Foresite Capital's 5.1% stake in CASI — 787,121 shares

Rhea-AI Filing Summary

Foresite Capital Fund VI, L.P., together with its general partner Foresite Capital Management VI, LLC and James Tananbaum, report beneficial ownership of 787,121 ordinary shares of CASI Pharmaceuticals, representing 5.1% of the outstanding class based on 15,492,581 shares outstanding. All 787,121 shares are reported as directly owned by Foresite Capital Fund VI, with the reporting persons asserting sole voting and sole dispositive power over those shares and no shared power. The filing includes a certification that the securities were not acquired to change or influence control of the issuer and indicates the holdings are held as passive investments. The filers executed a joint filing agreement.

Positive

• Beneficial ownership of 787,121 shares (5.1% of class)
• Reporting persons assert sole voting and sole dispositive power over those shares
• Filing includes certification that holdings were not acquired to change or influence control (passive)

Negative

• None.

Insights

Financial Analyst

5.1% passive stake is material disclosure but indicates no intent to influence control; watch for future changes.

The filing discloses a 787,121-share position, equal to 5.1% of CASI's ordinary shares based on 15,492,581 shares outstanding. Because the reporting persons used Schedule 13G and certify the holdings were not acquired to influence control, this is presented as a passive ownership stake. The statement that sole voting and dispositive power is held by the general partner and the managing member clarifies who can exercise voting rights. For investors, the filing is a material ownership disclosure but contains no operational or control-related actions.

Corporate Governance Expert

Sole voting/dispositive claims by the GP and managing member clarify authority; Schedule 13G signals passive intent.

The report identifies Foresite Capital Fund VI as the direct owner and names Foresite Capital Management VI and James Tananbaum as entities claiming sole voting and dispositive authority over the 787,121 shares. The joint filing agreement is noted, and the certification affirms the position is not intended to effect control changes. From a governance perspective, the disclosure clarifies who holds vote execution rights while indicating no declared activist intent, but it places the holder above the 5% reporting threshold, making it a publicly visible stakeholder.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 1)

CASI Pharmaceuticals, Inc.

(Name of Issuer)

Ordinary Shares, par value $0.0001

(Title of Class of Securities)

G1933S101

(CUSIP Number)

06/30/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No. G1933S101

1

Names of Reporting Persons

Foresite Capital Fund VI, L.P.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 787,121.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 787,121.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

787,121.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.1 %

12

Type of Reporting Person (See Instructions)

PN

Comment for Type of Reporting Person: Note to Row 5: 787,121 shares, except that Foresite Capital Management VI, LLC ("FCM VI"), the general partner of Foresite Capital Fund VI, L.P. ("FCF VI"), may be deemed to have sole power to vote these shares, and James Tananbaum ("Tananbaum"), the managing member of FCM VI, may be deemed to have sole power to vote these shares. Note to row 6: See response to row 5. Note to Row 7: 787,121 shares, except that FCM VI, the general partner of FCF VI, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM VI, may be deemed to have sole power to dispose of these shares. Note to row 8: See response to row 7. Note to Row 11: This percentage is calculated based upon 15,492,581 Ordinary Shares outstanding of CASI Pharmaceuticals, Inc. (the "Issuer") as of December 31, 2024, as set forth in the Issuer's Form 20-F filed with the Securities and Exchange Commission on March 31, 2025.

SCHEDULE 13G

CUSIP No. G1933S101

1

Names of Reporting Persons

Foresite Capital Management VI, LLC

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 787,121.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 787,121.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

787,121.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.1 %

12

Type of Reporting Person (See Instructions)

OO

Comment for Type of Reporting Person: Note to Row 5: 787,121 shares, all of which are directly owned by FCF VI. FCM VI, the general partner of FCF VI, may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM VI, may be deemed to have sole power to vote these shares. Note to row 6: See response to row 5. Note to Row 7: 787,121 shares, all of which are directly owned by FCF VI. FCM VI, the general partner of FCF VI, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM VI, may be deemed to have sole power to dispose of these shares. Note to row 8: See response to row 7. Note to Row 11: This percentage is calculated based upon 15,492,581 Ordinary Shares outstanding of the Issuer as of December 31, 2024, as set forth in the Issuer's Form 20-F filed with the Securities and Exchange Commission on March 31, 2025.

SCHEDULE 13G

CUSIP No. G1933S101

1

Names of Reporting Persons

James Tananbaum

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 787,121.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 787,121.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

787,121.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.1 %

12

Type of Reporting Person (See Instructions)

IN

Comment for Type of Reporting Person: Note to Row 5: 787,121 shares, all of which are directly owned by FCF VI. Tananbaum is the managing member of FCM VI, which is the general partner of FCF VI. Tananbaum may be deemed to have sole power to vote these shares. Note to row 6: See response to row 5. Note to Row 7: 787,121 shares, all of which are directly owned by FCF VI. Tananbaum is the managing member of FCM VI, which is the general partner of FCF VI. Tananbaum may be deemed to have sole power to dispose of these shares. Note to row 8: See response to row 7. Note to Row 11: This percentage is calculated based upon 15,492,581 Ordinary Shares outstanding of the Issuer as of December 31, 2024, as set forth in the Issuer's Form 20-F filed with the Securities and Exchange Commission on March 31, 2025.

SCHEDULE 13G

Item 1.
(a)	Name of issuer: CASI Pharmaceuticals, Inc.
(b)	Address of issuer's principal executive offices: 1701-1702, China Central Office Tower 1 No. 81 Jianguo Road, Chaoyang District Beijing, F4, 100025
Item 2.
(a)	Name of person filing: This Schedule is filed by Foresite Capital Fund VI, L.P., a Delaware limited partnership ("FCF VI"), Foresite Capital Management VI, LLC, a Delaware limited liability company ("FCM VI") and James Tananbaum. The foregoing entities and individuals are collectively referred to as the "Reporting Persons."
(b)	Address or principal business office or, if none, residence: c/o Foresite Capital Management 900 Larkspur Landing Circle, Suite 150Larkspur, CA 94939 See Row 4 of cover page for each Reporting Person.
(c)	Citizenship: See Row 4 of cover page for each Reporting Person.
(d)	Title of class of securities: Ordinary Shares, par value $0.0001
(e)	CUSIP No.: G1933S101
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: See Row 9 of cover page for each Reporting Person.
(b)	Percent of class: See Row 11 of cover page for each Reporting Person.
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: See Row 5 of cover page for each Reporting Person.
	(ii) Shared power to vote or to direct the vote: See Row 6 of cover page for each Reporting Person.
	(iii) Sole power to dispose or to direct the disposition of: See Row 7 of cover page for each Reporting Person.
	(iv) Shared power to dispose or to direct the disposition of: See Row 8 of cover page for each Reporting Person.
Item 5.	Ownership of 5 Percent or Less of a Class.
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. Under certain circumstances set forth in the limited partnership agreement of FCF VI and the limited liability company agreement of FCM VI, the partners or members, as the case may be, of each of such entities may be deemed to have the right to receive dividends from, or the proceeds from the sale of, shares of the Issuer directly or indirectly owned by each such entity of which they are a partner or member.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Foresite Capital Fund VI, L.P.

Signature:	/s/ James Tananbaum
Name/Title:	James Tananbaum, Managing Member of the General Partner
Date:	08/12/2025

Foresite Capital Management VI, LLC

Signature:	/s/ James Tananbaum
Name/Title:	James Tananbaum, Managing Member
Date:	08/12/2025

James Tananbaum

Signature:	/s/ James Tananbaum
Name/Title:	James Tananbaum
Date:	08/12/2025

Exhibit Information

Exhibit A Agreement of Joint Filing The undersigned hereby agree that a single Schedule 13G (or any amendment thereto) relating to the Ordinary Shares of the Issuer shall be filed on behalf of each of the undersigned. Note that a copy of the applicable Agreement of Joint Filing is already on file with the appropriate agencies.

FAQ

How many CASI (CASI) shares does Foresite Capital Fund VI beneficially own?

The filing reports 787,121 shares beneficially owned by Foresite Capital Fund VI.

What percentage of CASI does the 787,121-share position represent?

The reported position represents 5.1% of CASI's ordinary shares based on 15,492,581 shares outstanding.

Who are the reporting persons in the CASI Schedule 13G/A?

The filing is by Foresite Capital Fund VI, L.P., Foresite Capital Management VI, LLC and James Tananbaum.

Does the filing indicate the holders intend to influence CASI's control?

The filing includes a certification stating the securities were not acquired to change or influence control and are held as passive investments.

What voting and dispositive powers are reported over the CASI shares?

The reporting persons state they have sole voting power and sole dispositive power over the 787,121 shares and report no shared power.