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Caris Life Sciences (NASDAQ: CAI) nearly doubles 2025 revenue and turns cash positive

Filing Impact
(Moderate)
Filing Sentiment
(Neutral)
Form Type
8-K

Rhea-AI Filing Summary

Caris Life Sciences delivered a breakout 2025, nearly doubling revenue and turning profitable in the fourth quarter. Q4 2025 revenue reached $292.9 million, up 125% year over year, with gross margin expanding to 75% and net income of $82.0 million. Full-year 2025 revenue was $812.0 million, up 97%, with gross margin improving to 66%. The company still reported a full-year net loss of $68.1 million, but generated positive Adjusted EBITDA of $137.7 million, operating cash flow of $83.2 million, and free cash flow of $66.9 million.

Management expects 2026 revenue of $1.0 billion to $1.02 billion, implying approximately 23% to 26% growth, driven by about 20% higher clinical therapy selection volume and 21% to 22% molecular profiling growth. They also expect to remain positive on free cash flow and Adjusted EBITDA. The company highlighted an interim readout from its Achieve 1 study supporting the planned first-half 2026 launch of Caris Detect, a multi-cancer early detection test, and recent partnerships with Everlywell and Genentech.

Positive

  • Hypergrowth and margin expansion: 2025 revenue rose 97% to $812.0 million, Q4 revenue grew 125%, and gross margin improved from 43% to 66%, indicating strong operating leverage in molecular profiling.
  • Profitability and cash inflection: Adjusted EBITDA improved from a $189.6 million loss to $137.7 million positive, and free cash flow swung from negative $253.6 million to positive $66.9 million in 2025.
  • Strong 2026 outlook: Management guides 2026 revenue to $1.0–$1.02 billion (about 23%–26% growth) with expectations to remain positive on free cash flow and Adjusted EBITDA.
  • Strategic pipeline and partnerships: Interim Achieve 1 readout supports a planned first-half 2026 launch of Caris Detect, alongside new collaborations with Everlywell and Genentech in multi-cancer early detection and target discovery.

Negative

  • None.

Insights

Caris posts hypergrowth, margin expansion, and turns cash-flow positive.

Caris Life Sciences reported 2025 revenue of $812.0 million, up 97%, with Q4 revenue of $292.9 million up 125%. Gross margin expanded from 43% to 66% for the year, showing strong operating leverage as molecular profiling services scaled.

Profitability metrics improved sharply: Adjusted EBITDA swung from a $189.6 million loss in 2024 to a $137.7 million gain in 2025, while free cash flow improved from negative $253.6 million to positive $66.9 million. The Q4 net income of $82.0 million versus a prior-year loss underscores the earnings inflection.

For 2026, guidance calls for revenue of $1.0 billion–$1.02 billion, or roughly 23%–26% growth, with molecular profiling up 21%–22% and continued positive free cash flow and Adjusted EBITDA. Execution around the planned first-half 2026 launch of Caris Detect and the Everlywell and Genentech collaborations will be key drivers discussed in future updates.

0002019410FALSE00020194102026-02-262026-02-26

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
_______________________________
FORM 8-K
_______________________________
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the
Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): February 26, 2026
CARIS LIFE SCIENCES, INC.
(Exact name of registrant as specified in its charter)
Texas001-4270685-2077369
(State or other jurisdiction of
incorporation)
(Commission
File Number)
(IRS Employer
Identification No.)
750 W. John Carpenter Freeway Suite 800
 Irving, TX
75039
(Address of principal executive offices)(Zip Code)
Registrant’s telephone number, including area code: (866) 771-8946
Not Applicable
(Former name or former address, if changed since last report)
_______________________________
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Securities registered pursuant to Section 12(b) of the Act:
Title of each classTrading Symbol(s)Name of each exchange on which registered
Common Stock, $0.001 par valueCAIThe Nasdaq Stock Market LLC
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).
Emerging growth company
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.



Item 2.02    Results of Operations and Financial Condition.
On February 26, 2026, Caris Life Sciences, Inc. (the “Company”) issued a press release announcing its financial results for the quarter and year ended December 31, 2025. A copy of the Company’s press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated by reference herein solely for purposes of this Item 2.02 disclosure.
Item 7.01    Regulation FD Disclosure.
Also on February 26, 2026, the Company posted on the "News" section under "News & Events" on its website information regarding the completion of the interim readout of Achieve 1, the Company’s study supporting the upcoming launch of Caris Detect, its multi-cancer early detection (MCED) test. The website contents referenced herein are not incorporated into this Current Report on Form 8-K.
___________________________
The information in this Current Report on Form 8-K, including Exhibit 99.1 furnished herewith, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth in such filing.
Item 9.01    Financial Statements and Exhibits.
(d) Exhibits
Exhibit No.Description
99.1
Press Release issued February 26, 2026.
104Cover Page Interactive Data File (embedded within the Inline XBRL document).



SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
Date: February 26, 2026
CARIS LIFE SCIENCES, INC.
By:/s/ Luke Power
Name:Luke Power
Title:Senior Vice President, Chief Financial Officer and Chief Accounting Officer


Exhibit 99.1
Caris Life Sciences Reports Fourth Quarter and Full Year 2025 Financial Results and Provides 2026 Outlook
Full year revenue growth of 97% driven by strong performance in molecular profiling services
Expects full year 2026 revenue to be in the range of $1.0 billion to $1.02 billion
IRVING, Texas, February 26, 2026— Caris Life Sciences, Inc. (NASDAQ: CAI), a leading, patient centric, next-generation AI TechBio company and precision medicine pioneer, today reported financial results for the quarter and full year ended December 31, 2025.
Fourth Quarter 2025 Financial Highlights
Reported total revenue of $292.9 million, an increase of 125% over the corresponding prior year period.
Completed approximately 52,700 clinical therapy selection cases, an increase of approximately 20% over the corresponding prior year period, and consisting of approximately 44,150 MI Profile cases and approximately 8,550 Caris Assure cases.
Reported gross margin of 75%, an approximate 2,000 bps improvement over the corresponding prior year period.
Reported net income of $82.0 million.
Reported positive Adjusted EBITDA of $106.1 million.
Reported positive net cash provided by operating activities of $44.8 million, and positive free cash flow of $39.7 million.
Full Year 2025 Financial Highlights
Reported total revenue of $812.0 million, an increase of 97% over the corresponding prior year.
Completed approximately 199,300 clinical therapy selection cases, an increase of approximately 22% over the corresponding prior year, and consisting of approximately 170,300 MI Profile cases and approximately 29,000 Caris Assure cases.
Reported gross margin of 66%, an approximate 2,300 bps improvement over the corresponding prior year period.
Reported net loss of $68.1 million.
Reported positive Adjusted EBITDA of $137.7 million.
Reported positive net cash provided by operating activities of $83.2 million, and positive free cash flow of $66.9 million.
“Demand for our platform continued to accelerate in 2025, driving strong growth in volume and revenue and expanding adoption across our solutions. We are focused on building on this momentum, advancing our pipeline, and are particularly excited about the planned launch of our Caris Detect solution in the first half of 2026, which we believe represents a significant growth opportunity for Caris and an important step forward for precision medicine,” said David Dean Halbert, Founder, Chairman and CEO of Caris Life Sciences.



Recent Operating Highlights
Surpassed 1,016,000 total profiles and 740,000 total matched profiles through December 31, 2025.
More than 627,000 Whole Exome and 678,000 Whole Transcriptome profiles through December 31, 2025.
Announced partnership with Everlywell to launch Caris’ forthcoming MCED assay, Caris Detect.
Announced collaboration with Genentech to discover novel therapeutic targets in cancers with high unmet clinical need.
Fourth Quarter 2025 Financial Results
Total revenue was $292.9 million for the three months ended December 31, 2025, compared to $129.9 million for the three months ended December 31, 2024, an increase of $163.0 million, or 125%.
The increase in total revenue was driven primarily by a 199% growth in molecular profiling services revenue, which was $282.1 million for the three months ended December 31, 2025, compared to $94.4 million for the three months ended December 31, 2024. The increase in molecular profiling services revenue was primarily driven by an increase in total clinical case volume and ASP improvements across therapy selection solutions.
Gross profit, calculated as total revenue less cost of services, for the three months ended December 31, 2025 and 2024, was $220.9 million and $70.7 million, respectively, representing a gross margin of 75% and 54%, respectively.
Operating expenses were $132.5 million for the three months ended December 31, 2025, compared to $107.7 million for the three months ended December 31, 2024, an increase of $24.8 million, or 23%. The increase was primarily driven by increased stock-based compensation expense and headcount-related costs.
Net income was $82.0 million for the three months ended December 31, 2025, as compared to a net loss of $36.9 million for the three months ended December 31, 2024. Net income per share attributable to common shareholders, basic and diluted, was $0.29 and $0.28 per share, respectively, for the three months ended December 31, 2025, as compared to a net loss per share attributable to common shareholders, basic and diluted, of $1.73, for the three months ended December 31, 2024.
Net cash provided by operating activities was $44.8 million for the three months ended December 31, 2025, as compared to net cash used in operating activities of $38.9 million for the three months ended December 31, 2024, a 215% improvement. The improvement was driven by improved reimbursement from molecular profiling services.
Full Year 2025 Financial Results
Total revenue was $812.0 million for the year ended December 31, 2025, compared to $412.3 million for the year ended December 31, 2024, an increase of $399.8 million, or 97%.
The increase in total revenue was driven primarily by a 120% growth in molecular profiling services revenue, which was $766.7 million for the year ended December 31, 2025, compared to $349.1 million for the year ended December 31, 2024. The increase in molecular profiling services revenue was primarily driven by an increase in total clinical case volume and ASP improvements across therapy selection solutions.



Gross profit, calculated as total revenue less cost of services, for the years ended December 31, 2025 and 2024 was $539.2 million and $178.8 million, respectively, representing a gross margin of 66% and 43%, respectively.
Operating expenses were $494.1 million for the year ended December 31, 2025, compared to $435.9 million for the year ended December 31, 2024, an increase of $58.2 million, or 13%. The increase was primarily driven by increased stock-based compensation expense and headcount-related costs.
Net loss was $68.1 million for the year ended December 31, 2025, as compared to a net loss of $281.9 million for the year ended December 31, 2024. Net loss per share attributable to common shareholders, basic and diluted, was $3.22 per share for the year ended December 31, 2025, as compared to a net loss per share attributable to common shareholders, basic and diluted, of $10.66 for the year ended December 31, 2024.
Net cash provided by operating activities was $83.2 million for the year ended December 31, 2025, as compared to net cash used in operating activities of $245.2 million for the year ended December 31, 2024, a 134% improvement. The improvement was driven by improved reimbursement from molecular profiling services.
2026 Financial Outlook and Guidance
Caris Life Sciences expects full year 2026 revenue to be in the range of $1.0 billion to $1.02 billion, representing growth of approximately 23% to 26% compared to full year 2025. Clinical therapy selection volume is expected to grow approximately 20% compared to full year 2025.
Within this revenue range:
Molecular profiling revenue is expected to grow approximately 21% to 22% year over year in 2026. Excluding out-of-year revenue from over collections recorded in 2025, this range implies growth of approximately 26% to 28%.
Pharma & research revenue is expected to be in the range of $75 million to $85 million for the year ending December 31, 2026.
Caris Life Sciences expects GAAP operating expenses to be in the range of $590 million to $595 million, representing a 19% to 20% increase due to commercial expansion and increase in pipeline trial activities, and expects to remain positive on Free Cash Flow and Adjusted EBITDA.
Conference Call Information
Event:
Caris Fourth Quarter 2025 Financial Results Conference Call
Date:Thursday, February 26, 2026
Time:3:30 p.m. CT (4:30 p.m. ET)
Webcast Link:
https://edge.media-server.com/mmc/p/49czfgs4
Accompanying materials will be posted on our investor relations website at https://investor.carislifesciences.com prior to the conference call. A replay of the conference call will be available on our investor relations website shortly after the conclusion of the call.
About Caris Life Sciences
Caris Life Sciences® (Caris) is a leading, patient-centric, next-generation AI TechBio company and precision medicine pioneer actively developing and commercializing innovative solutions to transform healthcare. Through comprehensive molecular profiling (Whole Genome, Whole Exome and Whole Transcriptome Sequencing), advanced AI and machine learning, Caris has created the



large-scale, multimodal clinico-genomic database and computing capability needed to analyze and further unravel the molecular complexity of disease. This convergence of next-generation sequencing, AI and machine learning technologies and high-performance computing provides a differentiated platform for developing the latest generation of advanced precision medicine diagnostic solutions for early detection, diagnosis, monitoring, therapy selection and drug development.
Caris was founded with a vision to realize the potential of precision medicine to improve the human condition. Headquartered in Irving, Texas, Caris has offices in Phoenix, New York, Cambridge (MA), Tokyo, Japan and Basel, Switzerland. Caris or its distributor partners provide services in the U.S. and other international markets.
We intend to use the investor page of our website, https://investor.carislifesciences.com, as a distribution channel of material information about the Company and for complying with our disclosure obligations under Regulation FD. The information we post on our investor webpage may be deemed material. Accordingly, investors should subscribe to our investor alerts, in addition to following our press releases, SEC filings, public conference calls and webcasts.
Forward-Looking Statements
This press release contains forward-looking statements, within the meaning of the Private Securities Litigation Reform Act of 1995 and other federal securities laws. All statements other than statements of historical facts contained in this press release are forward-looking statements, including statements regarding our business, solutions, plans, objectives, goals, industry trends, financial outlook and guidance. In some cases forward-looking statements can be identified by words such as “may,” “will,” “should,” “would,” “expect,” “plan,” “anticipate,” “could,” “intend,” “target,” “project,” “potential,” “contemplate,” “believe,” “estimate,” “predict,” “potential” or “continue” or similar expressions.
You should not rely upon forward-looking statements as predictions of future events. Although we believe that the expectations reflected in these forward-looking statements are reasonable based on information currently available to us, we cannot guarantee that the future results, discoveries, levels of activity, performance or events and circumstances reflected in forward-looking statements will be achieved or occur. Forward-looking statements involve known and unknown risks and uncertainties, some of which are beyond our control. Risks and uncertainties that could cause our actual results to differ materially from those indicated or implied by the forward-looking statements in this press release include, among other things: developments in the precision medicine industry; our future financial performance, results of operations or other operational results or metrics; development, analytical and clinical validation, timing and performance of future solutions by us and our competitors; commercial market acceptance for our solutions, including acceptance of preventive as well as diagnostic testing paradigms, and our ability to meet resulting demand; the rapidly evolving competitive environment in which we operate; third-party payer reimbursement and coverage decisions related to our solutions; risks related to data management, storage, and processing capabilities and our ability to integrate and deploy artificial intelligence and advanced data analytics technologies; our ability to protect and enhance our intellectual property; regulatory requirements, decisions or approvals (including the timing and conditions thereof) related to our solutions; reliance on third-party suppliers; risks related to data security, patient privacy, and compliance with healthcare data protection regulations as well as potential cybersecurity threats to our data platforms; our compliance with laws and regulations; the outcome of government investigations and litigation; risks related to our indebtedness; and our ability to hire and retain key personnel as well as risks, uncertainties, and other factors described in the section titled “Risk Factors” and elsewhere in our Annual Report on Form 10-K filed on or about March 3, 2026, and in our other filings we make with the SEC from time to time. We undertake no obligation to update any forward-looking



statements to reflect changes in events, circumstances or our beliefs after the date of this press release, except as required by law.
Non-GAAP Measures
We use Adjusted EBITDA and free cash flow, financial measures not calculated in accordance with generally accepted accounting principles in the United States (“GAAP”), to supplement our consolidated financial statements, which are presented in accordance with GAAP. We believe the non-GAAP financial measures we use, are useful in evaluating our performance and liquidity. Our non-GAAP financial measures have limitations as analytical tools, however, and you should not consider them in isolation or as substitutes for analysis of our results as reported under GAAP. Other companies, including other companies in our industry, may not use these measures or may calculate these measures differently than as presented herein, limiting their usefulness as comparative measures.
We define Adjusted EBITDA as net loss, adjusted to exclude interest income, interest expense, changes in fair value of financial instruments, other expense, net, the provision for (benefit from) income taxes, depreciation and amortization, and stock-based compensation expense. We use Adjusted EBITDA in conjunction with GAAP measures as part of our overall assessment of our performance, including the preparation of our annual operating budget and quarterly forecasts, to evaluate the effectiveness of our business strategies, and to communicate with our board of directors concerning our financial performance. We believe Adjusted EBITDA provides useful information to investors and others in understanding and evaluating our operating results in the same manner as our management team and board of directors. Adjusted EBITDA provides a useful measure for period-to-period comparisons of our business, as it removes the effect of certain non-cash expenses and certain variable charges.
We define free cash flow as net cash provided by (used in) operating activities less purchases of property and equipment. We believe free cash flow is a useful measure of liquidity that provides an additional basis for assessing our ability to generate cash.
A reconciliation of the historical non-GAAP financial measures used in this press release to the respective comparable GAAP financial measures, can be found below.
Caris Life Sciences Media:
Corporate Communications
CorpComm@CarisLS.com
214.294.5606
Investor Relations:
InvestorRelations@CarisLS.com
917.689.3511



Caris Life Sciences, Inc.
Condensed Consolidated Statements of Operations and Comprehensive Loss
(unaudited)
(amounts in thousands, except share and per share data)Three Months Ended December 31,Years Ended December 31,
2025202420252024
Revenue:
Molecular profiling services$282,126 $94,423 $766,719 $349,115 
Pharma research and development services10,760 35,492 45,314 63,145 
Total revenue292,886 129,915 812,033 412,260 
Costs and operating expenses:
Cost of Services - Molecular profiling services69,158 55,941 262,353 223,075 
Cost of Services - Pharma research and development services2,814 3,273 10,512 10,403 
Selling and marketing expense44,151 37,525 167,506 152,602 
General and administrative expense56,507 43,113 224,965 169,386 
Research and development expense31,845 27,109 101,584 113,916 
Total costs and operating expenses204,475 166,961 766,920 669,382 
Income (Loss) from operations88,411 (37,046)45,113 (257,122)
Other expense, net:
Interest income7,015 970 16,497 7,122 
Interest expense(11,356)(13,262)(56,853)(50,025)
Changes in fair value of financial instruments— 12,417 (52,285)18,484 
Other expense, net(2,113)(26)(20,560)(349)
Total other expense, net(6,454)99 (113,201)(24,768)
Income (Loss) before income taxes and provision for income taxes81,957 (36,947)(68,088)(281,890)
Provision for income taxes— — — — 
Net income (loss)81,957 (36,947)(68,088)(281,890)
Other comprehensive income, net of tax:
Unrealized gain on available-for-sale securities— — — 
Foreign currency translation adjustments188 726 (15)
Comprehensive income (loss)82,145 (36,942)(67,362)(281,898)
Net income (loss) attributable to common shareholders:
Net income (loss)81,957 (36,947)(68,088)(281,890)
Deemed dividend from Series D redeemable convertible preferred stock— — (384,436)— 
Adjustments of redeemable convertible preferred stock to redemption value— (24,999)(85,433)(96,367)
Net income (loss) attributable to common shareholders$81,957 $(61,946)$(537,957)$(378,257)
Net income (loss) per share attributable to common shareholders:
Basic$0.29 $(1.73)$(3.22)$(10.66)
Diluted$0.28 $(1.73)$(3.22)$(10.66)
Weighted-average shares used in computing net income (loss) per share attributable to common shareholders:
Basic282,215,46535,828,916167,205,61635,496,832
Diluted296,089,04135,828,916167,205,61635,496,832



Caris Life Sciences, Inc.
Condensed Consolidated Balance Sheets
(unaudited)
(amounts in thousands, except share data)As of December 31,
20252024
Assets
Current assets:
Cash, cash equivalents, and restricted cash$797,799 $65,442 
Short-term marketable securities2,295 2,201 
Accounts receivable112,140 88,244 
Supplies63,625 39,572 
Prepaid expenses and other current assets21,941 20,270 
Total current assets997,800 215,729 
Property and equipment, net63,170 67,817 
Goodwill19,344 19,344 
Other assets45,349 40,844 
Total assets$1,125,663 $343,734 
Liabilities, Redeemable Convertible Preferred Stock, and Shareholders' Equity (Deficit)
Current liabilities:
Accounts payable$39,206 $27,791 
Accrued expenses and other current liabilities87,770 77,542 
Current portion of indebtedness169 60,090 
Total current liabilities127,145 165,423 
Long-term indebtedness, net of debt discounts378,823 319,438 
Warrant liabilities— 91,642 
Other long-term liabilities42,388 44,418 
Total liabilities548,356 620,921 
Commitments and contingencies
Redeemable convertible preferred stock:
Series A preferred stock, par value $0.001: no and 490,000,000 shares authorized as of December 31, 2025 and December 31, 2024, respectively; no and 485,795,293 shares issued and outstanding as of December 31, 2025 and December 31, 2024, respectively; and $296,335 aggregate liquidation preference as of December 31, 2024
— 709,261 
Series B preferred stock, par value $0.001: no and 30,000,000 shares authorized as of December 31, 2025 and December 31, 2024, respectively; no and 29,629,630 shares issued and outstanding as of December 31, 2025 and December 31, 2024, respectively; and $16,000 aggregate liquidation preference as of December 31, 2024
— 42,963 
Series C preferred stock, par value $0.001: no and 142,000,000 shares authorized as of December 31, 2025 and December 31, 2024, respectively; no and 116,200,835 shares issued and outstanding as of December 31, 2025 and December 31, 2024, respectively; and $408,715 aggregate liquidation preference as of December 31, 2024
— 408,715 
Series D preferred stock, par value $0.001: no and 102,600,000 shares authorized as of December 31, 2025 and December 31, 2024, respectively; no and 102,516,283 shares issued and outstanding as of December 31, 2025 and December 31, 2024, respectively; and $1,060,712 aggregate liquidation preference as of December 31, 2024
— 1,060,712 
Redeemable convertible preferred stock— 2,221,651 
Shareholders' equity (deficit):
Preferred stock, $0.001 par value per share; 100,000,000 and no shares authorized as of December 31, 2025 and December 31, 2024, respectively; no shares issued and outstanding as of December 31, 2025 and December 31, 2024
— — 
Common stock $0.001 par value; 2,800,000,000 and 1,150,000,000 shares authorized as of December 31, 2025 and December 31, 2024, respectively; 284,137,810 and 36,686,819 shares issued as of December 31, 2025 and December 31, 2024, respectively; 282,526,097 and 36,504,319 shares outstanding as of December 31, 2025 and December 31, 2024, respectively; shares issued and outstanding include 23,446 and 662,000 unvested shares subject to repurchase as of December 31, 2025 and December 31, 2024, respectively
283 38 
Treasury stock at cost, 1,611,713 and 182,500 shares of common stock as of December 31, 2025 and December 31, 2024, respectively
(16,896)(330)
Additional paid-in capital3,141,720 — 
Related party promissory note receivable— (26,456)
Accumulated deficit(2,548,736)(2,472,300)
Accumulated other comprehensive income936 210 
Total shareholders' equity (deficit)577,307 (2,498,838)
Total liabilities, redeemable convertible preferred stock, and shareholders' equity (deficit)$1,125,663 $343,734 



Caris Life Sciences, Inc.
Condensed Consolidated Statement of Cash Flows
(unaudited)
(amounts in thousands)Years Ended December 31,
20252024
Cash flows from operating activities
Net loss$(68,088)$(281,890)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization22,615 48,913 
Stock-based compensation expense70,006 18,643 
Non-cash operating lease expense5,585 5,601 
Amortization of debt discounts12,768 7,054 
Changes in fair value of financial instruments52,285 (18,484)
Loss on debt extinguishment19,895 — 
Other1,216 4,031 
Changes in operating assets and liabilities:
Accounts receivable(29,789)(33,816)
Supplies(20,750)5,459 
Prepaid expenses and other current assets(5,150)(1,408)
Other assets48 121 
Accounts payable11,035 (226)
Accrued expenses and other liabilities11,479 803 
Net cash provided by (used in) operating activities83,155 (245,199)
Cash flows from investing activities
Maturities of marketable securities— 61,376 
Purchases of property and equipment(16,260)(8,444)
Net cash provided by (used in) investing activities(16,260)52,932 
Cash flows from financing activities
Payments made on finance lease obligations(106)(157)
Proceeds from exercise of stock options7,637 1,530 
Payment of taxes withheld from net settlement of exercised options and vested RSUs(18,551)— 
Payment of deferred offering costs(7,710)(1,059)
Proceeds from the 2023 term loan, net of issuance costs— 199,978 
Repurchase of common stock(113)— 
Issuance of Series E Preferred Stock, net of issuance costs87,637 — 
Issuance of Series F Preferred Stock, net of issuance costs33,601 — 
Issuance of the 2025 Convertible Notes, net of issuance costs27,865 — 
Issuance of the 2025 Warrants10,270 — 
Payments of 2023 term loan amendment fee(4,000)— 
Proceeds from initial public offering, net of underwriting discounts and commissions528,459 — 
Net cash provided by financing activities664,989 200,292 
Effect of exchange rate changes on cash, cash equivalents, and restricted cash130 (4)
Net increase in cash, cash equivalents, and restricted cash
732,014 8,021 
Cash, cash equivalents, and restricted cash at beginning of period68,028 60,007 
Cash, cash equivalents, and restricted cash at end of period$800,042 $68,028 



Reconciliation of GAAP Net Loss to Adjusted EBITDA
(unaudited)
(amounts in thousands)Three Months Ended December 31,Years Ended December 31,
2025202420252024
Net loss$81,957 $(36,947)$(68,088)$(281,890)
Interest income(7,015)(970)(16,497)(7,122)
Interest expense11,356 13,262 56,853 50,025 
Changes in fair value of financial instruments— (12,417)52,285 (18,484)
Other expense, net2,113 26 20,560 349 
Provision for income taxes— — — — 
Depreciation and amortization expense4,291 9,066 22,615 48,913 
Stock-based compensation expense13,367 4,977 70,006 18,643 
Adjusted EBITDA$106,069 $(23,003)$137,734 $(189,566)

Reconciliation of Net Cash Provided by (Used in) Operating Activities to Free Cash Flow
(unaudited)
(amounts in thousands)
Three Months Ended December 31,Twelve Months Ended December 31,
2025202420252024
Net cash provided by (used in) operating activities$44,780 $(38,922)$83,155 $(245,199)
Less: purchases of property and equipment(5,090)(2,290)(16,260)(8,444)
Free cash flow$39,690 $(41,212)$66,895 $(253,643)

FAQ

How did Caris Life Sciences (CAI) perform financially in Q4 2025?

Caris Life Sciences posted very strong Q4 2025 results with total revenue of $292.9 million, up 125% year over year. Gross margin expanded to 75%, and the company generated $82.0 million in net income, reflecting a sharp turnaround from the prior-year loss.

What were Caris Life Sciences’ full-year 2025 results?

For 2025, Caris Life Sciences reported $812.0 million in revenue, a 97% increase from 2024, with gross margin improving to 66%. The company recorded a net loss of $68.1 million but achieved positive Adjusted EBITDA of $137.7 million and free cash flow of $66.9 million.

What guidance did Caris Life Sciences (CAI) give for 2026?

Caris Life Sciences expects 2026 revenue between $1.0 billion and $1.02 billion, implying about 23%–26% growth versus 2025. The company also anticipates approximately 20% clinical therapy selection volume growth and plans to remain positive on both free cash flow and Adjusted EBITDA.

How are Caris Life Sciences’ molecular profiling services performing?

Molecular profiling services drove results, generating $766.7 million of 2025 revenue, up 120% from 2024. In Q4 2025, molecular profiling revenue reached $282.1 million, supported by higher clinical case volumes and better average selling prices across therapy selection solutions.

Did Caris Life Sciences improve its cash flow position in 2025?

Yes. Net cash provided by operating activities was $83.2 million in 2025, compared with a $245.2 million use of cash in 2024. Free cash flow improved to $66.9 million, highlighting stronger reimbursement and underlying cash generation from molecular profiling services.

What is Caris Detect and when is Caris Life Sciences launching it?

Caris Detect is Caris Life Sciences’ forthcoming multi-cancer early detection (MCED) test. An interim Achieve 1 study readout has been completed, and the company is planning a first-half 2026 launch, positioning it as a significant future growth opportunity in precision medicine.

What strategic partnerships did Caris Life Sciences announce recently?

Caris Life Sciences announced a partnership with Everlywell to launch its Caris Detect MCED assay and a collaboration with Genentech to discover novel therapeutic targets in cancers with high unmet clinical need, supporting both diagnostic and biopharma-focused growth avenues.

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5.43B
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Biotechnology
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United States
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