STOCK TITAN

Crinetics (Nasdaq: CRNX) agrees to $85 cash-per-share sale to Vertex

(High)
(Neutral)
Form Type
8-K

Rhea-AI Filing Summary

Crinetics Pharmaceuticals agreed to be acquired by Vertex Pharmaceuticals for $85.00 per share in cash, implying a total equity value of about $10.0 billion, or $8.8 billion net of estimated cash acquired. Closing is anticipated in the third quarter of 2026, subject to regulatory approvals and approval by Crinetics stockholders.

For the quarter ended June 30, 2026, Crinetics reported $25.1 million in revenue, up from $1.0 million a year earlier, including $24.0 million in net product revenue from PALSONIFY. Net loss was $120.9 million, or $1.14 per share. Cash, cash equivalents and investment securities totaled $1.2 billion at June 30, 2026.

The company highlighted PALSONIFY commercial uptake, with 245 enrollment forms in the quarter, 385 unique prescribers within the first three quarters of launch, and over 70% of treated patients on reimbursed therapy. Crinetics also received U.S. FDA Rare Pediatric Disease Designation for atumelnant in classic congenital adrenal hyperplasia.

Positive

  • Vertex agreed to acquire Crinetics for $85.00 per share in cash, valuing the company at about $10.0 billion, or approximately $8.8 billion net of estimated cash acquired, subject to customary regulatory and stockholder approvals.

Negative

  • None.

Filing Explained

Crinetics withdrew its previously issued guidance and will not hold a second-quarter earnings call or webcast, limiting additional management commentary while the proposed Vertex transaction remains subject to regulatory and stockholder approvals.

Item 2.02 Results of Operations and Financial Condition Financial
Disclosure of earnings results, typically an earnings press release or preliminary financials.
Item 9.01 Financial Statements and Exhibits Exhibits
Financial statements, pro forma financial information, and exhibit attachments filed with this report.
Acquisition price per share $85.00 per share Cash consideration Vertex agreed to pay for each Crinetics share
Acquisition equity value $10.0 billion Approximate total equity value of Vertex’s acquisition of Crinetics
Total revenue Q2 2026 $25.1 million Revenue for the quarter ended June 30, 2026
PALSONIFY net product revenue Q2 2026 $24.0 million Net product revenue from PALSONIFY in Q2 2026
Net loss Q2 2026 $120.9 million Net loss for the quarter ended June 30, 2026
Cash and investments $1.2 billion Cash, cash equivalents and investment securities as of June 30, 2026
PALSONIFY enrollment forms 245 Enrollment forms received during the second quarter of 2026
Reimbursed PALSONIFY patients Over 70% Portion of PALSONIFY-treated patients on reimbursed therapy at end of Q2 2026
Rare Pediatric Disease Designation regulatory
"the U.S. Food and Drug Administration (FDA) has granted a Rare Pediatric Disease Designation"
A rare pediatric disease designation is an official regulatory status given to a drug or therapy that targets a serious or life‑threatening condition primarily affecting children and is uncommon in the population. It matters to investors because the status often brings financial and development perks — such as tax credits, reduced fees, faster review and periods of market protection — which can lower costs, speed approval and improve the commercial outlook; think of it as a VIP pass that makes bringing a scarce, child‑focused treatment to market easier and potentially more profitable.
congenital adrenal hyperplasia medical
"for the treatment of classic congenital adrenal hyperplasia (CAH) in both pediatric patients"
Congenital adrenal hyperplasia is a group of inherited disorders in which the adrenal glands lack an enzyme needed to make certain hormones, causing a chronic imbalance of cortisol, aldosterone and/or sex hormones. Think of it as a factory assembly line missing a key part, so the body overproduces some products and underproduces others, requiring lifelong monitoring or hormone treatment. For investors, it matters because diagnosis, ongoing therapy, newborn screening and potential new drugs or gene therapies can drive medical spending, regulatory approvals and market opportunity in endocrinology and rare disease care.
acromegaly medical
"growing adoption of PALSONIFY as the preferred choice for the acromegaly community"
Acromegaly is a rare hormonal disorder in adults caused when the body makes too much growth hormone, usually because of a noncancerous pituitary tumor, leading to gradual enlargement of the hands, feet and facial features and other health problems. For investors, it matters because it creates a defined market for diagnostics, long‑term therapies and surgical or drug innovations; understanding its prevalence and treatment options helps assess potential revenue and regulatory risk for healthcare companies.
G-protein coupled receptors technical
"core expertise in targeting G-protein coupled receptors (GPCRs) with small molecules"
Cell-surface proteins that detect outside signals — such as hormones, neurotransmitters or sensory cues — and translate them into internal actions that change how a cell behaves, like a doorbell that triggers different responses inside a house. They are prime drug targets because tweaking these receptors can alter important biological processes; successful drugs that activate or block them often drive clinical advances, approvals and significant revenue for pharmaceutical portfolios, so their status matters to investors.
Merger Agreement regulatory
"transactions contemplated by the Merger Agreement by and among Crinetics, Vertex and"
A merger agreement is a binding contract that lays out the exact terms for two companies to combine, including the price, what each side will deliver, and the conditions that must be met before the deal is completed. Investors care because it sets the timetable, payouts and risks — like a blueprint or prenup that shows whether the deal is likely to close, how ownership will change, and what could cancel or alter the payout they expect.
Revenue $25.1 million up from $1.0 million in the same period of 2025
PALSONIFY net product revenue $24.0 million up from $10.3 million in the first quarter of 2026
Net loss $120.9 million compared with a $115.6 million net loss in the same period of 2025
Net loss per share $1.14 compared with $1.23 per share in the same period of 2025
Cash, cash equivalents and investment securities $1.2 billion compared with $1.0 billion as of December 31, 2025
Guidance

In light of the proposed transaction with Vertex, Crinetics withdrew its previously issued guidance and did not provide updated guidance.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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FAQ

What acquisition did Crinetics Pharmaceuticals (CRNX) announce with Vertex?

Crinetics agreed to be acquired by Vertex for $85.00 per share in cash, giving an equity value of about $10.0 billion, or $8.8 billion net of estimated cash acquired. Closing is anticipated in the third quarter of 2026, subject to regulatory and Crinetics stockholder approvals.

How did Crinetics (CRNX) perform financially in the second quarter of 2026?

Crinetics generated $25.1 million in revenue in Q2 2026, up from $1.0 million a year earlier, driven by PALSONIFY. The company reported a $120.9 million net loss, or $1.14 per share, reflecting significant ongoing R&D and commercial investments.

What were PALSONIFY sales and adoption metrics for Crinetics (CRNX) in Q2 2026?

PALSONIFY delivered $24.0 million in net product revenue in Q2 2026. Crinetics received 245 enrollment forms, had 385 unique prescribers within the first three quarters of launch, and reported that over 70% of treated patients were on reimbursed therapy.

What was Crinetics’ (CRNX) cash position as of June 30, 2026?

As of June 30, 2026, Crinetics held $1.2 billion in cash, cash equivalents, and investment securities. Total assets were $1.32 billion, and total stockholders’ equity was $1.19 billion, providing substantial financial resources for its operations.

What regulatory milestone did Crinetics (CRNX) report for atumelnant?

The U.S. FDA granted Rare Pediatric Disease Designation to atumelnant, a once-daily oral ACTH receptor antagonist in Phase 3 development for classic congenital adrenal hyperplasia in pediatric and adult patients, potentially supporting future priority review voucher eligibility if approved.

Is Crinetics (CRNX) providing guidance or hosting an earnings call for Q2 2026?

Crinetics withdrew its previously issued guidance and is not providing updated guidance in light of the proposed Vertex transaction. The company also stated it will not host an earnings conference call or webcast for its second quarter 2026 results.
0001658247false00016582472026-08-032026-08-03

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
_________________________________________________________
FORM 8-K
_________________________________________________________
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): August 3, 2026
_________________________________________________________
Crinetics Pharmaceuticals, Inc.
(Exact name of Registrant as Specified in Its Charter)
_________________________________________________________
Delaware001-3858326-3744114
(State or Other Jurisdiction
of Incorporation)
(Commission File Number)(IRS Employer
Identification No.)
6055 Lusk Boulevard
San Diego, California
92121
(Address of Principal Executive Offices)(Zip Code)
Registrant’s Telephone Number, Including Area Code: (858) 450-6464
(Former Name or Former Address, if Changed Since Last Report)
_________________________________________________________
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
o    Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o    Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o    Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o    Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Securities registered pursuant to Section 12(b) of the Act:
Title of each classTrading
Symbol(s)
Name of each exchange on which registered
Common Stock, par value $0.001 per shareCRNXNasdaq Global Select Market
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).
Emerging growth company o
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. o



Item 2.02 Results of Operations and Financial Condition.
On August 3, 2026, Crinetics Pharmaceuticals, Inc. (the “Company” or “Crinetics”) issued a press release reporting its financial results for the period ended June 30, 2026. The full text of the press release is attached as Exhibit 99.1 to this Current Report on Form 8-K.
In accordance with General Instruction B.2 of Form 8-K, the information contained or incorporated herein, including the press release furnished as Exhibit 99.1, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed to be incorporated by reference into any filing under the Securities Act of 1933, as amended, or the Exchange Act, whether made before or after the date hereof, except as expressly set forth by specific reference in such filing to this Current Report on Form 8-K.
Item 9.01 Financial Statements and Exhibits.
(d)Exhibits
Exhibit No.Description
99.1
Press Release dated August 3, 2026.
104Cover Page Interactive Data File (embedded within the Inline XBRL document)



SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
Crinetics Pharmaceuticals, Inc.
Date:
August 3, 2026
By:/s/ R. Scott Struthers, Ph.D.
R. Scott Struthers, Ph.D.
President and Chief Executive Officer
(Principal Executive Officer)

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Exhibit 99.1
Crinetics Pharmaceuticals Reports Second Quarter 2026 Financial Results
and Provides Business Update

Announced Vertex Agreement to Acquire Crinetics for Total Equity Value of Approximately $10.0 Billion, or Approximately $8.8B Net of Estimated Cash Acquired

PALSONIFY® (Paltusotine) Net Product Revenue of $24.0 Million for Second-Quarter 2026


SAN DIEGO – August 3, 2026 – Crinetics Pharmaceuticals, Inc. (Nasdaq: CRNX), a global pharmaceutical company focused on the discovery, development and commercialization of novel therapeutics for endocrine diseases and endocrine-related tumors, today reported financial results for the second quarter ended June 30, 2026.

Company Announcements and Second Quarter Highlights:
-On July 6, 2026, Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) and Crinetics announced that the companies have entered into a definitive agreement under which Vertex will acquire Crinetics for $85.00 per share in cash, for a total equity value of approximately $10.0 billion, or approximately $8.8 billion net of estimated cash acquired. The transaction was unanimously approved by both the Vertex and Crinetics Boards of Directors and is anticipated to close in the third quarter of 2026, subject to customary closing conditions, including receipt of regulatory approvals and approval by Crinetics stockholders.
-Announced that the U.S. Food and Drug Administration (FDA) has granted a Rare Pediatric Disease Designation (RPDD) to atumelnant, a novel, once-daily oral adrenocorticotropic hormone (ACTH) receptor antagonist investigational candidate in Phase 3 clinical development for the treatment of classic congenital adrenal hyperplasia (CAH) in both pediatric patients and adults.
-Reported $24.0 million in net product revenue, reflecting the growing adoption of PALSONIFY as the preferred choice for the acromegaly community.
-Received 245 enrollment forms1 during the second quarter of 2026. Breadth and depth of PALSONIFY prescribers continued to expand, with 385 unique healthcare providers (HCPs) having prescribed PALSONIFY within the first three quarters of launch.
-Over 70% of patients treated with PALSONIFY at the end of the second quarter of 2026 were on reimbursed therapy.

Second Quarter 2026 Financial Results:
Revenue was $25.1 million for the quarter ended June 30, 2026, compared to $1.0 million for the same period in 2025. Revenue for the quarter ended June 30, 2026 includes $24.0 million in net product revenue from the U.S. commercial launch of PALSONIFY, up from $10.3 million in net product revenue reported in the first quarter of 2026.
Cost of product revenue was $0.2 million for the quarter ended June 30, 2026, primarily related to distribution, packaging, and fulfillment of PALSONIFY.
1 An enrollment form is an official document containing both HCP and patient consent, submitted to CrinetiCARE or specialty pharmacies (Orsini or Biologics) to initiate a patient on PALSONIFY. Enrollment forms metric also includes direct dispenses from pituitary treatment centers (PTCs) or community practices to patients.





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Research and development expenses were $99.9 million for the quarter ended June 30, 2026, compared to $80.3 million for the same period in 2025, and compared to $100.1 million in the quarter ended March 31, 2026. The increase compared to the prior year period was primarily attributable to increased investment in our clinical programs and an increase in personnel costs. Research and development expenses for the current quarter were generally consistent with the sequential period.
Selling, general and administrative expenses were $57.6 million for the quarter ended June 30, 2026, compared to $49.8 million for the same period in 2025, and compared to $50.8 million in the quarter ended March 31, 2026. The increase compared to the prior year period is related to investments in our corporate infrastructure as we transition into a commercial-stage company. The increase compared to the prior quarter reflects timing of commercial investment and costs related to the proposed transaction with Vertex.
Net loss was $120.9 million for the quarter ended June 30, 2026, compared to net loss of $115.6 million for the same period in 2025.
Cash, cash equivalents, and investment securities totaled $1.2 billion as of June 30, 2026, compared to $1.0 billion as of December 31, 2025.

Business Outlook and Conference Call
In light of Crinetics’ July 6, 2026 announcement regarding the proposed transaction with Vertex, Crinetics will not be providing updated guidance and is withdrawing its previously issued guidance. In addition, Crinetics will not host an earnings conference call or webcast reporting on its second quarter 2026 results.

About Crinetics Pharmaceuticals
Crinetics Pharmaceuticals is a global pharmaceutical company committed to transforming the treatment of endocrine diseases and endocrine-related tumors through science rooted in patient needs. Crinetics is focused on discovering, developing, and commercializing novel therapies, with a core expertise in targeting G-protein coupled receptors (GPCRs) with small molecules that have specifically tailored pharmacology and properties.

Crinetics’ first commercial product, PALSONIFY™ (paltusotine), is the first once-daily, oral treatment approved by the U.S. FDA and EMA for the treatment of adults with acromegaly who had an inadequate response to surgery and/or for whom surgery is not an option. Paltusotine is also in clinical development for carcinoid syndrome associated with neuroendocrine tumors. Crinetics’ deep pipeline of programs includes late-stage investigational candidate atumelnant, which is currently in development for congenital adrenal hyperplasia and ACTH-dependent Cushing’s syndrome, and CRN09682, a nonpeptide drug conjugate candidate that is being developed to treat somatostatin receptor 2 (SST2) expressing neuroendocrine tumors and other SST2 expressing solid tumors. Additional discovery programs are focused on a variety of endocrine targets such as thyroid stimulating hormone (TSH), parathyroid hormone (PTH), somatostatin receptor 3 (SST3), and growth hormone (GH), as well as GPCR-targeted oncology indications.
Forward-Looking Statements
This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. All statements other than statements of historical facts contained in this press release are forward-looking statements, including statements related to the expected growth and commercial trajectory of PALSONIFY sales, the expected insurance coverage and reimbursement environment for PALSONIFY, the ability of PALSONIFY to become the preferred choice or the standard of care for acromegaly, statements regarding the plans and timelines for the clinical development of atumelnant and paltusotine for the treatment of carcinoid syndrome;





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and statements related to Crinetics, Vertex and the transactions (the “Transactions”) contemplated by the Merger Agreement by and among Crinetics, Vertex and Clark Merger Sub Inc. (the “Merger Agreement”). In some cases, you can identify forward-looking statements by terms such as “may,” “will,” “should,” “expect,” “plan,” “anticipate,” “could,” “intend,” “target,” “project,” “contemplates,” “believes,” “estimates,” “predicts,” “potential,” “upcoming” or “continue” or the negative of these terms or other similar expressions. These forward-looking statements speak only as of the date of this press release and are subject to a number of risks, uncertainties and assumptions, including, without limitation, Crinetics may not be able to obtain, maintain and enforce its patents and other intellectual property rights, and it may be prohibitively difficult or costly to protect such rights; geopolitical events may disrupt Crinetics’ business and that of the third parties on which it depends, including delaying or otherwise disrupting clinical studies and preclinical studies, interruptions or additional costs or tariffs imposed on the manufacturing and supply chain, or impairing employee productivity; unexpected adverse side effects, complications and/or drug interactions or inadequate efficacy of Crinetics’ product candidates that may limit their development, regulatory approval and/or commercialization; Crinetics’ dependence on third parties in connection with product manufacturing, research and preclinical and clinical testing; regulatory developments or political changes, including policies related to pricing and pharmaceutical drug reimbursement, in the United States and foreign countries; the timing and outcome of research, development and regulatory review is uncertain, and Crinetics’ drug candidates may not advance in development or be approved for marketing; Crinetics may use its capital resources sooner than expected or our cash burn rate may accelerate; any future impacts to our business resulting from geopolitical developments outside our control; the occurrence of any event or circumstance that could give rise to the right of Crinetics or Vertex to terminate the Merger Agreement, including circumstances requiring payment of a termination fee pursuant to the Merger Agreement; failure to obtain applicable regulatory or Crinetics’ stockholder approval in a timely manner or otherwise; the risk that the Transactions may not close in the anticipated timeframe or at all due to one or more of the other closing conditions not being satisfied or waived; the possibility that competing offers will be made; the risk that there may be unexpected costs, charges or expenses resulting from the Transactions; risks related to the ability of the Company and Vertex to successfully integrate the businesses and the possibility that integration may be more difficult, time consuming or costly than expected; the risk that the Transactions disrupt Crinetics’ or Vertex’s current plans and operations; the risk that certain restrictions during the pendency of the proposed transaction may impact Crinetics’ ability to pursue certain business opportunities or strategic transactions; risks related to disruption of each company’s management’s time and attention from ongoing business operations due to the Transactions; the risk that any announcements relating to the Transactions could have adverse effects on the market price of Crinetics’ and/or Vertex’s common stock, credit ratings or operating results; the risk of litigation that could be instituted against the parties or their respective directors, managers or officers and/or regulatory actions related to the Transactions, including the effects of any outcomes related thereto; the effects of the Transactions on relationships with employees, other business partners or governmental entities; the difficulty of predicting the timing or outcome of regulatory approvals or actions, if any; the impact of competitive products and pricing; that Vertex may not realize the potential benefits of the Transactions; other business effects, including the effects of industry, economic or political conditions outside of the companies’ control; and actual or contingent liabilities related to the Transactions. Forward-looking statements in this communication should be evaluated together with the many uncertainties that affect Vertex’s and Crinetics’ businesses, particularly those risks listed under the heading “Risk Factors” and the other cautionary factors discussed in the parties’ periodic reports filed with the SEC, including Vertex’s and Crinetics’ annual reports on Form 10-K for the year ended December 31, 2025, and quarterly reports on Form 10-Q and current reports on Form 8-K, all of which are available on the SEC’s website at www.sec.gov.). The events and





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circumstances reflected in Crinetics’ forward-looking statements may not be achieved or occur and actual results could differ materially from those projected in the forward-looking statements. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. Except as required by applicable law, Crinetics does not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise.






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CRINETICS PHARMACEUTICALS, INC.
Condensed Consolidated Statements of Operations
(In thousands, except per share data)
(Unaudited)

Three months ended June 30,Six months ended June 30,
2026202520262025
Revenue:
Product revenue, net$24,038 $— $34,344 $— 
Collaboration and license revenue1,080 1,031 1,508 1,392 
Total revenue25,118 1,031 35,852 1,392 
Operating expenses:
Cost of product revenue154 — 354 — 
Research and development99,850 80,301 199,931 156,541 
Selling, general and administrative57,573 49,842 108,404 85,368 
Total operating expenses157,577 130,143 308,689 241,909 
Loss from operations(132,459)(129,112)(272,837)(240,517)
Total other income, net11,60413,47524,13728,106
Net loss$(120,855)$(115,637)$(248,700)$(212,411)
Net loss per share — basic and diluted$(1.14)$(1.23)$(2.37)$(2.27)
Weighted average shares — basic and diluted105,560 93,791 104,834 93,448 























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CRINETICS PHARMACEUTICALS, INC.
Condensed Consolidated Balance Sheets
(In thousands, except per share data)
(Unaudited)

June 30, 2026December 31, 2025
ASSETS
CURRENT ASSETS
Cash and cash equivalents$55,498 $101,536 
Investment securities, amortized cost of $1,153,283 at June 30, 2026 and $924,317 at December 31, 2025
1,150,275 926,353 
Trade accounts receivable, net11,957 592 
Inventory3,488 2,022 
Prepaid expenses and other current assets23,144 17,839 
Total current assets1,244,362 1,048,342 
Property and equipment, net13,073 14,296 
Operating lease right-of-use assets39,107 40,492 
Restricted cash, net of current portion800 800 
Prepaid expenses and other assets, net of current portion24,541 22,327 
TOTAL ASSETS$1,321,883 $1,126,257 
LIABILITIES AND STOCKHOLDERS’ EQUITY
CURRENT LIABILITIES
Accounts payable and accrued expenses$42,439 $41,770 
Accrued compensation and related expenses29,222 35,578 
Deferred revenue1,669 1,235 
Operating lease liabilities6,585 6,489 
Total current liabilities79,915 85,072 
Operating lease liabilities, non-current40,606 42,052 
Deferred revenue, non-current3,465 3,810 
Other non-current liabilities5,935 3,240 
TOTAL LIABILITIES129,921 134,174 
Commitments and contingencies
STOCKHOLDERS’ EQUITY
Preferred stock, $0.001 par; 10,000 shares authorized; no shares issued or outstanding at June 30, 2026 or December 31, 2025
— — 
Common stock and paid-in capital, $0.001 par; 200,000 shares authorized; 105,808 shares issued and outstanding at June 30, 2026; 95,575 shares issued and outstanding at December 31, 2025
2,862,360 2,407,757 
Accumulated other comprehensive (loss) income(3,008)1,865 
Accumulated deficit(1,666,127)(1,417,427)
Stock held in trust(1,263)(112)
TOTAL STOCKHOLDERS’ EQUITY1,191,962 992,083 
TOTAL LIABILITIES AND STOCKHOLDERS’ EQUITY$1,321,883 $1,126,257 









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Investors:
Gayathri Diwakar
Head of Investor Relations
gdiwakar@crinetics.com
(858) 345-6340

Media:
Natalie Badillo
Head of Corporate Communications
nbadillo@crinetics.com
(858) 345-6075




Filing Exhibits & Attachments

4 documents