Entera Bio Ltd. has a new large shareholder group led by Vivo Opportunity entities. Vivo Opportunity, LLC may be deemed to beneficially own 11,817,401 Ordinary Shares, representing 6.9% of Entera Bio’s Ordinary Shares outstanding. These shares are held through Vivo Opportunity Fund Holdings, L.P., Vivo Opportunity Co-Invest, L.P., and Vivo Opportunity Co-Invest (Cycle 3), L.P.
Vivo Opportunity Cayman, LLC may be deemed to beneficially own an additional 437,500 Ordinary Shares, or 0.3% of the class, held by Vivo Opportunity Cayman Fund, L.P. The ownership percentages are based on 172,251,411 Ordinary Shares outstanding, which includes 122,961,215 Ordinary Shares issued in a private placement completed on July 28, 2026. Each Vivo entity reports sole voting and dispositive power over its respective holdings.
Positive
None.
Negative
None.
Key Figures
Vivo Opportunity, LLC beneficial ownership:11,817,401 Ordinary SharesVivo Opportunity, LLC percent of class:6.9%Vivo Opportunity Cayman, LLC beneficial ownership:437,500 Ordinary Shares+4 more
7 metrics
Vivo Opportunity, LLC beneficial ownership11,817,401 Ordinary SharesShares that Vivo Opportunity, LLC may be deemed to beneficially own
Vivo Opportunity, LLC percent of class6.9%Percentage of Entera Bio Ordinary Shares attributed to Vivo Opportunity, LLC
Vivo Opportunity Cayman, LLC beneficial ownership437,500 Ordinary SharesShares that Vivo Opportunity Cayman, LLC may be deemed to beneficially own
Vivo Opportunity Cayman, LLC percent of class0.3%Percentage of Entera Bio Ordinary Shares attributed to Vivo Opportunity Cayman, LLC
Total shares outstanding172,251,411 Ordinary SharesOrdinary Shares outstanding after including the July 28, 2026 private placement
Private placement shares issued122,961,215 Ordinary SharesOrdinary Shares issued in the private placement on July 28, 2026
Shares outstanding pre-private placement49,290,196 Ordinary SharesOrdinary Shares outstanding immediately prior to the private placement
Key Terms
beneficially own, dispositive power, Schedule 13G, private placement, +1 more
5 terms
beneficially ownfinancial
"may be deemed to beneficially own an aggregate of 11,817,401 shares"
Beneficially own means having the economic rights and risks of a security—such as the right to receive dividends, sell the shares, or profit from price changes—whether or not your name appears on the official share register. Think of it like renting a car: you use it and reap the benefits even if the title lists someone else. Investors care because beneficial ownership determines who truly controls value, must be disclosed under securities rules, and can signal potential influence or trading activity that affects a stock’s price.
dispositive powerfinancial
"Sole Dispositive Power 11,817,401.00 8 | Shared Dispositive Power 0.00"
Dispositive power is the authority to decide the final outcome of an asset, legal claim, contract, or corporate action — in effect the power to dispose of or resolve something. For investors it matters because whoever holds that authority can determine who gets paid, who controls an asset or vote, and how risks and returns are allocated; think of it like holding the key that lets you lock in the winner or loser in a deal.
Schedule 13Gregulatory
"The percentages reported in this Item 4(b) are based on 172,251,411 Ordinary Shares"
A Schedule 13G is a formal document that investors file with the government when they acquire a large ownership stake in a company, usually for investment purposes rather than control. It helps keep the public informed about who owns significant parts of a company's shares, which can influence how the company is managed and how investors make decisions. Filing this schedule is important for transparency and understanding the ownership landscape of publicly traded companies.
private placementfinancial
"Ordinary Shares issued in the Private Placement, as disclosed in the Securities Purchase Agreement"
A private placement is a sale of securities directly to a selected group of investors, typically institutions or accredited investors, instead of through a public offering. It lets a company raise money faster and with fewer regulatory steps; for existing shareholders it matters because the newly issued shares, often sold at a discount, increase the share count and can dilute their ownership.
general partnerfinancial
"Vivo Opportunity Cayman, LLC is the general partner of Vivo Opportunity Cayman Fund, L.P."
A general partner is the person or firm that runs an investment partnership and legally represents it — they make the day-to-day decisions, choose which assets to buy or sell, and are responsible for the partnership’s obligations. Investors care because the general partner’s judgment, risk-taking and fee and profit-sharing arrangements determine both the potential returns and the level of exposure to losses; think of the GP as the ship’s captain whose skill and honesty shape the voyage’s outcome.
What percentage of Entera Bio (ENTX) does Vivo Opportunity, LLC report owning?
Vivo Opportunity, LLC may be deemed to beneficially own 11,817,401 Ordinary Shares of Entera Bio, representing 6.9% of the outstanding Ordinary Shares. These are held through three affiliated limited partnerships listed in the Schedule 13G filing.
How many Entera Bio (ENTX) shares are outstanding according to this Schedule 13G?
The filing states there are 172,251,411 Ordinary Shares of Entera Bio outstanding. This total combines 49,290,196 shares outstanding before a private placement and 122,961,215 shares issued in that private placement on July 28, 2026.
What is Vivo Opportunity Cayman, LLC’s reported stake in Entera Bio (ENTX)?
Vivo Opportunity Cayman, LLC may be deemed to beneficially own 437,500 Ordinary Shares of Entera Bio, equal to 0.3% of the class. These shares are held of record by Vivo Opportunity Cayman Fund, L.P., for which it acts as general partner.
Which entities are included in the Vivo group reporting holdings in Entera Bio (ENTX)?
The reporting group includes Vivo Opportunity Fund Holdings, L.P., Vivo Opportunity Co-Invest, L.P., Vivo Opportunity Co-Invest (Cycle 3), L.P., Vivo Opportunity, LLC, Vivo Opportunity Cayman Fund, L.P. and Vivo Opportunity Cayman, LLC, each listing its own shareholdings and control structure.
How is the Entera Bio (ENTX) private placement reflected in this ownership filing?
Ownership percentages are calculated using a share count that includes a private placement closed on July 28, 2026. The total 172,251,411 shares outstanding includes 122,961,215 Ordinary Shares issued in that private placement, as referenced in a Securities Purchase Agreement.
Do the Vivo entities report shared or sole voting power over Entera Bio (ENTX) shares?
Each Vivo entity reports sole voting power and sole dispositive power over its respective Entera Bio Ordinary Shares. The filing shows no shared voting or shared dispositive power for any of the reporting entities in this Schedule 13G.
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
UNDER THE SECURITIES EXCHANGE ACT OF 1934
Entera Bio Ltd.
(Name of Issuer)
Ordinary Shares, par value of NIS 0.0000769
(Title of Class of Securities)
M40527109
(CUSIP Number)
07/28/2026
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Rule 13d-1(b)
Rule 13d-1(c)
Rule 13d-1(d)
schemaVersion:
SCHEDULE 13G
CUSIP Number(s):
M40527109
1
Names of Reporting Persons
Vivo Opportunity Fund Holdings, L.P.
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
4,330,882.00
6
Shared Voting Power
0.00
7
Sole Dispositive Power
4,330,882.00
8
Shared Dispositive Power
0.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
4,330,882.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
2.5 %
12
Type of Reporting Person (See Instructions)
PN
SCHEDULE 13G
CUSIP Number(s):
M40527109
1
Names of Reporting Persons
Vivo Opportunity Co-Invest, L.P.
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
2,718,137.00
6
Shared Voting Power
0.00
7
Sole Dispositive Power
2,718,137.00
8
Shared Dispositive Power
0.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
2,718,137.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
1.6 %
12
Type of Reporting Person (See Instructions)
PN
SCHEDULE 13G
CUSIP Number(s):
M40527109
1
Names of Reporting Persons
Vivo Opportunity Co-Invest (Cycle 3), L.P.
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
4,768,382.00
6
Shared Voting Power
0.00
7
Sole Dispositive Power
4,768,382.00
8
Shared Dispositive Power
0.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
4,768,382.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
2.8 %
12
Type of Reporting Person (See Instructions)
PN
SCHEDULE 13G
CUSIP Number(s):
M40527109
1
Names of Reporting Persons
Vivo Opportunity, LLC
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
11,817,401.00
6
Shared Voting Power
0.00
7
Sole Dispositive Power
11,817,401.00
8
Shared Dispositive Power
0.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
11,817,401.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
6.9 %
12
Type of Reporting Person (See Instructions)
OO
SCHEDULE 13G
CUSIP Number(s):
M40527109
1
Names of Reporting Persons
Vivo Opportunity Cayman Fund, L.P.
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
CAYMAN ISLANDS
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
437,500.00
6
Shared Voting Power
0.00
7
Sole Dispositive Power
437,500.00
8
Shared Dispositive Power
0.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
437,500.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
0.3 %
12
Type of Reporting Person (See Instructions)
PN
SCHEDULE 13G
CUSIP Number(s):
M40527109
1
Names of Reporting Persons
Vivo Opportunity Cayman, LLC
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
CAYMAN ISLANDS
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
437,500.00
6
Shared Voting Power
0.00
7
Sole Dispositive Power
437,500.00
8
Shared Dispositive Power
0.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
437,500.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
0.3 %
12
Type of Reporting Person (See Instructions)
OO
SCHEDULE 13G
Item 1.
(a)
Name of issuer:
Entera Bio Ltd.
(b)
Address of issuer's principal executive offices:
Kiryat Hadassah, Minrav Building Fifth Floor Jerusalem, Israel 9112002
Item 2.
(a)
Name of person filing:
Vivo Opportunity Fund Holdings, L.P., Vivo Opportunity Co-Invest, L.P. and Vivo Opportunity Co-Invest (Cycle 3), L.P. and their General Partner Vivo Opportunity, LLC.
Vivo Opportunity Cayman Fund, L.P. and its General Partner Vivo Opportunity Cayman, LLC.
(b)
Address or principal business office or, if none, residence:
192 Lytton Avenue, Palo Alto, CA 94301
(c)
Citizenship:
Vivo Opportunity Fund Holdings, L.P., Vivo Opportunity Co-Invest, L.P. and Vivo Opportunity Co-Invest (Cycle 3), L.P. are Delaware limited partnerships.
Vivo Opportunity, LLC is a Delaware limited liability company.
Vivo Opportunity Cayman Fund, L.P. is a Cayman Islands limited partnership.
Vivo Opportunity Cayman, LLC is a Cayman Islands limited liability company.
(d)
Title of class of securities:
Ordinary Shares, par value of NIS 0.0000769
(e)
CUSIP Number(s):
M40527109
Item 3.
If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)
Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)
Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)
Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)
Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)
An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)
An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)
A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)
A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)
A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)
A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
please specify the type of institution:
(k)
Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.
Ownership
(a)
Amount beneficially owned:
Vivo Opportunity, LLC may be deemed to beneficially own an aggregate of 11,817,401 shares of the Issuer's securities, consisting of (i) 4,330,882 Ordinary Shares of the Issuer held of record by Vivo Opportunity Fund Holdings, L.P., (ii) 2,718,137 Ordinary Shares of the Issuer held of record by Vivo Opportunity Co-Invest, L.P., and (iii) 4,768,382 Ordinary Shares of the Issuer held of record by Vivo Opportunity Co-Invest (Cycle 3), L.P.
Vivo Opportunity Cayman, LLC may be deemed to beneficially own 437,500 Ordinary Shares of the Issuer held of record by Vivo Opportunity Cayman Fund, L.P. Vivo Opportunity Cayman, LLC is the general partner of Vivo Opportunity Cayman Fund, L.P.
(b)
Percent of class:
Vivo Opportunity Fund Holdings, L.P.: 2.5
Vivo Opportunity Co-Invest, L.P.: 1.6
Vivo Opportunity Co-Invest (Cycle 3), L.P.: 2.8
Vivo Opportunity, LLC: 6.9
Vivo Opportunity Cayman Fund, L.P.: 0.3
Vivo Opportunity Cayman, LLC: 0.3
The percentages reported in this Item 4(b) are based on 172,251,411 Ordinary Shares of the Issuer outstanding, which is the sum of (i) 49,290,196 Ordinary Shares outstanding immediately prior to the closing of a private placement by the Issuer on July 28, 2026 (the "Private Placement"), and (ii) 122,961,215 Ordinary Shares issued in the Private Placement, as disclosed in the Securities Purchase Agreement filed as Exhibit 10.1 to the Issuer's Current Report on Form 8-K filed with the Securities and Exchange Commission on July 28, 2026.
(c)
Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote:
Vivo Opportunity Fund Holdings, L.P.: 4,330,882 Ordinary Shares
Vivo Opportunity Co-Invest, L.P.: 2,718,137 Ordinary Shares
Vivo Opportunity Co-Invest (Cycle 3), L.P.: 4,768,382 Ordinary Shares
Vivo Opportunity, LLC: 11,817,401 Ordinary Shares
Vivo Opportunity Cayman Fund, L.P.: 437,500 Ordinary Shares
Vivo Opportunity Cayman, LLC: 437,500 Ordinary Shares
(ii) Shared power to vote or to direct the vote:
N/A
(iii) Sole power to dispose or to direct the disposition of:
Vivo Opportunity Fund Holdings, L.P.: 4,330,882 Ordinary Shares
Vivo Opportunity Co-Invest, L.P.: 2,718,137 Ordinary Shares
Vivo Opportunity Co-Invest (Cycle 3), L.P.: 4,768,382 Ordinary Shares
Vivo Opportunity, LLC: 11,817,401 Ordinary Shares
Vivo Opportunity Cayman Fund, L.P.: 437,500 Ordinary Shares
Vivo Opportunity Cayman, LLC: 437,500 Ordinary Shares
(iv) Shared power to dispose or to direct the disposition of:
N/A
Item 5.
Ownership of 5 Percent or Less of a Class.
Not Applicable
Item 6.
Ownership of more than 5 Percent on Behalf of Another Person.
Not Applicable
Item 7.
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
Not Applicable
Item 8.
Identification and Classification of Members of the Group.
Not Applicable
Item 9.
Notice of Dissolution of Group.
Not Applicable
Item 10.
Certifications:
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
Vivo Opportunity Fund Holdings, L.P.
Signature:
/s/ Kevin Dai
Name/Title:
Kevin Dai/Managing Member of Vivo Opportunity, LLC, General Partner
Date:
08/04/2026
Vivo Opportunity Co-Invest, L.P.
Signature:
/s/ Kevin Dai
Name/Title:
Kevin Dai/Managing Member of Vivo Opportunity, LLC, General Partner
Date:
08/04/2026
Vivo Opportunity Co-Invest (Cycle 3), L.P.
Signature:
/s/ Kevin Dai
Name/Title:
Kevin Dai/Managing Member of Vivo Opportunity, LLC, General Partner
Date:
08/04/2026
Vivo Opportunity, LLC
Signature:
/s/ Kevin Dai
Name/Title:
Kevin Dai/Managing Member
Date:
08/04/2026
Vivo Opportunity Cayman Fund, L.P.
Signature:
/s/ Kevin Dai
Name/Title:
Kevin Dai/Managing Member of Vivo Opportunity Cayman, LLC, General Partner