FMR LLC reports 11.9% stake in Annexon (NASDAQ: ANNX)

Rhea-AI Filing Summary

Annexon Inc. Schedule 13G/A shows FMR LLC beneficially owns 19,518,496.35 shares of common stock, representing 11.9% of the class as of 06/30/2026. The filing lists sole dispositive power of 19,518,496.35 shares and sole voting power of 19,492,404 shares. The filing is an amendment and notes a power of attorney and an attached 13d-1(k) exhibit.

Insights

Institutional Ownership Analyst

FMR LLC holds a notable passive stake in Annexon at 11.9%.

FMR LLC is reported as beneficial owner of 19,518,496.35 shares with sole dispositive power. The disclosure is in a Schedule 13G/A amendment format, which typically indicates passive investment intent under applicable rules.

Key dependencies include any agreements referenced (the 13d-1(k) exhibit) and whether holdings change in subsequent filings; timing and any trading activity are not included in the excerpt.

Key Figures

Report date: 06/30/2026 Beneficial ownership: 19,518,496.35 shares Percent of class: 11.9% +3 more

6 metrics

Report date 06/30/2026 ownership reporting date on amendment cover

Beneficial ownership 19,518,496.35 shares Amount beneficially owned by FMR LLC

Percent of class 11.9% Percent of common stock beneficially owned

Sole voting power 19,492,404 shares Sole power to vote reported on cover

Sole dispositive power 19,518,496.35 shares Sole power to dispose or direct disposition

CUSIP 03589W102 Annexon common stock CUSIP on filing

Key Terms

beneficially owned, Schedule 13G/A, 13d-1(k) agreement, sole dispositive power

4 terms

beneficially owned regulatory

"Amount beneficially owned: 19518496.35"

Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.

Schedule 13G/A regulatory

"Item 1. (a) Name of issuer: ANNEXON INC"

A Schedule 13G/A is an amended public filing with the U.S. securities regulator that updates a previous Schedule 13G, disclosing when an individual or group holds a substantial (typically over 5%) stake in a company and is claiming a passive, non‑controlling intent. Investors monitor these updates because rising or falling holdings can signal changing confidence, potential future moves, or shifts in voting power — like watching a public ledger where large shareholders quietly adjust their positions.

13d-1(k) agreement regulatory

"Please see Exhibit 99 for 13d-1(k) (1) agreement."

sole dispositive power regulatory

"7 | Sole Dispositive Power 19,518,496.35"

Sole dispositive power is the exclusive legal authority to decide what happens to a security — for example, whether to sell, transfer, or retain shares — without needing anyone else’s permission. Investors care because it signals who truly controls the economic outcome of an investment: like holding the only key to a safe, the holder can realize gains or losses and may trigger regulatory reporting, insider rules, or influence over corporate ownership.

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Available on EDGAR 07/08/2026 - 10:12 AM Accepted by SEC EDGAR 07/08/2026 - 10:11 AM Learn about SEC filing dates

FAQ

What stake does FMR LLC report in Annexon (ANNX)?

FMR LLC reports beneficial ownership of 19,518,496.35 shares, equal to 11.9% of Annexon's common stock as of 06/30/2026. The filing lists sole dispositive power for the same share count and sole voting power of 19,492,404 shares.

Does the Schedule 13G/A indicate FMR LLC is an active or passive investor?

The filing is a Schedule 13G/A amendment, which is normally used for passive investors under SEC rules. The excerpt does not state any change to control or an intent to influence management; it lists ownership amounts and a referenced 13d-1(k) exhibit.

What voting and dispositive powers does FMR LLC report for ANNX shares?

The filing reports sole voting power of 19,492,404 shares and sole dispositive power of 19,518,496.35 shares. Shared voting and dispositive powers are reported as 0.00 in the provided excerpt.

Is there additional documentation referenced in the filing for Annexon ownership?

Yes; the amendment references a power of attorney effective April 13, 2026 and incorporates an exhibit: a 13d-1(k) agreement (Exhibit 99). The excerpt includes a signature block dated 07/07/2026 for authorization.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 6)

ANNEXON INC

(Name of Issuer)

COMMON STOCK

(Title of Class of Securities)

03589W102

(CUSIP Number)

06/30/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 03589W102

1

Names of Reporting Persons

FMR LLC

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 19,492,404.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 19,518,496.35
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

19,518,496.35

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

11.9 %

12

Type of Reporting Person (See Instructions)

HC

SCHEDULE 13G

CUSIP Number(s): 03589W102

1

Names of Reporting Persons

Abigail P. Johnson

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 19,518,496.35
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

19,518,496.35

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

11.9 %

12

Type of Reporting Person (See Instructions)

IN

SCHEDULE 13G

Item 1.
(a)	Name of issuer: ANNEXON INC
(b)	Address of issuer's principal executive offices: 1400 Sierra Point Parkway,Bldg C Suite 200,Brisbane,CA,US,94005
Item 2.
(a)	Name of person filing: FMR LLC
(b)	Address or principal business office or, if none, residence: 245 Summer Street, Boston, Massachusetts 02210
(c)	Citizenship: Not applicable
(d)	Title of class of securities: COMMON STOCK
(e)	CUSIP No.: 03589W102
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 19518496.35
(b)	Percent of class: 11.9 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: Please see the responses to Items 5 and 6 on the cover page.
	(ii) Shared power to vote or to direct the vote: 0.00
	(iii) Sole power to dispose or to direct the disposition of: 19518496.35
	(iv) Shared power to dispose or to direct the disposition of: 0.00
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. One or more other persons are known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the COMMON STOCK of ANNEXON INC. No one other person's interest in the COMMON STOCK of ANNEXON INC is more than five percent of the total outstanding COMMON STOCK.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. See attached Exhibit 99.
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

FMR LLC

Signature:	Richard Bourgelas
Name/Title:	Duly authorized under Power of Attorney effective as of April 13, 2026, by and on behalf of FMR LLC and its direct and indirect subsidiaries*
Date:	07/07/2026

Abigail P. Johnson

Signature:	Richard Bourgelas
Name/Title:	Duly authorized under Power of Attorney effective as of April 13, 2026, by and on behalf of Abigail P. Johnson*
Date:	07/07/2026

Comments accompanying signature: *This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on April 29,2026, accession number: 0000315066-26-000738.

Exhibit Information

Please see Exhibit 99 for 13d-1(k) (1) agreement.