EcoR1, affiliates report ~9.9% holdings in Eloxx (NASDAQ: ELOX)

Rhea-AI Filing Summary

Eloxx Pharmaceuticals, Inc. Schedule 13G filing shows EcoR1 Capital, LLC, EcoR1 Capital Fund Qualified, L.P. and Oleg Nodelman reporting shared beneficial ownership of common stock. The filing lists 403,586 shares (EcoR1 and Mr. Nodelman) and 377,635 shares (Qualified Fund), representing 9.9% and 9.3% of the class respectively. The percentages are calculated using 4,036,314 shares outstanding following an offering disclosed in a prospectus filed 06/09/2026. The reporting persons state the holdings were not acquired to change control and disclaim group membership beyond the joint filing.

Insights

Institutional Ownership Analyst

Large passive stakes reported by an institutional investor and related persons.

The filing shows EcoR1 Capital and affiliates hold 403,586 shares (reported as 9.9%) and the Qualified Fund holds 377,635 shares (9.3%), calculated on an outstanding base of 4,036,314 shares as of the prospectus dated 06/09/2026.

These positions are presented as shared voting/dispositive power rather than sole control; the signers disclaim group control and state the stakes were not acquired to change issuer control. Subsequent filings would show any trading activity or changes in percent ownership.

Corporate Governance Specialist

Beneficial ownership near 10% triggers typical disclosure thresholds and ownership limits.

The reporting notes pre-funded warrants and a 9.99% beneficial ownership limitation used in percentage calculations. That qualifier appears to cap exercises or holdings for conversion instruments and is cited verbatim in the cover comments.

Because the filing disclaims intent to influence control and attaches an agreement for joint filing, governance implications are routine disclosure; monitor future filings for any schedule amendments or Form 4s that would indicate active transactions.

Key Figures

EcoR1 shares beneficially owned: 403,586 shares Qualified Fund shares beneficially owned: 377,635 shares Percent of class (EcoR1 / Nodelman): 9.9% +2 more

5 metrics

EcoR1 shares beneficially owned 403,586 shares reported holdings for EcoR1 and Oleg Nodelman

Qualified Fund shares beneficially owned 377,635 shares reported holdings for EcoR1 Capital Fund Qualified, L.P.

Percent of class (EcoR1 / Nodelman) 9.9% calculated using 4,036,314 shares outstanding after offering

Percent of class (Qualified Fund) 9.3% calculated using 4,036,314 shares outstanding after offering

Shares outstanding used in calculation 4,036,314 shares outstanding following offering disclosed in prospectus filed 06/09/2026

Key Terms

Beneficial ownership limitation, Shared dispositive power, Pre-funded warrants

3 terms

Beneficial ownership limitation regulatory

"subject to a 9.99% beneficial ownership limitation"

A beneficial ownership limitation is a rule that caps the percentage of a company’s shares an investor can be treated as owning or controlling for voting, regulatory or tax purposes. It matters to investors because it can restrict how many shares a person or group can buy or vote, affect takeover chances, and influence share liquidity and value — like a speed limit that prevents any single driver from taking over the whole road.

Shared dispositive power financial

"Shared Dispositive Power 403,586.00"

Pre-funded warrants financial

"pre-funded warrants to acquire 50,000 shares of Common Stock"

Pre-funded warrants are financial instruments that give investors the right to purchase a company's stock at a set price, but with most or all of the purchase price paid upfront. They function like a coupon or gift card for stock, allowing investors to buy shares later at a fixed price, which can be beneficial if they want to avoid future price increases. This makes them important for investors seeking flexibility and certainty in their investment plans.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 06/16/2026 - 07:11 PM Accepted by SEC EDGAR 06/16/2026 - 07:10 PM Learn about SEC filing dates

FAQ

What stake does EcoR1 Capital hold in ELOX?

EcoR1 Capital reports beneficial ownership of 403,586 shares, equal to 9.9% of the class. The percentage is calculated using 4,036,314 shares outstanding following the offering disclosed in the prospectus dated 06/09/2026.

How is Oleg Nodelman connected to the reported holdings?

Oleg Nodelman is reported with shared voting and dispositive power over 403,586 shares (9.9%). The filing states Mr. Nodelman is control person of EcoR1 and signed the joint filing dated 06/16/2026.

What basis was used to calculate the ownership percentages?

Percentages are calculated using (1) the reported beneficial holdings and pre-funded warrants and (2) 4,036,314 shares outstanding after the offering disclosed in the prospectus filed on 06/09/2026, per the cover comments.

Does this filing indicate EcoR1 seeks control of Eloxx?

No; the reporting persons certify the securities were not acquired to change or influence control and disclaim group membership beyond the joint filing. The signatures dated 06/16/2026 attest to that statement.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

Eloxx Pharmaceuticals, Inc.

(Name of Issuer)

Comon Stock

(Title of Class of Securities)

29014R301

(CUSIP Number)

06/09/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 29014R301

1

Names of Reporting Persons

EcoR1 Capital, LLC

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 403,586.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 403,586.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

403,586.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

9.9 %

12

Type of Reporting Person (See Instructions)

IA, OO

Comment for Type of Reporting Person: Percentage calculated based on (1) 400,000 shares of Common Stock beneficially owned by the reporting person and pre-funded warrants to acquire 50,000 shares of Common Stock, subject to a 9.99% beneficial ownership limitation, and (2) 4,036,314 shares of Common Stock outstanding following the completion of the offering of securities by the Issuer disclosed in the prospectus filed by the Issuer on June 9, 2026.

SCHEDULE 13G

CUSIP Number(s): 29014R301

1

Names of Reporting Persons

Oleg Nodelman

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 403,586.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 403,586.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

403,586.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

9.9 %

12

Type of Reporting Person (See Instructions)

HC, IN

Comment for Type of Reporting Person: Percentage calculated based on (1) 400,000 shares of Common Stock beneficially owned by the reporting person and pre-funded warrants to acquire 50,000 shares of Common Stock, subject to a 9.99% beneficial ownership limitation, and (2) 4,036,314 shares of Common Stock outstanding following the completion of the offering of securities by the Issuer disclosed in the prospectus filed by the Issuer on June 9, 2026.

SCHEDULE 13G

CUSIP Number(s): 29014R301

1

Names of Reporting Persons

EcoR1 Capital Fund Qualified, L.P.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 377,635.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 377,635.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

377,635.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

9.3 %

12

Type of Reporting Person (See Instructions)

PN

Comment for Type of Reporting Person: Percentage calculated based on (1) 374,280 shares of Common Stock beneficially owned by the reporting person and pre-funded warrants to acquire 46,785 shares of Common Stock, subject to a 9.99% beneficial ownership limitation, and (2) 4,036,314 shares of Common Stock outstanding following the completion of the offering of securities by the Issuer disclosed in the prospectus filed by the Issuer on June 9, 2026.

SCHEDULE 13G

Item 1.
(a)	Name of issuer: Eloxx Pharmaceuticals, Inc.
(b)	Address of issuer's principal executive offices: P.O. Box 274, 10 Court Street, Arlington, MA 02476
Item 2.
(a)	Name of person filing: EcoR1 Capital, LLC, a Delaware limited liability company ("EcoR1") EcoR1 Capital Fund Qualified, L.P., a Delaware limited partnership ("Qualified Fund") Oleg Nodelman Qualified Fund is filing this statement jointly with the other reporting persons, but not as a member of a group, and it expressly disclaims membership in a group. In addition, the filing of this Schedule 13G on behalf of Qualified Fund should not be construed as an admission that it is, and it disclaims that it is, a beneficial owner, as defined in Rule 13d-3 under the Act, of any securities covered by this Schedule 13G. Each reporting person also disclaims beneficial ownership of the securities reported herein except to the extent of that person's pecuniary interest therein.
(b)	Address or principal business office or, if none, residence: 357 Tehama Street #3 San Francisco, CA 94103
(c)	Citizenship: See Item 4 of the cover sheet for each reporting person.
(d)	Title of class of securities: Comon Stock
(e)	CUSIP Number(s): 29014R301
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: EcoR1: 403,586 Oleg Nodelman: 403,586 Qualified Fund: 377,635
(b)	Percent of class: EcoR1: 9.9% Oleg Nodelman: 9.9% Qualified Fund: 9.3%
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: EcoR1: 0 Oleg Nodelman: 0 Qualified Fund: 0
	(ii) Shared power to vote or to direct the vote: EcoR1: 403,586 Oleg Nodelman: 403,586 Qualified Fund: 377,635
	(iii) Sole power to dispose or to direct the disposition of: EcoR1: 0 Oleg Nodelman: 0 Qualified Fund: 0
	(iv) Shared power to dispose or to direct the disposition of: EcoR1: 403,586 Oleg Nodelman: 403,586 Qualified Fund: 377,635
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	Not Applicable
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	If a group has filed this schedule pursuant to §240.13d-1(b)(1)(ii)(K), so indicate under Item 3(k) and attach an exhibit stating the identity and Item 3 classification of each member of the group. If a group has filed this schedule pursuant to §240.13d-1(c) or §240.13d-1(d), attach an exhibit stating the identity of each member of the group. EcoR1 is the general partner and investment adviser of investment funds, including Qualified Fund. Mr. Nodelman is the control person of EcoR1.
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

EcoR1 Capital, LLC

Signature:	/s/ Oleg Nodelman
Name/Title:	Manager
Date:	06/16/2026

Oleg Nodelman

Signature:	/s/ Oleg Nodelman
Name/Title:	Reporting person
Date:	06/16/2026

EcoR1 Capital Fund Qualified, L.P.

Signature:	/s/ Oleg Nodelman
Name/Title:	Manager of the General Partner, EcoR1 Capital, LLC
Date:	06/16/2026

Exhibit Information

EXHIBIT 99 - AGREEMENT REGARDING JOINT FILING OF STATEMENT ON SCHEDULE 13D OR 13G