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Alto Neuroscience Inc. (ANRO) Financials

ANRO
FY2025 annual
Net Income -$63.2M -2.9% YoY
EPS (Diluted) -$2.19 +12.4% YoY
Free Cash Flow -$51.8M -4.6% YoY
Operating Cash Flow -$51.8M -9.2% YoY
Market Cap $866.9M as of Oct 13, 2026
Price / Sales n/m no revenue reported
Price / Earnings n/m net loss, so no earnings multiple, FY2025
Price / Book 4.0x on $219.2M equity, Q2 FY2026

A multiple compares the market's price with a filed figure; it says what the market pays, not how the business is doing. The market capitalization is the vendor's as of Oct 13, 2026; every other figure is from the SEC filings on this page. Not financial advice.

Source SEC Filings (10-K/10-Q) Latest period Q2 FY2026, ended Jun 30, 2026 Reported Currency USD FYE December

Newest figures come from the 10-Q for Q2 FY2026, filed Aug 12, 2026. Each column of the statement tables below links to the filing it was taken from, and every filing is listed on the ANRO SEC filings page.

This page shows Alto Neuroscience Inc. (ANRO) financial statements, including the income statement, balance sheet, cash flow statement, and key financial ratios. View 3 years of annual fundamentals and quarterly data, with year-over-year growth rates and compound annual growth rates (CAGR). All figures are derived from SEC filings (10-K and 10-Q reports).

Rhea AI ANRO FY2025

ANRO remains a research-funded business: operating losses consume cash, while financing rather than operations has built its balance sheet.

In FY2025, the net loss was $63.2M while operating cash flow was -$51.8M, so accounting losses translated into nearly comparable cash use rather than being mainly noncash. With capital spending of only $24K, the cash requirement reflects ongoing operations more than reinvestment in physical assets.

The cost base is development-led: R&D was $45.6M versus SG&A of $20.7M in FY2025, indicating that research absorbs more than twice the administrative spend. Those two categories essentially explain the operating loss of $66.4M, rather than indicating a mature operating model with substantial overhead leverage.

Funding, not operations, changed the capital structure. Equity moved from -$71.7M in FY2023 to $151.5M in FY2024, a balance-sheet transformation that coincided with external financing. Financing cash flow remained positive at $60.1M in FY2025 even as operating cash flow was -$51.8M, showing that operations had not yet become self-funding.

[ NOT FINANCIAL ADVICE ]

Financial Health Signals

Financial health score not available

Alto Neuroscience Inc. does not currently provide enough eligible data for a peer-relative financial health score, so none is published. The signals and metrics below are current.

Piotroski F-Score Partial
2/7

Alto Neuroscience Inc. passes 2 of 7 computable financial strength tests (2 of the nine could not be computed from available data). 2 of 4 profitability signals pass, no leverage/liquidity signals pass (rising debt, declining liquidity, or share dilution).

Earnings Quality No Cash Backing
N/A

Alto Neuroscience Inc. reported a net loss of $63.2M while operations used $51.8M of cash. With neither figure positive, the ratio between the two carries no quality signal.

Interest Coverage At Risk
N/A

Alto Neuroscience Inc. reported an operating loss of $66.4M against $2.5M in interest expense. There is no operating profit to cover interest, so interest must be met from cash reserves or from financing rather than from operations.

Key Financial Metrics

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Earnings & Revenue

EBITDA
-$28.9M
YoY-55.7%
QoQ-7.3%

Alto Neuroscience Inc.'s EBITDA was -$28.9M in Q2 2026, measuring earnings before interest, taxes, depreciation, and amortization. This represents a decrease of 55.7% from the same quarter a year earlier. Against the prior quarter it is down 7.3%.

Net Income
-$27.6M
YoY-56.1%
QoQ-5.3%

Alto Neuroscience Inc. reported -$27.6M in net income in Q2 2026. This represents a decrease of 56.1% from the same quarter a year earlier. Against the prior quarter it is down 5.3%.

EPS (Diluted)
-$0.65
QoQ+18.8%

Alto Neuroscience Inc. earned -$0.65 per diluted share (EPS) in Q2 2026. Against the prior quarter it is up 18.8%.

Revenue

Not reported for Q2 2026.

Cash & Balance Sheet

Free Cash Flow
-$19.8M
YoY-43.4%
QoQ+28.5%

Alto Neuroscience Inc. recorded an outflow of $19.8M in free cash flow in Q2 2026, representing a cash shortfall after capex. This represents a decrease of 43.4% from the same quarter a year earlier. Against the prior quarter it is up 28.5%.

Cash & Debt
$243.7M
YoY+65.1%
QoQ-7.6%

Alto Neuroscience Inc. held $243.7M in cash against $12.4M in long-term debt as of Q2 2026.

Shares Outstanding
39M
QoQ+11.8%

Alto Neuroscience Inc. had 39M shares outstanding in Q2 2026. Against the prior quarter it is up 11.8%.

Dividends Per Share

Not reported for Q2 2026.

Margins & Returns

Return on Equity
-12.6%
YoY+1.7pp
QoQ-1.8pp

Alto Neuroscience Inc.'s ROE was -12.6% in Q2 2026, measuring profit generated per dollar of shareholder equity. This is up 1.7 percentage points from the same quarter a year earlier. Against the prior quarter it is down 1.8 percentage points.

Gross Margin

Not reported for Q2 2026.

Operating Margin

Not reported for Q2 2026.

Net Margin

Not reported for Q2 2026.

Capital Allocation

R&D Spending
$22.1M
YoY+68.5%
QoQ+8.9%

Alto Neuroscience Inc. invested $22.1M in research and development in Q2 2026. This represents an increase of 68.5% from the same quarter a year earlier. Against the prior quarter it is up 8.9%.

Capital Expenditures
$0
QoQ-100.0%

Alto Neuroscience Inc. reported no capital expenditure in Q2 2026. Against the prior quarter it is down 100.0%.

Share Buybacks

Not reported for Q2 2026.

ANRO Income Statement

Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

ANRO quarterly income statement
MetricQ2'2610-QQ1'2610-QQ4'2510-QQ3'2510-QQ2'2510-QQ1'2510-QQ4'2410-KQ3'2410-Q
R&D Expenses$22.1M+68.5%$20.3M+103.5%N/A$10.5M-19.4%$13.1M-0.5%$10.0M+0.2%N/A$13.1M+63.9%
SG&A Expenses$7.0M+26.3%$6.8M+20.0%N/A$4.4M-24.0%$5.6M+7.8%$5.7M+28.6%N/A$5.8M+232.7%
Operating Income-$29.1M-55.9%-$27.1M-73.1%N/A-$15.0M+20.8%-$18.7M-1.9%-$15.7M-9.0%N/A-$18.9M-94.3%
EBITDA-$28.9M-55.7%-$27.0M-73.8%N/A-$14.8M+21.1%-$18.6M-1.9%-$15.5M-8.5%N/A-$18.7M-94.3%
Interest Expense$491K-24.0%$545K-8.9%N/A$650K+86.2%$646K+86.2%$598K+72.8%N/A$349K-3.9%
Income TaxN/AN/AN/AN/AN/A$0N/AN/A
Net Income-$27.6M-56.1%-$26.2M-73.0%N/A-$14.2M+15.5%-$17.7M-10.5%-$15.2M-13.1%N/A-$16.8M-83.6%
EPS (Basic)-$0.650.0%-$0.80-42.9%-$0.45+19.6%-$0.52+16.1%-$0.65-8.3%-$0.56+26.3%-$0.56+81.2%-$0.62+74.6%
EPS (Diluted)-$0.65-$0.80-42.9%-$0.45+19.6%-$0.52+16.1%-$0.65-8.3%-$0.56-$0.56-$0.62
Diluted Shares (Avg)43M33M+21.6%N/A27M+0.5%27M+0.6%27MN/A27M

Not reported in any period shown, so not listed: Revenue, Cost of Revenue, Gross Profit.

ANRO Balance Sheet

Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

ANRO quarterly balance sheet
MetricQ2'2610-QQ1'2610-QQ4'2510-QQ3'2510-QQ2'2510-QQ1'2510-QQ4'2410-KQ3'2410-Q
Total Assets$254.1M+60.9%$276.3M+60.7%$184.7M+4.0%$147.0M-23.3%$157.9M-20.0%$171.9M-18.1%$177.5M+104.9%$191.6M
Current Assets$247.3M+65.0%$269.1M+64.6%$177.7M+4.9%$139.4M-24.0%$149.8M-23.3%$163.5M-21.5%$169.3M+98.3%$183.5M
Cash & Equivalents$243.7M+65.1%$263.8M+64.1%$176.5M+4.9%$137.8M-24.2%$147.6M-23.6%$160.8M-21.9%$168.2M+103.8%$181.7M+254.3%
Short-Term Investments$0$0$0$0$0$0$0$0
Long-Term Investments$0$0$0$0$0$0$0$0
Total Liabilities$34.8M+1.0%$32.9M+0.2%$33.5M+28.6%$35.4M+33.5%$34.5M+96.0%$32.8M+95.1%$26.1M-83.5%$26.6M
Current Liabilities$16.7M+104.8%$13.1M+80.7%$11.3M+13.2%$9.0M-35.5%$8.1M-17.4%$7.3M-9.4%$10.0M+78.4%$14.0M
Non-Current Liabilities$18.2M-31.0%$19.8M-22.6%$22.2M+38.2%$26.4M+110.5%$26.3M+240.2%$25.6M+190.1%$16.1M-89.5%$12.5M
Long-Term Debt$12.4M-38.3%$13.9M-30.4%$16.2M+57.7%$20.3M+206.5%$20.1M+159.9%$19.9M+126.3%$10.3M+4.0%$6.6M
Total Equity$219.2M+77.7%$243.4M+75.0%$151.1M-0.2%$111.6M-32.4%$123.4M-31.4%$139.1M-28.0%$151.5M+311.3%$165.1M+370.1%
Retained Earnings-$255.5M-49.2%-$227.9M-48.4%-$201.6M-45.7%-$185.5M-50.5%-$171.3M-61.0%-$153.6M-69.9%-$138.4M-79.8%-$123.2M

Not reported in any period shown, so not listed: Inventory, Accounts Receivable, Goodwill.

ANRO Cash Flow Statement

Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

ANRO quarterly cash flow statement
MetricQ2'2610-QQ1'2610-QQ4'2510-QQ3'2510-QQ2'2510-QQ1'2510-QQ4'2410-KQ3'2410-Q
Operating Cash Flow-$19.8M-43.4%-$27.1M-63.6%-$11.5M+11.6%-$9.9M+15.4%-$13.8M-17.8%-$16.6M-50.7%-$13.0M-13.0%-$11.7M-51.0%
Depreciation & Amortization$200K+100.0%$184K+7.6%$157K$200K0.0%$100K0.0%$171K+76.3%N/A$200K+100.0%
Stock-Based Compensation$3.6M+77.3%$2.8M+43.5%N/A$2.2M+9.6%$2.0M+6.2%$2.0M-9.7%N/A$2.0M+269.3%
Capital Expenditures$0$556K+2216.7%$0-100.0%$0-100.0%$0-100.0%$24K-89.3%$506K+43.8%$1.0M+2237.2%
Free Cash Flow-$19.8M-43.4%-$27.6M-66.7%-$11.5M+14.9%-$9.9M+22.1%-$13.8M-14.5%-$16.6M-47.9%-$13.5M-13.9%-$12.7M-63.1%
Investing Cash Flow$0-$556K-2216.7%$0+100.0%$0+100.0%$0+100.0%-$24K+89.3%-$506K-43.8%-$1.0M-2237.2%
Financing Cash Flow-$273K-144.5%$114.9M+1159.4%$50.2M+102318.4%$153K-88.4%$613K+362.0%$9.1M-93.2%$49K-99.9%$1.3M+2587.8%

Not reported in any period shown, so not listed: Dividends Paid, Share Buybacks.

ANRO Financial Ratios

Margins and returns are percentages; the remaining ratios are unitless multiples. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

ANRO quarterly financial ratios
MetricQ2'2610-QQ1'2610-QQ4'2510-QQ3'2510-QQ2'2510-QQ1'2510-QQ4'2410-KQ3'2410-Q
Return on Equity-12.6%+1.7pp-10.8%+0.1ppN/A-12.7%-2.5pp-14.3%-5.4pp-10.9%-4.0ppN/A-10.2%
Return on Assets-10.9%+0.3pp-9.5%-0.7ppN/A-9.7%-0.9pp-11.2%-3.1pp-8.8%-2.4ppN/A-8.8%
Current Ratio14.85-3.6x20.52-2.0x15.69-1.2x15.42+2.3x18.43-1.4x22.53-3.5x16.92+1.7x13.10
Debt-to-Equity0.06-0.1x0.06-0.1x0.110.0x0.18+0.1x0.16+0.1x0.14+0.1x0.070.04

Not reported in any period shown, so not listed: Gross Margin, Operating Margin, Net Margin, Asset Turnover, FCF Margin.

Similar Companies

Newest fiscal year on record for each company. The health score is the peer-relative Financial Health Score for that year; a dash means no score is published for it.

Company Fiscal year Revenue Net income Net margin Market cap Health score
Alto Neuroscience Inc. ANRO FY2025 N/A -$63.2M N/A $866.9M —
Atossa Therapeutics, Inc. ATOS FY2025 N/A -$34.8M N/A $23.8M —
Cassava Sciences, Inc. SAVA FY2025 N/A -$91.0M N/A $115.0M —
MacroGenics, Inc. MGNX FY2025 $149.5M -$75K -0.1% $237.0M 57/100
Adagene Inc. ADAG FY2025 $7.7M -$17.6M N/A $184.0M 63/100
Spero Therapeutics, Inc. SPRO FY2025 $66.8M $8.6M 12.8% $68.7M 65/100

Frequently Asked Questions

Is Alto Neuroscience Inc. profitable?

No, Alto Neuroscience Inc. (ANRO) reported a net income of -$63.2M in fiscal year 2025.

What is Alto Neuroscience Inc.'s earnings per share (EPS)?

Alto Neuroscience Inc. (ANRO) reported diluted earnings per share of -$2.19 for fiscal year 2025. This represents a 12.4% change compared to the previous fiscal year. EPS represents the portion of a company's net income allocated to each outstanding share of common stock and is widely used to evaluate profitability on a per-share basis.

What is Alto Neuroscience Inc.'s EBITDA?

Alto Neuroscience Inc. (ANRO) had EBITDA of -$65.7M in fiscal year 2025, measuring earnings before interest, taxes, depreciation, and amortization.

As of fiscal year 2025, Alto Neuroscience Inc. (ANRO) had $176.5M in cash and equivalents against $16.2M in long-term debt.

Alto Neuroscience Inc. (ANRO) has a return on equity of -41.8% for fiscal year 2025, measuring how efficiently the company generates profit from shareholder equity.

Alto Neuroscience Inc. (ANRO) recorded an outflow of $51.8M in free cash flow during fiscal year 2025. This represents a -4.6% change compared to the previous fiscal year. Free cash flow represents the cash a company generates after accounting for capital expenditures, and is widely used to assess financial flexibility and shareholder value.

Alto Neuroscience Inc. (ANRO) recorded an outflow of $51.8M in operating cash flow during fiscal year 2025, representing cash used by core business activities.

Alto Neuroscience Inc. (ANRO) had $184.7M in total assets as of fiscal year 2025, including both current and long-term assets.

Alto Neuroscience Inc. (ANRO) invested $24K in capital expenditures during fiscal year 2025, funding long-term assets and infrastructure.

Alto Neuroscience Inc. (ANRO) invested $45.6M in research and development during fiscal year 2025.

Alto Neuroscience Inc. (ANRO) had 32M shares outstanding as of fiscal year 2025.

Alto Neuroscience Inc. (ANRO) had a current ratio of 15.69 as of fiscal year 2025, which is generally considered healthy.

Alto Neuroscience Inc. (ANRO) had a debt-to-equity ratio of 0.11 as of fiscal year 2025, measuring the company's financial leverage by comparing total debt to shareholder equity.

Alto Neuroscience Inc. (ANRO) had a return on assets of -34.2% for fiscal year 2025, measuring how efficiently the company uses its assets to generate profit.

Alto Neuroscience Inc. (ANRO) has no price-to-earnings ratio at the moment: net loss, so no earnings multiple (FY2025). The market capitalization is $866.9M as of Oct 13, 2026; a multiple compares that price with a filed figure and says nothing about the quality of the business.

Alto Neuroscience Inc. (ANRO) has no price-to-sales ratio at the moment: no revenue reported. The market capitalization is $866.9M as of Oct 13, 2026; a multiple compares that price with a filed figure and says nothing about the quality of the business.

At the end of fiscal year 2025, Alto Neuroscience Inc. (ANRO) held $176.5M in cash, cash equivalents and investments, and reported an operating cash outflow of $51.8M over that year. Dividing the one by the other, the reported balance equals about 41 months of the outflow reported that year. This is arithmetic over figures already filed, not a projection: it assumes nothing about future spending, financing or operations.

Alto Neuroscience Inc. (ANRO) has a Piotroski F-Score of 2 out of 7 computable signals; 2 of the nine could not be computed from available data, so the full-scale strength rating is not shown. The F-Score evaluates nine binary signals across profitability (positive ROA, positive cash flow, improving ROA, earnings quality), leverage (decreasing debt, improving liquidity, no share dilution), and operating efficiency (improving gross margin, improving asset turnover). Scores of 7 to 9 indicate strong and improving fundamentals. Learn more in our complete guide to financial health indicators.

Alto Neuroscience Inc. (ANRO) reported a net loss of $63.2M while operations used $51.8M of cash. With neither figure positive, the ratio between the two carries no quality signal. This ratio compares operating cash flow to net income. A ratio above 1.0x means the company generates more cash than its reported earnings, indicating sustainable, cash-backed profits. Ratios below 1.0x suggest earnings rely on accounting accruals rather than actual cash generation. Learn more in our complete guide to financial health indicators.

Alto Neuroscience Inc. (ANRO) reported an operating loss of $66.4M against $2.5M in interest expense. There is no operating profit to cover interest, so interest must be met from cash reserves or from financing rather than from operations. This ratio divides operating income by interest expense. Ratios above 5x indicate strong debt-servicing ability, while ratios below 2x suggest the company may face difficulty meeting interest payments if earnings decline. Learn more in our complete guide to financial health indicators.

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