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Alto Neuroscience (ANRO) widens Q2 loss but extends cash runway to 2030

Filing Impact
(High)
Filing Sentiment
(Neutral)
Form Type
8-K

Rhea-AI Filing Summary

Alto Neuroscience, Inc. reported second quarter 2026 results and pipeline updates focused on its lead program ALTO-207 for treatment-resistant depression. The company expanded ALTO-207 development to include a planned Phase 3 monotherapy trial in addition to an ongoing potentially registrational Phase 2b adjunctive trial, with topline Phase 2b data expected in 2H 2027. Independent data published in Nature Medicine reinforced the dopaminergic mechanism underlying ALTO-207 and showed significant effects on anhedonia. Enrollment continues in Phase 2b trials of ALTO-300 in major depressive disorder and ALTO-100 in bipolar depression, with data expected in 2027.

Alto completed an approximately $100 million registered direct offering in July 2026, resulting in pro forma cash of about $338 million, which the company expects to fund planned operations through 2030. As of June 30, 2026, cash, cash equivalents, and restricted cash were $244.2 million. For the quarter, research and development expenses rose to $22.1 million and general and administrative expenses to $7.0 million, leading to a net loss of $27.6 million compared to $17.7 million a year earlier.

Positive

  • Pro forma cash of approximately $338 million after a ~$100 million July 2026 offering is expected to fund planned operations through 2030, supporting execution of multiple late-stage clinical trials.
  • ALTO-207 program significantly advanced with an additional planned Phase 3 monotherapy trial in TRD alongside the ongoing potentially registrational Phase 2b adjunctive trial and planned Phase 3 adjunctive trial.
  • Strong external clinical evidence for pramipexole’s antidepressant effects, including a Nature Medicine publication (Hedges' g=0.62, p=0.006) and prior PAX-D and meta-analysis data, supports the mechanistic rationale for ALTO-207.
  • Multiple Phase 2b trials on track for ALTO-300 in MDD and ALTO-100 in bipolar depression, with topline data expected in 1H and mid-2027, respectively, providing several potential value-creating catalysts.

Negative

  • Net loss widened to $27.6 million for Q2 2026 from $17.7 million a year earlier, driven by higher operating expenses.
  • Research and development expenses increased to $22.1 million from $13.1 million in Q2 2025, reflecting heavier spending on the clinical pipeline and contributing to greater cash burn.
  • Accumulated deficit grew to $255.5 million as of June 30, 2026, highlighting continuing cumulative losses typical of a clinical-stage biopharmaceutical company.

Filing Explained

The July financing was completed as an underwritten registered direct offering, issuing 3,776,436 common shares for approximately $94.6 million of net proceeds; the added shares increase the share count and reduce existing holders’ percentage ownership absent offsetting changes.

Item 2.02 Results of Operations and Financial Condition Financial
Disclosure of earnings results, typically an earnings press release or preliminary financials.
Item 9.01 Financial Statements and Exhibits Exhibits
Financial statements, pro forma financial information, and exhibit attachments filed with this report.
Cash, cash equivalents, and restricted cash $244.2 million As of June 30, 2026
Pro forma cash after July 2026 offering $338 million Including net proceeds of July 2026 offering
Q2 2026 research and development expenses $22.1 million Quarter ended June 30, 2026; up from $13.1 million in Q2 2025
Q2 2026 general and administrative expenses $7.0 million Quarter ended June 30, 2026; up from $5.6 million in Q2 2025
Q2 2026 net loss $27.6 million Quarter ended June 30, 2026; compared to $17.7 million in Q2 2025
Accumulated deficit $255.5 million As of June 30, 2026
Shares issued in July 2026 offering 3,776,436 shares Underwritten registered direct offering at $26.48 per share
Total assets $254.1 million As of June 30, 2026
treatment-resistant depression medical
"ALTO-207 is being developed to address the significant unmet medical need in TRD"
A form of major depression that does not improve after a person has tried standard treatments such as common antidepressant medications and therapy; think of it as a stubborn problem that doesn’t respond to the usual fixes. It matters to investors because it represents a large unmet medical need and a higher-risk, higher-reward area for drug developers, with potential for premium pricing, regulatory scrutiny, and durable demand if an effective new therapy is approved.
Phase 2b medical
"PACE-1 Trial (Phase 2b adjunctive TRD trial): Enrollment in the ongoing"
Phase 2b is a stage in the development of a new medicine or treatment where researchers test its effectiveness and safety in a larger group of people. This step helps determine whether the treatment works well enough to move forward and if it has manageable side effects, which is important for investors because successful results can lead to potential approval and market opportunity.
Phase 3 medical
"an additional planned Phase 3 trial evaluating ALTO-207 as monotherapy in TRD"
Phase 3 is the late-stage clinical testing step for a new drug or medical treatment, where the product is given to large groups of patients to confirm effectiveness, monitor side effects, and compare it to standard care. Successful Phase 3 results are often the final scientific hurdle before regulators decide on approval and market launch—like passing a final exam before graduation—and can sharply change a company's valuation and future revenue prospects.
Precision Psychiatry Platform medical
"Alto’s Precision Psychiatry Platform™ measures brain biomarkers by analyzing EEG activity"
A precision psychiatry platform is a technology system that gathers medical, biological, and behavioral data to help match individuals with the most likely effective mental-health treatments, much like a GPS recommends the best route based on current traffic. It matters to investors because platforms that reduce trial-and-error care can improve patient outcomes, lower costs, speed product adoption, and create scalable services or software that can generate recurring revenue and competitive advantage.
Hedges' g financial
"demonstrating significant effects on anhedonia (Hedges' g=0.62, p=0.006)"
A statistical measure of effect size that quantifies the difference between two groups' average outcomes in standard units, with a correction that reduces bias when sample sizes are small. Think of it like measuring how many “standard steps” apart two group averages are, which lets readers compare the strength of results across different studies or tests. For investors, it clarifies how large and consistent reported effects are when assessing research or trial claims.
registered direct offering financial
"completed an underwritten registered direct offering of 3,776,436 shares of common stock"
A registered direct offering is a way for a company to sell new shares of its stock directly to select investors with regulatory approval. This method allows the company to raise funds quickly and efficiently without needing a public auction, similar to offering exclusive access to a limited number of buyers. For investors, it often provides an opportunity to purchase shares at a favorable price, while giving the company immediate access to capital.
Research and development expenses $22.1 million Increased from $13.1 million in the same quarter of 2025
General and administrative expenses $7.0 million Increased from $5.6 million in the same quarter of 2025
Net loss $27.6 million Increased from $17.7 million in the same quarter of 2025
Cash, cash equivalents, and restricted cash $244.2 million Increased from $177.0 million as of December 31, 2025
Guidance

The company expects its pro forma cash position of approximately $338 million, including the July 2026 financing, to fund planned operations through 2030.

FAQ

What were Alto Neuroscience (ANRO) cash and pro forma cash positions as of Q2 2026?
Alto reported $244.2 million in cash, cash equivalents, and restricted cash as of June 30, 2026. Including net proceeds from its July 2026 offering, pro forma cash was approximately $338 million, which the company expects to fund planned operations through 2030.

How much did Alto Neuroscience (ANRO) lose in Q2 2026 and how did this compare to 2025?
Alto incurred a net loss of $27.6 million for the quarter ended June 30, 2026, compared with a net loss of $17.7 million in the same period of 2025, reflecting higher research and development and general and administrative expenses.

What are the key clinical milestones upcoming for Alto Neuroscience (ANRO)?
Planned milestones include early 2027 initiation of the ALTO-207 PACE-2 Phase 3 adjunctive TRD trial, 1H 2027 ALTO-300 Phase 2b MDD topline data, mid-2027 ALTO-100 Phase 2b bipolar depression data, and 2H 2027 ALTO-207 PACE-1 Phase 2b data and PACE-3 Phase 3 monotherapy trial initiation.

What financing did Alto Neuroscience (ANRO) complete in 2026 and on what terms?
In July 2026, Alto completed an underwritten registered direct offering of 3,776,436 shares of common stock at $26.48 per share, generating gross proceeds of about $100.0 million and net proceeds of approximately $94.6 million to support ALTO-207 development and general purposes.

How is Alto Neuroscience (ANRO) advancing its ALTO-207 program in treatment-resistant depression?
ALTO-207 is being evaluated in a potentially registrational Phase 2b adjunctive TRD trial (PACE-1) with topline data expected in 2H 2027. Alto plans an early 2027 Phase 3 adjunctive trial (PACE-2) and a 2H 2027 Phase 3 monotherapy trial (PACE-3), subject to FDA alignment.

What were Alto Neuroscience (ANRO) operating expenses in Q2 2026?
For Q2 2026, research and development expenses were $22.1 million and general and administrative expenses were $7.0 million, resulting in total operating expenses of $29.1 million, up from $18.7 million in the same quarter of 2025.

What key external evidence supports Alto Neuroscience’s (ANRO) ALTO-207 mechanism?
An independent trial (PRIME-PRAXOL) published in Nature Medicine showed pramipexole significantly reduced anhedonia versus placebo (SHAPS mean difference −4.04; Hedges' g=0.62; p=0.006), complementing prior PAX-D and meta-analysis data supporting dopaminergic treatment in depression.

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Understanding 8-K Material Events →
0001999480False00019994802026-08-122026-08-12

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
_____________________
FORM 8-K
_____________________

CURRENT REPORT
Pursuant to Section 13 or 15(d)
of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): August 12, 2026
_____________________
ALTO NEUROSCIENCE, INC.
(Exact Name of Registrant as Specified in its Charter)
_____________________
Delaware
 001-41944
83-4210124
(State or Other Jurisdiction
of Incorporation)		(Commission
File Number)		(IRS Employer
Identification No.)
650 Castro Street, Suite 450, Mountain View, CA
94041
(Address of principal executive offices)(Zip Code)
Registrant’s telephone number, including area code: (650) 200-0412
N/A
(Former name or former address, if changed since last report)
_____________________
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
oWritten communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
oSoliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
oPre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
oPre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))


Securities registered pursuant to Section 12(b) of the Act:
Title of each classTrading
Symbol(s)		Name of each exchange
on which registered
Common Stock, $0.0001 par value per shareANRONew York Stock Exchange

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).
Emerging growth company x
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. o


Item 2.02 Results of Operations and Financial Condition.
On August 12, 2026, Alto Neuroscience, Inc. (the “Company”) reported financial results for the fiscal quarter ended June 30, 2026. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K (the “Current Report”) and is incorporated by reference herein.
The information in this Item 2.02 of this Current Report (including Exhibit 99.1 attached hereto) is being furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”) or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Exchange Act or the Securities Act of 1933, as amended, except as expressly set forth by specific reference in such filing.

Item 9.01    Financial Statements and Exhibits.

(d)Exhibits.
Exhibit No.Description
99.1
Press Release of Alto Neuroscience, Inc.
104Cover Page Interactive Data File (embedded within the Inline XBRL document).


SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
ALTO NEUROSCIENCE, INC.
Dated: August 12, 2026
By:/s/ Amit Etkin
Amit Etkin, M.D., Ph.D.
President and Chief Executive Officer

Exhibit 99.1
Alto Neuroscience Reports Second Quarter 2026 Financial Results and Recent Business Highlights
– ALTO-207 development expanded: an additional Phase 3 trial evaluating ALTO-207 as monotherapy in treatment-resistant depression (TRD) is now planned, alongside the ongoing potentially registrational Phase 2b trial; topline Phase 2b data on track for 2H 2027 –
– Independent investigator-led study results published in Nature Medicine reinforce the dopaminergic mechanism underlying ALTO-207, demonstrating significant effects on anhedonia (Hedges' g=0.62, p=0.006) –
– Approximately $100 million financing completed in July 2026; pro forma cash of approximately $338 million expected to fund planned operations through 2030 –
 
MOUNTAIN VIEW, Calif.--(BUSINESS WIRE) -- Alto Neuroscience, Inc. (“Alto”) (NYSE: ANRO), a clinical-stage biopharmaceutical company focused on the development of novel precision medicines for neuropsychiatric disorders, today reported financial results for the quarter ended June 30, 2026, and highlighted recent progress across its pipeline of clinical-stage product candidates.
“The second quarter further strengthened the case for ALTO-207 and our conviction in the opportunity ahead of it,” said Amit Etkin, M.D., Ph.D., founder and chief executive officer of Alto Neuroscience. “The Nature Medicine publication of PRIME-PRAXOL provides another independent, peer-reviewed dataset showing that dopaminergic treatment produces large effects in depression, and, just as importantly, a reminder of the tolerability challenge that ALTO-207 is designed to address. With enrollment in our potentially registrational Phase 2b trial tracking as planned and pro forma cash of approximately $338 million, we are now positioned to pursue ALTO-207 in both the adjunctive and monotherapy settings, broadening the potential label and the commercial opportunity, with expected runway through 2030.”
Second Quarter and Recent Pipeline Highlights
ALTO-207: Independent Nature Medicine publication reinforces mechanism; monotherapy Phase 3 trial added to development plan
ALTO-207 is a fixed-dose combination of pramipexole, a dopamine D3-preferring D3/D2 agonist with demonstrated antidepressant effect across multiple independent trials, and ondansetron, a selective 5-HT3 receptor antagonist. The fixed-dose combination is designed to enable rapid titration to higher pramipexole doses by mitigating the dose-limiting nausea and vomiting associated with pramipexole. This combination approach — and its use to enable higher pramipexole dosing in the treatment of depression — is the subject of Alto's issued method-of-treatment patent estate described below. ALTO-207 is being developed to address the significant unmet medical need in TRD, which is estimated to affect approximately 7 million adults in the United States.
•In June 2026, results from PRIME-PRAXOL — an independent, randomized, double-blind, placebo-controlled trial conducted by investigators at Lund University, Sweden — were published in Nature Medicine. Adults with major depressive disorder (MDD), dysthymia, or bipolar depression and clinically significant anhedonia received flexible-dose pramipexole or placebo added to ongoing treatment for nine weeks, followed by a six-month open-label extension.
•The trial met its primary endpoint, with pramipexole reducing anhedonia significantly more than placebo on the Snaith–Hamilton Pleasure Scale (SHAPS) (mean difference −4.04; 95% CI −6.89 to −1.18; p=0.006; Hedges' g=0.62).


•Significant improvements were also observed on independent measures of anhedonia (DARS; p=0.008) and apathy (AES-S; p<0.001), and improvements were maintained through the six-month open-label period.
•In an exploratory analysis included in the publication, an MDD diagnosis was significantly associated with greater SHAPS improvement at week 9 relative to dysthymia (p=0.038).
•In an additional analysis of the trial data not included in the publication, the MDD subgroup showed a larger effect on SHAPS at week 9 (Hedges' g=0.99) and a larger effect on the Hamilton Depression Rating Scale (HDRS-6) (Hedges' g=0.64).
•Consistent with prior studies, adverse events were common in the pramipexole arm despite slow titration, including nausea in approximately 60% of participants — the dose-limiting tolerability constraint that the ALTO-207 fixed-dose combination is designed to address.
•These findings are consistent with the broader body of evidence supporting ALTO-207, including the PAX-D study conducted by the University of Oxford and published in The Lancet Psychiatry (Cohen's d=0.87 versus placebo at 12 weeks in TRD) and a meta-analysis of pramipexole in depression (Hedges' g=0.64, p<0.001).

•The broad development program for ALTO-207, collectively the PACE program (Pramipexole-ondansetron Assessment of Clinical Efficacy in depression), remains on track across three large, well-controlled clinical trials;
•PACE-1 Trial (Phase 2b adjunctive TRD trial): Enrollment in the ongoing, potentially registrational, Phase 2b trial of ALTO-207 as an adjunctive treatment in approximately 178 adults with TRD is on track with topline data expected in 2H 2027. MADRS is the primary endpoint in the trial, which is aligned with FDA standards in depression and supports the potential for the trial to contribute to a future registrational package alongside the planned Phase 3 trials.
•PACE-2 Trial (Phase 3 adjunctive TRD trial): Alto remains on track to initiate its Phase 3 trial of ALTO-207 as adjunctive treatment in TRD by early 2027, following alignment with the FDA on the planned trial design. The Phase 3 trial is designed to run in parallel with the ongoing Phase 2b trial rather than await its topline data, an approach Alto believes can meaningfully accelerate the path to a potential NDA submission.
•PACE-3 Trial (Phase 3 monotherapy TRD trial): In July 2026, Alto announced plans to accelerate and expand the clinical development of ALTO-207, including an additional planned Phase 3 trial evaluating ALTO-207 as monotherapy in TRD. The Company believes a monotherapy dataset, alongside the planned adjunctive Phase 3 trial, could support a broader label and expand the addressable population for ALTO-207 if approved. Alto expects to initiate this trial in the second half of 2027 pending alignment with the FDA.

•Alto's patent estate covering ALTO-207 includes multiple method-of-treatment patents protecting the use of ondansetron to mitigate pramipexole-related side effects to enable higher pramipexole dosing in the treatment of depression. Together with the Company's broader estate of issued and pending patents, Alto expects patent coverage of ALTO-207 through at least the mid-2040s.
ALTO-300 and ALTO-100: Phase 2b trials on track
•Enrollment remains ongoing in the Phase 2b trials of ALTO-300 in MDD and ALTO-100 in bipolar depression (BPD), conducted under the enhanced eligibility review and patient data quality procedures the Company implemented earlier this year, which continue to perform as intended.
•Topline data remain expected in 1H 2027 for the ALTO-300 Phase 2b MDD trial and mid-2027 for the ALTO-100 Phase 2b BPD trial.


Corporate Highlights
•In July 2026, Alto completed an underwritten registered direct offering of 3,776,436 shares of common stock at $26.48 per share, for gross proceeds of approximately $100.0 million and net proceeds of approximately $94.6 million. The Company intends to use the proceeds, together with existing cash, to accelerate and expand the clinical development of ALTO-207, including the additional planned Phase 3 monotherapy trial in TRD, and for general working capital purposes.
•In June 2026, Alto was added to the Russell 2000® Index and the broad-market Russell 3000® Index, effective June 29, 2026, as part of the 2026 Russell US Indexes reconstitution.
•In May 2026, Alto appointed Andrew Miller, Ph.D., founder of Karuna Therapeutics, to its Board of Directors. During his tenure, Dr. Miller was CEO, COO, and led research and development at Karuna through its acquisition by Bristol Myers Squibb, and brings extensive neuropsychiatric drug development and company-building experience to Alto.
Expected Upcoming Milestones
•Early 2027 — ALTO-207 PACE-2 (Phase 3 adjunctive TRD) trial initiation
•1H 2027 — ALTO-300 Phase 2b MDD trial topline data
•Mid-2027 — ALTO-100 Phase 2b BPD trial topline data
•2H 2027 — ALTO-207 PACE-1 (Phase 2b adjunctive TRD) trial topline data
•2H 2027 — ALTO-207 PACE-3 (Phase 3 monotherapy TRD) trial initiation
Second Quarter 2026 Financial Highlights
Cash Position: As of June 30, 2026, the Company had cash, cash equivalents, and restricted cash of approximately $244.2 million, compared to approximately $177.0 million as of December 31, 2025. Giving effect to the net proceeds of the July 2026 offering, the Company's pro forma cash position following the offering was approximately $338 million.
R&D Expenses: Research and development expenses for the quarter ended June 30, 2026, were $22.1 million, as compared to $13.1 million for the same period in 2025.
G&A Expenses: General and administrative expenses for the quarter ended June 30, 2026, were $7.0 million, as compared to $5.6 million for the same period in 2025.
Net Loss: The Company incurred a net loss of $27.6 million for the quarter ended June 30, 2026, as compared to a net loss of $17.7 million for the same period in 2025.
About Alto Neuroscience
Alto Neuroscience is a clinical-stage biopharmaceutical company with a mission to redefine psychiatry by leveraging neurobiology to develop personalized and highly effective treatment options. Alto’s Precision Psychiatry Platform™ measures brain biomarkers by analyzing EEG activity, neurocognitive assessments, wearable data, and other factors to better identify which patients are more likely to respond to Alto product candidates. Alto’s clinical-stage pipeline includes novel drug candidates in treatment-resistant depression, major depressive disorder, bipolar depression, schizophrenia, and other mental health conditions. For more information, visit www.altoneuroscience.com or follow Alto on X.


Forward-Looking Statements
This press release may contain forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. These statements may be identified by words such as “aims,” “anticipates,” “believes,” “could,” “estimates,” “expects,” “forecasts,” “goal,” “intends,” “look forward,” “may,” “on track,” “plans,” “possible,” “potential,” “seeks,” “will” and variations of these words or similar expressions that are intended to identify forward-looking statements, although not all forward-looking statements contain these words. Forward-looking statements in this press release include, but are not limited to, statements regarding Alto’s expectations with regard to the potential benefits, activity, effectiveness and safety of its product candidates and Precision Psychiatry Platform (“Platform”); statements regarding patient compliance and the effectiveness of Alto’s clinical trial execution measures, including its eligibility review and patient and data quality procedures, and the impact of those measures on patient and data quality and the timing of trial readouts; statements regarding Alto’s expectations for the design, timing, and results of its Phase 2b and planned Phase 3 trials of ALTO-207; Alto’s expectations with regard to the design and results of its research and development programs and clinical trials, including the timing of enrollment and the timing and availability of data from such trials; Alto’s clinical and regulatory development plans for its product candidates, including the timing or likelihood of regulatory filings and approvals for its product candidates and regulatory alignment; Alto’s business strategy, financial position, including anticipated cash runway, and the sufficiency of its financial resources to fund its operations through expected milestones; and other statements that are not historical fact. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various factors, including: uncertainties inherent in the initiation, progress and completion of clinical trials and clinical development of Alto’s product candidates; the risk that Alto may not realize the intended benefits of its Platform or its eligibility review and patient and data quality procedures; availability and timing of results from clinical trials; whether initial or interim results from a clinical trial will be predictive of the final results of the trial or the results of future trials; the risk that clinical trials may have unsatisfactory outcomes; the risk that Alto’s projections regarding its financial position and expected cash runway are inaccurate or that its conduct of its business requires more cash than anticipated; and other important factors, any of which could cause Alto’s actual results to differ from those contained in the forward-looking statements, which are described in greater detail in Alto’s Annual Report on Form 10-K for the fiscal year ended December 31, 2025 and other filings Alto may make with the SEC. Any forward-looking statements contained in this press release speak only as of the date hereof, and Alto expressly disclaims any obligation to update any forward-looking statements contained herein, whether because of any new information, future events, changed circumstances or otherwise, except as required by law.
Availability of Information on Alto's Website
Alto routinely uses its investor relations website to post presentations to investors and other important information, including information that may be material. Accordingly, Alto encourages investors and others interested in Alto to review the information it makes public on its investor relations website.



ALTO NEUROSCIENCE, INC.
Consolidated Statements of Operations and Comprehensive Loss
(in thousands, except per share amounts)
(unaudited)
Three months ended
June 30,		Six months ended
June 30,
2026202520262025
Operating expenses:
Research and development$22,108 $13,124 $42,402 $23,098 
General and administrative7,021 5,558 13,865 11,260 
Total operating expenses29,129 18,682 56,267 34,358 
Loss from operations(29,129)(18,682)(56,267)(34,358)
Other income (expense):
Interest income2,112 1,683 3,673 3,510 
Interest expense(491)(646)(1,036)(1,244)
Loss on debt extinguishment— — — (681)
Other, net(130)(61)(245)(102)
Total other income, net1,491 976 2,392 1,483 
Net loss$(27,638)$(17,706)$(53,875)$(32,875)
Other comprehensive income (loss):
Change in fair value attributable to instrument specific credit risk— 22 7 156 
Foreign currency translation4 (5)(12)(24)
Total other comprehensive income (loss)$4 $17 $(5)$132 
Comprehensive loss$(27,634)$(17,689)$(53,880)$(32,743)
Net loss per share attributable to common stockholders, basic and diluted$(0.65)$(0.65)$(1.34)$(1.21)
Weighted-average number of common shares outstanding, basic and diluted42,81327,07240,17927,061

ALTO NEUROSCIENCE, INC.
Selected Condensed Consolidated Balance Sheet Data
(in thousands)
(unaudited)
June 30,December 31,
20262025
Cash, cash equivalents, and restricted cash$244,233 $176,984 
Total assets254,066 184,689 
Total liabilities34,817 33,547 
Accumulated deficit(255,509)(201,634)
Investor & Media Contact:
Nick Smith
investors@altoneuroscience.com
media@altoneuroscience.com



Source: View Original Filing on SEC EDGAR

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