aTyr Pharma: Federated Hermes reports 5.06% stake

The 5.06% reported position comes with differing sole and shared voting and dispositive power entries, plus a disclaimer covering Managed Funds securities.

Rhea-AI Filing Summary

aTyr Pharma Inc.'s ownership report states that Federated Hermes, Inc., the Voting Shares Irrevocable Trust, Thomas R. Donahue, Ann C. Donahue and J. Christopher Donahue reported beneficial ownership of 4,965,414 common shares, or 5.06%, as of September 30, 2026. Federated Hermes and the trust each listed sole voting and dispositive power over that amount; Thomas R. Donahue, Ann C. Donahue and J. Christopher Donahue listed shared voting and dispositive power. Thomas, Ann and J. Christopher are identified as trustees of the trust, and J. Christopher is also identified as Federated Hermes' president. The reporting persons expressly disclaim beneficial ownership of securities held by the Managed Funds.

Key Figures

Reported beneficial ownership: 4,965,414 shares Percent of class: 5.06% Sole voting and dispositive power: 4,965,414 shares +1 more

4 metrics

Reported beneficial ownership 4,965,414 shares Cover pages for the reporting persons; September 30, 2026

Percent of class 5.06% Cover pages for the reporting persons

Sole voting and dispositive power 4,965,414 shares Federated Hermes, Inc. and the Voting Shares Irrevocable Trust cover pages

Shared voting and dispositive power 4,965,414 shares Thomas R. Donahue, Ann C. Donahue and J. Christopher Donahue cover pages

Key Terms

beneficial ownership, Sole Voting Power, Shared Voting Power, Sole Dispositive Power, +1 more

5 terms

beneficial ownership regulatory

"beneficial ownership of the securities held by any of the Managed Funds"

Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.

Sole Voting Power regulatory

"Sole Voting Power 4,965,414.00"

Sole voting power is the exclusive right to cast votes attached to a shareholder’s stock without needing approval from anyone else. Like holding the only remote control for a TV, it lets that holder decide corporate matters such as board members, mergers, and policy changes, making it important to investors because it concentrates control and can strongly influence a company’s strategy and the value of its shares.

Shared Voting Power regulatory

"Shared Voting Power 4,965,414.00"

Shared voting power occurs when two or more parties jointly have the right to vote or decide how a block of company shares is cast, like co-owners who must agree before moving a piece of furniture. Investors care because who controls voting rights affects board elections, major corporate decisions and takeover outcomes, and shared control can alter regulatory disclosures and the practical influence any holder has over a company’s direction and value.

Sole Dispositive Power regulatory

"Sole Dispositive Power 4,965,414.00"

Sole dispositive power is the exclusive legal authority to decide what happens to a security — for example, whether to sell, transfer, or retain shares — without needing anyone else’s permission. Investors care because it signals who truly controls the economic outcome of an investment: like holding the only key to a safe, the holder can realize gains or losses and may trigger regulatory reporting, insider rules, or influence over corporate ownership.

Shared Dispositive Power regulatory

"Shared Dispositive Power 4,965,414.00"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many ATYR shares did the reporting persons report?

The reporting persons listed 4,965,414 shares, or 5.06% of aTyr Pharma Inc. common stock, as of September 30, 2026. Federated Hermes and the Voting Shares Irrevocable Trust listed sole voting and dispositive power, while the three Donahues listed shared power. They disclaimed beneficial ownership of securities held by the Managed Funds.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 10/07/2026 - 07:19 AM Accepted by SEC EDGAR 10/07/2026 - 07:18 AM Learn about SEC filing dates

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 12)

aTYR PHARMA INC

(Name of Issuer)

COMMON STOCK

(Title of Class of Securities)

002120202

(CUSIP Number)

09/30/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 002120202

1

Names of Reporting Persons

Federated Hermes, Inc.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

PENNSYLVANIA

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 4,965,414.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 4,965,414.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

4,965,414.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.06 %

12

Type of Reporting Person (See Instructions)

HC

SCHEDULE 13G

CUSIP Number(s): 002120202

1

Names of Reporting Persons

Voting Shares Irrevocable Trust

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

PENNSYLVANIA

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 4,965,414.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 4,965,414.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

4,965,414.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.06 %

12

Type of Reporting Person (See Instructions)

OO

Comment for Type of Reporting Person: In accordance with Rule 13d-4 under the Exchange Act, Federated Hermes, Inc.; the Voting Shares Irrevocable Trust; Thomas R. Donahue; Ann C. Donahue; and J. Christopher Donahue declare that this report should not be construed as an admission that any of them is the beneficial owner of the securities held by any of the Managed Funds, and each of Federated Hermes, Inc.; the Voting Shares Irrevocable Trust; Thomas R. Donahue; Ann C. Donahue; and J. Christopher Donahue expressly disclaim beneficial ownership of such securities.

SCHEDULE 13G

CUSIP Number(s): 002120202

1

Names of Reporting Persons

Thomas R. Donahue

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 4,965,414.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 4,965,414.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

4,965,414.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.06 %

12

Type of Reporting Person (See Instructions)

IN

Comment for Type of Reporting Person: In accordance with Rule 13d-4 under the Exchange Act, Federated Hermes, Inc.; the Voting Shares Irrevocable Trust; Thomas R. Donahue; Ann C. Donahue; and J. Christopher Donahue declare that this report should not be construed as an admission that any of them is the beneficial owner of the securities held by any of the Managed Funds, and each of Federated Hermes, Inc.; the Voting Shares Irrevocable Trust; Thomas R. Donahue; Ann C. Donahue; and J. Christopher Donahue expressly disclaim beneficial ownership of such securities.

SCHEDULE 13G

CUSIP Number(s): 002120202

1

Names of Reporting Persons

Ann C. Donahue

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 4,965,414.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 4,965,414.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

4,965,414.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.06 %

12

Type of Reporting Person (See Instructions)

IN

Comment for Type of Reporting Person: In accordance with Rule 13d-4 under the Exchange Act, Federated Hermes, Inc.; the Voting Shares Irrevocable Trust; Thomas R. Donahue; Ann C. Donahue; and J. Christopher Donahue declare that this report should not be construed as an admission that any of them is the beneficial owner of the securities held by any of the Managed Funds, and each of Federated Hermes, Inc.; the Voting Shares Irrevocable Trust; Thomas R. Donahue; Ann C. Donahue; and J. Christopher Donahue expressly disclaim beneficial ownership of such securities.

SCHEDULE 13G

CUSIP Number(s): 002120202

1

Names of Reporting Persons

J. Christopher Donahue

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 4,965,414.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 4,965,414.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

4,965,414.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.06 %

12

Type of Reporting Person (See Instructions)

IN

Comment for Type of Reporting Person: In accordance with Rule 13d-4 under the Exchange Act, Federated Hermes, Inc.; the Voting Shares Irrevocable Trust; Thomas R. Donahue; Ann C. Donahue; and J. Christopher Donahue declare that this report should not be construed as an admission that any of them is the beneficial owner of the securities held by any of the Managed Funds, and each of Federated Hermes, Inc.; the Voting Shares Irrevocable Trust; Thomas R. Donahue; Ann C. Donahue; and J. Christopher Donahue expressly disclaim beneficial ownership of such securities.

SCHEDULE 13G

Item 1.
(a)	Name of issuer: aTYR PHARMA INC
(b)	Address of issuer's principal executive offices: 10240 Sorrento Valley Road, Suite 300, San Diego, CA 92121
Item 2.
(a)	Name of person filing: Federated Hermes, Inc.
(b)	Address or principal business office or, if none, residence: 1001 Liberty Avenue, Pittsburgh, PA 15222-3779
(c)	Citizenship: Pennsylvania
(d)	Title of class of securities: COMMON STOCK
(e)	CUSIP No.: 002120202
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: See response to Item 9 on each cover page.
(b)	Percent of class: See response to Item 11 on each cover page.
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: See response to Item 5 on each cover page.
	(ii) Shared power to vote or to direct the vote: See response to Item 6 on each cover page.
	(iii) Sole power to dispose or to direct the disposition of: See response to Item 7 on each cover page.
	(iv) Shared power to dispose or to direct the disposition of: See response to Item 8 on each cover page.
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	Not Applicable
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. See Exhibit "1" Attached
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Federated Hermes, Inc.

Signature:	/s/J. Christopher Donahue
Name/Title:	J. Christopher Donahue, as President of Federated Hermes, Inc.
Date:	10/07/2026

Voting Shares Irrevocable Trust

Signature:	/s/Thomas R. Donahue
Name/Title:	Thomas R. Donahue, as Trustee of Voting Shares Irrevocable Trust
Date:	10/07/2026

Signature:	/s/Ann C. Donahue
Name/Title:	Ann C. Donahue, as Trustee of Voting Shares Irrevocable Trust
Date:	10/07/2026

Signature:	/s/J. Christopher Donahue
Name/Title:	J. Christopher Donahue, as Trustee of Voting Shares Irrevocable Trust
Date:	10/07/2026

Thomas R. Donahue

Signature:	/s/Thomas R. Donahue
Name/Title:	Thomas R. Donahue
Date:	10/07/2026

Ann C. Donahue

Signature:	/s/Ann C. Donahue
Name/Title:	Ann C. Donahue
Date:	10/07/2026

J. Christopher Donahue

Signature:	/s/J. Christopher Donahue
Name/Title:	J. Christopher Donahue
Date:	10/07/2026

Comments accompanying signature: SEE EXHIBITS 2 AND 3 ATTACHED Exhibit Information EXHIBIT 1 ITEM 3 CLASSIFICATION OF REPORTING PERSONS EXHIBIT 2 AGREEMENT FOR JOINT FILING OF SCHEDULE 13G EXHIBIT 3 POWER OF ATTORNEY