Welcome to our dedicated page for Cytomx Therapeutics SEC filings (Ticker: CTMX), a comprehensive resource for investors and traders seeking official regulatory documents including 10-K annual reports, 10-Q quarterly earnings, 8-K material events, and insider trading forms.
Tracking R&D swings at a clinical-stage biotech is hard enough—doing it inside CytomX Therapeutics’ two-hundred-plus-page reports can feel impossible. If you have ever typed “Where can I find the CytomX Therapeutics quarterly earnings report 10-Q filing?” or “How do I monitor CytomX Therapeutics insider trading Form 4 transactions?”, you already know the challenge. Stock Titan turns that complexity into clarity, with CytomX Therapeutics SEC filings explained simply.
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Understanding CytomX Therapeutics SEC documents with AI means spending minutes—not hours—on the disclosures that drive this pioneering probody technology developer.
CytomX Therapeutics (CTMX) filed a Form 4 reporting a stock option grant to its Chief Business Officer, Rachael Lester. The award covers 650,000 options to buy common stock at an exercise price of $3.74 per share, granted on 10/20/2025.
Per the vesting terms, 25% of the shares vest on the one-year anniversary of October 20, 2025, with the remainder vesting in equal monthly installments so that the grant is fully vested on the fourth anniversary. The options expire on 10/19/2035. Ownership is reported as Direct (D).
CytomX Therapeutics (CTMX) filed a Form 3 initial statement of beneficial ownership for its Chief Business Officer, Rachael Lester. The filing states that no securities are beneficially owned.
The reported event date is 10/20/2025. The form was signed by Christopher Ogden as attorney-in-fact, referencing Exhibit 24.1 (Power of Attorney).
CytomX Therapeutics insider grant to Chief Medical Officer
Yu-Waye Chu, Chief Medical Officer of CytomX Therapeutics, acquired equity awards on 09/26/2025 consisting of a stock option to purchase 87,500 shares of common stock at an exercise price of $2.90 and 43,750 Performance Stock Units (PSUs), each PSU representing one contingent share. The option vests monthly at 1/48th beginning on the Vesting Commencement Date of 09/26/2025 and becomes fully vested on the fourth anniversary if the reporting person remains in service. The PSUs vest in three tranches, with 1/3 vesting upon achievement of each of three specified clinical milestones, subject to continued service. All reported holdings are direct.
CytomX Therapeutics (CTMX) Chief Financial Officer Christopher Ogden reported option and performance‑unit awards on Sept 26, 2025. He was granted a stock option to buy 78,250 shares at a $2.90 exercise price that vests monthly over four years beginning Sept 26, 2025, and 39,150 Performance Stock Units (PSUs) that vest in three tranches tied to clinical milestones, each PSU convertible into one share on vesting. Following these awards, Mr. Ogden beneficially owns 78,250 option shares and 39,150 PSUs, all held directly. The option expires Sept 25, 2035. The filing is signed Sept 30, 2025.
Marcia Belvin, SVP and Chief Scientific Officer of CytomX Therapeutics (CTMX), was granted equity awards on 09/26/2025. The filing reports a stock option to purchase 36,300 shares with an exercise price of $2.90 and 18,150 Performance Stock Units (PSUs) that convert to one share each upon vesting. The option vests monthly at 1/48th beginning on the Vesting Commencement Date of 09/26/2025, reaching full vesting on the fourth anniversary if service continues. The PSUs vest in three equal tranches upon achievement of specified clinical milestones, subject to continued service. The Form 4 was signed by an attorney-in-fact on 09/30/2025.
Perceptive Advisors, Joseph Edelman and Perceptive Life Sciences Master Fund report a shared beneficial ownership stake of 9,680,185 shares in CytomX Therapeutics, representing 5.9% of the outstanding common stock based on 164,912,906 shares outstanding. The Master Fund directly holds the shares, while Perceptive Advisors, as investment manager, and Mr. Edelman, as managing member, may be deemed to beneficially own those shares. All three reporting persons disclose no sole voting or dispositive power and shared voting and dispositive power over the reported shares.
OrbiMed Advisors LLC reported beneficial ownership of 8,461,500 shares of CytomX Therapeutics common stock, representing 5.4% of the class. The Schedule 13G filing states OrbiMed has shared voting and dispositive power over all reported shares and no sole voting or dispositive power. The filing identifies the reporting person as an investment adviser organized in Delaware and confirms these shares are held on behalf of other persons. The filing includes a certification that the position was not acquired to change or influence control of the issuer.
Point72 entities and Steven A. Cohen reported a 5.1% passive stake in CytomX Therapeutics (CTMX). The filing shows 8,084,623 shares are beneficially owned jointly by Point72 Asset Management, Point72 Capital Advisors and Mr. Cohen, with shared voting and dispositive power and no sole voting or dispositive power reported. The disclosure states these shares are held through Point72 Associates and that the positions were not acquired to influence control of the company. Ownership totals are reported as of the close of business on June 30, 2025.
Tang Capital Management and related entities report ownership of 11,065,662 shares of CytomX Therapeutics common stock, representing 7.0% of the outstanding class. The filing shows no sole voting or dispositive power; all reported shares are held with shared voting and dispositive power. The percentages are calculated using 157,544,369 shares outstanding per the issuer prospectus. The filers certify the stake is not held to influence control of the company.
On August 13, 2025, CytomX Therapeutics provided an update on its CX-2051 Phase 1 study. Dose expansions at 7.2 mg/kg, 8.6 mg/kg, and 10 mg/kg, given every three weeks, have each enrolled approximately 20 patients as planned. The company reported a single Grade 5 treatment-related acute kidney injury in a patient with a complex medical history, including a solitary kidney; the event was believed to be secondary to nausea, vomiting and diarrhea and was reported to the FDA on July 18, 2025. The study's Safety Review Committee convened on July 14, 2025 and supported continued study execution and enrollment.
The CTMX-2051-101 study remains ongoing and a Phase 1 data update is expected by Q1 2026. The filing discloses enrollment progress, the serious adverse event and regulatory reporting but does not provide additional efficacy or broader safety data.
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