Apogee Therapeutics CFO sells 2,000 APGE shares at $65 in plan

Apogee Therapeutics, Inc. (APGE) reported an insider stock sale by its Chief Financial Officer, who is a reporting officer of the company.

Rhea-AI Filing Summary

Apogee Therapeutics, Inc. (APGE) reported an insider stock sale by its Chief Financial Officer, who is a reporting officer of the company. On 11/14/2025, the officer sold 2,000 shares of common stock at a price of $65 per share, in a transaction coded as an "S" sale. After this transaction, the officer beneficially owned 197,871 shares of Apogee common stock in direct ownership form. The sale was executed under a pre-arranged Rule 10b5-1 trading plan that was adopted on September 27, 2024, which is designed to allow insiders to sell shares according to a preset schedule.

Insider Trade Summary

Net Seller: 2,000 shares

Net Sell 1 txn

Insider Henderson Jane

Role Chief Financial Officer

Sold 2,000 shs ($130K)

Type	Security	Shares	Price	Value
Sale	Common Stock	2,000	$65.00	$130K

Holdings After Transaction: Common Stock — 197,871 shares (Direct)

Footnotes (1)

1. F1. This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 27, 2024.

FAQ

What insider transaction did Apogee Therapeutics (APGE) report?

Apogee Therapeutics reported that its Chief Financial Officer executed a sale of 2,000 shares of common stock on 11/14/2025, coded as an "S" sale.

At what price were the Apogee Therapeutics (APGE) shares sold in this Form 4?

The reported insider transaction shows that 2,000 shares of Apogee Therapeutics common stock were sold at a price of $65 per share.

How many Apogee Therapeutics shares does the officer own after the transaction?

Following the reported sale, the officer beneficially owns 197,871 shares of Apogee Therapeutics common stock in direct ownership.

Which Apogee Therapeutics insider is involved in this Form 4 filing?

The filing relates to an officer of Apogee Therapeutics who serves as Chief Financial Officer and is a reporting person for the company.

Was the Apogee Therapeutics insider sale made under a Rule 10b5-1 plan?

Yes. The explanation states that the transaction was executed under a Rule 10b5-1 trading plan adopted on September 27, 2024.

Is this Apogee Therapeutics Form 4 filed for one or multiple reporting persons?

The Form 4 is indicated as being filed by one reporting person, rather than by a group.

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Accepted by SEC EDGAR 11/14/2025 - 08:00 PM Learn about SEC filing dates

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

X

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Henderson Jane

(Last) (First) (Middle)

C/O APOGEE THERAPEUTICS, INC.

221 CRESCENT ST., BLDG. 17, STE. 102B

(Street)

WALTHAM MA 02453

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Apogee Therapeutics, Inc. [ APGE ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief Financial Officer

3. Date of Earliest Transaction (Month/Day/Year)
11/14/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	11/14/2025		S(1)		2,000	D	$65	197,871	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 27, 2024.

	/s/ Matthew Batters, as attorney-in-fact for Jane Pritchett Henderson	11/14/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.