Schedule 13G/A: FMR LLC Discloses 15.7M Shares (14.3%) in Annexon

Rhea-AI Filing Summary

Filing: Schedule 13G/A (Amendment No. 3) reporting beneficial ownership in Annexon Inc. (ANNX) as of 06/30/2025; signature dated 08/05/2025.

Key facts

• Reporting persons: FMR LLC and Abigail P. Johnson.
• Aggregate beneficial ownership: 15,695,226.36 shares, representing 14.3% of the class.
• Voting/dispositive powers reported: FMR LLC sole voting power 15,690,765.00; sole dispositive power 15,695,226.36; shared powers 0.00; Abigail P. Johnson reports sole dispositive power 15,695,226.36; no voting power.

Certification: Signatory certifies the securities are held in the ordinary course of business and not to change or influence control of the issuer. Exhibit 99 and Exhibit 24 references included.

Positive

• Material disclosure of ownership: Reporting persons disclose 15,695,226.36 shares (14.3%) beneficial ownership in ANNX.
• Clear voting/dispositive breakdown: FMR LLC reports sole voting power 15,690,765 and sole dispositive power 15,695,226.36; shared powers reported as 0.00.
• Certification included: Statement that securities are held in the ordinary course of business and not for the purpose of changing or influencing control.

Negative

• None.

Insights

Securities Analyst

TL;DR: FMR LLC and Abigail P. Johnson report a material 14.3% stake in ANNX; disclosure is informational, not an activist signal.

The Schedule 13G/A discloses an aggregate beneficial ownership of 15,695,226.36 shares (14.3%) in Annexon Inc. The cover-page and Item 4 detail sole voting and dispositive powers held by FMR LLC and sole dispositive power reported for Abigail P. Johnson, with all shared powers at 0.00. The filing includes a certification that the holdings are held in the ordinary course of business and not for purposes of changing control. For investors, this is a material ownership disclosure that may affect float and potential investor composition but does not, by itself, indicate governance action.

Corporate Governance Expert

TL;DR: A >5% institutional stake (14.3%) is material for governance monitoring though the filer disclaims intent to influence control.

The document identifies FMR LLC and Abigail P. Johnson as reporting persons and documents precise voting and dispositive figures, including FMR LLC's sole voting power of 15,690,765 and sole dispositive power of 15,695,226.36. The signature block references a power of attorney and cross-references Exhibit 24 and Exhibit 99. From a governance perspective, the filing requires boards and investors to note an influential shareholder position, while the certification asserts passive intent; further filings or communications would be needed to alter the governance implications.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 3)

ANNEXON INC

(Name of Issuer)

COMMON STOCK

(Title of Class of Securities)

03589W102

(CUSIP Number)

06/30/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No. 03589W102

1

Names of Reporting Persons

FMR LLC

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 15,690,765.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 15,695,226.36
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

15,695,226.36

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

14.3 %

12

Type of Reporting Person (See Instructions)

HC

SCHEDULE 13G

CUSIP No. 03589W102

1

Names of Reporting Persons

Abigail P. Johnson

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 15,695,226.36
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

15,695,226.36

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

14.3 %

12

Type of Reporting Person (See Instructions)

IN

SCHEDULE 13G

Item 1.
(a)	Name of issuer: ANNEXON INC
(b)	Address of issuer's principal executive offices: 1400 Sierra Point Parkway,Bldg C Suite 200,Brisbane,CA,US,94005
Item 2.
(a)	Name of person filing: FMR LLC
(b)	Address or principal business office or, if none, residence: 245 Summer Street, Boston, Massachusetts 02210
(c)	Citizenship: Not applicable
(d)	Title of class of securities: COMMON STOCK
(e)	CUSIP No.: 03589W102
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 15695226.36
(b)	Percent of class: 14.3 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: Please see the responses to Items 5 and 6 on the cover page.
	(ii) Shared power to vote or to direct the vote: 0.00
	(iii) Sole power to dispose or to direct the disposition of: 15695226.36
	(iv) Shared power to dispose or to direct the disposition of: 0.00
Item 5.	Ownership of 5 Percent or Less of a Class.
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. One or more other persons are known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the COMMON STOCK of ANNEXON INC. No one other person's interest in the COMMON STOCK of ANNEXON INC is more than five percent of the total outstanding COMMON STOCK.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. See attached Exhibit 99.
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

FMR LLC

Signature:	Richard Bourgelas
Name/Title:	Duly authorized under Power of Attorney effective as of May 23, 2023, by and on behalf of FMR LLC and its direct and indirect subsidiaries*
Date:	08/05/2025

Abigail P. Johnson

Signature:	Richard Bourgelas
Name/Title:	Duly authorized under Power of Attorney effective as of May 23, 2023, by and on behalf of Abigail P. Johnson*
Date:	08/05/2025

Comments accompanying signature: *This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on August 8, 2023, accession number: 0000315066-23-002397.

Exhibit Information

Please see Exhibit 99 for 13d-1(k) (1) agreement.

FAQ

What stake in ANNX does FMR LLC report?

FMR LLC reports beneficial ownership of 15,695,226.36 shares, representing 14.3% of Annexon Inc.

Does Abigail P. Johnson hold voting power in ANNX according to the filing?

The filing reports Abigail P. Johnson has 0.00 sole voting power and sole dispositive power of 15,695,226.36 shares.

When is the event date and filing signature date on the Schedule 13G/A?

Date of event requiring the filing is 06/30/2025 and the signature is dated 08/05/2025.

Does the filing indicate the holdings are intended to influence control of Annexon?

No; the certification states the securities are held in the ordinary course of business and were not acquired to change or influence control.

Are any shared voting or dispositive powers reported?

No; the filing reports shared voting power 0.00 and shared dispositive power 0.00.