STOCK TITAN

Crinetics CCO cashes out at $85 in Vertex merger

The reported insider trading involves Crinetics Pharmaceuticals shares at $85.00 per share.

(Very High)
(Neutral)
Form Type
4

Rhea-AI Filing Summary

Crinetics Pharmaceuticals, Inc. (CRNX) disclosed that Chief Commercial Officer Isabel Kalofonos reported merger-related dispositions effective September 1, 2026. In connection with the merger of Crinetics into a wholly owned subsidiary of Vertex Pharmaceuticals, each share of Crinetics common stock was canceled and converted into the right to receive $85.00 per share in cash, subject to tax withholding. The filing reports cancellation of common shares, restricted stock units and stock options, which were converted into cash rights based on the Merger Consideration or, for certain out-of-the-money options, canceled for no consideration.

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Insider Kalofonos Isabel
Role Chief Commercial Officer
Type Security Shares Price Value
Disposition Stock Option (Right to Buy) F4, F5 97,500 $44.41 $4.33M
Disposition Stock Option (Right to Buy) F4, F5 55,000 $41.21 $2.27M
Disposition Common Stock F1, F2 1,669 $85.00 $142K
Disposition Common Stock F3 34,000 $85.00 $2.89M
Holdings After Transaction: Stock Option (Right to Buy) — 0 contracts (Direct); Common Stock — 0 shares (Direct)
Footnotes (5)
  1. F1. Includes 835 shares acquired under the Issuer's Employee Stock Purchase Plan.
  2. F2. Pursuant to the Agreement and Plan of Merger, dated as of July 6, 2026 (the "Merger Agreement"), by and among Crinetics Pharmaceuticals, Inc., a Delaware corporation (the "Company"), Vertex Pharmaceuticals Incorporated, a Massachusetts corporation ("Parent"), and Clark Merger Sub, Inc., a Delaware corporation and a wholly owned subsidiary of Parent ("Merger Sub"), Merger Sub merged with and into the Company, with the Company surviving as a wholly owned subsidiary of Parent (the "Merger"), effective as of September 1, 2026 (the "Effective Time"). At the Effective Time, each share of common stock of the Company, par value $0.001 per share (the "Company Common Stock"), issued and outstanding immediately prior to the Effective Time, except as provided in the Merger Agreement, was canceled and automatically converted into the right to receive $85.00 per share in cash, without interest and subject to any applicable tax withholdings (the "Merger Consideration").
  3. F3. The transaction reported on this line reflects the cancellation in the Merger of restricted stock units of the Company (each, a "Company RSU"), each of which represented a contingent right to receive one share of the Issuer's Common Stock. Immediately prior to the Effective Time, each Company RSU that was then outstanding but not vested became immediately vested in full. At the Effective Time, each outstanding Company RSU was canceled and converted into the right to receive an amount in cash equal to the Merger Consideration, less any applicable tax withholding.
  4. F4. The transaction reported on this line reflects the cancellation in the Merger of options to purchase shares of Company Common Stock (each, a "Company Stock Option"). Immediately prior to the Effective Time, each Company Stock Option that was then outstanding but not vested became immediately vested in full. At the Effective Time, (i) each outstanding Company Stock Option having a per share exercise price less than the Merger Consideration was canceled and converted into the right to receive an amount in cash equal to the difference between the Merger Consideration and the applicable per share exercise price, less any applicable tax withholding, and (ii) any Company Stock Option having a per share exercise price equal to or greater than the Merger Consideration was canceled for no consideration.
  5. F5. The transaction reported on this line reflects the cancellation in the Merger of Company Stock Options having a per share exercise price less than the Merger Consideration and the price reported in Column 8 represents the difference between the Merger Consideration and the applicable per share exercise price of the Company Stock Options.
Merger Consideration per share $85.00 per share Cash paid for each share of Crinetics common stock at the effective time of the merger
Common Stock canceled 1,669 shares Common shares of Crinetics reported as canceled and converted into cash rights on September 1, 2026
Restricted Stock Units canceled 34,000 units Crinetics RSUs that became vested, then were canceled and converted into cash based on the Merger Consideration
Stock Options canceled (grant 1) 97,500 options Crinetics stock options with a per share exercise price of $40.59 canceled and converted into cash equal to the $85.00 Merger Consideration minus the exercise price
Cash per option (grant 1) reported in Column 8 $44.41 per option Difference between the $85.00 Merger Consideration and the $40.59 exercise price for 97,500 options
Stock Options canceled (grant 2) 55,000 options Crinetics stock options with a per share exercise price of $43.79 canceled and converted into cash equal to the $85.00 Merger Consideration minus the exercise price
Cash per option (grant 2) reported in Column 8 $41.21 per option Difference between the $85.00 Merger Consideration and the $43.79 exercise price for 55,000 options
Merger Consideration financial
"was canceled and automatically converted into the right to receive $85.00 per share in cash"
Merger consideration is the total payment a company or buyer offers to shareholders of a target company in exchange for combining the two businesses, and can include cash, shares in the surviving company, debt assumption, or a mix of these. Investors care because the form and amount affect the deal’s value, tax consequences, immediate cash received versus future ownership, and the risk and upside of holding new shares — similar to choosing between cash now or stock that could grow later.
restricted stock units financial
"reflects the cancellation in the Merger of restricted stock units of the Company"
Restricted stock units are a type of company reward where employees are promised shares of stock, but they only fully own these shares after meeting certain conditions, like staying with the company for a set time. They matter because they can become valuable assets and are often used to motivate employees to help the company succeed.
Company Stock Option financial
"reflects the cancellation in the Merger of options to purchase shares of Company Common Stock"
disposition to issuer regulatory
"transaction code "D" with description "Disposition to issuer""

FAQ

What did CRNX Chief Commercial Officer Isabel Kalofonos report in this Form 4?

She reported dispositions of common stock, restricted stock units and stock options of Crinetics Pharmaceuticals, Inc. on September 1, 2026, all resulting from the completion of a merger in which Crinetics became a wholly owned subsidiary of Vertex Pharmaceuticals.

What consideration did CRNX shareholders receive in the Vertex merger?

Each share of Crinetics common stock was converted into the right to receive $85.00 per share in cash, without interest and subject to applicable tax withholdings, as the Merger Consideration described for the acquisition by Vertex Pharmaceuticals.

How were CRNX restricted stock units treated in the merger?

Each Crinetics restricted stock unit became fully vested immediately before the effective time and was then canceled and converted into the right to receive a cash amount equal to the $85.00 Merger Consideration per unit, less any applicable tax withholding.

How were CRNX stock options held by Isabel Kalofonos treated?

Each Crinetics stock option was canceled in the merger. Options with a per-share exercise price less than $85.00 were converted into a cash right equal to the difference between $85.00 and the exercise price, less tax withholding, while options with exercise prices at or above $85.00 were canceled for no consideration.

Were the transactions in this CRNX Form 4 open-market sales?

No. The transactions are reported with code D (disposition to issuer) and footnotes explain they reflect cancellations for cash or no consideration in connection with the merger, not voluntary open-market purchases or sales.

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Learn about SEC filing dates
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
X
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Kalofonos Isabel

(Last)(First)(Middle)
C/O CRINETICS PHARMACEUTICALS, INC.
6055 LUSK BOULEVARD

(Street)
SAN DIEGO CALIFORNIA 92121

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Crinetics Pharmaceuticals, Inc. [ CRNX ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director10% Owner
XOfficer (give title below)Other (specify below)
Chief Commercial Officer
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
09/01/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock09/01/2026D1,669(1)D$85(2)34,000D
Common Stock09/01/2026D34,000D$85(3)0D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (Right to Buy)$40.5909/01/2026D97,500 (4)(5)01/10/2035Common Stock97,500$44.41(4)(5)0D
Stock Option (Right to Buy)$43.7909/01/2026D55,000 (4)(5)02/23/2036Common Stock55,000$41.21(4)(5)0D
Explanation of Responses:
1. Includes 835 shares acquired under the Issuer's Employee Stock Purchase Plan.
2. Pursuant to the Agreement and Plan of Merger, dated as of July 6, 2026 (the "Merger Agreement"), by and among Crinetics Pharmaceuticals, Inc., a Delaware corporation (the "Company"), Vertex Pharmaceuticals Incorporated, a Massachusetts corporation ("Parent"), and Clark Merger Sub, Inc., a Delaware corporation and a wholly owned subsidiary of Parent ("Merger Sub"), Merger Sub merged with and into the Company, with the Company surviving as a wholly owned subsidiary of Parent (the "Merger"), effective as of September 1, 2026 (the "Effective Time"). At the Effective Time, each share of common stock of the Company, par value $0.001 per share (the "Company Common Stock"), issued and outstanding immediately prior to the Effective Time, except as provided in the Merger Agreement, was canceled and automatically converted into the right to receive $85.00 per share in cash, without interest and subject to any applicable tax withholdings (the "Merger Consideration").
3. The transaction reported on this line reflects the cancellation in the Merger of restricted stock units of the Company (each, a "Company RSU"), each of which represented a contingent right to receive one share of the Issuer's Common Stock. Immediately prior to the Effective Time, each Company RSU that was then outstanding but not vested became immediately vested in full. At the Effective Time, each outstanding Company RSU was canceled and converted into the right to receive an amount in cash equal to the Merger Consideration, less any applicable tax withholding.
4. The transaction reported on this line reflects the cancellation in the Merger of options to purchase shares of Company Common Stock (each, a "Company Stock Option"). Immediately prior to the Effective Time, each Company Stock Option that was then outstanding but not vested became immediately vested in full. At the Effective Time, (i) each outstanding Company Stock Option having a per share exercise price less than the Merger Consideration was canceled and converted into the right to receive an amount in cash equal to the difference between the Merger Consideration and the applicable per share exercise price, less any applicable tax withholding, and (ii) any Company Stock Option having a per share exercise price equal to or greater than the Merger Consideration was canceled for no consideration.
5. The transaction reported on this line reflects the cancellation in the Merger of Company Stock Options having a per share exercise price less than the Merger Consideration and the price reported in Column 8 represents the difference between the Merger Consideration and the applicable per share exercise price of the Company Stock Options.
Remarks:
/s/ Tobin Schilke, as attorney-in-fact09/01/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)