Fulcrum Therapeutics: BlackRock reports 8.1% stake

BlackRock Portfolio Management LLC reported beneficial ownership of 6,155,437 shares of Fulcrum Therapeutics, Inc. common stock, equal to 8.1% of the class.

Rhea-AI Filing Summary

BlackRock Portfolio Management LLC reported beneficial ownership of 6,155,437 shares of Fulcrum Therapeutics, Inc. common stock, equal to 8.1% of the class. It reported sole voting power over 5,436,791 shares and sole dispositive power over 6,155,437 shares, with no shared voting or dispositive power.

Key Figures

Beneficial ownership: 6,155,437 shares Percent of class: 8.1% Sole voting power: 5,436,791 shares +3 more

6 metrics

Beneficial ownership 6,155,437 shares Fulcrum Therapeutics, Inc. common stock

Percent of class 8.1% Common stock

Sole voting power 5,436,791 shares Shares BlackRock Portfolio Management LLC could vote or direct the vote

Sole dispositive power 6,155,437 shares Shares BlackRock Portfolio Management LLC could dispose of or direct the disposition

Shared voting power 0 shares Common stock

Shared dispositive power 0 shares Common stock

Key Terms

beneficial ownership, sole voting power, sole dispositive power

3 terms

beneficial ownership financial

"securities beneficially owned, or deemed to be beneficially owned"

Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.

sole voting power financial

"Sole power to vote or to direct the vote"

Sole voting power is the exclusive right to cast votes attached to a shareholder’s stock without needing approval from anyone else. Like holding the only remote control for a TV, it lets that holder decide corporate matters such as board members, mergers, and policy changes, making it important to investors because it concentrates control and can strongly influence a company’s strategy and the value of its shares.

sole dispositive power financial

"Sole power to dispose or to direct the disposition"

Sole dispositive power is the exclusive legal authority to decide what happens to a security — for example, whether to sell, transfer, or retain shares — without needing anyone else’s permission. Investors care because it signals who truly controls the economic outcome of an investment: like holding the only key to a safe, the holder can realize gains or losses and may trigger regulatory reporting, insider rules, or influence over corporate ownership.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many FULC shares did BlackRock Portfolio Management LLC report beneficially owning?

BlackRock Portfolio Management LLC reported beneficial ownership of 6,155,437 shares of Fulcrum Therapeutics, Inc. common stock, or 8.1% of the class.

How many FULC shares did BlackRock Portfolio Management LLC report sole voting power over?

BlackRock Portfolio Management LLC reported sole voting power over 5,436,791 shares and sole dispositive power over 6,155,437 shares.

AI-generated analysis. How Rhea-AI works. Not financial advice.

See more from StockTitan in Google Search and AI answers. Adds StockTitan as a preferred source · opens Google

Add on Google Not now

Available on EDGAR 10/27/2026 - 04:10 PM EDT Accepted by SEC EDGAR 10/27/2026 - 04:09 PM EDT Learn about SEC filing dates

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 1)

FULCRUM THERAPEUTICS INC

(Name of Issuer)

Common Stock

(Title of Class of Securities)

359616109

(CUSIP Number)

09/30/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 359616109

1

Names of Reporting Persons

BlackRock Portfolio Management LLC

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 5,436,791.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 6,155,437.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

6,155,437.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

8.1 %

12

Type of Reporting Person (See Instructions)

HC

SCHEDULE 13G

Item 1.
(a)	Name of issuer: FULCRUM THERAPEUTICS INC
(b)	Address of issuer's principal executive offices: 26 LANDSDOWNE STREET CAMBRIDGE MA 02139
Item 2.
(a)	Name of person filing: BlackRock Portfolio Management LLC In accordance with SEC Release No. 34-39538 (January 12, 1998), this Schedule 13G reflects the securities beneficially owned, or deemed to be beneficially owned, by certain business units (collectively, the "Reporting Business Units") of BlackRock, Inc. and its subsidiaries and affiliates. It does not include securities, if any, beneficially owned by other business units whose beneficial ownership of securities are disaggregated from that of the Reporting Business Units in accordance with such release.
(b)	Address or principal business office or, if none, residence: BlackRock Portfolio Management LLC, 50 Hudson Yards New York, NY 10001
(c)	Citizenship: See Item 4 of Cover Page
(d)	Title of class of securities: Common Stock
(e)	CUSIP No.: 359616109
Item 4.	Ownership
(a)	Amount beneficially owned: 6155437
(b)	Percent of class: 8.1 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 5436791
	(ii) Shared power to vote or to direct the vote: 0
	(iii) Sole power to dispose or to direct the disposition of: 6155437
	(iv) Shared power to dispose or to direct the disposition of: 0
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. Various persons have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of the common stock of FULCRUM THERAPEUTICS INC. No one person's interest in the common stock of FULCRUM THERAPEUTICS INC is more than five percent of the total outstanding common shares.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. See Exhibit 99
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

BlackRock Portfolio Management LLC

Signature:	Spencer Fleming
Name/Title:	Managing Director
Date:	10/27/2026

Exhibit Information

Exhibit 24: Power of Attorney Exhibit 99: Item 7