Welcome to our dedicated page for Aptevo Therapeutics SEC filings (Ticker: APVO), a comprehensive resource for investors and traders seeking official regulatory documents including 10-K annual reports, 10-Q quarterly earnings, 8-K material events, and insider trading forms.
Aptevo Therapeutics Inc. filings document the regulatory record of a clinical-stage biotechnology company developing immune-oncology candidates based on ADAPTIR and ADAPTIR-FLEX platforms. Its 8-K reports record clinical updates for mipletamig in acute myeloid leukemia, annual financial results, material agreements, executive and board changes, and other public-company events.
The company’s proxy and registration filings disclose shareholder voting matters, proposed charter and administrative amendments, Nasdaq share-issuance approvals, common-stock financing arrangements, and capital-structure information related to its standby equity purchase agreement. These filings also provide formal context for governance, securities issuance mechanics, and the funding disclosures associated with Aptevo’s oncology pipeline.
Aptevo Therapeutics Inc. reported new clinical results from its RAINIER study. On September 16, 2025, the company announced a 100% remission rate in Cohort 3 of its Phase 1b/2 RAINIER trial. The study evaluates mipletamig, a first-in-class CD123 x CD3 bispecific antibody, combined with venetoclax and azacitidine in newly diagnosed acute myeloid leukemia patients who are not candidates for intensive chemotherapy.
The company released these data through a press release, which is included as an exhibit to this report, highlighting the importance Aptevo places on this clinical milestone in its oncology pipeline.
Aptevo Therapeutics Inc. filed a current report describing a pipeline update. On September 4, 2025, the company issued a press release announcing expansion of its anti-cancer pipeline through the filing of two provisional patents for trispecific drug candidates, APVO452 and APVO451. These candidates are being developed for prostate cancer and multiple additional solid tumor types that the company describes as having significant unmet medical needs. The press release with more scientific and development details is included as Exhibit 99.1 to the report.
L1 Capital Global Opportunities Master Fund, Ltd. reports beneficial ownership of 164,300 warrants of Aptevo Therapeutics Inc. The filing amends a prior Schedule 13G and clarifies that the reported 164,300 warrants are subject to a 4.99% beneficial ownership limitation and correspond to 4.99% of Aptevo's common stock based on 3,287,918 shares outstanding as of August 11, 2025.
The amendment notes that it does not include an additional 1,345,075 warrants that are also subject to the 4.99% limitation. The reporting entity is organized in the Cayman Islands; David Feldman and Joel Arber are identified as its directors. The filing includes a certification that the securities were not acquired to influence control of the issuer.
Aptevo Therapeutics disclosed that CVI Investments, Inc. and Heights Capital Management, Inc. report beneficial ownership of 357,842 shares of common stock, equal to 9.9% of the class. The reported position consists of shares issuable upon exercise of warrants; the filing shows 0 sole voting or dispositive power and 357,842 shared voting and dispositive power for the reporting persons.
The filing cites the company’s proxy indicating 3,224,156 shares outstanding as of June 20, 2025. Heights Capital is identified as the investment manager to CVI and may exercise voting and dispositive power over CVI’s holdings; both reporting persons disclaim beneficial ownership except for their pecuniary interest. The statement includes a certification that the securities were not acquired to change or influence control of the issuer.
Ayrton Capital LLC, Alto Opportunity Master Fund, SPC – Segregated Master Portfolio B, and Waqas Khatri report beneficial ownership of 358,150 shares of Aptevo Therapeutics Inc. common stock (CUSIP 03835L405), representing 9.99% of the class. The reported shares are issuable on exercise of warrants held by the Reporting Persons and are subject to a 9.99% beneficial ownership blocker. The percentage calculation is based on 3,224,156 shares outstanding per the issuer's prospectus dated June 20, 2025, and the holdings are reported as of June 30, 2025. Each Reporting Person disclaims shared voting or dispositive power and reports sole voting and dispositive power over the 358,150 issuable shares. The filing includes a certification that the securities are held in the ordinary course of business and not for the purpose of changing or influencing control.
Aptevo Therapeutics (APVO) reported a net loss of $12.6 million for the six months ended June 30, 2025 and a three-month loss of $6.2 million, driven by research and development and general and administrative expenses. Cash and cash equivalents were $9.41 million at June 30, 2025, and net cash used in operating activities for the six months was $13.7 million, resulting in an accumulated deficit of $260.2 million.
The company disclosed that substantial doubt exists about its ability to continue as a going concern for the one-year period from issuance. Since quarter-end Aptevo completed multiple equity financings that raised $15.9 million and entered a $25.0 million standby equity purchase agreement, and established an ATM program (originally $50.0 million, prospectus later updated to $8.0 million available under Form S-3 limits). The company also has 12,585,033 common warrants outstanding that could generate additional proceeds if exercised.
Aptevo Therapeutics announced that it furnished a press release reporting its financial results for the period ended June 30, 2025. The press release is attached to the filing as Exhibit 99.1 and is incorporated by reference into the report. The company states the information is being furnished, not filed, and therefore is not subject to certain liabilities under the federal securities laws and will not be incorporated by reference into future SEC filings unless expressly referenced. The 8-K itself contains no financial figures or metrics; readers must consult the attached press release for the reported results.
Abdun-Nabi Daniel, identified as a director of Aptevo Therapeutics, reported the grant of 7,200 Restricted Stock Units (RSUs) with a transaction date of 08/06/2025. The filing states the RSUs convert one-for-one into common stock of the issuer.
The RSUs are reported as directly owned following the grant and are set to vest in full on the first anniversary of the grant date. The Form 4 shows no sale or disposition associated with this reported transaction and lists beneficial ownership after the transaction as 7,200 shares (upon conversion).
Aptevo Therapeutics Inc. (APVO) reports that Daphne Taylor, the company's SVP and Chief Financial Officer, acquired 11,500 Restricted Stock Units (RSUs) on 08/06/2025. The filing shows these RSUs convert one-for-one into common stock and are recorded as a direct holding following the reported transaction.
The RSUs carry a $0 price in the filing and vest in full on the first anniversary of the grant, meaning they will convert into 11,500 common shares when vested. The form reflects an insider equity grant reported under Form 4 and does not disclose the company’s total outstanding shares, so the percentage dilution from this grant cannot be determined from this filing alone.
Aptevo Therapeutics director Grant Grady III reported a grant of 7,200 Restricted Stock Units (RSUs) in a Form 4 covering a transaction dated 08/06/2025. The RSUs convert one-for-one into common stock and are reported as direct holdings of 7,200 shares following the grant. The RSUs vest in full on the first anniversary of the grant.
The form is signed by attorney-in-fact SoYoung Kwon on 08/08/2025, and the filing shows a $0 price for the RSUs.