Filed pursuant to Rule 424(b)(3)
Registration No.: 333-281489
PROSPECTUS SUPPLEMENT No. 5
(To the Prospectus dated March 30, 2026)
BIODEXA PHARMACEUTICALS PLC
170,150 Ordinary Shares Representing 3,403 American
Depositary Shares
This prospectus supplement
No. 5 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form
F-1, as amended, effective as of March 30, 2026 (the “Prospectus”), related to the resale by the selling shareholders identified
in the Prospectus of up to an aggregate of 170,150 of our ordinary shares, nominal value £0.000001 per share, represented by 3,403
American Depositary Shares (the “Depositary Shares”).
This Prospectus Supplement
is being filed in order to incorporate into and include in the Prospectus the information contained in our attached Report on Form 6-K,
filed with the Securities and Exchange Commission on October 8, 2026.
This Prospectus Supplement
should be read in conjunction with the Prospectus and is qualified by reference to the Prospectus except to the extent that the information
in this Prospectus Supplement supersedes the information contained therein.
Our Depositary Shares are
listed on the NASDAQ Capital Market under the symbol “BDRX.” The last reported closing price of Depositary Shares on the NASDAQ
Capital Market on October 12, 2026 was $0.3832.
Investing in our securities
involves risks. See “Risk Factors” beginning on page 9 of the Prospectus and in the documents incorporated by reference in
the Prospectus for a discussion of the factors you should carefully consider before deciding to purchase these securities.
Neither the Securities
and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus
is truthful or complete. Any representation to the contrary is a criminal offense.
______________________________
The date of this Prospectus Supplement is October
13, 2026.
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM 6-K
REPORT OF FOREIGN PRIVATE ISSUER
PURSUANT TO RULE 13a-16 OR 15d-16 OF THE
SECURITIES EXCHANGE ACT OF 1934
For the month of October 2026
Commission File Number 001-37652
Biodexa Pharmaceuticals PLC
(Translation of registrant’s name into English)
1 Caspian Point,
Caspian Way
Cardiff, CF10 4DQ, United Kingdom
(Address of principal executive offices)
Indicate by check mark whether the registrant files or will file annual
reports under cover of Form 20-F or Form 40-F:
Form 20-F x Form
40-F ¨
Indicate by check mark if the registrant is submitting the Form 6-K
in paper as permitted by Regulation S-T Rule 101(b)(1): ¨
Indicate by check mark if the registrant is submitting the Form 6-K
in paper as permitted by Regulation S-T Rule 101(b)(7): ¨
On October 8, 2026, Biodexa
Pharmaceuticals PLC (the “Company”) announced a ratio change of its American Depositary Shares (“ADSs”) from one
(1) ADS representing fifty (50) of its ordinary shares, to a new ratio of one (1) ADS representing four hundred (400) ordinary shares
(the “Ratio Change”). The effective date of the Ratio Change is expected to be on or about October 26, 2026.
Pursuant to the Ratio Change,
ADS holders will be required on a mandatory basis to surrender their ADSs for cancellation and exchange to receive one (1) new ADS (New
CUSIP: 59564R864) for every eight (8) old ADSs (Old CUSIP: 59564R872). No fractional ADSs will be allocated. The aggregate fractions,
if any, will be sold and the net proceeds will be distributed to the entitled ADS holder. The Company's Depositary, JPMorgan Chase Bank,
N.A. will contact ADS holders and arrange for the exchange of their existing ADSs for new ADSs.
For ADS holders, the Ratio
Change will have the same effect as a one-for-eight reverse ADS split. The ordinary shares of the Company will not be affected by this
change.
The information in this
Report on Form 6-K shall be deemed to be incorporated by reference into the registration statements on Form S-8 (File No. 333-209365)
and Form F-3 (File No. 333-290554) of the Company (including any prospectuses forming a part of such registration statements) and
to be a part thereof from the date on which this report is filed, to the extent not superseded by documents or reports subsequently filed
or furnished.
SIGNATURE
Pursuant to the requirements of the Securities Exchange
Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
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Biodexa Pharmaceuticals PLC |
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| Date: October 8, 2026 |
By: |
/s/ Stephen Stamp |
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Stephen Stamp |
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Chief Executive Officer |
