equipment, net		$	239,399			$	227,564

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NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS — (Unaudited) (Continued)

9. LEASES

Future lease payments under non-cancelable leases at June 30, 2025 consist of the following:

		June 30,
(In thousands)		2025
2025			5,152
2026			10,380
2027			9,513
2028			9,574
Thereafter			59,695
Total operating lease payments		$	94,314
Less: imputed interest			(21,636	)
Total operating lease liabilities		$	72,678

At June 30, 2025, the weighted average incremental borrowing rate and the weighted average remaining lease term for all operating leases held by the Company were 3.8% and 6.5 years, respectively. Cash paid for lease liabilities was $2.6 million and $5.1 million during the three and six months ended June 30, 2025, respectively, as compared to $2.5 million and $5.0 million during the three and six months ended June 30, 2024, respectively. The Company recorded operating lease expense from continuing operations of $1.9 million and $3.7 million during the three and six months ended June 30, 2025, respectively, as compared to $1.8 million and $3.6 million during the three and six months ended June 30, 2024, respectively.

10. ACCOUNTS PAYABLE AND ACCRUED EXPENSES

Accounts payable and accrued expenses consist of the following:

		June 30,				December 31,
(In thousands)		2025				2024
Accounts payable		$	99,206			$	45,630
Accrued compensation			56,544				70,960
Accrued other			89,999				68,742
Total accounts payable and accrued expenses		$	245,749			$	185,332

A summary of the Company’s current provision for sales discounts, allowances and reserves was as follows:

		June 30,				December 31,
(In thousands)		2025				2024
Medicaid rebates		$	189,021			$	202,044
Product discounts			16,832				19,351
Medicare Part D			23,913				26,933
Other			23,407				24,124
Total accrued sales discounts, allowances and reserves		$	253,173			$	272,452

Included in accounts payable was approximately $43.3 million and $11.4 million of amounts payable related to state U.S. Medicaid rebates as of June 30, 2025 and December 31, 2024, respectively.

11. SHAREHOLDERS’ EQUITY

In February 2024, the Company announced approval by its board of directors of a share repurchase program authorizing the Company to repurchase its ordinary shares in an aggregate amount of up to $400.0 million (exclusive of any fees, commissions or other expenses related to such repurchases) from time to time (the “Repurchase Program”), with the specific timing and amounts of repurchases under the Repurchase Program dependent on a variety of factors, including but not limited to ongoing assessments of the Company’s needs, alternative investment opportunities, the market price of its ordinary shares and general market conditions. The Repurchase Program has no set expiration date and may be suspended or discontinued at any time. During the six months ended June 30, 2025, the Company did not repurchase any of its ordinary shares under the Repurchase Program. As of June 30, 2025, the remaining amount authorized under the Repurchase Program was $200.0 million.

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12. SHARE-BASED COMPENSATION

The following table presents share-based compensation expense included in the accompanying condensed consolidated statements of income and comprehensive income:

		Three Months Ended								Six Months Ended
		June 30,								June 30,
(In thousands)		2025				2024				2025				2024
Cost of goods manufactured and sold		$	1,479			$	(279	)		$	3,261			$	2,627
Research and development			6,510				6,021				12,401				16,299
Selling, general and administrative			16,977				14,859				32,114				34,430
Total share-based compensation expense		$	24,966			$	20,601			$	47,776			$	53,356

At each of June 30, 2025 and December 31, 2024, $3.1 million of share-based compensation expense was capitalized and recorded as “Inventory”, and $0.6 million and none, respectively, of share-based compensation expense was capitalized and recorded as “Property, plant and equipment, net” in the accompanying condensed consolidated balance sheets.

13. EARNINGS PER ORDINARY SHARE

Basic earnings per ordinary share from continuing operations is calculated based upon net income from continuing operations available to holders of ordinary shares, divided by the weighted average number of ordinary shares outstanding. Basic loss per ordinary share from discontinued operations is calculated based upon net loss from discontinued operations available to holders of ordinary shares, divided by the weighted average number of ordinary shares outstanding. For the calculation of diluted earnings (loss) per ordinary share from continuing operations and discontinuing operations, the Company utilizes the treasury stock method and adjusts the weighted average number of ordinary shares outstanding for the potential dilutive effect of outstanding ordinary share equivalents such as stock options and restricted stock unit awards.

		Three Months Ended								Six Months Ended
		June 30,								June 30,
(In thousands)		2025				2024				2025				2024
Numerator:
Net income from continuing operations		$	87,098			$	94,658			$	109,562			$	133,606
Net loss from discontinued operations			—				(3,300	)			—				(5,420	)
Net income		$	87,098			$	91,358			$	109,562			$	128,186
Denominator:
Weighted average number of ordinary shares outstanding			164,959				168,321				164,188				168,152
Effect of dilutive securities:
Stock options			1,649				839				1,967				1,284
Restricted stock unit awards			1,749				1,817				2,315				2,524
Dilutive ordinary share equivalents			3,398				2,656				4,282				3,808
Shares used in calculating diluted earnings per ordinary share			168,357				170,977				168,470				171,960

The following potential ordinary share equivalents were not included in the net earnings per ordinary share calculation because the effect would have been anti-dilutive:

		Three Months Ended								Six Months Ended
		June 30,								June 30,
(In thousands)		2025				2024				2025				2024
Stock options			9,901				14,049				8,919				12,339
Restricted stock unit awards			2,505				2,765				2,386				2,507
Total			12,406				16,814				11,305				14,846

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14. INCOME TAXES

The Company recognizes income taxes under the asset and liability method. Deferred income taxes are recognized for differences between the financial reporting and tax bases of assets and liabilities at enacted statutory tax rates in effect for the years in which the differences are expected to reverse. The effect on deferred taxes of a change in tax rates is recognized in income in the period that includes the enactment date. In determining future taxable income, the Company is responsible for assumptions that it utilizes, including the amount of Irish and non-Irish pre-tax operating income, the reversal of temporary differences and the implementation of feasible and prudent tax planning strategies. These assumptions require significant judgment about the forecasts of future taxable income and are consistent with the plans and estimates that the Company uses to manage the underlying business.

The Company recorded income tax provisions on income from continuing operations of $17.7 million and $20.8 million during the three and six months ended June 30, 2025, respectively, and of $22.1 million and $30.0 million during the three and six months ended June 30, 2024, respectively. The income tax provisions during each of the three and six months ended June 30, 2025 and 2024 were primarily attributable to taxes on income earned in Ireland.

The Company’s effective tax rate during the six months ended June 30, 2025 and 2024 was 15.9% and 18.3%, respectively. The decrease in the effective tax rate was primarily due to an increase in windfall benefits from employee equity activity and an expense recorded in 2024 related to the sale of the Athlone Facility. The effective tax rates during the six months ended June 30, 2025 and 2024 exceeded the Irish statutory tax rate of 12.5%, primarily due to non-deductible expenses and income that was taxable at rates higher than the Irish statutory tax rate.

On July 4, 2025, the One Big Beautiful Bill (the “OBB Bill”) was signed into law. This legislation permanently extends, with modifications, several individual, business, and international tax provisions originally enacted under the Tax Cuts and Jobs Act of 2017. The Company performed an initial assessment of the OBB Bill and expects this legislation to result in a material increase in cash flows provided by operating activities and a material decrease in net U.S. deferred tax assets over the next number of years.

15. SEGMENT REPORTING

Segment Information

Following the adoption of ASU 2023-07, the Company is required to disclose significant segment expenses that are regularly provided to its CODM. The Company’s CODM is periodically provided R&D expenses, selling and marketing expenses, and general and administrative expenses. Other external R&D expenses are composed of general research and development expenses and other external projects. Other internal R&D expenses include allocation expenses, travel expenses, and fees, taxes and dues.

20

ALKERMES PLC AND SUBSIDIARIES

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS — (Unaudited) (Continued)

The Company’s significant segment expenses are as follows:

		Three Months Ended								Six Months Ended
		June 30,								June 30,
(In thousands)		2025				2024				2025				2024
REVENUES:
Total revenue		$	390,657			$	399,131			$	697,167			$	749,503
EXPENSES:
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below)			49,460				61,472				98,657				120,116
External R&D expenses:
Development programs:
Alixorexton			23,795				12,589				41,649				23,045
LYBALVI			5,050				3,710				8,901				8,751
Other external R&D expenses			10,589				10,014				21,562				18,803
Total external R&D expenses			39,434				26,313				72,112				50,599
Internal R&D expenses:
Employee-related			30,651				26,235				62,005				60,780
Occupancy			3,308				2,720				6,455				5,768
Depreciation			1,474				1,375				2,942				2,803
Other internal R&D expenses			2,503				3,006				5,673				7,310
Total internal R&D expenses			37,936				33,336				77,075				76,661
R&D expenses			77,370				59,649				149,187				127,260
Selling, general and administrative expenses:
Selling and marketing expense			121,175				119,667				244,109				245,284
General and administrative expense			49,674				48,446				98,444				102,578
Total selling, general and administrative expense			170,849				168,113				342,553				347,862
Other segment income (expenses)(1)			(5,880	)			(15,239	)			2,792				(20,659	)
NET INCOME FROM CONTINUING OPERATIONS			87,098				94,658				109,562				133,606
LOSS ON DISCONTINUED OPERATIONS, NET OF TAX			—				(3,300	)			—				(5,420	)
NET INCOME		$	87,098			$	91,358			$	109,562			$	128,186

1.“Other segment income (expenses)” during the three and six months ended June 30, 2025 and 2024, includes “Amortization of acquired intangible assets”, “Other income, net” and “Income tax provision”.

16. COMMITMENTS AND CONTINGENT LIABILITIES

Litigation

From time to time, the Company may be subject to legal proceedings and claims in the ordinary course of business. On a quarterly basis, the Company reviews the status of each significant matter and assesses its potential financial exposure. If the potential loss from any claim, asserted or unasserted, or legal proceeding is considered probable and the amount can be reasonably estimated, the Company would accrue a liability for the estimated loss. Because of uncertainties related to claims and litigation, accruals are based on the Company’s best estimates, utilizing all available information. On a periodic basis, as additional information becomes available, or based on specific events such as the outcome of litigation or settlement of claims, the Company may reassess the potential liability related to these matters and may revise these estimates, which could result in material adverse adjustments to the Company’s operating results. At June 30, 2025, there were no potential material losses from claims, asserted or unasserted, or legal proceedings that the Company determined were probable of occurring.

21

ALKERMES PLC AND SUBSIDIARIES

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS — (Unaudited) (Continued)

INVEGA TRINZA ANDA Litigation

In September 2020, Janssen Pharmaceutica, Janssen Pharmaceuticals, Inc., and Janssen Research & Development, LLC initiated a patent infringement lawsuit in the U.S. District Court for the District of New Jersey (the “NJ District Court”) against Mylan Laboratories Limited (“Mylan Labs”) and other Mylan entities following the filing by Mylan Labs of an abbreviated new drug application (“ANDA”) seeking approval from the U.S. Food and Drug Administration (“FDA”) to market a generic version of INVEGA TRINZA before the expiration of U.S. Patent No. 10,143,693 (the “’693 Patent”). Requested judicial remedies include recovery of litigation costs and injunctive relief. In May 2023, the NJ District Court issued an opinion in favor of the Janssen entities on the issues of infringement and validity of the ’693 Patent and the Mylan entities filed a notice of appeal of the decision. In March, 2025, the U.S. Court of Appeals for the Federal Circuit (the “Federal Circuit Court”) issued a decision affirming the NJ District Court opinion and in May 2025, Mylan Labs filed a petition for panel rehearing or rehearing en banc. The Company is not a party to this proceeding.

VUMERITY ANDA Litigation

In July 2023, Biogen Inc., Biogen Swiss Manufacturing GmbH and Alkermes Pharma Ireland Limited (“APIL”) filed a patent infringement lawsuit in the U.S. District Court for the District of Delaware (the “DE District Court”) against Zydus Worldwide DMCC, Zydus Pharmaceuticals (USA) Inc. and Zydus Lifesciences Limited (collectively, “Zydus”) following the filing by Zydus of an ANDA seeking approval from the FDA to engage in the commercial manufacture, use or sale of a generic version of VUMERITY (diroximel fumarate) delayed-release capsules for oral use, 231 mg, before expiration of the Company’s U.S. Patent Nos. 8,669,281; 9,090,558; and 10,080,733 (the “VUMERITY patents”). The filing of the lawsuit triggered a stay of FDA approval of the ANDA for up to 30 months in accordance with the U.S. Drug Price Competition and Patent Term Restoration Act of 1984 (the “Hatch-Waxman Act”). On July 21, 2025, the parties entered into a confidential settlement agreement, pursuant to which Zydus was granted a license under the VUMERITY patents to engage in the commercial manufacture, use or sale of a generic version of VUMERITY in the United States beginning on an agreed date immediately prior to expiration of the latest to expire of the VUMERITY patents, or earlier under certain customary circumstances. In connection with the settlement agreement, the DE District Court dismissed the litigation pursuant to the parties’ stipulation of dismissal.

Government Matters

The Company has received a subpoena and civil investigative demands from U.S. state and federal governmental authorities for documents related to VIVITROL. The Company is cooperating with the investigations.

Product Liability and Other Legal Proceedings

The Company is involved in litigation and other legal proceedings incidental to its normal business activities, including a product liability case alleging that the FDA-approved VIVITROL labeling was inadequate and that VIVITROL caused the individual to suffer from opioid overdose and death. The Company intends to vigorously defend itself in these matters.

In addition, in January 2023, Acorda Therapeutics, Inc. (“Acorda”) filed a petition with the U.S. District Court for the Southern District of New York (the “NY Southern District Court”) asking the court to confirm in part and modify in part the final arbitral award rendered by an arbitration panel in October 2022 and, as part of the requested modification, seeking an additional approximately $66.0 million in damages. In August 2023, the NY Southern District Court confirmed the final arbitral award and declined to modify the final award to increase the damages awarded thereunder. In September 2023, Acorda filed a notice of appeal of the NY Southern District Court decision to the Federal Circuit Court. On July 25, 2025, the Federal Circuit Court transferred the appeal due to lack of jurisdiction to the U.S. Court of Appeals for the Second Circuit.

Guarantees

In connection with the Separation, the Company entered into an assignment and assumption of lease agreement (the “Assignment”) pursuant to which Alkermes, Inc., a wholly owned subsidiary of the Company, assigned to Mural Oncology, Inc. (“Mural US”), a subsidiary of Mural, an operating lease for approximately 180,000 square feet of corporate office space, administrative areas and laboratories located at 852 Winter Street in Waltham, Massachusetts (the “852 Winter Street Lease”), as described in more detail in Note 10, Leases in the “Notes to Consolidated Financial Statements” in the Annual Report. Although all of the rights, title and interest in, to and under the 852 Winter Street

22

ALKERMES PLC AND SUBSIDIARIES

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS — (Unaudited) (Continued)

Lease were transferred to Mural US as of November 15, 2023 pursuant to the Assignment, the Company ratified and reaffirmed for the remainder of the lease term its guarantor obligations in respect of the lease under that certain Guaranty dated as of May 16, 2014. Upon completion of the Separation, the Assignment was accounted for as a termination of the original lease and the Company de-recognized the right-of-use asset and lease liability related to the 852 Winter Street Lease. At June 30, 2025, the fair value of the guarantee was not material to the Company.

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Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations

The following discussion should be read in conjunction with the accompanying condensed consolidated financial statements and related notes beginning on page 5 in this Form 10-Q, and “Part II, Item 7—Management’s Discussion and Analysis of Financial Condition and Results of Operations” and the audited financial statements and notes thereto accompanying our Annual Report.

Executive Summary

Net income from continuing operations was $87.1 million and $109.6 million or $0.53 and $0.67 per ordinary share—basic and $0.52 and $0.65 per ordinary share—diluted, for the three and six months ended June 30, 2025, respectively, compared to net income from continuing operations of $94.7 million and $133.6 million or $0.56 per and $0.79 ordinary share—basic and $0.55 and $0.78 per ordinary share—diluted, for the three and six months ended June 30, 2024, respectively.

The decreases in net income from continuing operations of $7.6 million and $24.0 million during the three and six months ended June 30, 2025, as compared to the three and six months ended June 30, 2024, respectively, were primarily due to decreases of $8.5 million and $52.3 million, respectively, in revenues, primarily related to lower manufacturing and royalty revenues, partially offset by increases in product sales, net. During the three and six months ended June 30, 2025, as compared to the three and six months ended June 30, 2024, total expenses increased by $8.4 million and decreased by $5.9 million, respectively, and income tax provision decreased by $4.4 million and $9.2 million, respectively.

These items are discussed in greater detail later in the “Results of Operations” section in this “Part I, Item 2—Management’s Discussion and Analysis of Financial Condition and Results of Operations” in this Form 10-Q.

Products

Marketed Products

The key marketed products discussed below have generated, or are expected to generate, significant revenues for us. See the descriptions of the marketed products below and “Part I, Item 1A—Risk Factors” in our Annual Report and “Part II, Item 1A—Risk Factors” in this Form 10-Q for important factors that could adversely affect our marketed products. See the “Patents and Proprietary Rights” section in “Part I, Item 1—Business” in our Annual Report for information with respect to the IP protection for these marketed products.

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The following provides summary information regarding our proprietary products that we commercialize:

Proprietary Products

Product		Indication(s)			Territory
		Initiation or re-initiation of ARISTADA for the treatment of Schizophrenia			U.S.
		Schizophrenia			U.S.
		Schizophrenia; Bipolar I disorder			U.S.
		Alcohol dependence; Opioid dependence			U.S.

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The following provides summary information regarding certain key third-party products using our proprietary technologies under license and our key licensed product, that are commercialized by our licensees:

Key Third-Party Products Using Our Proprietary Technologies

Product		Indication(s)		Licensee		Licensed Territory
INVEGA SUSTENNA / XEPLION		INVEGA SUSTENNA: Schizophrenia; Schizoaffective disorder XEPLION: Schizophrenia		Janssen Pharmaceutica (together with Janssen Pharmaceuticals, Inc., Janssen International and their affiliates “Janssen”)		Worldwide
INVEGA TRINZA / TREVICTA		Schizophrenia		Janssen		Worldwide
INVEGA HAFYERA / BYANNLI		Schizophrenia		Janssen		Worldwide

Our Key Licensed Product

Product		Indication(s)		Licensee		Licensed Territory
VUMERITY		Multiple sclerosis		Biogen		Worldwide

Proprietary Products

We have developed and now commercialize products designed to help address the unmet needs of people living with opioid dependence, alcohol dependence, schizophrenia and bipolar I disorder. See the “Patents and Proprietary Rights” section in “Part I, Item 1—Business” in our Annual Report for information with respect to the IP protection for our proprietary products.

ARISTADA and ARISTADA INITIO

ARISTADA (aripiprazole lauroxil) is an extended-release intramuscular injectable suspension approved in the U.S. for the treatment of schizophrenia. ARISTADA utilizes our proprietary LinkeRx technology. ARISTADA is a prodrug; once in the body, ARISTADA is likely converted by enzyme-mediated hydrolysis to N-hydroxymethyl aripiprazole, which is then hydrolyzed to aripiprazole. ARISTADA is available in four dose strengths with once-monthly dosing options (441 mg, 662 mg and 882 mg), a six-week dosing option (882 mg) and a two-month dosing option (1064 mg). ARISTADA is packaged in a ready-to-use, pre-filled syringe product format. We exclusively manufacture and commercialize ARISTADA in the U.S.

In May 2025, U.S. Patent No. 12,311,027 relating to ARISTADA was granted. The patent has claims to pharmaceutical compositions that confer long-term stability of the ARISTADA formulation and methods of treating schizophrenia and expires in 2033.

ARISTADA INITIO (aripiprazole lauroxil) leverages our proprietary LinkeRx and NanoCrystal technologies and provides an extended-release formulation of aripiprazole lauroxil in a smaller particle size compared to ARISTADA, thereby enabling faster dissolution and more rapid achievement of relevant levels of aripiprazole in the body. ARISTADA INITIO, combined with a single 30 mg dose of oral aripiprazole, is indicated for the initiation of ARISTADA when used for the treatment of schizophrenia in adults. The first ARISTADA dose may be administered on the same day as the ARISTADA INITIO regimen or up to 10 days thereafter. We exclusively manufacture and commercialize ARISTADA INITIO in the U.S.

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LYBALVI

LYBALVI (olanzapine and samidorphan) is a once-daily, oral atypical antipsychotic drug approved in the U.S. for the treatment of adults with schizophrenia and for the treatment of adults with bipolar I disorder, as a maintenance monotherapy or for the acute treatment of manic or mixed episodes, as monotherapy or an adjunct to lithium or valproate. LYBALVI is a combination of olanzapine, an atypical antipsychotic, and samidorphan, an opioid antagonist, in a single bilayer tablet. LYBALVI is available in fixed dosage strengths composed of 10 mg of samidorphan and 5 mg, 10 mg, 15 mg or 20 mg of olanzapine. We exclusively manufacture and commercialize LYBALVI in the U.S.

VIVITROL

VIVITROL (naltrexone for extended-release injectable suspension) is a once-monthly, non-narcotic, injectable medication approved in the U.S. for the treatment of alcohol dependence in patients able to abstain from alcohol in an outpatient setting prior to initiation of treatment with VIVITROL and for the prevention of relapse to opioid dependence, following opioid detoxification. VIVITROL uses our polymer-based microsphere injectable extended-release technology to deliver and maintain therapeutic medication levels in the body through one intramuscular injection every four weeks. We exclusively manufacture and commercialize VIVITROL in the U.S.

Products Using Our Proprietary Technologies and Licensed Product

We have licensed products to third parties for commercialization and have licensed our proprietary technologies to third parties to enable them to develop, commercialize and/or manufacture products. See the “Proprietary Technology Platforms” and “Patents and Proprietary Rights” sections in “Part I, Item 1—Business” in our Annual Report for information with respect to our proprietary technologies and the IP protection for these products. We receive royalties and/or manufacturing and other revenues from the commercialization of these products under our collaborative arrangements with these third parties. Such arrangements, among others, include the following:

Products Using Our Proprietary Technologies

INVEGA SUSTENNA/XEPLION, INVEGA TRINZA/TREVICTA and INVEGA HAFYERA/BYANNLI

The long-acting INVEGA products are long-acting atypical antipsychotics owned and commercialized worldwide by Janssen. We believe that these products incorporate our technologies.

INVEGA SUSTENNA is approved in the U.S. for the treatment of schizophrenia and for the treatment of schizoaffective disorder as either a monotherapy or adjunctive therapy. Paliperidone palmitate extended-release injectable suspension is approved in the European Union (“EU”) and other countries outside of the U.S. for the treatment of schizophrenia and is marketed and sold under the trade name XEPLION. INVEGA SUSTENNA/XEPLION is manufactured by Janssen.

INVEGA TRINZA is approved in the U.S. for the treatment of schizophrenia in patients who have been adequately treated with INVEGA SUSTENNA for at least four months. TREVICTA is approved in the EU for the maintenance treatment of schizophrenia in adult patients who are clinically stable on XEPLION. INVEGA TRINZA/TREVICTA is manufactured by Janssen.

INVEGA HAFYERA is approved in the U.S. for the treatment of schizophrenia in patients who have been adequately treated with INVEGA SUSTENNA for at least four months or INVEGA TRINZA for at least three months. BYANNLI is approved in the EU for the maintenance treatment of schizophrenia in adult patients who are clinically stable on XEPLION or TREVICTA. INVEGA HAFYERA/BYANNLI is manufactured by Janssen.

For a discussion of legal proceedings related to certain of the patents covering INVEGA TRINZA, see Note 16, Commitments and Contingent Liabilities in the “Notes to Condensed Consolidated Financial Statements” in this Form 10-Q and for information about risks relating to such legal proceedings, see “Part I, Item 1A—Risk Factors” in our Annual Report and specifically the section entitled “Uncertainty over IP in the biopharmaceutical industry has been the source of litigation and other legal proceedings, and we or our licensees may face claims against IP rights covering our products and competition from generic drug manufacturers.”

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Licensed Product

VUMERITY

VUMERITY (diroximel fumarate) is a novel, oral fumarate with a distinct chemical structure that is approved in the U.S., the EU and several other countries for the treatment of relapsing forms of multiple sclerosis in adults, including clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.

Under our license and collaboration agreement with Biogen, Biogen holds the exclusive, worldwide license to develop and commercialize VUMERITY. For more information about the license and collaboration agreement with Biogen, see the “Collaborative Arrangements—Biogen” section in “Part I, Item 1—Business” in our Annual Report. For a discussion of legal proceedings related to certain of the patents covering VUMERITY, see Note 16, Commitments and Contingent Liabilities in the “Notes to Condensed Consolidated Financial Statements” in this Form 10-Q, and for information about risks relating to such legal proceedings, see “Part I, Item 1A—Risk Factors” in our Annual Report and specifically the section entitled “Uncertainty over IP in the biopharmaceutical industry has been the source of litigation and other legal proceedings, and we or our licensees may face claims against IP rights covering our products and competition from generic drug manufacturers.”

Key Development Program

Our R&D is focused on the development of innovative medicines in the field of neuroscience that are designed to address unmet patient needs. As part of our ongoing R&D efforts, we have devoted, and will continue to devote, significant resources to conducting preclinical work and clinical studies to advance the development of new pharmaceutical products. The discussion below highlights our current key development program. Drug development involves a high degree of risk and investment, and the status, timing and scope of our development programs are subject to change. Important factors that could adversely affect our drug development efforts are discussed in “Part I, Item 1A—Risk Factors” in our Annual Report and “Part II, Item 1A—Risk Factors” in this Form 10-Q. See the “Patents and Proprietary Rights” section in “Part I, Item 1—Business” in our Annual Report for information with respect to the IP protection for our key development program.

Alixorexton (formerly referred to as ALKS 2680)

Alixorexton is a novel, investigational, oral, selective orexin 2 receptor agonist in development as a once-daily treatment for narcolepsy type 1 (“NT1”), narcolepsy type 2 (“NT2”) and idiopathic hypersomnia (“IH”). Orexin, a neuropeptide produced in the lateral hypothalamus, is considered to be the master regulator of wakefulness due to its activation of multiple, downstream wake-promoting pathways that project widely throughout the brain. Targeting the orexin system may address excessive daytime sleepiness across hypersomnolence disorders, whether or not deficient orexin signaling is the underlying cause of disease. Once-daily oral administration of alixorexton was previously evaluated in a phase 1 study in healthy volunteers and patients with NT1, NT2 and IH and is currently being evaluated in the phase 2 Vibrance-1, Vibrance-2 and Vibrance-3 studies in patients with NT1, NT2 and IH, respectively. In July 2025, we announced that alixorexton achieved the primary endpoint in the Vibrance-1 study in patients with NT1 and that we are proceeding with plans for initiation of a phase 3 program in narcolepsy.

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Results of Operations

Product Sales, Net

Our product sales, net, consist of sales of VIVITROL, ARISTADA and ARISTADA INITIO, and LYBALVI, primarily to wholesalers, specialty distributors and pharmacies. The following table presents the adjustments deducted from product sales, gross to arrive at product sales, net, for sales of VIVITROL, ARISTADA and ARISTADA INITIO, and LYBALVI during the three and six months ended June 30, 2025 and 2024:

	Three Months Ended																		Six Months Ended
	June 30,																		June 30,
(In millions, except for % of Sales)	2025				% of Sales					2024				% of Sales					2025				% of Sales					2024				% of Sales
Product sales, gross	$	564.8				100.0		%		$	533.0				100.0		%		$	1,037.6				100.0		%		$	1,000.3				100.0		%
Adjustments to product sales, gross:
Medicaid rebates		(105.2	)			(18.6	)	%			(122.6	)			(23.0	)	%			(199.5	)			(19.2	)	%			(227.6	)			(22.8	)	%
Chargebacks		(64.4	)			(11.4	)	%			(56.5	)			(10.6	)	%			(118.3	)			(11.4	)	%			(107.0	)			(10.7	)	%
Product discounts		(41.4	)			(7.3	)	%			(38.4	)			(7.2	)	%			(78.7	)			(7.6	)	%			(72.7	)			(7.3	)	%
Medicare Part D		(20.5	)			(3.7	)	%			(21.5	)			(4.0	)	%			(38.2	)			(3.7	)	%			(38.9	)			(3.9	)	%
Other		(26.1	)			(4.6	)	%			(24.7	)			(4.6	)	%			(51.2	)			(4.9	)	%			(51.3	)			(5.1	)	%
Total adjustments		(257.6	)			(45.6	)	%			(263.7	)			(49.5	)	%			(485.9	)			(46.8	)	%			(497.5	)			(49.8	)	%
Product sales, net	$	307.2				54.4		%		$	269.3				50.5		%		$	551.7				53.2		%		$	502.8				50.2		%

The increase in product sales, gross during the three months ended June 30, 2025, as compared to the three months ended June 30, 2024, was due to increases of 14% and 2% in the number of units sold for LYBALVI and ARISTADA/ARISTADA INITIO, respectively, and a 3% price increase for each of our proprietary products that went into effect on January 1, 2025. These increases were partially offset by a 1% decrease in the number of units sold for VIVITROL.

The increase in product sales, gross during the six months ended June 30, 2025, as compared to the six months ended June 30, 2024, was primarily due to a 17% increase in the number of LYBALVI units sold and the 3% price increase for each of our proprietary products that went into effect on January 1, 2025. These increases were partially offset by 3% decreases in the number of units sold for each of VIVITROL and ARISTADA/ARISTADA INITIO.

The decreases in Medicaid rebates, as a percentage of sales, during the three and six months ended June 30, 2025, as compared to the three and six months ended June 30, 2024, were primarily due to actual Medicaid rebates related to VIVITROL and ARISTADA/ARISTADA INITIO, which were lower than original estimates by approximately $9.0 million and $17.7 million for VIVITROL during the three and six months ended June 30, 2025, respectively, and by approximately $7.2 million for ARISTADA/ARISTADA INITIO during the three months ended June 30, 2025.

The following table compares product sales, net earned during the three and six months ended June 30, 2025 and 2024:

	Three Months Ended												Six Months Ended
	June 30,												June 30,
(In millions)	2025				2024				Change				2025				2024				Change
VIVITROL	$	121.7			$	111.9			$	9.8			$	222.7			$	209.5			$	13.2
ARISTADA and ARISTADA INITIO		101.3				86.0				15.3				174.8				164.9				9.9
LYBALVI		84.3				71.4				12.9				154.3				128.4				25.9
Product sales, net	$	307.2			$	269.3			$	38.0			$	551.7			$	502.8			$	49.0

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Manufacturing and Royalty Revenues

The following table compares manufacturing and royalty revenues earned during the three and six months ended June 30, 2025 and 2024:

	Three Months Ended												Six Months Ended
	June 30,												June 30,
(In millions)	2025				2024				Change				2025				2024				Change
Manufacturing and royalty revenues:
Long-acting INVEGA products	$	30.3			$	78.7			$	(48.4	)		$	48.1			$	141.4			$	(93.3	)
VUMERITY		39.4				35.2				4.2				67.2				66.5				0.7
RISPERDAL CONSTA		3.8				3.6				0.2				12.9				6.3				6.6
Other		9.9				12.4				(2.5	)			17.2				32.5				(15.3	)
Manufacturing and royalty revenues	$	83.4			$	129.9			$	(46.5	)		$	145.4			$	246.7			$	(101.3	)

The decreases in royalty revenues related to the long-acting INVEGA products during the three and six months ended June 30, 2025, as compared to the three and six months ended June 30, 2024, were primarily due to the expiration of our royalty on net sales of INVEGA SUSTENNA in the U.S. in August 2024. We expect royalty revenues from net sales of the long-acting INVEGA products to continue to be lower for the remainder of 2025, as the royalty revenues related to net sales of INVEGA SUSTENNA in the U.S. comprised a significant portion of the overall royalty revenues for the long-acting INVEGA products. In addition, each of INVEGA SUSTENNA and INVEGA TRINZA is currently subject to Paragraph IV litigation in response to companies seeking to market generic versions of such product. Increased competition from new products or generic versions of any one or more of the long-acting INVEGA products may lead to reduced unit sales of the long-acting INVEGA products, including those not yet genericized, and increased pricing pressure. For a discussion of the legal proceedings related to INVEGA TRINZA, see Note 16, Commitments and Contingent Liabilities in the “Notes to Condensed Consolidated Financial Statements” in this Form 10-Q, and for information about risks relating to these legal proceedings, see “Part I, Item 1A—Risk Factors” in our Annual Report, and specifically the section entitled “Uncertainty over IP in the biopharmaceutical industry has been the source of litigation and other legal proceedings, and we or our licensees may face claims against IP rights covering our products and competition from generic drug manufacturers.”

The increases in VUMERITY revenue during the three and six months ended June 30, 2025, as compared to the three and six months ended June 30, 2024, were due to increases of $6.6 million and $9.4 million, respectively, in royalty revenue, offset by decreases of $2.5 million and $8.6 million, respectively, in manufacturing revenue. The increases in VUMERITY royalty revenue were primarily due to increases in end-market sales of the product. The decreases in VUMERITY manufacturing revenue were primarily due to reductions in the number of batches manufactured for sale to Biogen. The increase in RISPERDAL CONSTA revenue during the six months ended June 30, 2025, as compared to the six months ended June 30, 2024, was due to a $6.9 million increase in manufacturing revenue, primarily due to an increase in the number of batches made available to Janssen for sale in the U.S., which has a higher selling price than product sold outside of the U.S. The decreases in Other manufacturing and royalty revenue during the three and six months ended June 30, 2025, as compared to the three and six months ended June 30, 2024, were primarily due to decreases of $3.1 million and $13.6 million, respectively, in revenue from FAMPYRA, as our manufacturing obligations for FAMPYRA concluded on December 31, 2024.

Costs and Expenses

Cost of Goods Manufactured and Sold

	Three Months Ended												Six Months Ended
	June 30,												June 30,
(In millions)	2025				2024				Change				2025				2024				Change
Cost of goods manufactured and sold	$	49.5			$	61.5			$	(12.0	)		$	98.7			$	120.1			$	(21.4	)

The decreases in the cost of goods manufactured and sold during the three and six months ended June 30, 2025, as compared to the three and six months ended June 30, 2024, were primarily related to decreases of $13.7 million and $20.7 million, respectively, in the cost of goods manufactured for certain legacy products following the sale of the Athlone Facility in May 2024 and decreases in the cost of goods sold for VIVITROL during each period due to decreases in the number of units sold, as discussed above. These decreases were partially offset by increases in the cost of goods sold for LYBALVI due to increases in the number of units sold in each period, as discussed above.

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Research and Development Expenses

For each of our R&D programs, we incur both external and internal expenses. External R&D expenses include fees for clinical and preclinical activities performed by contract research organizations, consulting fees, and costs related to laboratory services, the purchase of drug product materials and third-party manufacturing development activities. Internal R&D expenses include employee-related expenses, occupancy costs, depreciation and general overhead. We track external R&D expenses for each of our development programs; however, internal R&D expenses are not tracked by individual program as they can benefit multiple development programs or our products or technologies in general.

The following table sets forth our external R&D expenses for the three and six months ended June 30, 2025 and 2024 relating to our then-current development programs and our internal R&D expenses, listed by the nature of such expenses:

		Three Months Ended												Six Months Ended
		June 30,												June 30,
(In millions)		2025				2024				Change				2025				2024				Change
External R&D expenses:
Development programs:
Alixorexton		$	23.8			$	12.5			$	11.3			$	41.6			$	23.0			$	18.6
LYBALVI			5.0				3.8				1.2				8.9				8.8				0.1
Other external R&D expenses			10.6				10.0				0.6				21.6				18.8				2.8
Total external R&D expenses			39.4				26.3				13.1				72.1				50.6				21.5
Internal R&D expenses:
Employee-related			30.6				26.3				4.3				62.0				60.8				1.2
Occupancy			3.3				2.8				0.5				6.4				5.8				0.6
Depreciation			1.5				1.4				0.1				2.9				2.8				0.1
Other			2.6				2.8				(0.2	)			5.8				7.3				(1.5	)
Total internal R&D expenses			38.0				33.3				4.7				77.1				76.7				0.4
Research and development expenses		$	77.4			$	59.6			$	17.8			$	149.2			$	127.3			$	21.9

These amounts are not necessarily predictive of future R&D expenses. In an effort to allocate our spending most effectively, we continually evaluate our products under development based on the performance of such products in preclinical and/or clinical trials, our expectations regarding the likelihood of their regulatory approval and our view of their future potential commercial viability, among other factors.

The increases in expenses related to alixorexton during the three and six months ended June 30, 2025, as compared to the three and six months ended June 30, 2024, were primarily due to increased spend related to the advancement of the development program for the product, including initiation of our Vibrance-3 phase 2 clinical study and costs related to our long-term extension study for the product, partially offset by the completion of our first-in-human phase 1 clinical study for the product in the first half of 2024. The increase in expenses related to LYBALVI during the three months ended June 30, 2025, as compared to the three months ended June 30, 2024, was primarily due to increased spend on our pediatric program related to the product. The increase in other external R&D expenses during the six months ended June 30, 2025, as compared to the six months ended June 30, 2024, was primarily due to activities associated with our preclinical development programs. The increases in employee-related expenses during the three and six months ended June 30, 2025, as compared to the three and six months ended June 30, 2024, were primarily due to increases in labor and benefits expense related to a 10% increase in R&D-related headcount. The increase in employee-related expenses during the six months ended June 30, 2025, as compared to the six months ended June 30, 2024, was partially offset by a decrease in share-based compensation expense.

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Selling, General and Administrative Expense

		Three Months Ended												Six Months Ended
		June 30,												June 30,
(In millions)		2025				2024				Change				2025				2024				Change
Selling and marketing expense		$	121.2			$	119.7			$	1.5			$	244.1			$	245.3			$	(1.2	)
General and administrative expense			49.6				48.4				1.2				98.5				102.6				(4.1	)
Selling, general and administrative expense		$	170.8			$	168.1			$	2.7			$	342.6			$	347.9			$	(5.3	)

The increase in selling and marketing expense during the three months ended June 30, 2025, as compared to the three months ended June 30, 2024, was primarily due to an increase of $10.4 million in employee-related expenses, primarily due to a 13% increase in sales and marketing-related headcount, partially offset by a decrease of $8.9 million in marketing spend, primarily related to decreases in media spend for our proprietary products.

The decrease in selling and marketing expense during the six months ended June 30, 2025, as compared to the six months ended June 30, 2024, was primarily due to a decrease of $13.3 million in in marketing spend, primarily related to decreases in media spend for our proprietary products, partially offset by an increase of $12.1 million in employee-related expenses, primarily due to the increase in sales and marketing-related headcount noted above.

The increase in general and administrative expense during the three months ended June 30, 2025, as compared to the three months ended June 30, 2024, was primarily due to an increase of $2.0 million in employee-related expenses, primarily due to a 6% increase in general and administrative-related headcount and an increase of $1.0 million in professional services fees, primarily related to an increase in legal expenses. These increases were offset by a decrease of $1.4 million related to branded prescription drug fees.

The decrease in general and administrative expense during the six months ended June 30, 2025, as compared to the six months ended June 30, 2024, was primarily due to a decrease of $1.4 million related to branded prescription drug fees, a decrease of $1.2 million in professional service fees and a decrease of $0.7 million in share-based compensation expense. The decrease in professional service fees was primarily related to the timing of legal expenses. The decrease in share-based compensation expense was partially offset by a $1.1 million increase in salary expense, primarily due to the increase in general and administrative-related headcount noted above.

Other Income, Net

		Three Months Ended												Six Months Ended
		June 30,												June 30,
(In millions)		2025				2024				Change				2025				2024				Change
Interest income		$	11.1			$	10.7			$	0.4			$	21.2			$	20.1			$	1.1
Interest expense			—				(5.9	)			5.9				—				(11.9	)			11.9
Other income, net			0.8				2.0				(1.2	)			2.4				2.2				0.2
Total other income, net		$	11.9			$	6.8			$	5.1			$	23.6			$	10.4			$	13.2

Interest income consists of interest earned on our cash and available-for-sale investments. Interest expense consists of interest incurred on our previously outstanding term loans (the “Former Term Loans”) that were scheduled to become due in 2026 under our former amended and restated credit agreement, which we prepaid in full and terminated in December 2024. See Note 12, Long-Term Debt in the “Notes to Consolidated Financial Statements” accompanying our Annual Report for additional information regarding our Former Term Loans.

Income Tax Provision

		Three Months Ended												Six Months Ended
		June 30,												June 30,
(In millions)		2025				2024				Change				2025				2024				Change
Income tax provision			17.7				22.1			$	(4.4	)		$	20.8			$	30.0			$	(9.2	)

The income tax provisions in each of the three and six months ended June 30, 2025 and 2024 were primarily attributable to taxes on income earned in Ireland.

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Liquidity and Financial Condition

Our financial condition is summarized as follows:

		June 30, 2025												December 31, 2024
(In millions)		U.S.				Ireland				Total				U.S.				Ireland				Total
Cash and cash equivalents		$	106.4			$	414.8			$	521.2			$	70.3			$	220.8			$	291.1
Investments—short-term			204.4				290.1				494.5				203.6				256.9				460.5
Investments—long-term			18.3				20.0				38.3				24.6				48.5				73.1
Total cash and investments		$	329.1			$	724.9			$	1,054.0			$	298.5			$	526.2			$	824.7

At June 30, 2025 our investments consisted of the following:

						Gross
		Amortized				Unrealized								Allowance for				Estimated
(In millions)		Cost				Gains				Losses				Credit Losses				Fair Value
Investments—short-term available-for-sale		$	492.6			$	1.9			$	—			$	—			$	494.5
Investments—long-term available-for-sale			38.3				—				(0.1	)			—				38.2
Investments—long-term held-to-maturity			0.1				—				—				—				0.1
Total		$	531.0			$	1.9			$	(0.1	)		$	—			$	532.8

Sources and Uses of Cash

We generated $249.0 million and $167.1 million of cash from operating activities during the six months ended June 30, 2025 and 2024, respectively. We expect that our existing cash, cash equivalents and investments will be sufficient to finance our anticipated working capital and other cash requirements, including capital expenditures, for not less than twelve months following the date from which our financial statements were issued. Subject to market conditions, interest rates and other factors, we may pursue opportunities to obtain financing in the future, including debt and equity offerings, corporate collaborations, bank borrowings, arrangements relating to assets or other financing methods or structures.

Our investment objectives are, first, to preserve liquidity and conserve capital and, second, to generate investment income. We mitigate credit risk in our cash reserves by maintaining a well-diversified portfolio that limits the amount of investment exposure as to institution, maturity and investment type. Our available-for-sale investments consist primarily of short and long-term U.S. government and agency debt securities and corporate debt securities. Our held-to-maturity investments consist of investments that are held as collateral under certain letters of credit related to certain of our lease agreements.

We classify available-for-sale investments in an unrealized loss position that do not mature within 12 months as long-term investments. We have the intent and ability to hold these investments until recovery, which may be at maturity, and it is more-likely-than-not that we would not be required to sell these securities before recovery of their amortized cost.

We have no off-balance sheet arrangements that are reasonably likely to have a material effect on our financial condition, changes in financial condition, revenues or expenses, results of operations, liquidity, capital expenditures, or capital resources in the next 12 months.

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Information about our cash flows, by category, is presented in the accompanying condensed consolidated statements of cash flows. The discussion of our cash flows that follows does not include the impact of any adjustments to remove discontinued operations and is stated on a total company consolidated basis. The following table summarizes our cash flows for the six months ended June 30, 2025 and 2024:

		Six Months Ended
		June 30,
(In millions)		2025				2024
Cash and cash equivalents, beginning of period		$	291.1			$	457.5
Cash flows provided by operating activities			249.0				167.1
Cash flows (used in) provided by investing activities			(20.1	)			12.0
Cash flows provided by (used in) financing activities			1.2				(101.4	)
Cash and cash equivalents, end of period		$	521.2			$	535.2

Operating Activities

Cash flows provided by operating activities represent the cash receipts and disbursements related to all of our activities other than investing and financing activities. Operating cash flow is derived by adjusting our net income for non-cash operating items such as depreciation, amortization and share-based compensation and changes in operating assets and liabilities, which reflect timing differences between the receipt and payment of cash associated with transactions and when they are recognized in our results of operations.

Cash flows provided by operating activities for the six months ended June 30, 2025 primarily consisted of $109.6 million of net income, adjusted for non-cash items, including $47.8 million of share-based compensation, $15.2 million of depreciation and amortization and changes of $74.1 million in working capital.

Cash flows provided by operating activities for the six months ended June 30, 2024 primarily consisted of $128.2 million of net income, adjusted for non-cash items, including $53.4 million of share-based compensation, $14.7 million of depreciation and amortization, $21.7 million of deferred income taxes and a gain of $1.5 million on the sale of the Athlone Facility, partially offset by changes of $51.5 million in working capital.

Investing Activities

Cash flows used in investing activities for the six months ended June 30, 2025 were primarily due to the purchase of $23.1 million of property, plant and equipment, partially offset by $1.3 million in net sales of investments. Cash flows provided by investing activities for the six months ended June 30, 2024 were primarily due to proceeds of approximately $97.9 million related to the sale of the Athlone Facility, which included a payment of approximately $91.0 million for the facility and certain related assets, partially offset by $71.0 million in net purchase of investments and the purchase of $15.5 million of property, plant and equipment.

Financing Activities

Cash flows provided by financing activities for the six months ended June 30, 2025 were due to $31.6 million of cash that we received upon exercises of employee stock options, offset by $30.4 million of employee taxes paid related to the net share settlement of equity awards. Cash flows used in financing activities for the six months ended June 30, 2024 primarily related to $84.7 million used to repurchase our ordinary shares under the Repurchase Program and $29.0 million of employee taxes paid related to the net share settlement of equity awards, partially offset by $13.8 million of cash that we received upon exercises of employee stock options.

Critical Accounting Estimates

The discussion and analysis of our financial condition and results of operations is based on our financial statements, which have been prepared in accordance with GAAP. The preparation of these financial statements requires us to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of our financial statements, and the reported amounts of revenues and expenses during the reporting period. Actual results may differ from these estimates under different conditions or using different assumptions.

See the “Critical Accounting Estimates” section in “Part II, Item 7—Management’s Discussion and Analysis of Financial Condition and Results of Operations” in our Annual Report for a discussion of our critical accounting estimates.

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New Accounting Standards

See the “New Accounting Pronouncements” section in Note 2, Summary of Significant Accounting Policies in the “Notes to Condensed Consolidated Financial Statements” in this Form 10-Q for discussion of certain recent accounting standards applicable to us.

Item 3. Quantitative and Qualitative Disclosures About Market Risk

Market risks related to our investment portfolio, and the ways we manage such risks, are summarized in “Part II, Item 7A—Quantitative and Qualitative Disclosures About Market Risk” in our Annual Report. We regularly review our marketable securities holdings and shift our investment holdings to those that best meet our investment objectives, which are to preserve capital, provide sufficient liquidity to satisfy operating requirements and generate investment income. Apart from such adjustments to our investment portfolio, there have been no material changes to our market risks since December 31, 2024, and we do not anticipate any near-term changes in the nature of our market risk exposures or in our management’s objectives and strategies with respect to managing such exposures.

We are exposed to non-U.S. currency exchange risk related primarily to royalty revenues that we receive on certain of our products, partially offset by certain operating costs arising from expenses and payables in connection with our Irish operations that are settled predominantly in euro. These non-U.S. currency exchange rate risks are summarized in “Part II, Item 7A—Quantitative and Qualitative Disclosures About Market Risk” in our Annual Report. There has been no material change in our assessment of our sensitivity to non-U.S. currency exchange rate risk since December 31, 2024.

Item 4. Controls and Procedures

a) Evaluation of Disclosure Controls and Procedures

Our management has evaluated, with the participation of our principal executive officer and interim principal financial officer, the effectiveness of our disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act) as of June 30, 2025. Based upon that evaluation, our principal executive officer and interim principal financial officer each concluded that, as of the end of the period covered by this report, our disclosure controls and procedures were effective to provide reasonable assurance that (a) the information required to be disclosed by us in the reports that we file or submit under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms, and (b) such information is accumulated and communicated to our management, including our principal executive officer and interim principal financial officer, as appropriate, to allow timely decisions regarding required disclosure. In designing and evaluating our disclosure controls and procedures, our management recognized that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving the desired control objectives, and our management necessarily was required to apply its judgment in evaluating the cost-benefit relationship of possible controls and procedures.

b) Change in Internal Control Over Financial Reporting

During the three months ended June 30, 2025, there have been no changes in our internal control over financial reporting that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

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PART II. OTHER INFORMATION

Item 1. Legal Proceedings

For information regarding legal proceedings, see the discussion of legal proceedings in Note 16, Commitments and Contingent Liabilities in the “Notes to Condensed Consolidated Financial Statements” in this Form 10-Q, which discussion is incorporated into this Part II, Item 1 by reference.

Item 1A. Risk Factors

The below risk factor should be read in conjunction with the risk factors disclosed in “Part I, Item 1A—Risk Factors” of our Annual Report.

Changes in global trade or other policies, including tariffs or other restrictions imposed by the U.S. government or governments of other nations, could have an adverse effect on our business, results of operations, or financial condition.

As a global biopharmaceutical company, changes in and uncertainties from global trade or other policies, including tariffs or other restrictions imposed by the U.S. government or governments of other nations, may have an adverse effect on us. For example, in April 2025, the U.S. government announced the imposition of a baseline 10% tariff on imports from virtually all countries and additional customized tariffs on certain imports (including country-specific and product-specific tariffs), following its imposition of a 25% tariff on certain imports from Mexico and Canada earlier in 2025. In response, certain countries have imposed, or announced intentions to impose, tariffs on U.S. imports. Although some of these tariffs are temporarily paused, their impact has already been seen, and we expect will continue to be seen, in global markets. Our proprietary products are manufactured at our manufacturing facility in the U.S. and are sold exclusively in the U.S.; however, certain materials in our supply chain are sourced internationally and certain of the third-party products from which we derive revenue are manufactured outside the U.S. Our related costs, revenues and/or profits may be impacted to varying degrees by recent or future changes in global trade or other policies. In addition, the recent changes, tensions and uncertainties related to global trade policies have caused, and may continue to cause, significant volatility in global markets, including the market for our ordinary shares. The price of our ordinary shares has fluctuated significantly, and may continue to fluctuate, as a result of these and similar developments. The U.S. government has also indicated that it may impose a supplemental tariff on all pharmaceutical imports or take additional actions in respect of pharmaceutical companies incorporated outside of the U.S., which has caused, and may continue to cause, uncertainty as to the extent of the impacts of changes in global trade on the pharmaceutical industry as a whole and on our business. Additional changes to the policies of the U.S. or other nations that affect the geopolitical landscape or global trade, economic or market conditions, and other direct or indirect impacts of such policies, are uncertain and unpredictable, and could, in the future, have a material adverse effect on our business, results of operations, or financial condition and the market price of our ordinary shares.

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Item 2. Unregistered Sales of Equity Securities and Use of Proceeds

The following table summarizes purchases of our ordinary shares made by or on behalf of us or any of our affiliated purchasers, as defined in Rule 10b-18(a)(3) under the Exchange Act, during the three months ended June 30, 2025:

Period		Total Number of Ordinary Shares Purchased (a)(1)				Average Price Paid per Ordinary Share (b)				Total Number of Ordinary Shares Purchased as Part of Publicly Announced Program (c)(2)				Approximate Dollar Value (in millions) of Ordinary Shares that May Yet Be Purchased Under the Program (d)(2)
April 1, 2025 – April 30, 2025			21,598			$	28.12				—			$	200.0
May 1, 2025 – May 31, 2025			30,590				30.59				—				200.0
June 1, 2025 – June 30, 2025			4,269				31.52				—				200.0
Totals			56,457			$	29.72				—

(1)Consists of ordinary shares acquired during the three months ended June 30, 2025 to satisfy tax withholding obligations related to the vesting of equity awards.

(2)In February 2024, we announced approval by our board of directors of the Repurchase Program, which authorized the repurchase of our ordinary shares in an aggregate amount of up to $400.0 million (exclusive of any fees, commissions or other expenses related to such repurchases) from time to time. The specific timing and amounts of repurchases under the Repurchase Program will depend on a variety of factors, including but not limited to ongoing assessments of our needs, alternative investment opportunities, the market price of our ordinary shares and general market conditions. The Repurchase Program has no set expiration date and may be suspended or discontinued at any time.

Item 5. Other Information

During the three months ended June 30, 2025, the following contracts, instructions or written plans for the purchase or sale of the Company’s securities that are or were intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act (each, a “Rule 10b5-1 plan”) were adopted by the officers (as defined in Rule 16a-1(f) under the Exchange Act) and directors of the Company: on June 13, 2025, Nancy Lurker, a director, adopted a Rule 10b5-1 plan providing for the sale of up to 2,000 ordinary shares of the Company; this plan is scheduled to expire on December 11, 2025. During the three months ended June 30, 2025, no other directors or officers of the Company adopted, modified or terminated a Rule 10b5-1 plan or a trading plan not intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act.

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Item 6. Exhibits

The following exhibits are filed or furnished as part of this Form 10-Q:

EXHIBIT INDEX

Exhibit No.		Description of Exhibit
10.1 †		Alkermes plc 2018 Stock Option and Incentive Plan, as amended (incorporated by reference from Exhibit 10.1 to the Alkermes plc Current Report on Form 8-K (File No. 001-35299) filed on May 21, 2025.
31.1 #		Rule 13a-14(a)/15d-14(a) Certification.
31.2 #		Rule 13a-14(a)/15d-14(a) Certification.
32.1 ‡		Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
101.SCH #		Inline XBRL Taxonomy Extension Schema Document with Embedded Linkbase Documents.
104 #		Cover Page Interactive Data File (formatted as Inline XBRL with applicable taxonomy extension information contained in Exhibit 101).

# Filed herewith.

‡ Furnished herewith.

† Indicates a management contract or any compensatory plan, contract or arrangement.

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

	ALKERMES PLC
	(Registrant)
	By:	/s/ Richard F. Pops
		Richard F. Pops
		Chairman and Chief Executive Officer
		(Principal Executive Officer)
	By:	/s/ Blair C. Jackson
		Blair C. Jackson
		Executive Vice President, Chief Operating Officer
		(Interim Principal Financial Officer)
Date: July 29, 2025

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FAQ

How did ALKS’s total revenue change in Q2 2025?

Total revenue slipped 2 % YoY to $390.7 million, as lower royalties offset higher product sales.

Which ALKS products drove growth this quarter?

VIVITROL $121.7 m, ARISTADA $101.3 m, and LYBALVI $84.3 m all posted double-digit percentage gains.

Why did royalty revenue decline for Alkermes?

Royalties from long-acting INVEGA products fell 61 % after U.S. patent expiry for INVEGA SUSTENNA in Aug-24.

What is Alkermes’ current cash position?

Cash & equivalents rose to $521 million at 30 Jun 25, almost doubling since year-end.

Has Alkermes repurchased additional shares in 2025?

No. The company executed no buybacks YTD; $200 million remains authorized under the program.

What impact does the Zydus settlement have on VUMERITY?

It grants Zydus a license only immediately before patent expiry, effectively keeping U.S. exclusivity intact until then.