Welcome to our dedicated page for Crispr Therapeut SEC filings (Ticker: CRSP), a comprehensive resource for investors and traders seeking official regulatory documents including 10-K annual reports, 10-Q quarterly earnings, 8-K material events, and insider trading forms.
CRISPR Therapeutics AG filings document operating results, pipeline disclosures and capital-structure matters for a Swiss biopharmaceutical company developing gene-based medicines. Form 8-K reports furnish quarterly and annual financial results, business highlights for CASGEVY and investigational programs, clinical and regulatory updates across cardiovascular, autoimmune, immuno-oncology and regenerative medicine, and material-event disclosures.
The filing record also includes proxy materials covering shareholder voting and executive compensation, shelf-registration and prospectus-supplement disclosures for common-share offerings, and material definitive agreements for convertible senior notes due 2031. These filings describe common shares, equity financing mechanics, debt terms, governance matters and business disclosures tied to the company’s CRISPR/Cas9, LNP, CAR-T and siRNA platforms.
CRISPR Therapeutics AG Chief Executive Officer Samarth Kulkarni reported RSU vesting and a related tax sale. On March 14, 2026, 20,625 Restricted Stock Units vested and were converted into 20,625 Common Shares at a conversion price of $0.00 per share.
The vested RSUs are part of an 82,500-share award granted on March 14, 2025, scheduled to vest in four equal annual installments through March 14, 2029. On March 16, 2026, 10,349 Common Shares were sold at $48.26 per share to cover tax withholding obligations under the company’s RSU Settlement Policy, which the footnotes state does not represent a discretionary trade. After these transactions, Kulkarni directly holds 245,834 Common Shares and 61,875 Restricted Stock Units.
CRISPR Therapeutics completed a private offering of $600.0 million aggregate principal amount of convertible senior notes due 2031, generating approximately $585.2 million in net proceeds for general corporate purposes. The notes are senior unsecured obligations with an effective coupon of 1.125%, increased to 1.7308% to offset anticipated Swiss withholding tax.
Holders may convert at an initial rate of 13.0617 common shares per $1,000 principal amount, implying a conversion price of about $76.56 per share, a 45.0% premium to the $52.80 last reported sale price on the Nasdaq Global Market on March 10, 2026. Initially, a maximum of 11,363,580 common shares may be delivered upon conversion based on the initial maximum conversion rate.
The notes mature on March 1, 2031, pay interest semiannually starting September 1, 2026, and are redeemable at the company’s option on or after March 6, 2029 if share price conditions are met. They were sold in an unregistered Rule 144A private placement, and the shares issuable upon conversion are expected to be delivered in transactions exempt under Section 3(a)(9).
CRISPR Therapeutics AG General Counsel and Secretary James R. Kasinger reported an RSU vesting and related share sale. On March 10, 2026, he acquired 5,500 Common Shares at $0.00 per share through the exercise of Restricted Stock Units, reflecting part of a 22,000-share award granted on March 10, 2023.
On March 11, 2026, he sold 2,800 Common Shares at an average price of $52.80 per share. A footnote states these shares were sold to cover tax withholding obligations under the company’s RSU Settlement Policy and were not a discretionary trade. After these transactions, he directly owned 87,815 Common Shares.
CRISPR Therapeutics AG Chief Executive Officer Samarth Kulkarni reported compensation-related share activity. On March 10, 2026, 19,250 restricted stock units were exercised into 19,250 Common Shares at $0.00 per share, reflecting vesting of part of a prior equity award.
On March 11, 2026, 9,798 Common Shares were sold at $52.80 per share. A footnote explains this amount was required to be sold to cover tax withholding tied to the RSU vesting under the company’s RSU Settlement Policy, and therefore did not represent a discretionary trade. After these transactions, Kulkarni directly held 235,558 Common Shares.
CRISPR Therapeutics AG is raising capital through a private offering of $550 million aggregate principal amount of convertible senior notes due 2031, sold to qualified institutional buyers. The offering was upsized from a previously proposed $350 million.
The notes carry an effective coupon of 1.125%, increased to 1.7308% to offset anticipated Swiss withholding tax, and mature on March 1, 2031 unless earlier converted, redeemed or repurchased. They are initially convertible at 13.0617 common shares per $1,000 principal amount, implying a conversion price of about $76.56 per share, a roughly 45% premium to the $52.80 share price on March 10, 2026. CRISPR Therapeutics estimates net proceeds of approximately $536.3 million, or $585.2 million if the purchasers’ option is fully exercised, and plans to use the funds for general corporate purposes.
CRISPR Therapeutics AG Chief Executive Officer Samarth Kulkarni reported RSU vesting and a related share sale. On February 18, 2026, he acquired 13,250 Common Shares at $0.00 per share through the exercise/settlement of restricted stock units.
On February 19, 2026, he sold 6,967 Common Shares at an average price of $52.58 per share. A footnote explains that this sale was required to cover tax withholding obligations under the company’s RSU Settlement Policy and was not a discretionary trade. After these transactions, he directly held 226,106 Common Shares.
The restricted stock units were originally granted on February 18, 2022 for 53,000 Common Shares, vesting in four equal annual installments through February 18, 2026.
CRISPR Therapeutics AG General Counsel and Secretary James R. Kasinger reported a mix of equity transactions involving company stock. On February 18, 2026, he acquired 3,825 Common Shares through the exercise and settlement of restricted stock units at a price of $0.00 per share, increasing his direct holdings to 87,227 Common Shares. On February 19, 2026, 2,112 Common Shares were sold at an average price of $52.58 per share to cover tax withholding obligations related to the RSU vesting, as required by the company’s RSU Settlement Policy and not as a discretionary trade. After these transactions, he directly owned 85,115 Common Shares.
Orbis Investment Management Ltd and Allan Gray Australia Pty Ltd report beneficial ownership of 5,950,145 shares of CRISPR Therapeutics common stock, representing 6.2% of the class as of 12/31/2025. Orbis holds 5,934,328 shares and Allan Gray holds 15,817 shares, each with sole voting and dispositive power over its respective holdings.
Both firms are non-U.S. institutions equivalent to investment advisers and state that the securities are held in the ordinary course of business, not to change or influence control of CRISPR Therapeutics. Other persons have rights to receive dividends or sale proceeds on the shares each firm beneficially owns.
CRISPR Therapeutics describes its business as a leader in CRISPR/Cas9 gene-editing medicines, highlighted by CASGEVY, the first approved CRISPR-based therapy for severe sickle cell disease and transfusion‑dependent beta thalassemia in patients 12 and older across multiple regions.
The company outlines four core franchises: hemoglobinopathies, in vivo liver gene editing, allogeneic CAR T cell therapies for autoimmune diseases and oncology, and regenerative medicine for Type 1 diabetes. It estimates about 60,000 eligible SCD and TDT patients in key Western and Middle Eastern markets.
Pipeline updates include CTX310 in Phase 1b for cardiovascular disease, where a single-course treatment cut ANGPTL3 by up to 89%, triglycerides by up to 84%, and LDL by up to 87% in early data, and CTX611, a long‑acting siRNA Factor XI inhibitor now in Phase 2. Zugo‑cel, its next‑generation allogeneic CD19 CAR T, shows high response rates in relapsed or refractory large B‑cell lymphoma and early remission signals in systemic lupus erythematosus.
CRISPR Therapeutics reported fourth quarter and full-year 2025 results, showing early CASGEVY commercialization alongside higher losses as it invests in its pipeline. CASGEVY generated $54 million in Q4 2025 revenue and $116 million for the full year, with 64 patients infused in 2025 and 147 initiating treatment.
Cash, cash equivalents and marketable securities were $1,975.8 million as of December 31, 2025, slightly above $1,903.8 million a year earlier. Q4 2025 R&D expense rose to $83.5 million from $71.7 million, and collaboration expense jumped to $53.7 million from $10.4 million due to the absence of a prior-year cost deferral.
Net loss widened to $130.6 million for Q4 2025 versus $37.3 million a year ago, and to $581.6 million for 2025 versus $366.3 million in 2024. The company highlighted progress across in vivo liver editing, its siRNA collaboration, autoimmune and oncology CAR-T programs, and regenerative medicine, with multiple clinical and data updates expected in 2026.