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Amylyx CFO James M. Frates sells 40,000 shares

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Form Type
4

Rhea-AI Filing Summary

Amylyx Pharmaceuticals, Inc. Chief Financial Officer James M. Frates exercised options for 20,000 common shares at $6.88 per share on November 9 and another 20,000 on November 10, 2026. He sold 20,000 shares on each date: 7,700 at a weighted average $29.3887 and 12,300 at $30.1105 on November 9; 12,800 at $30.3209 and 7,200 at $30.9698 on November 10. The transactions were effected under a Rule 10b5-1 trading plan adopted April 10, 2026.

Insider FRATES JAMES M
Role Chief Financial Officer
Sold 40,000 shs ($1.21M)
Approx. gross sale proceeds $1.21M
Approx. exercise cost $275K
Approx. pre-tax spread $933K
Share of Position Sold 14.6%
Type Security Shares Price Value
Exercise Stock Option (right to buy) F1, F10 20,000 $0.00 $0.00
Exercise Common Stock F1 20,000 $6.88 $138K
Sale Common Stock F1, F4 12,800 $30.3209 $388K
Sale Common Stock F1, F5 7,200 $30.9698 $223K
Exercise Stock Option (right to buy) F1, F10 20,000 $0.00 $0.00
Exercise Common Stock F1 20,000 $6.88 $138K
Sale Common Stock F1, F2 7,700 $29.3887 $226K
Sale Common Stock F1, F3 12,300 $30.1105 $370K
Holding Common Stock F6 -- -- --
Holding Common Stock F7 -- -- --
Holding Common Stock F8 -- -- --
Holding Common Stock F9 -- -- --
Holdings After Transaction: Stock Option (right to buy) — 323,835 options (Direct); Common Stock — 233,625 shares (Direct); Common Stock — 166,531 shares (Indirect, By Trust)
Holdings Before and After: Stock Option (right to buy), 363,835 to 323,835 options (Direct); Common Stock, 233,625 to 233,625 shares (Direct)
Other Insiders: 2 other insiders reported open-market sales of this stock in the 30 days up to this filing.
Footnotes (10)
  1. F1. The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on April 10, 2026.
  2. F2. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $28.81 to $29.71. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
  3. F3. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.82 to $30.29. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
  4. F4. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.86 to $30.73. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
  5. F5. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $30.905 to $31.15. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
  6. F6. Shares held by the JAMES M. FRATES 2025 GRAT NO 1 U/A DTD 12/12/2025, for which the Reporting Person serves as trustee and is the sole annuitant. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.
  7. F7. Shares held by the James M. Frates 2024 Grantor Retained Annuity Trust No. 1, for which the Reporting Person serves as trustee and is the sole annuitant. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.
  8. F8. Shares held by the FRATES FAMILY 2013 IRREV TRUST, for which the Reporting Person serves as trustee. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.
  9. F9. Shares held by the JAMES M. FRATES 2026 GRANTOR RETAINED ANNUITY TRUST NO. 1, for which the Reporting Person serves as trustee and is the sole annuitant. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.
  10. F10. This option is fully vested and exercisable.
Options exercised 20,000 shares November 9, 2026
Options exercised 20,000 shares November 10, 2026
Option exercise price $6.88 per share Options exercised on November 9 and November 10, 2026
Shares sold and weighted-average price 7,700 shares at $29.3887 per share November 9, 2026
Shares sold and weighted-average price 12,300 shares at $30.1105 per share November 9, 2026
Shares sold and weighted-average price 12,800 shares at $30.3209 per share November 10, 2026
Shares sold and weighted-average price 7,200 shares at $30.9698 per share November 10, 2026
Plan adoption date April 10, 2026 Rule 10b5-1 trading plan covering the reported transactions
Rule 10b5-1 trading plan regulatory
"Rule 10b5-1 trading plan adopted on April 10, 2026"
A Rule 10b5-1 trading plan is a pre-arranged schedule that allows company insiders to buy or sell stock at specific times, even if they have inside information. It helps prevent accusations of unfair trading by making these transactions look planned and transparent, rather than sneaky or illegal.
weighted average price financial
"The price reported in Column 4 is a weighted average price"
Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.
Stock Option (right to buy) financial
"Stock Option (right to buy)"
fully vested and exercisable financial
"This option is fully vested and exercisable"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many AMLX shares did the CFO sell, and at what prices?

James M. Frates sold 20,000 AMLX shares on November 9, 2026: 7,700 at a weighted average $29.3887 and 12,300 at $30.1105. On November 10, 2026, he sold 20,000 shares: 12,800 at $30.3209 and 7,200 at $30.9698. The sales were made under a Rule 10b5-1 plan adopted April 10, 2026.

How many AMLX options did the CFO exercise, and at what price?

James M. Frates exercised options for 20,000 common shares at $6.88 per share on each of November 9 and November 10, 2026. The reported option was fully vested and exercisable.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
FRATES JAMES M

(Last)(First)(Middle)
C/O AMYLYX PHARMACEUTICALS, INC.
55 CAMBRIDGE PARKWAY, SUITE 6W

(Street)
CAMBRIDGE MASSACHUSETTS 02142

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Amylyx Pharmaceuticals, Inc. [ AMLX ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director10% Owner
XOfficer (give title below)Other (specify below)
Chief Financial Officer
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
11/09/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock11/09/2026M(1)20,000A$6.88253,625D
Common Stock11/09/2026S(1)7,700D$29.3887(2)245,925D
Common Stock11/09/2026S(1)12,300D$30.1105(3)233,625D
Common Stock11/10/2026M(1)20,000A$6.88253,625D
Common Stock11/10/2026S(1)12,800D$30.3209(4)240,825D
Common Stock11/10/2026S(1)7,200D$30.9698(5)233,625D
Common Stock100,000IBy Trust(6)
Common Stock15,459IBy Trust(7)
Common Stock11,072IBy Trust(8)
Common Stock40,000IBy Trust(9)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (right to buy)$6.8811/09/2026M(1)20,000 (10)01/25/2031Common Stock20,000$0343,835D
Stock Option (right to buy)$6.8811/10/2026M(1)20,000 (10)01/25/2031Common Stock20,000$0323,835D
Explanation of Responses:
1. The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on April 10, 2026.
2. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $28.81 to $29.71. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
3. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.82 to $30.29. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
4. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.86 to $30.73. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
5. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $30.905 to $31.15. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
6. Shares held by the JAMES M. FRATES 2025 GRAT NO 1 U/A DTD 12/12/2025, for which the Reporting Person serves as trustee and is the sole annuitant. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.
7. Shares held by the James M. Frates 2024 Grantor Retained Annuity Trust No. 1, for which the Reporting Person serves as trustee and is the sole annuitant. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.
8. Shares held by the FRATES FAMILY 2013 IRREV TRUST, for which the Reporting Person serves as trustee. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.
9. Shares held by the JAMES M. FRATES 2026 GRANTOR RETAINED ANNUITY TRUST NO. 1, for which the Reporting Person serves as trustee and is the sole annuitant. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.
10. This option is fully vested and exercisable.
/s/ Joshua B. Cohen, as Attorney in Fact11/12/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

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