[Form 4] CryoPort, Inc. Insider Trading Activity

Rhea-AI Filing Summary

On 08/04/2025 Cryoport (CYRX) filed a Form 4 showing that President & CEO Jerrell Shelton exercised 25,000 stock options at an exercise price of $5 on 07/31/2025. This was a cash exercise with no subsequent sale of the underlying shares. As a result, Shelton’s direct holdings rose to 1,037,419 common shares.

The option was originally granted on 08/20/2015 and vested in equal monthly installments over 48 months; the filing confirms the award is now fully exercised and retired. The transaction modestly increases insider ownership and may indicate management confidence, but represents only about 2.4 % of Shelton’s total stake and does not involve open-market buying. No additional financial metrics, earnings data, or strategic commentary were included in the filing.

Positive

• CEO increased direct ownership by 25,000 shares, signalling continued commitment to the company.
• No shares were sold, eliminating near-term selling pressure and suggesting confidence in future performance.

Negative

• The transaction is small, adding only ~2.4 % to the CEO’s existing stake, limiting its signaling power.
• Shares were acquired via option exercise rather than open-market purchase, providing a weaker valuation signal.

Insights

Securities Analyst

TL;DR – CEO adds 25k shares via option exercise; no sale, modestly positive signal but limited market impact.

The cash exercise at $5 eliminates 25,000 fully-vested options and lifts Shelton’s direct stake to roughly 1.04 million shares. Lack of selling removes immediate supply pressure and can be interpreted as incremental confidence, yet the size is immaterial relative to his existing position and Cryoport’s 49 million basic shares outstanding. Because the shares were not bought on the open market, the purchase does not necessarily reflect valuation views. Overall impact on share price or valuation is expected to be neutral to mildly positive.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

SHELTON JERRELL

(Last) (First) (Middle)

C/O CRYOPORT INC.

112 WESTWOOD PLACE, SUITE 350

(Street)

BRENTWOOD TN 37027

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Cryoport, Inc. [ CYRX ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	President, CEO

3. Date of Earliest Transaction (Month/Day/Year)
07/31/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	07/31/2025		M		25,000(1)	A	$5	1,037,419	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (right to buy)	$5	07/31/2025		M			25,000(1)	(2)	08/20/2025	Common Stock	25,000	$0.00	25,000	D

Explanation of Responses:

1. This transaction involved a cash exercise of a stock option without a subsequent sale of the underlying shares of common stock.

2. 1/48 of the options vested on the 19th of each month for forty-eight months beginning on 8/19/2015.

	/s/ Jerrell Shelton	08/04/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

How many CYRX shares did CEO Jerrell Shelton acquire in this Form 4?

He acquired 25,000 common shares through option exercise.

What was the exercise price of the options?

The options were exercised at $5.00 per share.

What is Shelton’s total direct ownership after the transaction?

His direct holdings stand at 1,037,419 CYRX shares.

Were any shares sold in connection with the option exercise?

No; the filing states there was no sale of the underlying shares.

When were the options originally granted and how did they vest?

Granted on 08/20/2015, vesting 1⁄48 monthly beginning 08/19/2015 over 48 months.

Does the Form 4 include any earnings or guidance information?

No. The filing only details insider transactions and includes no financial performance data.