[Form 4] ARDELYX, INC. Insider Trading Activity

Rhea-AI Filing Summary

Ardelyx, Inc. (ARDX) reported an insider equity transaction by Senior Vice President of Finance Joseph J. Reilly. On 11/21/2025, he sold 11,086 shares of common stock at an average price of $5.5369 per share. Following this transaction, he beneficially owned 108,914 shares directly.

The sale was executed pursuant to an automatic sell-to-cover feature tied to previously granted restricted stock units. When the RSUs vested, a portion of the resulting shares was automatically sold to cover applicable withholding taxes, rather than as a discretionary sale of shares.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Reilly Joseph James

(Last) (First) (Middle)

C/O ARDELYX, INC.

400 FIFTH AVENUE, SUITE 210

(Street)

WALTHAM MA 02451

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
ARDELYX, INC. [ ARDX ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	See Remarks

3. Date of Earliest Transaction (Month/Day/Year)
11/21/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	11/21/2025		S(1)		11,086	D	$5.5369	108,914	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the restricted stock units ("RSUs") awards, the shares were sold upon the vesting of the RSUs solely to cover applicable withholding taxes.

Remarks:

Senior Vice President of Finance

	/s/ Elizabeth Grammer, Attorney-in-Fact for Joseph J. Reilly	11/25/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What insider transaction did Ardelyx (ARDX) report in this Form 4?

The filing reports that Senior Vice President of Finance Joseph J. Reilly sold 11,086 shares of Ardelyx common stock on 11/21/2025 and held 108,914 shares afterward.

At what price were the Ardelyx (ARDX) shares sold in the reported transaction?

The 11,086 Ardelyx common shares were sold at an average price of $5.5369 per share.

Why were Joseph J. Reilly’s Ardelyx (ARDX) shares sold?

The shares were sold pursuant to an automatic sell-to-cover provision tied to restricted stock unit vesting, solely to cover applicable withholding taxes.

How many Ardelyx (ARDX) shares does the insider beneficially own after the transaction?

After the 11,086-share sale, Joseph J. Reilly beneficially owned 108,914 Ardelyx common shares directly.

What is Joseph J. Reilly’s role at Ardelyx (ARDX)?

The filing identifies Joseph J. Reilly as Senior Vice President of Finance at Ardelyx, Inc.

Is this Ardelyx (ARDX) Form 4 filed by one reporting person or a group?

The Form 4 is indicated as filed by one reporting person.