Janus Henderson Group plc (NYSE: JHG) discloses 12.2% CAMP4 stake

Rhea-AI Filing Summary

Janus Henderson Group plc filed a Schedule 13G reporting beneficial ownership of 6,307,636 shares of CAMP4 Therapeutics Corp common stock, representing 12.2% of the class. The filing states that Janus Henderson Investors US LLC may be deemed the beneficial owner of these shares and also holds 1,241,382 pre-funded warrants that cannot be exercised if doing so would push ownership above 9.99%. All voting and dispositive power over the reported shares is shared, with no sole voting or dispositive power. The securities are described as acquired and held in the ordinary course of business and not for the purpose of changing or influencing control of CAMP4.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

CAMP4 THERAPEUTICS CORP

(Name of Issuer)

Common Stock

(Title of Class of Securities)

13463J101

(CUSIP Number)

12/31/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No. 13463J101

1

Names of Reporting Persons

JANUS HENDERSON GROUP PLC

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

JERSEY

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 6,307,636.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 6,307,636.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

6,307,636.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

12.2 %

12

Type of Reporting Person (See Instructions)

IA, HC

SCHEDULE 13G

Item 1.
(a)	Name of issuer: CAMP4 THERAPEUTICS CORP
(b)	Address of issuer's principal executive offices: ONE KENDALL SQUARE, BUILDING 1400 WEST, 3RD FLOOR CAMBRIDGE, MA 02139
Item 2.
(a)	Name of person filing: Janus Henderson Group plc
(b)	Address or principal business office or, if none, residence: 201 Bishopsgate EC2M 3AE, United Kingdom
(c)	Citizenship: Y9
(d)	Title of class of securities: Common Stock
(e)	CUSIP No.: 13463J101
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: JHIUS may be deemed to be the beneficial owner of 6,307,636 shares, as well as an additional 1,241,382 pre-funded warrants which cannot be exercised to the extent they result in ownership in excess of 9.99%.
(b)	Percent of class: 12.2 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 0
	(ii) Shared power to vote or to direct the vote: 6307636
	(iii) Sole power to dispose or to direct the disposition of: 0
	(iv) Shared power to dispose or to direct the disposition of: 6307636
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. The interest of one person, Janus Henderson Enterprise Fund, an investment company registered under the Investment Company Act of 1940, in ICU Medical Common Stock amounted to 1,230,753 shares or 5.0%
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. See Exihibit 99
Item 8.	Identification and Classification of Members of the Group.
	If a group has filed this schedule pursuant to §240.13d-1(b)(1)(ii)(K), so indicate under Item 3(k) and attach an exhibit stating the identity and Item 3 classification of each member of the group. If a group has filed this schedule pursuant to §240.13d-1(c) or §240.13d-1(d), attach an exhibit stating the identity of each member of the group. N/A
Item 9.	Notice of Dissolution of Group.
	Notice of dissolution of a group may be furnished as an exhibit stating the date of the dissolution and that all further filings with respect to transactions in the security reported on will be filed, if required, by members of the group, in their individual capacity. See Item 5. N/A

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

JANUS HENDERSON GROUP PLC

Signature:	Kristin Mariani
Name/Title:	Head of North America Compliance, CCO
Date:	01/08/2026

Exhibit Information

Exhibit 24: Power of Attorney Exhibit 99: Item 7

FAQ

What ownership stake in CAMP4 does Janus Henderson Group plc (JHG) report?

Janus Henderson Group plc reports beneficial ownership of 6,307,636 CAMP4 Therapeutics Corp common shares, representing 12.2% of the outstanding common stock.

What type of SEC filing did Janus Henderson Group plc (JHG) submit for CAMP4?

Janus Henderson Group plc submitted a Schedule 13G, which is a beneficial ownership report for holders of more than 5% of a class of registered equity securities.

Does Janus Henderson Group plc (JHG) hold any CAMP4 warrants in addition to common stock?

Yes. The filing states that Janus Henderson Investors US LLC may be deemed to beneficially own 1,241,382 pre-funded warrants for CAMP4 shares, which cannot be exercised to the extent they would cause ownership to exceed 9.99%.

How much voting and dispositive power over CAMP4 shares does Janus Henderson report?

The reporting person has 0 shares with sole voting and dispositive power and 6,307,636 shares with shared voting and shared dispositive power.

What is the stated purpose of Janus Henderson Group plc’s (JHG) CAMP4 share holdings?

The securities are certified as acquired and held in the ordinary course of business and not for the purpose of, or with the effect of, changing or influencing the control of CAMP4 Therapeutics Corp.

Who signed the Schedule 13G related to CAMP4 for Janus Henderson Group plc (JHG)?

The Schedule 13G was signed by Kristin Mariani, identified as Head of North America Compliance, CCO, on 01/08/2026.