Check the appropriate box below if the Form 8-K filing is intended to simultaneously
satisfy the filing obligation of the registrant under any of the following provisions:
Indicate by check mark whether the registrant is an emerging growth company
as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act
of 1934 (§ 240.12b-2 of this chapter).
If an emerging growth company, indicate by check mark if the registrant
has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
to Section 13(a) of the Exchange Act. ☐
On August 11, 2026, Anavex Life Sciences Corp. (“Anavex” or
the “Company”) issued a press release announcing the filing of the Company’s definitive proxy statement for its 2026
Annual Meeting of Stockholders (the “Press Release”). The Press Release includes an open letter to Anavex’s stockholders
highlighting, among other things, plans to refresh Anavex’s Board of Directors at the 2026 Annual Meeting of Stockholders.
A copy of the Press Release is furnished as Exhibit 99.1 to this Current
Report and is incorporated herein by reference.
The information included in this Item 7.01, including Exhibit 99.1, shall
not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”),
or otherwise subject to the liabilities of that section, and it shall not be deemed incorporated by reference in any filing under the
Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such filing.
Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
EXHIBIT 99.1

Anavex Life Sciences Highlights Highly Qualified
Board and Decisive Actions
to Create Long-Term Value for Stockholders
Files Definitive Proxy Statement and Mails Letter
to Stockholders
Urges Stockholders to Vote “FOR” All
Six Anavex Director Nominees on the WHITE Proxy Card
Underscores PVG’s Lack of Clear Plan and Inexperienced
Slate of Director Nominees
NEW YORK, NY, August 11, 2026 – Anavex Life Sciences Corp. (“Anavex”
or the “Company”) (Nasdaq: AVXL), a clinical-stage biopharmaceutical company focused on developing innovative treatments for
central nervous system (“CNS”) diseases with high unmet medical needs, today announced that it has filed definitive proxy
materials with the Securities and Exchange Commission (“SEC”) in connection with its upcoming 2026 Annual Meeting of Stockholders
(the “2026 Annual Meeting”) scheduled to be held on September 24, 2026. Stockholders of record as of July 31, 2026 will be
entitled to vote at the meeting. Anavex’s definitive proxy materials can be accessed for free by visiting EDGAR on the SEC website
at www.SEC.gov.
In conjunction with the definitive proxy statement filing, the current
Anavex Board members standing for reelection at the 2026 Annual Meeting are mailing a letter to the Company’s stockholders. Key
takeaways from the letter include:
| ● | Executing
a Clear Strategy to Enhance Long-Term Stockholder Value: Following a significant leadership
transition, the Board has taken decisive action to stabilize the company and create value
for stockholders. The Special Committee of the Board moved quickly to appoint Dr. Terrie
Kellmeyer as interim CEO to help support the Company’s next phase of execution. Anavex
is moving ahead with oral blarcamesine (ANAVEX®2-73) across three CNS indications while
prioritizing FDA engagement to establish a clear, data-driven regulatory path forward. |
| ● | Advancing
Board Refreshment with Two Highly Qualified, Independent Director Candidates: Following
a thorough search process, the Executive Committee of the Board nominated Mr. Gautam Patel
and Dr. Adrian Senderowicz, two highly qualified, independent candidates who will bring directly
relevant life sciences, capital markets and drug development expertise to the Board and are
expected to immediately contribute to the Company’s strategy and help create value
across the business. If Anavex’s recommended nominees are elected at the 2026 Annual
Meeting, half of the Board will have been refreshed since the beginning of 2026, and all
Board members will be independent. |
| ● | PVG
is Attempting to Take Control with No Clear Plan: PVG’s own proxy statement offers
no discussion of any plan or strategy for the Company. Stockholders should carefully consider
whether PVG has made the case that its nominees can effectively guide Anavex through a critical
regulatory and development period. |
| ● | PVG’s Nominees Lack Critical Drug Development and Regulatory Expertise: Based on the Company’s review, PVG’s
slate is concentrated almost entirely in investment management and equity research, with limited demonstrated experience actually governing
or operating a public company. Only one of six nominees has a clinical medical background, and none have direct experience in FDA regulatory
affairs or pharmaceutical drug development, presenting a meaningful gap for a board overseeing a clinical-stage biopharmaceutical company. |
The full text of the letter being mailed to stockholders follows:
Dear Anavex Stockholder,
The future direction of the Company is in your hands. Patrick
Adams, through his fund PVG Asset Management Corporation (“PVG”), is attempting to take control of the Anavex Board of Directors
at the Company’s Annual Meeting of Stockholders on September 24, 2026. If successful, Mr. Adams will gain effective control of the
Company without paying you a premium for your investment and despite only owning 0.35% of the Company’s outstanding shares of common
stock.[1]
We urge you to vote “FOR” Anavex’s six
highly qualified, independent director nominees on the WHITE universal proxy card today for the following three reasons:
Reason #1: Anavex’s current Board members standing for
election have taken decisive action to position the Company for long-term value creation
Your current Board members standing for election at the 2026
Annual Meeting have taken decisive action to stabilize the Company and create long-term value for stockholders.
Soon after the termination of our former CEO in April 2026, we
appointed Dr. Terrie Kellmeyer, the Company’s former Senior Vice President of Clinical Development and a Senior Advisor to Anavex,
as interim CEO. Dr. Kellmeyer has spent her entire career in drug development, building and leading clinical and regulatory functions
across the full lifecycle of drug development, and we are confident she is the right person to lead the Company during this period of
transition. We also conducted a thorough search supported by an independent search firm and identified Mr. Gautam Patel and Dr. Adrian
Senderowicz – two highly qualified, independent director candidates who bring life sciences, capital markets, and drug development
expertise to the Board.
We are urgently moving ahead with our lead candidate, oral blarcamesine
(ANAVEX®2-73), across three CNS indications – early Alzheimer’s disease, Rett syndrome, and Fragile X syndrome –
and are prioritizing FDA engagement to establish a clear, data-driven regulatory path forward.
The Board, alongside Dr. Kellmeyer and the rest of the management
team, has laid out a plan to advance its programs that have the greatest potential for success:
[1] Ownership data as of
July 31, 2026
| ● | Alzheimer’s Disease Program: In March 2026, the Company opened an investigational new drug application (IND) for early
Alzheimer’s disease with the FDA, a key step enabling U.S. clinical studies and substantive FDA discussions on the path forward.
Two foundational clinical pharmacology studies are now underway under this IND: an absorption, distribution, metabolism and excretion
(ADME) study expected to begin in the third calendar quarter of 2026, and a drug-drug interaction (DDI) study where dosing has already
started. Both studies are designed to strengthen the regulatory pathway across all blarcamesine indications in parallel with our ongoing
early Alzheimer’s disease program. We intend to engage with the FDA on a U.S. clinical development strategy, informed in part by
our review of the EMA’s CHMP assessment report. Additionally, we reinforced our commitment to the Alzheimer’s community through
our participation in the AAIC conference in London this July. |
| ● | Rett Syndrome Program: Blarcamesine already holds Orphan Drug, Rare Pediatric Disease, and Fast Track designations from the
FDA for Rett syndrome, and we have aligned with the FDA on a Phase 3 trial protocol for adult patients, a critical step toward a registrational
path. We intend to discuss expanding the protocol to include pediatric patients, with more details to come as that conversation progresses. |
| ● | Fragile X Syndrome Program: Blarcamesine has received Orphan Drug Designation from the FDA for Fragile X syndrome, and building
on that designation, we plan to open discussions with the FDA on a clinical development strategy for the program, with further details
to follow as it advances. |
As it relates to our Nasdaq listing, on May 20, 2026, Anavex
received a delinquency notification from Nasdaq for failing to timely file its Quarterly Report on Form 10-Q for the quarter ended March
31, 2026. The notice did not affect the Company’s listing, and we are in compliance with all other requirements for the continued
listing of our common stock on The Nasdaq Global Select Market. We have submitted a compliance plan to Nasdaq and released preliminary
second fiscal quarter financial results and a business update to keep stockholders informed. We are working diligently to complete our
outstanding periodic filings and fully regain compliance as quickly as possible.
Reason #2: Anavex’s recommended nominees have the right
skills, qualifications, and expertise and, if elected, half of the Board will have been refreshed in just seven months
Your current Board members standing for election are entirely
independent and will continue to bring critical institutional knowledge that we believe will advance the right path forward. Following
a thorough search process, we are also nominating two new, independent candidates, Mr. Gautam Patel and Dr. Adrian Senderowicz, who will
bring significant, relevant life sciences experience and complementary skills to the Board that are expected to immediately contribute
to the Company’s strategy and help create value across the business. Upon election, half of the Anavex Board will have been refreshed
since the beginning of 2026, and all of the Board members will be independent.
To ensure our continued progress without disruption, Anavex
is seeking your vote on the WHITE proxy card “FOR” the Company’s six director nominees, comprising four
current independent directors and two newly nominated independent candidates:
| √ | Dr.
Jiong Ma (Independent Chair): Partner at Phoenix Venture Partners and experienced
operator with 30+ years of experience investing in, building and scaling technology and life
sciences companies globally. |
| √ | Dr.
Peter Donhauser: Physician and clinical research leader with 20+ years of experience
in integrated medical care, clinical trial oversight and private practice leadership. |
| √ | Dr.
Axel Paeger: CEO of AMEOS Group, a leading European healthcare provider, with 30+ years
of clinical, operational and executive leadership experience. |
| √ | Mr.
Gautam Patel (new independent nominee): Managing Director at Tarsadia Investments
with 30+ years of corporate finance, investment management and board leadership experience
across life sciences, financial services and technology. |
| √ | Dr.
Adrian Senderowicz (new independent nominee): Former Chief Medical Officer at
public and private clinical-stage companies with 30+ years of clinical and regulatory leadership
experience across the life sciences industry. |
| √ | Dr.
Claus van der Velden: CFO and Managing Director of NetCologne GmbH, a regional telecommunications
provider in Germany, bringing 20+ years of experience leading public company finance,
governance and enterprise oversight functions. |
Reason #3: Patrick Adams is seeking effective control of Anavex
without disclosing any strategy to create value and without paying you a premium for that control
We believe electing any of the PVG nominees would introduce unnecessary
risk and disruption at a critical moment for the Company, its pipeline and its stockholders. PVG’s own proxy statement offers no
discussion of any plan or strategy for the Company, and it discloses only very limited information about PVG, Mr. Adams, and their nominees
– including their backgrounds, ownership, and any arrangements tied to the solicitation. PVG and Mr. Adams together own just 0.35%
of Anavex’s outstanding shares yet are seeking effective control of your Board without paying stockholders any premium, asking you
to trust an unproven slate with no stated direction for the Company.
Beyond the absence of any stated strategy, PVG’s own nominee
disclosures raise serious questions about whether any of their nominees would provide the right skills, qualifications, or expertise necessary
to contribute to your Board. PVG’s slate is concentrated almost entirely in investment management and equity research, with limited
demonstrated experience actually governing or operating a public company. Only one of the six nominees has a clinical medical background,
and none have direct experience in FDA regulatory affairs or pharmaceutical drug development, presenting a meaningful and concerning gap
for a board tasked with overseeing a clinical-stage biopharmaceutical company through FDA engagement and a critical regulatory period.
Reject PVG’s Brazen Attempt to Acquire Control of the
Company Without Paying You a Premium; Vote “FOR” Anavex’s Six Highly Qualified Director Nominees on the WHITE Proxy
Card Today
Your Board nominees have spent the past several months overseeing
a disciplined, data-driven clinical strategy while taking decisive action to refresh its membership and leadership, bringing in highly
qualified new independent directors and installing experienced interim leadership through a critical transition. PVG, by contrast, has
not offered stockholders any strategy of its own, and its nominees have limited public company governance experience and no meaningful
FDA regulatory or drug development background. At a moment when this Company needs steady, qualified oversight to advance its CNS pipeline,
your current Board has demonstrated exactly that, while PVG has not made the case that its nominees can do the same. We urge you to
vote FOR all six of Anavex’s nominees on the enclosed WHITE proxy card.
If you have any questions or require any assistance with voting
your shares, please call:

Innisfree M&A Incorporated
500 Fifth Avenue, 21st Floor
New York, NY 10110
Stockholders may call toll-free at (877)
750-0831
Brokers, banks and other nominees may call
collect at (212) 750-5833
We look forward to engaging with investors as we move toward
the Annual Meeting and are unwavering in our commitment to act in the best interests of the Company and all stockholders.
Sincerely,
|
Dr. Jiong Ma
Independent Chair |
Dr. Peter Donhauser
Independent Director |
Dr. Axel Paeger
Independent Director |
Dr. Claus van der Velden
Independent Director |
About Anavex Life Sciences Corp.
Anavex Life Sciences Corp. (Nasdaq: AVXL) is a publicly traded biopharmaceutical
company dedicated to the development of novel therapeutics for the treatment of neurodegenerative, neurodevelopmental, and neuropsychiatric
disorders. Further information is available at www.anavex.com.
Forward-Looking Statements
This press release contains forward-looking statements within the meaning
of the Private Securities Litigation Reform Act of 1995. Statements that are not historical facts, including statements regarding the
Company’s plans, strategies and expectations regarding the 2026 Annual Meeting, director nominations, the proxy solicitation, the
Company’s go-forward strategy, clinical development programs, business prospects, and potential actions of the Board and the Executive
Committee, are forward-looking statements. These statements can be identified by the use of forward-looking terminology, including the
words “believes,” “anticipates,” “plans,” “estimates,” “expects,” “intends,”
“may,” “will,” “would,” “could” and similar expressions, or the negative thereof. Many
factors may cause actual results to differ materially from those projected in any of such forward-looking statements, including the risks
and uncertainties set forth in the Company’s Annual Report on Form 10-K for the fiscal year ended September 30, 2025, and subsequent
filings and furnishings with the SEC, which should be considered together with any forward-looking statement. Readers are cautioned not
to place undue reliance on these forward-looking statements, which speak only as of the date hereof. All forward-looking statements are
qualified in their entirety by this cautionary statement, and Anavex Life Sciences Corp. undertakes no obligation to revise or update
this press release to reflect events or circumstances after the date hereof except as required by law.
Important Additional Information and Where to Find It
The Company has filed a definitive proxy
statement on Schedule 14A, an accompanying WHITE proxy card, and other relevant documents with the SEC in connection with the
solicitation of proxies from the Company’s stockholders for the 2026 Annual Meeting. THE COMPANY’S STOCKHOLDERS ARE
STRONGLY ENCOURAGED TO READ THE COMPANY’S DEFINITIVE PROXY STATEMENT (INCLUDING ANY AMENDMENTS OR SUPPLEMENTS THERETO), THE
ACCOMPANYING WHITE PROXY CARD AND OTHER DOCUMENTS FILED WITH THE SEC CAREFULLY AND IN THEIR ENTIRETY BECAUSE THEY CONTAIN IMPORTANT
INFORMATION. Stockholders are able to obtain the definitive proxy statement, any amendments or supplements to the proxy statement
and other documents that the Company files with the SEC at no charge at the SEC’s website at www.sec.gov. Copies are also
available at no charge at the Company’s website at www.anavex.com.
Certain Information Regarding Participants
The Company, its directors and certain of its executive officers may be
deemed to be “participants” (as defined in Schedule 14A under the Securities Exchange Act of 1934, as amended) in the solicitation
of proxies from the Company’s stockholders in connection with the matters to be considered at the 2026 Annual Meeting. Information
regarding the names of the Company’s directors and executive officers and certain other individuals and their direct or indirect
interests in the Company, by security holdings or otherwise, is set forth in the sections entitled “Compensation of Directors,”
“Executive Compensation,” and “Security Ownership of Certain Beneficial Owners and Management and Related Stockholder
Matters” of the Company’s Annual Report on Form 10-K for the fiscal year ended September 30, 2025 (available here), and any
subsequent filings on Forms 3, 4 and 5 filed with the SEC. Additional information regarding the identity of potential participants, and
their direct or indirect interests, by security holdings or otherwise, are set forth in the Company’s definitive proxy statement
for the 2026 Annual Meeting which has been filed with the SEC. These documents are available free of charge at the SEC’s website
at www.sec.gov.
Investor
Relations:
SCR Partners, LLC
Alex Arzeno
Tel: 203-550-3972
Email: alex@scr-ir.com
Tripp
Sullivan
Tel: 615-942-7077
Email: tsullivan@scr-ir.com
For Media:
Collected Strategies
Nick Lamplough / Dylan O’Keefe
AVXL-CS@collectedstrategies.com