Filed
Pursuant to Rule 424(b)(3)
File
No. 333-298808
PROSPECTUS
SUPPLEMENT NO. 2
(to
Prospectus dated September 17, 2026)
CDT
EQUITY INC.

673,023
Shares of Common Stock
This
prospectus supplement supplements the prospectus dated September 17, 2026 (the “Prospectus”), which forms a part of our registration
statement on Form S-1 (File No. 333-298808). This prospectus supplement is being filed to update and supplement the information in the
Prospectus with the information contained in our Form 8-K filed with the Securities and Exchange Commission (“SEC”) on September
25, 2026 (the “Form 8-K”). Accordingly, we have attached the Form 8-K to this prospectus supplement.
This
prospectus relates to the offer and resale of shares (the “Shares”) of our common stock, par value $0.0001 per share (the
“Common Stock”) of (i) up to 14,630 shares of our common stock (the “Warrant Shares”) underlying common stock
purchase warrants (the “Warrants”) issued to J.J. Astor & Co. (the “Lender”); (ii) 140,925 shares of Common
Stock (the “Conversion Shares”) issuable to the Lender pursuant to the senior secured convertible promissory note, dated
June 11, 2026, as amended and restated on July 31, 2026 and August 3, 2026, in $2,536,650 aggregate principal amount and an additional
$541,620 senior secured convertible promissory note issued to the Lender on August 31, 2026 (collectively, the “Notes”);
(iii) 1,284 shares of Common Stock issued to EX-ANIMO Ltd. (“EX-ANIMO”) on July 24, 2026 for certain consulting services;
(iv) 1,000 shares of Common Stock issued to Maxim Partners LLC on July 30, 2026 as consideration for services provided to the Company;
(v) 1,254 shares of Common Stock issued to Ian Burton on July 30, 2026 as consideration for services provided to the Company; (vi) 485,244
shares of Common Stock issued to shareholders of Sarborg Limited, a Cayman Islands company (“Sarborg”) pursuant to a Securities
Purchase Agreement, dated July 30, 2026; (vii) 1,343 shares of Common Stock issued to NJS Foresight Bio-Advisory LLC (“NJS”)
on July 31, 2026 as consideration for services provided to the Company; (viii) 1,343 shares of Common Stock issued to Thesprogen, PC
(“Thesprogen”) on July 31, 2026 as consideration for services provided to the Company; and (ix) 26,000 shares of Common Stock
issued to Sarborg pursuant to Amendment No. 1, dated August 31, 2026, to the Securities Purchase Agreement, dated February 19, 2026 (the
“Amendment”).
We
are registering the Shares on behalf of the Selling Stockholders to be offered and sold by them from time to time. We are not selling
any securities under this prospectus and will not receive any proceeds from the sale of our Common Stock by the Selling Stockholders
in the offering described in this prospectus. The Selling Stockholders may sell any, all or none of the Shares offered by this prospectus.
For more information, see “Use of Proceeds.”
The
Selling Stockholders, or their respective transferees, pledgees, donees or other successors-in-interest, may offer or sell the Shares
from time to time in a number of different ways and at varying prices, including through public or private transactions at prevailing
market prices, at prices related to prevailing market prices or at privately negotiated prices. See “Plan of Distribution”
on page 108 of this prospectus for more information about how the Selling Stockholders may sell or dispose of the Shares being registered
pursuant to this prospectus.
This
prospectus describes the general manner in which the Shares may be offered and sold. When the Selling Stockholders sell Shares under
this prospectus, we may, if necessary and required by law, provide a prospectus supplement that will contain specific information about
the terms of that offering. Any prospectus supplement may also add to, update, modify or replace information contained in this prospectus.
We urge you to read carefully this prospectus, any accompanying prospectus supplement and any documents we incorporate by reference into
this prospectus and any accompanying prospectus supplement before you make your investment decision.
On
September 24, 2026, the Company filed a certificate of amendment to the Company’s Second Amended and Restated Certificate of Incorporation
(the “Certificate of Amendment”) with the Secretary of State of Delaware to effectuate a 1-for-25 reverse stock split (the
“Reverse Stock Split”) of the outstanding shares of the Company’s Common Stock. Effective September 28, 2026 at 5:00
p.m. Eastern Time, every 25 shares of our Common Stock, either issued or outstanding, immediately prior to the filing and effectiveness
of our Certificate of Amendment, was automatically combined and converted (without any further act) into one fully paid and non-assessable
share of Common Stock. No fractional shares were issued as a result of the Reverse Stock Split. Stockholders of record who would otherwise
be entitled to receive a fractional share of Common Stock received a cash payment in lieu thereof at a price equal to the fraction to
which the stockholder would otherwise be entitled multiplied by the closing price per share of our Common Stock (as adjusted for the
Reverse Stock Split) on The Nasdaq Capital Market on September 28, 2026.
All
financial information, share numbers, option numbers, warrant numbers, other derivative security numbers and exercise prices appearing
in this registration statement have been adjusted to give effect to the Reverse Stock Split, except where otherwise stated.
Our
Common Stock is traded on The Nasdaq Capital Market under the trading symbol “CDT.” On October 1, 2026, the last reported
sale price of our Common Stock on The Nasdaq Capital Market was $1.25.
We
are an “emerging growth company,” as defined under the federal securities laws, and, as such, may elect to comply with certain
reduced public company reporting requirements for future filings.
Investing
in our securities involves a high degree of risk. Before buying any securities, you should carefully read the discussion of the risks
of investing in our securities in the section entitled “Risk Factors” beginning on page 8 of the Prospectus, and under similar
headings in any amendments or supplements to the Prospectus.
You
should rely only on the information contained in this Prospectus or any prospectus supplement or amendment hereto. We have not authorized
anyone to provide you with different information.
Neither
the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined
if this Prospectus or this prospectus supplement is truthful or complete. Any representation to the contrary is a criminal offense.
The
date of this prospectus supplement is October 2, 2026
UNITED
STATES
SECURITIES
AND EXCHANGE COMMISSION
Washington,
DC 20549
FORM
8-K
CURRENT
REPORT
Pursuant
to Section 13 or 15(d) of the Securities Exchange Act of 1934
Date
of Report (Date of earliest event reported): September 24, 2026
CDT
Equity Inc.
(Exact
name of registrant as specified in its charter)
| Delaware |
|
001-41245 |
|
87-3272543 |
| (State
or other jurisdiction |
|
(Commission |
|
(I.R.S.
Employer |
| of
incorporation) |
|
File
Number) |
|
Identification
No.) |
| 4851
Tamiami Trail North, Suite 200, Naples, FL |
|
34103 |
| (Address
of principal executive offices) |
|
(Zip
Code) |
(646)
491-9132
(Registrant’s
telephone number, including area code)
Not
Applicable
(Former
name or former address, if changed since last report)
Check
the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under
any of the following provisions (see General Instruction A.2. below):
| ☐ |
Written
communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |
| |
|
| ☐ |
Soliciting
material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
| |
|
| ☐ |
Pre-commencement
communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
| |
|
| ☐ |
Pre-commencement
communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |
Securities
registered pursuant to Section 12(b) of the Act:
| Title
of Each Class |
|
Trading
Symbol(s) |
|
Name
of each exchange on which registered |
| Common
Stock, $0.0001 par value per share |
|
CDT |
|
The
Nasdaq Stock Market LLC |
| Redeemable
Warrants, each whole warrant exercisable for one share of Common Stock |
|
CDTTW |
|
The
Nasdaq Stock Market LLC |
Indicate
by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405
of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).
Emerging
growth company ☒
If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying
with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Item
3.03 Material Modification to Rights of Security Holders.
To
the extent required by Item 3.03 of Form 8-K, the information contained in Item 5.03 of this Current Report on Form 8-K (the “Current
Report”) is incorporated herein by reference.
Item
5.03. Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year.
On
September 24, 2026, CDT Equity Inc. (the “Company”) filed a certificate of amendment to the Company’s Second Amended
and Restated Certificate of Incorporation (the “Amendment”) with the Secretary of State of the State of Delaware to effectuate
a 1-for-25 reverse stock split (the “Reverse Stock Split”) of the outstanding shares of the Company’s common stock,
par value $0.0001 per share (“Common Stock”). The Company’s stockholders previously approved future reverse stock splits
and granted the board of directors the authority to determine the exact split ratios and when to proceed with any such reverse stock
splits.
The
Reverse Stock Split will become effective on September 28, 2026, at 5:00 p.m., Eastern Time (the “Effective Time”) and the
Common Stock is expected to begin trading on The Nasdaq Capital Market on a Reverse Stock Split-adjusted basis on September 29, 2026,
at market open under the existing ticker symbol, “CDT.” As of the Effective Time, every 25 shares of the Company’s
issued and outstanding Common Stock will be combined into one share of Common Stock.
The
par value and other terms of the Common Stock will not be affected by the Reverse Stock Split. The Company’s post-Reverse Stock
Split Common Stock CUSIP number will be 20678X700.
No
fractional shares will be issued as a result of the Reverse Stock Split. Stockholders of record who would otherwise be entitled to receive
a fractional share of Common Stock will receive a cash payment in lieu thereof at a price equal to the fraction to which the stockholder
would otherwise be entitled multiplied by the closing price per share of the Common Stock (as adjusted for the Reverse Stock Split) on
the Nasdaq Capital Market on September 28, 2026.
The
foregoing description of the Amendment is qualified in its entirety by reference to the Amendment, a copy of which is filed as Exhibit
3.1 to this Current Report and is incorporated herein by reference.
Item
7.01. Regulation FD Disclosure.
On
September 25, 2026, the Company issued a press release announcing the Reverse Stock Split. The press release is furnished as Exhibit
99.1 and incorporated by reference herein.
The
information in this Item 7.01, including Exhibit 99.1 attached hereto, is being furnished and shall not be deemed “filed”
for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject
to the liabilities of that section. Such information shall not be incorporated by reference into any filing under the Securities Act
of 1933, as amended (the “Securities Act”), whether made before or after the date hereof, except as expressly set forth by
specific reference in such filing. The furnishing of this information will not be deemed an admission as to the materiality of any information
contained therein.
Forward-Looking
Statements
This
Current Report includes forward-looking statements. These statements are made under the “safe harbor” provisions of the U.S.
Private Securities Litigation Reform Act of 1995. These statements may be identified by words such as “will,” “would,”
“expected,” or the negative of such terms, or other comparable terminology, and include statements about the Reverse Stock
Split and the impacts, if any, on the Company’s Common Stock. Forward-Looking statements are statements that are not historical
facts. Such forward-looking statements are not guarantees of future performance and are subject to risks and uncertainties, which could
cause actual results to differ materially from the forward-looking statements contained herein due to many factors. These forward-looking
statements and such risks, uncertainties and other factors speak only as of the date of this Current Report, and the Company expressly
disclaims any obligation or undertaking to update or revise and forward-looking statement contained herein, or to reflect any change
in our expectations with regard thereto or any other change in events, conditions, or circumstances on which any such statement is based,
except to the extent otherwise required by applicable law.
Item
9.01. Financial Statements and Exhibits.
(d)
Exhibits.
| Exhibit
No. |
|
Description |
| |
|
|
| 3.1 |
|
Certificate of Amendment filed with the Delaware Secretary of State on September 24, 2026 |
| 99.1 |
|
Press Release, dated September 25, 2026 |
| 104 |
|
Cover
Page Interactive Data File (embedded within the Inline XBRL document) |
SIGNATURES
Pursuant
to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by
the undersigned hereunto duly authorized.
| |
CDT
EQUITY INC. |
| |
|
|
| September
25, 2026 |
By: |
/s/
James Bligh |
| |
Name: |
James
Bligh |
| |
Title: |
Chief
Executive Officer and Chief Financial Officer |
Exhibit
3.1
CERTIFICATE
OF AMENDMENT
OF
SECOND
AMENDED AND RESTATED CERTIFICATE OF INCORPORATION
OF
CDT
EQUITY INC.
(Pursuant
to Section 242 of the General Corporation Law of the State of Delaware)
CDT
Equity Inc., a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “Corporation”),
does hereby certify as follows:
| 1. |
That
Section 4.1 of Article IV of the Second Amended and Restated Certificate of Incorporation of the Corporation be and hereby is deleted
in its entirety and the following is inserted in lieu thereof: |
“Section
4.1 Authorized Capital Stock. The total number of shares of all classes of capital stock, each with a par value of $0.0001 per
share, which the Corporation is authorized to issue is 251,000,000 shares, consisting of (a) 250,000,000 shares of common stock (the
“Common Stock”), and (b) 1,000,000 shares of preferred stock (the “Preferred Stock”). The number of authorized
shares of Common Stock may be increased or decreased (but not below the number of shares thereof then outstanding) by the affirmative
vote of the holders of a majority in voting power of the stock of the Corporation with the power to vote thereon irrespective of the
provisions of Section 242(b)(2) of the DGCL or any successor provision thereof, and no vote of the holders of any of the Common Stock
or Preferred Stock voting separately as a class shall be required therefor.
Effective
September 28, 2026 at 5:00pm Eastern Time (the “Reverse Stock Split Effective Time”), a one-for-twenty-five
reverse stock split of the Corporation’s Common Stock shall become effective, pursuant to which each 25 shares of Common Stock
issued and outstanding and held of record by each stockholder of the Corporation or issued and held by the Corporation in treasury immediately
prior to the Reverse Stock Split Effective Time shall be reclassified and combined into one (1) validly issued, fully paid and nonassessable
share of Common Stock automatically and without any action by the holder thereof upon the Reverse Stock Split Effective Time, with no
corresponding reduction in the number of authorized shares of Common Stock (such reclassification and combination of shares, the “Reverse
Stock Split”). No fractional shares of Common Stock will be issued in connection with the Reverse Stock Split. If, upon aggregating
all of the shares of Common Stock held by a holder of Common Stock immediately following the Reverse Stock Split such holder would otherwise
be entitled to a fractional share of Common Stock, the Corporation shall pay in cash (without interest) to each such holder an amount
equal to such fraction multiplied by the closing price of the Common Stock on The Nasdaq Capital Market on the last trading day immediately
preceding the Reverse Stock Split Effective Time (with such closing price proportionately adjusted to give effect to the Reverse Stock
Split).
Each
stock certificate that, immediately prior to the Reverse Stock Split Effective Time, represented shares of Common Stock that were issued
and outstanding immediately prior to the Reverse Stock Split Effective Time shall, from and after the Reverse Stock Split Effective Time,
automatically and without the necessity of presenting the same for exchange, represent that number of whole shares of Common Stock after
the Reverse Stock Split Effective Time into which the shares formerly represented by such certificate have been reclassified as well
the right to receive cash in lieu of fractional shares of Common Stock to which such holder may be entitled; provided, however, that
each person of record holding a certificate that represented shares of Common Stock that were issued and outstanding immediately prior
to the Reverse Stock Split Effective Time shall receive, upon surrender of such certificate, a new certificate evidencing and representing
the number of whole shares of Common Stock after the Reverse Stock Split Effective Time into which the shares of Common Stock formerly
represented by such certificate shall have been reclassified as well as the right to receive cash in lieu of fractional shares of Common
Stock to which such holder may be entitled.”
| 2. |
That
the aforesaid amendment was duly adopted in accordance with the applicable provisions of Section 242 of the General Corporation Law
of the State of Delaware. |
IN
WITNESS WHEREOF, this Certificate of Amendment has been executed by a duly authorized officer of the Corporation on this 24th day of
September, 2026.
| CDT
EQUITY INC. |
|
| |
|
|
| By: |
/s/
James Bligh |
|
| Name: |
James
Bligh |
|
| Title: |
Chief
Executive Officer and Chief Financial Officer |
|
Exhibit
99.1
CDT
Equity Inc. Announces Reverse Stock Split
NAPLES,
Fla. and CAMBRIDGE, United Kingdom, September 25, 2026 (GLOBE NEWSWIRE) — CDT Equity Inc. (Nasdaq: CDT) (“CDT” or the
“Company”), announces that its board of directors has approved a 1-for-25 reverse stock split of the Company’s common
stock, to ensure continued compliance with the Nasdaq bid-price rule. The Company’s stockholders approved future reverse stock
splits, their timing, and granted the board of directors authority to determine future exact split ratios.
The
reverse stock split will become effective on September 28, 2026, at 5:00 pm, Eastern Time (the “Effective Time”), and the
Company’s common stock is expected to begin trading on a reverse stock split-adjusted basis on The Nasdaq Capital Market (“Nasdaq”)
at market open under the existing ticker symbol, “CDT” on September 29, 2026, the date which has been approved by Nasdaq
for the effectiveness of such split.
As
of the Effective Time, every 25 shares of the Company’s issued and outstanding common stock will be combined into one share of
common stock. The par value per share of the Company’s common stock will remain unchanged at $0.0001. Proportional adjustments
will be made to the number of shares of common stock issuable upon the exercise of the Company’s equity awards, convertible securities
and warrants, as well as the applicable exercise price, and the number of shares authorized and reserved for issuance pursuant to the
Company’s equity incentive plans.
The
Company’s common stock will continue to trade on Nasdaq under the symbol “CDT” following the reverse stock split, with
a new CUSIP number of 20678X700. After the effectiveness of the reverse stock split, the number of outstanding shares of common stock
will be reduced to approximately 1,124,515. No fractional shares will be issued in connection with the reverse stock split, and stockholders
who would otherwise be entitled to a fractional share will receive a proportional cash payment.
The
Company’s transfer agent, Continental Stock Transfer & Trust Co., will serve as the exchange agent for the reverse stock split.
Registered stockholders holding pre-reverse stock split shares of common stock electronically in book-entry form are not required to
take any action to receive post-reverse stock split shares. Those stockholders who hold their shares in brokerage accounts or in “street
name” will have their positions automatically adjusted to reflect the reverse stock split, subject to each broker’s particular
processes, and will not be required to take any action in connection with the reverse stock split.
About
CDT Equity Inc.
CDT
Equity Inc. (NASDAQ: CDT) is a data-driven biopharmaceutical development company focused on identifying, enhancing, and advancing high-potential
therapeutic assets through scientific innovation and strategic partnerships. Originally established as Conduit Pharmaceuticals, the company
has evolved into a broader, more agile platform that leverages artificial intelligence, solid-form chemistry, and efficient asset repositioning
to accelerate the development of novel treatments. Looking ahead, CDT is committed to creating shareholder value through licensing, strategic
M&A, and positioning the company as a platform for transformative innovation.
Cautionary
Statement Regarding Forward-Looking Statements
This
press release contains certain forward-looking statements within the meaning of the federal securities laws. All statements other than
statements of historical facts contained in this press release, including statements regarding the reverse stock split, CDT’s future
results of operations and financial position, CDT’s business strategy, prospective product candidates, product approvals, research
and development costs, timing and likelihood of success, plans and objectives of management for future operations, future results of
current and anticipated studies and business endeavors with third parties, and future results of current and anticipated product candidates,
are forward-looking statements. These forward-looking statements generally are identified by the words “believe,” “project,”
“expect,” “anticipate,” “estimate,” “intend,” “strategy,” “future,”
“opportunity,” “plan,” “may,” “should,” “will,” “would,” “will
be,” “will continue,” “will likely result,” and similar expressions. These forward-looking statements are
subject to a number of risks, uncertainties and assumptions, including, but not limited to; the effect that the reverse stock split may
have on the price of the Company’s common stock; the ability or inability to maintain the listing of CDT’s securities on
Nasdaq; the ability to recognize the anticipated benefits of the business combination completed in September 2023, which may be affected
by, among other things, competition; the ability of the combined company to grow and manage growth economically and hire and retain key
employees; the risks that CDT’s product candidates in development fail clinical trials or are not approved by the U.S. Food and
Drug Administration or other applicable authorities on a timely basis or at all; changes in applicable laws or regulations; the possibility
that CDT may be adversely affected by other economic, business, and/or competitive factors; and other risks and uncertainties identified
in other filings made by CDT with the U.S. Securities and Exchange Commission. Moreover, CDT operates in a very competitive and rapidly
changing environment. Because forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted
or quantified and some of which are beyond CDT’s control, you should not rely on these forward-looking statements as predictions
of future events. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance
on forward-looking statements, and except as required by law, CDT assumes no obligation and does not intend to update or revise these
forward-looking statements, whether as a result of new information, future events, or otherwise. CDT gives no assurance that it will
achieve its expectations.
Investors
CDT
Equity Inc.
Info@cdtequity.com