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Amylyx Pharmaceuticals, Inc. (AMLX) Financials

AMLX
FY2025 annual
Revenue $0 -100.0% YoY
Net Income -$144.7M +52.0% YoY
EPS (Diluted) -$1.53 +65.5% YoY
Free Cash Flow -$123.5M +26.4% YoY
Market Cap $3.5B as of Oct 3, 2026
Price / Sales n/m revenue is not positive, FY2025
Price / Earnings n/m net loss, so no earnings multiple, FY2025
Price / Book 14.8x on $239.2M equity, Q2 FY2026

A multiple compares the market's price with a filed figure; it says what the market pays, not how the business is doing. The market capitalization is the vendor's as of Oct 3, 2026; every other figure is from the SEC filings on this page. Not financial advice.

Source SEC Filings (10-K/10-Q) Latest period Q2 FY2026, ended Jun 30, 2026 Reported Currency USD FYE December

Newest figures come from the 10-Q for Q2 FY2026, filed Aug 6, 2026. Each column of the statement tables below links to the filing it was taken from, and every filing is listed on the AMLX SEC filings page.

Amylyx Pharmaceuticals, Inc. (AMLX) reported $0 in revenue for fiscal year 2025, down 100.0% from the prior fiscal year. This page shows its income statement, balance sheet, cash flow statement, and key financial ratios. View 5 years of annual fundamentals and quarterly data, with year-over-year growth rates and compound annual growth rates (CAGR). All figures are derived from SEC filings (10-K and 10-Q reports).

Rhea AI AMLX FY2025

The business remains loss-making, but 2025’s smaller deficit came from lower spending and financing capacity, not demonstrated operating scale.

Net loss narrowed from $302M in FY2024 to $145M in FY2025, but that improvement coincided with combined SG&A and R&D spending falling from $218M to $153M. The pattern points to cost reduction as the main mechanism, rather than scale-driven operating leverage.

Total liabilities were $27.4M against $332.6M of assets, a balance sheet funded far more by equity than obligations. Liquidity equaled 30.8 months of the latest reported annual operating outflow, while the current ratio was 14.3x, indicating substantial short-term financial flexibility.

FY2025 operating cash flow of -$123M tracked the $145M net loss, so the accounting loss broadly translated into cash use rather than arising mainly from noncash charges. The financing inflow of $257M alongside a higher share count is consistent with external capital supporting the balance sheet while operations remained cash-consuming.

[ NOT FINANCIAL ADVICE ]

Financial Health Signals

Financial health score not available

Amylyx Pharmaceuticals, Inc. does not currently provide enough eligible data for a peer-relative financial health score, so none is published. The signals and metrics below are current.

Altman Z-Score Safe
74.11

Amylyx Pharmaceuticals, Inc. scores 74.11, well above the 2.99 safe threshold. The score is driven primarily by a large market capitalization ($3.5B) relative to total liabilities ($27.4M). This indicates low bankruptcy risk based on profitability, leverage, and asset efficiency.

Distress-screening estimate for non-financial companies. Not computed for banks or insurers, where the Altman model does not apply.

Piotroski F-Score Partial
3/7

Amylyx Pharmaceuticals, Inc. passes 3 of 7 computable financial strength tests (2 of the nine could not be computed from available data). 2 of 4 profitability signals pass, 1 of 2 leverage/liquidity signals pass, neither operating efficiency signal passes.

Earnings Quality No Cash Backing
N/A

Amylyx Pharmaceuticals, Inc. reported a net loss of $144.7M while operations used $123.3M of cash. With neither figure positive, the ratio between the two carries no quality signal.

Key Financial Metrics

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Earnings & Revenue

EBITDA
-$45.6M
YoY-6.9%
QoQ-4.5%

Amylyx Pharmaceuticals, Inc.'s EBITDA was -$45.6M in Q2 2026, measuring earnings before interest, taxes, depreciation, and amortization. This represents a decrease of 6.9% from the same quarter a year earlier. Against the prior quarter it is down 4.5%.

Net Income
-$43.4M
YoY-4.8%
QoQ-5.2%

Amylyx Pharmaceuticals, Inc. reported -$43.4M in net income in Q2 2026. This represents a decrease of 4.8% from the same quarter a year earlier. Against the prior quarter it is down 5.2%.

EPS (Diluted)
-$0.39
YoY+15.2%
QoQ-5.4%

Amylyx Pharmaceuticals, Inc. earned -$0.39 per diluted share (EPS) in Q2 2026. This represents an increase of 15.2% from the same quarter a year earlier. Against the prior quarter it is down 5.4%.

Revenue

Not reported for Q2 2026.

Cash & Balance Sheet

Cash & Debt
$49.3M
YoY-15.1%
QoQ-78.5%

Amylyx Pharmaceuticals, Inc. held $49.3M in cash as of Q2 2026; long-term debt is not reported for that period.

Shares Outstanding
111M
YoY+25.0%
QoQ+0.2%

Amylyx Pharmaceuticals, Inc. had 111M shares outstanding in Q2 2026. This represents an increase of 25.0% from the same quarter a year earlier. Against the prior quarter it is up 0.2%.

Free Cash Flow

Not reported for Q2 2026.

Dividends Per Share

Not reported for Q2 2026.

Margins & Returns

Return on Equity
-18.2%
YoY+6.5pp
QoQ-3.0pp

Amylyx Pharmaceuticals, Inc.'s ROE was -18.2% in Q2 2026, measuring profit generated per dollar of shareholder equity. This is up 6.5 percentage points from the same quarter a year earlier. Against the prior quarter it is down 3.0 percentage points.

Gross Margin

Not reported for Q2 2026.

Operating Margin

Not reported for Q2 2026.

Net Margin

Not reported for Q2 2026.

Capital Allocation

R&D Spending
$23.8M
YoY-12.7%
QoQ-13.9%

Amylyx Pharmaceuticals, Inc. invested $23.8M in research and development in Q2 2026. This represents a decrease of 12.7% from the same quarter a year earlier. Against the prior quarter it is down 13.9%.

Share Buybacks

Not reported for Q2 2026.

Capital Expenditures

Not reported for Q2 2026.

AMLX Income Statement

Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

AMLX quarterly income statement
MetricQ2'2610-QQ1'2610-QQ4'2510-QQ3'2510-QQ2'2510-QQ1'2510-QQ4'2410-KQ3'2410-Q
RevenueN/AN/AN/A$0-100.0%$0$0-100.0%N/A$416K-99.6%
Cost of RevenueN/AN/AN/A$0$0-100.0%$0-100.0%N/A$0-100.0%
Gross ProfitN/AN/AN/A$0-100.0%$0+100.0%$0-100.0%N/A$416K-99.6%
R&D Expenses$23.8M-12.7%$27.6M+24.8%N/A$19.9M-6.5%$27.2M+16.6%$22.1M-39.6%N/A$21.2M-29.3%
SG&A Expenses$21.9M+40.2%$16.2M+3.1%N/A$16.2M-9.3%$15.6M-27.7%$15.7M-72.8%N/A$17.8M-63.4%
Operating Income-$45.7M-6.6%-$43.8M-15.8%N/A-$36.0M+52.4%-$42.9M+43.8%-$37.8M+69.0%N/A-$75.7M-504.2%
EBITDA-$45.6M-6.9%-$43.7M-16.0%N/A-$35.9M+52.4%-$42.7M+43.9%-$37.6M+69.1%N/A-$75.4M-496.6%
Income TaxN/AN/AN/A$0$0$0-100.0%N/A$0-100.0%
Net Income-$43.4M-4.8%-$41.3M-15.0%N/A-$34.4M+52.7%-$41.4M+43.0%-$35.9M+69.8%N/A-$72.7M-448.0%
EPS (Basic)-$0.39+15.2%-$0.37+11.9%-$0.28+48.1%-$0.37+65.4%-$0.46+57.0%-$0.42+76.0%-$0.54-871.4%-$1.07-445.2%
EPS (Diluted)-$0.39+15.2%-$0.37+11.9%-$0.28+48.1%-$0.37+65.4%-$0.46+57.0%-$0.42+76.0%-$0.54-871.4%-$1.07-456.7%
Diluted Shares (Avg)111M+24.7%111M+29.0%N/A93M+37.1%89M+31.0%86M+26.3%N/A68M-2.4%

Not reported in any period shown, so not listed: Interest Expense.

AMLX Balance Sheet

Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

AMLX quarterly balance sheet
MetricQ2'2610-QQ1'2610-QQ4'2510-QQ3'2510-QQ2'2510-QQ1'2510-QQ4'2410-KQ3'2410-Q
Total Assets$264.6M+36.0%$293.6M+33.7%$332.6M+71.8%$362.7M+44.7%$194.6M-41.4%$219.7M-47.4%$193.6M-62.6%$250.7M-46.3%
Current Assets$256.3M+37.2%$285.0M+31.9%$323.7M+70.9%$353.4M+44.1%$186.9M-42.8%$216.1M-47.4%$189.4M-59.2%$245.3M-43.5%
Cash & Equivalents$49.3M-15.1%$229.1M+283.4%$226.7M+192.9%$225.2M+213.4%$58.1M-22.6%$59.8M-65.0%$77.4M-54.5%$71.8M-46.9%
Short-Term Investments$201.4M+64.1%$50.6M-64.9%$90.3M-8.9%$118.8M-26.9%$122.7M-47.7%$144.3M-28.8%$99.1M-50.7%$162.6M-26.0%
InventoryN/AN/AN/AN/AN/AN/A$0-100.0%N/A
Accounts ReceivableN/AN/A$88K-80.3%$132K-92.4%$103K-97.5%$300K-98.5%$447K-98.9%$1.7M-94.1%
Long-Term Investments$0$0$0$0$0$0$0$0
Total Liabilities$25.4M-5.0%$20.4M+12.0%$27.4M-5.1%$30.7M-43.6%$26.7M-62.3%$18.3M-80.4%$28.9M-65.6%$54.5M+13.1%
Current Liabilities$21.1M-1.3%$16.0M-11.0%$22.7M-20.1%$25.8M-52.2%$21.4M-69.4%$17.9M-80.4%$28.4M-65.4%$53.9M+18.2%
Non-Current Liabilities$4.2M-19.8%$4.5M+1268.8%$4.7M+914.7%$5.0M+732.6%$5.3M+586.1%$327K-76.3%$463K-76.6%$595K-76.8%
Total Equity$239.2M+42.5%$273.2M+35.6%$305.3M+85.3%$332.0M+69.2%$167.9M-35.8%$201.4M-37.9%$164.8M-62.0%$196.2M-53.1%
Retained Earnings-$836.1M-22.2%-$792.7M-23.4%-$751.4M-23.9%-$718.4M-26.2%-$684.0M-37.8%-$642.6M-51.6%-$606.7M-98.9%-$569.1M-83.8%

Not reported in any period shown, so not listed: Goodwill, Long-Term Debt.

AMLX Cash Flow Statement

Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

AMLX quarterly cash flow statement
MetricQ2'2610-QQ1'2610-QQ4'2510-QQ3'2510-QQ2'2510-QQ1'2510-QQ4'2410-KQ3'2410-Q
Operating Cash Flow-$31.4M-24.5%-$36.9M+7.4%-$27.9M-$30.4M+26.9%-$25.2M+62.1%-$39.8M-8044.0%N/A-$41.6M-704.2%
Depreciation & Amortization$43K-69.5%$98K-37.2%$108K$120K-45.7%$141K-32.2%$156K-50.5%N/A$221K-26.8%
Stock-Based Compensation$8.3M+13.2%$6.1M-10.4%N/A$7.1M+4.0%$7.3M-23.2%$6.8M-31.1%N/A$6.8M-33.1%
Capital ExpendituresN/AN/A$86K$24K+26.3%$17K-80.9%$11K-83.6%N/A-$19K-94.7%
Free Cash FlowN/AN/A-$28.0M-$30.4M+26.9%-$25.3M+62.1%-$39.8M-7064.6%N/A-$41.6M-652.6%
Investing Cash Flow-$149.8M-751.5%$36.3M+183.1%$29.5M$5.2M-86.5%$23.0M+179.4%-$43.7M-5430.8%N/A$38.8M+135.9%
Financing Cash Flow$1.5M+4871.0%$3.2M-95.1%-$208K$191.6M+239407.5%-$31K-214.8%$65.7M+50023.7%N/A$80K-91.0%
Dividends Paid$0$0$0$0$0$0N/A$0

Not reported in any period shown, so not listed: Share Buybacks.

AMLX Financial Ratios

Margins and returns are percentages; the remaining ratios are unitless multiples. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

AMLX quarterly financial ratios
MetricQ2'2610-QQ1'2610-QQ4'2510-QQ3'2510-QQ2'2510-QQ1'2510-QQ4'2410-KQ3'2410-Q
Gross MarginN/AN/AN/AN/AN/AN/AN/A100.0%+5.1pp
Operating MarginN/AN/AN/AN/AN/AN/AN/A-18187.7%
Net MarginN/AN/AN/AN/AN/AN/AN/A-17476.9%
Return on Equity-18.2%+6.5pp-15.1%+2.7ppN/A-10.4%+26.7pp-24.7%+3.1pp-17.8%+18.8ppN/A-37.1%-42.0pp
Return on Assets-16.4%+4.9pp-14.1%+2.3ppN/A-9.5%+19.5pp-21.3%+0.6pp-16.4%+12.1ppN/A-29.0%-33.5pp
Current Ratio12.12+3.4x17.85+5.8x14.27+7.6x13.70+9.2x8.72+4.1x12.05+7.6x6.67+1.0x4.55-5.0x
Debt-to-Equity0.11-0.1x0.070.0x0.09-0.1x0.09-0.2x0.16-0.1x0.09-0.2x0.180.0x0.28+0.2x
Asset TurnoverN/AN/AN/A0.000.0x0.000.0x0.00-0.2xN/A0.00-0.2x
FCF MarginN/AN/AN/AN/AN/AN/AN/A-9997.4%

Reported as filed but not readable as a share of revenue in the periods where the ratio runs further from zero than a revenue base allows; no change figure is given where either compared period is one of those: Operating Margin, Net Margin, FCF Margin.

Similar Companies

Newest fiscal year on record for each company. The health score is the peer-relative Financial Health Score for that year; a dash means no score is published for it.

Company Fiscal year Revenue Net income Net margin Market cap Health score
Amylyx Pharmaceuticals, Inc. AMLX FY2025 $0 -$144.7M N/A $3.5B —
Stoke Therapeutics, Inc. STOK FY2025 $184.4M -$6.9M -3.7% $1.7B 83/100
Tourmaline Bio, Inc. TRML FY2024 N/A -$73.2M N/A $1.2B —
Dianthus Therapeutics, Inc. DNTH FY2025 $2.0M -$162.3M N/A $4.9B 55/100
LENZ Therapeutics, Inc. LENZ FY2025 $19.1M -$82.1M N/A $112.5M 56/100
Xeris Biopharma Holdings, Inc. XERS FY2025 $291.8M $554K 0.2% $1.7B 37/100

Frequently Asked Questions

What is Amylyx Pharmaceuticals, Inc.'s annual revenue?

Amylyx Pharmaceuticals, Inc. (AMLX) reported $0 in total revenue for fiscal year 2025. This represents a -100.0% change compared to the previous fiscal year. Revenue measures the total income earned from the company's primary business operations before any expenses are deducted.

How fast is Amylyx Pharmaceuticals, Inc.'s revenue growing?

Amylyx Pharmaceuticals, Inc. (AMLX) revenue declined by 100.0% year-over-year, from $87.4M to $0 in fiscal year 2025.

Is Amylyx Pharmaceuticals, Inc. profitable?

No, Amylyx Pharmaceuticals, Inc. (AMLX) reported a net income of -$144.7M in fiscal year 2025.

Amylyx Pharmaceuticals, Inc. (AMLX) reported diluted earnings per share of -$1.53 for fiscal year 2025. This represents a 65.5% change compared to the previous fiscal year. EPS represents the portion of a company's net income allocated to each outstanding share of common stock and is widely used to evaluate profitability on a per-share basis.

Amylyx Pharmaceuticals, Inc. (AMLX) had EBITDA of -$152.8M in fiscal year 2025, measuring earnings before interest, taxes, depreciation, and amortization.

Amylyx Pharmaceuticals, Inc. (AMLX) has a return on equity of -47.4% for fiscal year 2025, measuring how efficiently the company generates profit from shareholder equity.

Amylyx Pharmaceuticals, Inc. (AMLX) recorded an outflow of $123.5M in free cash flow during fiscal year 2025. This represents a 26.4% change compared to the previous fiscal year. Free cash flow represents the cash a company generates after accounting for capital expenditures, and is widely used to assess financial flexibility and shareholder value.

Amylyx Pharmaceuticals, Inc. (AMLX) recorded an outflow of $123.3M in operating cash flow during fiscal year 2025, representing cash used by core business activities.

Amylyx Pharmaceuticals, Inc. (AMLX) had $332.6M in total assets as of fiscal year 2025, including both current and long-term assets.

Amylyx Pharmaceuticals, Inc. (AMLX) invested $138K in capital expenditures during fiscal year 2025, funding long-term assets and infrastructure.

Amylyx Pharmaceuticals, Inc. (AMLX) invested $90.4M in research and development during fiscal year 2025.

Amylyx Pharmaceuticals, Inc. (AMLX) had 111M shares outstanding as of fiscal year 2025.

Amylyx Pharmaceuticals, Inc. (AMLX) had a current ratio of 14.27 as of fiscal year 2025, which is generally considered healthy.

Amylyx Pharmaceuticals, Inc. (AMLX) had a debt-to-equity ratio of 0.09 as of fiscal year 2025, measuring the company's financial leverage by comparing total debt to shareholder equity.

Amylyx Pharmaceuticals, Inc. (AMLX) had a return on assets of -43.5% for fiscal year 2025, measuring how efficiently the company uses its assets to generate profit.

Amylyx Pharmaceuticals, Inc. (AMLX) has no price-to-earnings ratio at the moment: net loss, so no earnings multiple (FY2025). The market capitalization is $3.5B as of Oct 3, 2026; a multiple compares that price with a filed figure and says nothing about the quality of the business.

Amylyx Pharmaceuticals, Inc. (AMLX) has no price-to-sales ratio at the moment: revenue is not positive (FY2025). The market capitalization is $3.5B as of Oct 3, 2026; a multiple compares that price with a filed figure and says nothing about the quality of the business.

At the end of fiscal year 2025, Amylyx Pharmaceuticals, Inc. (AMLX) held $317.0M in cash, cash equivalents and investments, and reported an operating cash outflow of $123.3M over that year. Dividing the one by the other, the reported balance equals about 31 months of the outflow reported that year. This is arithmetic over figures already filed, not a projection: it assumes nothing about future spending, financing or operations.

Amylyx Pharmaceuticals, Inc. (AMLX) has an Altman Z-Score of 74.11, placing it in the Safe Zone (low bankruptcy risk). The Z-Score combines five financial ratios (working capital, retained earnings, EBIT, market capitalization, and revenue relative to total assets) to predict the likelihood of bankruptcy. Scores above 2.99 indicate financial safety while scores below 1.81 suggest financial distress. Learn more in our complete guide to financial health indicators.

Amylyx Pharmaceuticals, Inc. (AMLX) has a Piotroski F-Score of 3 out of 7 computable signals; 2 of the nine could not be computed from available data, so the full-scale strength rating is not shown. The F-Score evaluates nine binary signals across profitability (positive ROA, positive cash flow, improving ROA, earnings quality), leverage (decreasing debt, improving liquidity, no share dilution), and operating efficiency (improving gross margin, improving asset turnover). Scores of 7 to 9 indicate strong and improving fundamentals. Learn more in our complete guide to financial health indicators.

Amylyx Pharmaceuticals, Inc. (AMLX) reported a net loss of $144.7M while operations used $123.3M of cash. With neither figure positive, the ratio between the two carries no quality signal. This ratio compares operating cash flow to net income. A ratio above 1.0x means the company generates more cash than its reported earnings, indicating sustainable, cash-backed profits. Ratios below 1.0x suggest earnings rely on accounting accruals rather than actual cash generation. Learn more in our complete guide to financial health indicators.

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