Genmab nine-month net profit falls to $698M

Q: What revenue did GMAB report for the first nine months of 2026?

GMAB reported $3,238 million in revenue for the first nine months of 2026, compared with $2,662 million in the same period of 2025, a reported increase of 22%. Royalties were $2,699 million.

Q: What is GMAB's 2026 financial guidance?

Genmab maintained revenue guidance of $4,325 million to $4,525 million and adjusted operating profit guidance of $1,065 million to $1,385 million for 2026. The corresponding midpoint figures are $4,425 million and $1,225 million.

Higher revenue came alongside lower net profit and operating cash flow versus the first nine months of 2025.

Available on EDGAR 11/05/2026 - 11:04 AM EST Accepted by SEC EDGAR 11/05/2026 - 11:04 AM EST

Filing Impact

(Moderate)

Filing Sentiment

(Neutral)How Sentiment works

Sentiment and the balance of points

Rhea-AI Sentiment reads the wording of the document, how positive or negative its language is on a 1 to 5 scale. The balance of points shown with the takes weighs what the document actually discloses, so the two can disagree, for example when a trial that missed its main goal is described in upbeat language.

How Sentiment works How the balance works

Form Type

6-K

Rhea-AI Filing Summary

Genmab A/S reported revenue of $3,238 million for the first nine months of 2026, up 22% from $2,662 million a year earlier. Royalty revenue rose 22% to $2,699 million, while global EPKINLY/TEPKINLY sales increased 47% to $491 million. Operating profit was $986 million versus $1,007 million, and net profit was $698 million versus $932 million.

Operating cash flow was $574 million compared with $885 million, while cash and cash equivalents were $1,860 million and borrowings were $4,992 million as of September 30, 2026. Adjusted operating profit was $1,108 million, compared with $1,016 million a year earlier; the company maintained its 2026 guidance issued August 6. Genmab borrowed $5.5 billion and used cash on hand to finance its December 2025 acquisition of Merus.

October Phase 3 results for Rina-S met the primary progression-free survival endpoint, with a statistically significant and clinically meaningful improvement versus investigator’s choice chemotherapy. Petosemtamab met both primary endpoints, overall survival and objective response rate; a separate epcoritamab study reported positive topline results. Genmab plans to engage regulatory authorities on next steps for Rina-S and petosemtamab.

3 points · 1 major

How this balance works

Rhea-AI gives every point it takes from this document a weight. Minor counts 1, Moderate 3 and Major 9, so one Major point outweighs several Minor ones. The bar adds up the weights on each side, and when neither side holds more than 65% of the total the balance reads Mixed.

It reads the document as published, with the same rules for every company, and it does not look at what the market expected or at how the stock traded, so a point can be objectively good on a day the stock falls.

Rhea-AI Sentiment measures something else, the tone of the wording.

How the balance works How Sentiment works

0 major · 2 points

How the balance works

Positive

Major pointOctober Phase 3 readouts met primary endpoints in Rina-S and petosemtamab trials.
Moderate pointRevenue reached $3,238 million, up 22% year over year.
Moderate pointAdjusted operating profit was $1,108 million, compared with $1,016 million.

Negative

Moderate pointNet profit was $698 million, versus $932 million a year earlier.
Moderate pointOperating cash flow was $574 million, versus $885 million a year earlier.

Filing Explained

Borrowing cash outflows included $288 million of principal repayments in the first nine months of 2026.

Genmab’s nine-month report identifies AbbVie’s Rina-S trade-secret case as unresolved, with no provision recorded for the disclosed legal matters.

AbbVie alleges trade-secret misappropriation involving Rina-S; after withdrawing its related ITC complaint, the ITC ended its investigation in July 2026, and the previously stayed district-court case resumed.

Separately, Genmab reports $256 million of interest expense and $68 million of amortization of borrowing fees during the nine months, attributing them to debt issued for the Merus acquisition and the June 2026 Term B loan amendment.

Key Figures

Revenue: $3,238 million Royalty revenue: $2,699 million Net profit: $698 million +4 more

7 metrics

Revenue $3,238 million Nine months ended September 30, 2026; $2,662 million in 2025.

Royalty revenue $2,699 million First nine months of 2026; $2,219 million in 2025.

Net profit $698 million First nine months of 2026; $932 million in 2025.

Net cash provided by operating activities $574 million First nine months of 2026; $885 million in 2025.

Adjusted operating profit $1,108 million First nine months of 2026; $1,016 million in 2025.

Cash and cash equivalents $1,860 million As of September 30, 2026.

Borrowings $4,992 million As of September 30, 2026.

Key Terms

Adjusted operating profit, progression-free survival, objective response rate, cash flow hedges

4 terms

Adjusted operating profit financial

"Adjusted operating profit, which excludes Acquisition and integration related charges"

Adjusted operating profit is a measure of a company’s routine profit from its core business activities after removing one‑time events, unusual costs or non‑cash items so the result reflects ongoing operations. Think of it like judging a car’s normal fuel efficiency after ignoring a single visit to the body shop; investors use it to compare underlying profitability across periods or peers and to judge whether the business is sustainably earning money, but the specific exclusions can be subjective.

progression-free survival medical

"met its primary endpoint of progression-free survival (PFS)"

Progression-free survival is the length of time during and after a treatment that a patient's disease does not get worse, measured from the start of treatment until the disease shows measurable signs of progression or the patient dies. Investors care because longer progression-free survival in clinical trials often signals that a drug is effective, improving chances of regulatory approval, market adoption, and revenue potential—think of it as a stopwatch showing how long a therapy can keep the illness at bay.

objective response rate medical

"primary endpoints of overall survival (OS) and objective response rate (ORR)"

The objective response rate (ORR) is the percentage of patients in a clinical trial whose tumors measurably shrink or disappear according to preset rules. Investors use it as a quick, objective signal of a drug’s ability to produce a clear treatment effect—like counting how many plants visibly respond after applying a new fertilizer—and higher ORR can improve odds of regulatory approval, commercial success, and company valuation.

cash flow hedges financial

"designated as cash flow hedges and qualify for hedge accounting treatment"

A cash flow hedge is an accounting label companies use when they enter financial contracts—like currency or interest-rate agreements—to protect expected future cash payments or receipts from unpredictable moves. For investors, it signals that the company is trying to smooth out future cash variability (think of locking in a price to avoid surprises), which can reduce reported profit swings but also means the company has exposure to derivative instruments and their associated risks.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What revenue did GMAB report for the first nine months of 2026?

GMAB reported $3,238 million in revenue for the first nine months of 2026, compared with $2,662 million in the same period of 2025, a reported increase of 22%. Royalties were $2,699 million.

What is GMAB's 2026 financial guidance?

Genmab maintained revenue guidance of $4,325 million to $4,525 million and adjusted operating profit guidance of $1,065 million to $1,385 million for 2026. The corresponding midpoint figures are $4,425 million and $1,225 million.

What did GMAB's Rina-S and petosemtamab Phase 3 trials report?

The RAINFOL-02 trial of Rina-S met its primary progression-free survival endpoint in the intent-to-treat and primary analysis set populations. The LiGeR-HN1 trial of petosemtamab met its overall survival and objective response rate endpoints, regardless of HPV status.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 6-K

REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16

OF THE SECURITIES EXCHANGE ACT OF 1934

FOR THE MONTH OF NOVEMBER 2026

COMMISSION FILE NUMBER 001-38976

Genmab A/S
(Exact name of Registrant as specified in its charter)

Carl Jacobsens Vej 30

2500 Valby

Denmark

+45 70 20 27 28
(Address of principal executive offices)

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form 20-F x Form 40-F

This report on Form 6-K shall be deemed to be incorporated by reference in Genmab A/S’s registration statements on Form S-8 (File No. 333-232693, 333-253519, 333-262970, 333-277273, 333-284876 and 333-293505) and to be a part thereof from the date on which this report is filed, to the extent not superseded by documents or reports subsequently filed or furnished.

EXHIBIT INDEX



Exhibit			Description of Exhibit
99.1			Interim Report Dated November 5, 2026

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.



			GENMAB A/S

			BY:			/s/ Anthony Pagano
						Name: Anthony Pagano
						Title: Executive Vice President & Chief Financial Officer

DATE: November 5, 2026

Exhibit 99.1

Genmab Announces Financial Results for the Nine Months of 2026

November 5, 2026 Copenhagen, Denmark;

Interim Report for the Nine Months Ended September 30, 2026

Highlights

•Epcoritamab approved in Europe (as TEPKINLY®) and Japan (as EPKINLY®) in combination with R² for the treatment of adult patients with relapsed or refractory FL

•Initiation of two new Phase 3 trials for petosemtamab in first- and second-line CRC

•Genmab revenue increased 22% compared to the first nine months of 2025, to $3,238 million

“The third quarter of 2026 reinforced the breadth of our late-stage portfolio. TEPKINLY plus R2 became the first bispecific-based therapy approved in Europe for second-line FL, extending epcoritamab's reach as a core therapy across B-cell malignancies. We also broadened our petosemtamab program with new Phase 3 studies in CRC, underscoring our confidence in this asset beyond head and neck cancer. As anticipated, we are now in our data-rich fourth quarter, where we have delivered pivotal readouts across our three late-stage assets, epcoritamab, Rina-S® (rinatabart sesutecan) and petosemtamab, supporting multiple regulatory submissions and potential launches in 2027,” said Jan van de Winkel, Ph.D., Chief Executive Officer of Genmab.

Financial Performance First Nine Months of 2026

•Revenue was $3,238 million for the first nine months of 2026 compared to $2,662 million for the first nine months of 2025. The increase of $576 million, or 22%, was primarily driven by higher DARZALEX® and Kesimpta® royalties and higher EPKINLY® net product sales.

•Royalty revenue was $2,699 million in the first nine months of 2026 compared to $2,219 million in the first nine months of 2025, an increase of $480 million, or 22%. The increase in royalties was driven by higher net sales of DARZALEX and Kesimpta.

•Net sales of DARZALEX by J&J were $12,410 million in the first nine months of 2026 compared to $10,448 million in the first nine months of 2025, an increase of $1,962 million or 19%.

•Global net sales of EPKINLY/TEPKINLY® were $491 million in the first nine months of 2026 compared to $333 million in the first nine months of 2025, an increase of $158 million or 47%.

•Cost of product sales were $234 million for the first nine months of 2026 compared to $157 million for the first nine months of 2025. The increase of $77 million, or 49%, was primarily driven by the profit-sharing amounts payable to AbbVie related to EPKINLY sales.

•Acquisition and integration related charges related to the integration of Merus were $87 million in the first nine months of 2026.

•Amortization of acquired intangible assets was $35 million for the first nine months of 2026 compared to $9 million for the first nine months of 2025. The increase of $26 million, was primarily driven by the amortization of the Merus technology platform.

•Operating expenses were $2,018 million in the first nine months of 2026 compared to $1,498 million in the first nine months of 2025, an increase of $520 million or 35%.

•Adjusted operating expenses, which exclude Acquisition and integration related charges and Amortization of acquired intangible assets, were $1,896 million for the first nine months of 2026 compared to $1,489 million for the first nine months of 2025. The increase of $407 million, or 27%, was primarily driven by investment in our product pipeline, including the advancement of Rina-S and petosemtamab, and our global commercialization capabilities in preparation for their anticipated launches.

•Operating profit was $986 million in the first nine months of 2026 compared to $1,007 million in the first nine months of 2025. Adjusted operating profit, which excludes Acquisition and integration related charges and Amortization of acquired intangible assets, was $1,108 million in the first nine months of 2026 compared to $1,016 million in the first nine months of 2025.

Non-IFRS Financial Measures

Our Adjusted operating expenses and adjusted operating profit excludes acquisition and integration related charges and amortization of acquired intangible assets. These charges were recognized in current as well as prior periods and will likely reoccur in future periods. These items are excluded from operating expenses and


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 1/45 CVR no. 2102 3884

Genmab Announces Financial Results for the Nine Months of 2026

operating profit because the Company believes they neither relate to the ordinary course of the Company's business nor reflect the Company's underlying business performance.

Non-IFRS information is intended to portray the results of our baseline performance, supplement or enhance management's, analysts' and investors’ overall understanding of our underlying financial performance and facilitate comparisons among current, past and future periods. This information is not intended to be considered in isolation or as a substitute for the related financial measures prepared in accordance with IFRS and may not be the same as or comparable to similarly titled measures presented by other companies due to possible differences in method and in the items being adjusted. We encourage investors to review our financial statements and publicly-filed reports in their entirety and not to rely on any single financial measure.

The reconciliations of financial performance from IFRS to Non-IFRS for the first nine months of 2026 and 2025 were as follows:


	2026 Actual		Exclude		2026 Adjusted		2025 Actual		Exclude		2025 Adjusted
(USD million)	IFRS		A&I*	Amort**	Non-IFRS		IFRS		A&I*	Amort**	Non-IFRS

Operating Expenses / Adj. Operating Expenses***	$	(2,018)	87	35	$	(1,896)	$	(1,498)	—	9	$	(1,489)
Operating Profit / Adj. Operating Profit	$	986	87	35	$	1,108	$	1,007	—	9	$	1,016

* Acquisition and integration related charges

** Amortization of intangible assets acquired through acquisitions

***Includes all expenses presented within Total costs and operating expenses, less cost of product sales.

Key Company Events Post-Quarter End

•October: Positive topline results from the Phase 3 EPCORE® DLBCL-2 trial evaluating fixed treatment duration epcoritamab in combination with standard of care rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP), compared to R-CHOP alone, in newly diagnosed patients with diffuse large B-cell lymphoma (DLBCL) with an International Prognostic Index (IPI) score of 2 to 5. Data will be submitted for presentation at a future medical meeting. Genmab and AbbVie Inc. (AbbVie) will engage global regulatory authorities to determine next steps.

•October: Positive topline results from the global Phase 3 RAINFOL™-02 trial of Rina-S in patients with platinum-resistant ovarian cancer (PROC) regardless of Folate Receptor Alpha (FRα) expression level or prior treatment with mirvetuximab. The trial met its primary endpoint of progression-free survival (PFS), with Rina-S demonstrating a statistically significant and clinically meaningful improvement compared with investigator’s choice chemotherapy in the intent-to-treat (ITT) and in the primary analysis set (PAS) populations. Based on these results, Genmab plans to engage with regulatory authorities worldwide regarding potential next steps. The data will also be submitted for presentation at a future medical meeting.

•October: Positive topline results from the global Phase 3 LiGeR-HN1 trial (NCT06525220) evaluating petosemtamab in combination with pembrolizumab versus pembrolizumab in patients with first-line (1L) PD-L1 positive recurrent/metastatic head and neck squamous cell carcinoma (HNSCC). The trial met both of its primary endpoints of overall survival (OS) and objective response rate (ORR), regardless of HPV status. Based on these positive topline results, Genmab plans to engage global regulatory authorities and will submit the full results from LiGeR-HN1 for presentation at a future medical meeting.

Outlook
Genmab is maintaining its 2026 financial guidance published August 6, 2026.

Conference Call
Genmab will hold a conference call to discuss the results for the first nine months of 2026 today, Thursday, November 5, at 6:00 pm CET, 5:00 pm GMT or 12:00 pm EST. To join the call please use the below registration link. Registered participants will receive an email with a link to access dial-in information as well as a unique


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 2/45 CVR no. 2102 3884

Genmab Announces Financial Results for the Nine Months of 2026

personal PIN: https://register-conf.media-server.com/register/BId05659f072f84d939ad27a26fc9fa0a9. A live and archived webcast of the call and relevant slides will be available at www.genmab.com/investor-relations.

Contact

Marisol Peron, Senior Vice President, Global Communications & Corporate Affairs

T: +1 609 524 0065; E: mmp@genmab.com

Andrew Carlsen, Vice President, Head of Investor Relations

T: +45 3377 9558; E: acn@genmab.com

R2 = rituximab and lenalidomide; FL = follicular lymphoma; CRC = colorectal cancer


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 3/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026


CONTENTS
MANAGEMENT’S REVIEW

CONSOLIDATED KEY FIGURES			5

OUTLOOK			6

PRODUCT PIPELINE AND TECHNOLOGY PROGRESS FIRST NINE MONTHS OF 2026			7

SIGNIFICANT RISKS AND UNCERTAINTIES			15

FINANCIAL REVIEW			16

CONDENSED CONSOLIDATED FINANCIAL STATEMENTS			26

NOTES TO THE CONDENSED CONSOLIDATED FINANCIAL STATEMENTS			30

ABOUT GENMAB			44

DIRECTORS’ AND MANAGEMENT’S STATEMENT ON THE INTERIM REPORT			45


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 4/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

CONSOLIDATED KEY FIGURES*


(USD million, unless otherwise indicated)	Three Months Ended September 30,				Nine Months Ended September 30,				Full Year
Income Statement	2026		2025		2026		2025		2025
Revenue	$	1,187	$	1,022	$	3,238	$	2,662	$	3,720
Cost of product sales**	(88)		(58)		(234)		(157)		(238)
Research and development expenses**	(451)		(354)		(1,329)		(1,071)		(1,592)
Selling, general and administrative expenses	(196)		(148)		(567)		(418)		(626)
Acquisition and integration related charges	(10)		—		(87)		—		(185)
Amortization of acquired intangible assets	(11)		(3)		(35)		(9)		(14)
Total costs and operating expenses	(756)		(563)		(2,252)		(1,655)		(2,655)
Operating profit	431		459		986		1,007		1,065
Net financial items	(77)		23		(263)		142		139
Net profit	$	342	$	401	$	698	$	932	$	963

Balance Sheet
Total non-current assets	$	9,748	2,550		$	9,748	$	2,550	$	9,988
Marketable securities	—		1,650		—		1,650		—
Cash and cash equivalents	1,860		1,761		1,860		1,761		1,715
Total assets	12,936		7,021		12,936		7,021		12,873
Borrowings	4,992		—		4,992		—		5,274
Share capital	10		10		10		10		10
Shareholders' equity	$	6,333	$	5,751	$	6,333	$	5,751	$	5,847

Cash Flow Statement
Investment in acquisitions, net of cash acquired	$	—	—		$	—	$	—	$	(7,215)
Net cash provided by operating activities	520		536		574		885		1,186
Net cash (used in) investing activities	(9)		(54)		(16)		(71)		(5,643)
Net cash (used in) / provided by financing activities	(151)		(21)		(403)		(440)		4,789
Investment in intangible assets	(7)		—		(8)		(18)		(18)
Investment in tangible assets	$	(4)	$	(2)	$	(11)	$	(24)	$	(37)

Financial Ratios and Other Information
Basic net profit per share	$	5.58	$	6.51	$	11.36	$	14.95	$	15.50
Diluted net profit per share	$	5.51	$	6.46	$	11.23	$	14.90	$	15.37

Shares outstanding	62,405,855		64,206,349		62,405,855		64,206,349		64,238,408
Average number of employees (FTE***)	3,184		2,663		3,118		2,656		2,694
Number of employees (FTE) at the end of the period	3,244		2,681		3,244		2,681		3,029

*On December 12, 2025, Genmab closed on the acquisition of Merus, including its late-stage breakthrough therapy asset petosemtamab. In order to finance the acquisition, Genmab incurred borrowings of $5.5 billion and utilized cash on hand. Genmab’s financial results of the first nine months of 2026 reflect the impact of these transactions.

** Excludes amortization of acquired intangible assets. Refer to Note 4 for further details.

*** Full-time equivalent


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 5/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

2026 FULL YEAR OUTLOOK


(USD million)		2026 Guidance²	2026 Guidance Mid-Point²
Revenue		4,325 - 4,525	$4,425
	Royalties	3,625 - 3,750	3,687
	Net product sales/Collaboration revenue¹	595 - 640	618
	Milestones/Reimbursement revenue	105 - 135	120
Gross profit		4,015 - 4,195	$4,105
Adjusted operating expenses		(2,810) - (2,950)	$(2,880)
Adjusted operating profit		1,065 - 1,385	$1,225

1 Net product sales/Collaboration revenue consists of EPKINLY net product sales in the U.S. and Japan, and Tivdak ex-U.S. net product sales plus Genmab's share of U.S. gross profits.

2 Adjusted operating expenses and operating profit exclude 2026 charges related to: 1) acquisition and integration-related charges of $90 million and 2) amortization of intangible assets acquired through acquisitions of $47 million.

Genmab is maintaining its 2026 financial guidance published August 6, 2026.

Revenue
Genmab expects its 2026 revenue to be in the range of $4.33 - 4.53 billion. Genmab’s projected revenue growth for 2026 is driven by higher royalties, net product sales and collaboration revenue.

Royalty growth relates mainly to DARZALEX and Kesimpta net sales growth. Net product sales/Collaboration revenue growth is driven by strong performance for EPKINLY.

Genmab’s projected revenue for 2026 primarily consists of DARZALEX royalties of approximately $2.83 billion at the midpoint. Such royalties are based on estimated DARZALEX 2026 net sales of $16.50 - 16.90 billion. DARZALEX royalties are partly offset by Genmab’s share of J&J’s royalty payments to Halozyme Therapeutics, Inc. (Halozyme) in connection with subcutaneous (SC) net sales as well as royalty reduction in countries and territories where there is no Genmab patent coverage.

The remainder of Genmab’s revenue consists primarily of royalties from TEPEZZA®, RYBREVANT®, TECVAYLI®, TALVEY®, TEPKINLY and BIZENGRI®, net product sales of EPKINLY and collaboration revenue from Tivdak, reimbursement revenue and milestones.

Adjusted Operating Expenses
Genmab is maintaining its 2026 adjusted operating expenses to be in the range of $2.81 - 2.95 billion. The increase in adjusted operating expenses is primarily related to investments in late-stage programs and launch readiness in key markets.

Adjusted Operating Profit
Genmab is maintaining its 2026 adjusted operating profit to be in the range of $1.07 - 1.39 billion.

Outlook: Risks and Assumptions
In addition to factors already mentioned, the estimates above are subject to change due to numerous reasons, including but not limited to: the achievement of certain milestones associated with Genmab’s collaboration agreements; the timing and variation of development activities (including activities carried out by Genmab’s collaboration partners) and related income and costs; DARZALEX, DARZALEX FASPRO, Kesimpta, TEPEZZA, RYBREVANT, TECVAYLI, TALVEY, TEPKINLY and BIZENGRI net sales and royalties paid to Genmab; changing rates of inflation; and currency exchange rates (the 2026 guidance assumes a USD/DKK exchange rate of 6.2). The financial guidance assumes that no significant new agreements are entered into during 2026


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 6/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

that could materially affect the results. Refer to the section “Significant Risks and Uncertainties” in this interim report for matters that may cause Genmab’s actual results to differ materially from 2026 Guidance.

The factors discussed above, as well as other factors that are currently unforeseeable, may result in further material adverse impacts on Genmab’s business and financial performance, including unfavorable impacts on the sales of Tivdak and EPKINLY/TEPKINLY, and on the net sales of DARZALEX, Kesimpta, TEPEZZA, RYBREVANT, TECVAYLI, TALVEY and BIZENGRI by Genmab’s collaboration partners and on Genmab’s royalties, collaboration revenue, reimbursement revenue and milestone revenue therefrom.

PRODUCT PIPELINE AND TECHNOLOGY PROGRESS NINE MONTHS OF 2026

At the end of the first nine months of 2026, Genmab’s proprietary pipeline, where we are responsible for at least 50% of development, consisted of multiple antibody products in active clinical development from early- to late-stage development, including our late-stage programs Rina-S and petosemtamab. Our approved medicines are EPKINLY/TEPKINLY, which Genmab is co-developing and co-commercializing in the U.S. and Japan in collaboration with AbbVie and Tivdak, which Genmab is co-developing globally and co-promoting in the U.S. in collaboration with Pfizer Inc. (Pfizer) and exclusively by Genmab outside of the U.S. and China. Beyond these investigational and approved medicines, our pipeline includes promising clinical and preclinical programs. In addition to our own pipeline, there are multiple antibody products in development by global pharmaceutical and biotechnology companies in our royalty portfolio, including seven approved medicines. An overview of the development status of our approved medicines and our late-stage investigational medicines is provided in the following section, including updates for the third quarter of 2026. For events that occurred during the first and second quarters of 2026, please refer to Genmab’s Q1 2026 and Genmab’s First Half 2026 reports. Detailed descriptions of dosing, efficacy and safety data from certain clinical trials have been disclosed in company announcements and media releases published via the Nasdaq Copenhagen A/S (Nasdaq Copenhagen) stock exchange and may also be found in Genmab’s filings with the U.S. Securities and Exchange Commission (U.S. SEC). Additional information is available on Genmab’s website, www.genmab.com. The information accessible through our website is not part of this report and is not incorporated by reference herein.


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Interim Report for the Nine Months of 2026

Genmab Proprietary Products1

Approved Medicines

Approved Product

Target

Developed By

Disease Indication2

EPKINLY

(epcoritamab-bysp, epcoritamab)

TEPKINLY

(epcoritamab)

CD3xCD20

Co-development Genmab/AbbVie

Approved in multiple territories including in the U.S. and Europe for adult patients with relapsed or refractory DLBCL after two or more lines of systemic therapy and in Japan for adult patients with certain types of relapsed or refractory large B-cell lymphoma (LBCL) after two or more lines of therapy.

Approved in multiple territories including the U.S., Europe and Japan for adult patients with relapsed or refractory FL after two or more lines of systemic therapy.

Approved in multiple territories including the U.S., Europe and Japan in combination with R2 for the treatment of adult patients with relapsed or refractory FL, following at least one prior systemic therapy.

Tivdak

(tisotumab vedotin-tftv, tisotumab vedotin)

Tissue factor (TF)

Co-development Genmab/Pfizer

Approved in multiple territories including the U.S., Europe and Japan for adult patients with recurrent/metastatic cervical cancer with disease progression on or after chemotherapy.

1Approved and investigational medicines where Genmab has ≥50% ownership, in co-development with partners as indicated.

2Refer to local country prescribing information for precise indication and safety information.


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 8/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

Pipeline, Including Further Development for Approved Medicines

Product

Developed By

Technology

Disease Indications

Most Advanced Development Phase

Preclinical

Epcoritamab

Co-development
Genmab/AbbVie

DuoBody®

Relapsed/refractory DLBCL

Relapsed/refractory FL

1L DLBCL

1L FL

NHL

Relapsed/refractory CLL & Richter's Syndrome

Aggressive mature B-cell neoplasms in pediatric patients

Rinatabart Sesutecan (Rina-S, GEN1184)

Genmab

ADC

2L+ PROC

2L+ Endometrial cancer

2L PSOC maintenance

2L PSOC platinum-doublet chemo replacement

NSCLC

Solid tumors

GI cancers

Petosemtamab

Genmab

Biclonics®

1L HNSCC

2L / 3L HNSCC

1L CRC

2L CRC

Advanced solid tumors including mCRC

GEN1059 (BNT314)

Co-development
Genmab/BioNTech SE (BioNTech)

DuoBody

Solid tumors

mCRC, in combination with pumitamig/chemo

GEN3018

Genmab

DuoBody

Relapsed or refractory AML or HR-MDS

GEN1079

Genmab

DuoHexa-Body®

Advanced solid tumors

GEN1106

Genmab

ADC

Solid tumors

GEN1119

Genmab

ADC

Solid tumors

1L = first line; NHL = non-Hodgkin lymphoma; CLL = chronic lymphocytic leukemia; ADC = antibody-drug conjugate; 2L+ = second line plus; 2L = second line; PSOC = platinum sensitive ovarian cancer; NSCLC = non-small cell lung cancer; GI = gastrointestinal; HNSCC = head and neck squamous cell carcinoma; 3L = third line; mCRC = metastatic colorectal cancer; AML = acute myeloid leukemia; HR-MDS = higher-risk myelodysplastic syndrome

EPKINLY/TEPKINLY (epcoritamab) – bispecific antibody approved to treat multiple B-cell malignancies in the U.S., Europe and Japan

•Epcoritamab (approved as EPKINLY and TEPKINLY) has received regulatory approvals in multiple territories including in the U.S. and Europe for adult patients with relapsed or refractory DLBCL after two or more lines of systemic therapy, and in Japan for adult patients with certain types of relapsed or refractory LBCL after two or more lines of systemic therapy

•EPKINLY/TEPKINLY has also been approved in multiple territories including the U.S., Japan and Europe for the treatment of adults with relapsed or refractory FL after two or more lines of systemic therapy

•In 2025, EPKINLY plus R2 became the first bispecific antibody combination regimen available in the U.S. as a treatment option for patients with relapsed/refractory FL

•More than 40 clinical trials across different treatment settings, lines of therapy and in combination regimens across histologies, including five Phase 3 trials


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•Two Breakthrough Therapy designations (BTDs) granted by the U.S. Food and Drug Administration (FDA) for relapsed/refractory FL: as monotherapy after two or more therapies and in combination with R2 following at least one prior systemic therapy

•SC bispecific antibody targeting CD3 and CD20, created using Genmab’s DuoBody technology platform

•Co-developed and co-commercialized in collaboration with AbbVie

Epcoritamab is a proprietary bispecific antibody created using Genmab’s DuoBody technology platform. Epcoritamab targets CD3, which is expressed on T-cells, and CD20, a clinically validated target on malignant B-cells. Genmab used technology licensed from Medarex Inc. (Medarex) to generate the CD20 antibody forming part of epcoritamab. Epcoritamab is marketed as EPKINLY in the U.S., Japan, and other regions, and as TEPKINLY in Europe and other regions. See local prescribing information for specific indications and safety information. In 2020, Genmab entered into a collaboration agreement with AbbVie to jointly develop and commercialize epcoritamab. The companies share commercialization responsibilities in the U.S. and Japan, with AbbVie responsible for further global commercialization.

Genmab records sales in the U.S. and Japan and receives tiered royalties between 22% and 26% on remaining global sales outside of these territories, subject to certain royalty reductions. The companies have a broad clinical development program for epcoritamab including five Phase 3 trials. Please consult the U.S. Prescribing Information for EPKINLY and the European Summary of Product Characteristics for TEPKINLY for the labeled indication and safety information.

Third Quarter 2026 Updates

•September: EPKINLY in combination with R2 is approved by the Japan Ministry of Health, Labour and Welfare for the treatment of relapsed or refractory FL.

•September: Multiple data presentations at the 14th Annual Meeting of the Society of Hematologic Oncology Conference (SOHO), including oral and poster presentations of primary Phase 3 results from the EPCORE® FL-1 trial.

•July: TEPKINLY in combination with R2 is approved by the European Commission for the treatment of relapsed or refractory FL.

Tivdak (tisotumab vedotin) – First ADC for recurrent or metastatic cervical cancer after disease progression in the U.S., Europe and Japan

•An ADC directed to TF, a protein prevalent on cervical cancer cells, which is associated with poor prognosis

•Tisotumab vedotin, approved as Tivdak, is the first ADC approved in multiple territories including the U.S., Europe and Japan for the treatment of recurrent or metastatic cervical cancer after prior therapy and is the only ADC with demonstrated OS data in this setting compared to chemotherapy

•Co-developed globally and co-promoted in the U.S. in collaboration with Pfizer, exclusively by Genmab outside of the U.S. and China

Tisotumab vedotin is an ADC composed of Genmab’s human monoclonal antibody directed to TF and Pfizer’s ADC technology that utilizes a protease-cleavable linker that covalently attaches the microtubule-disrupting agent monomethyl auristatin E (MMAE) to the antibody. Genmab used technology licensed from Medarex to generate the TF antibody forming part of tisotumab vedotin. Tisotumab vedotin, marketed as Tivdak, is the first ADC approved for the treatment of adult patients with recurrent or metastatic cervical cancer after prior therapy in multiple territories including the U.S., Europe and Japan. Tisotumab vedotin is being co-developed by Genmab and Pfizer. Under a joint commercialization agreement, Genmab is co-promoting Tivdak in the U.S. and is leading commercial operational activities in Japan, Europe and all other regions globally, excluding the U.S. and China. Pfizer is leading commercial operational activities in the U.S. and in China in connection with the sublicense of its rights to develop and commercialize tisotumab vedotin in China to Zai Lab.


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 10/45 CVR no. 2102 3884

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Genmab records sales for Europe, Japan and rest of world markets (excluding the U.S. and China), and will provide royalties with rates in the low teens to Pfizer on net sales. The companies have joint decision-making power on the worldwide development and commercialization strategy for Tivdak. Please consult the U.S. Prescribing Information and the European Summary of Product Characteristics for the labeled indication and safety information for Tivdak.

Rinatabart Sesutecan (Rina-S, GEN1184) – ADC with FDA Fast Track and Breakthrough Therapy Designations

•FRα-directed Type I Topoisomerase (TOPO1) inhibitor ADC being evaluated for potential treatment of FRα-expressing cancers

•FDA granted Fast Track Designation (FTD) for FRα-expressing cancers, BTD for recurrent or progressive endometrial cancer

•Five Phase 3 clinical trials active or announced in ovarian and endometrial cancers

•Phase 2 signal-seeking trials in additional indications recruiting

Rina-S is a novel FRα-directed TOPO1 ADC being evaluated for the potential treatment of ovarian cancer and other FRα-expressing cancers. Data suggests that Rina-S has robust single agent activity in various cancers across a broad range of FRα expression levels. In January 2024, Rina-S was granted FTD by the FDA for the treatment of FRα-expressing high-grade serous or endometrioid PROC. In August 2025, the FDA granted BTD for recurrent or progressive endometrial cancer. Five Phase three trials are active or have been announced: RAINFOL™-02 (NCT06619236) in 2L+ PROC completed enrollment in March 2026; RAINFOL-03 (NCT07166094) in 2L+ endometrial cancer, RAINFOL-04 (NCT07225270) in 2L PSOC maintenance and RAINFOL-07 (NCT07564141) in 2L PSOC platinum-doublet chemo replacement are recruiting; RAINFOL-08 in 1L pMMR endometrial cancer has been announced. A Phase 2 trial (RAINFOL-05, NCT07288177) in NSCLC and a Phase 2 trial in advanced GI cancers (RAINFOL-09, NCT07539311) are also recruiting.

Petosemtamab — Bispecific antibody with FTD and Two BTDs from the FDA

•Epidermal growth factor receptor, leucine-rich repeat-containing G-protein coupled receptor 5 (EGFRxLGR5) bispecific antibody being evaluated for potential treatment of EGFR-expressing cancers, focusing on HNSCC and CRC

•FDA granted FTD for recurrent/metastatic HNSCC and BTD for both 1L and 2L+ recurrent/metastatic HNSCC indications

•Four active Phase 3 trials: 1L and 2L/3L recurrent/metastatic HNSCC, 1L and 2L CRC

•Expansion opportunities including locally advanced HNSCC

Petosemtamab was added to Genmab’s portfolio with the acquisition of Merus N.V. (Merus). Petosemtamab is an EGFRxLGR5 bispecific antibody being evaluated for the potential treatment of HNSCC and other solid tumors including mCRC. Clinical data to date for petosemtamab has demonstrated meaningful anti tumor activity in both 1L and later line HNSCC settings. The FDA has granted FTD in recurrent/metastatic HNSCC and BTD for both 1L PD-L1 positive and 2L+ recurrent/metastatic HNSCC. The program includes four Phase 3 LiGeR trials: in first-line PD-L1+ r/m HNSCC (LiGeR-HN1; NCT06525220); in 2L/3L r/m HNSCC (LiGeR-HN2; NCT06496178), in first-line RAS/BRAF wild-type, unresectable or metastatic, left-sided CRC (LiGeR-CRC1; NCT07702032); and in second-line RAS/BRAF wild-type recurrent, unresectable or metastatic CRC (LiGeR-CRC2; NCT07775287). An ongoing Phase 1/2 trial evaluates petosemtamab across advanced solid tumors (NCT03526835). In November 2025, Merus announced that they had entered a global collaboration and license agreement with Halozyme to develop a SC formulation of petosemtamab.

Third Quarter 2026 Updates

•September: Initiation of the Phase 3 LiGeR-CRC2 trial of petosemtamab plus chemotherapy versus cetuximab or bevacizumab plus chemotherapy in second-line RAS/BRAF wild-type recurrent, unresectable or metastatic CRC.


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•August: Initiation of the Phase 3 LiGeR-CRC1 trial of petosemtamab plus chemotherapy versus cetuximab plus chemotherapy in first-line RAS/BRAF wild-type, unresectable or metastatic, left-sided CRC.

Early-stage and Preclinical Programs

•Early-stage pipeline includes the following programs in active clinical development: GEN1059 (BNT314), GEN3018, GEN1079, GEN1106 and GEN1119

•Broad preclinical pipeline that includes both partnered products and in-house programs based on our proprietary technologies and/or antibodies

•Multiple new Investigational New Drug (IND) applications expected to be submitted over the coming years

•Genmab has entered multiple strategic collaborations to support the expansion of our innovative pipeline

Our preclinical pipeline includes immune effector function enhanced antibodies, bispecific antibodies and ADCs created with our proprietary technology platforms. We are also collaborating with our partners to generate additional new antibody-based product concepts. A number of the preclinical programs are conducted in cooperation with our collaboration partners.

Royalty Medicines Portfolio1

In addition to Genmab’s own pipeline of investigational medicines and preclinical pipeline candidates, we have a diverse portfolio of royalty medicines in development with global pharmaceutical and biotechnology companies. These include the seven approved medicines listed below, along with the following investigational therapies in Phase 3 development: denecimig (Mim8, Novo Nordisk, which in September 2026 was recommended by the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) for approval in the EU as FREHEMGO®, to treat hemophilia A, with or without inhibitors, for adults and children), amlenetug (Lundbeck) and INCA33890 (Incyte Corporation).

The information in this section includes those therapies that have been approved by regulatory agencies in certain territories. Under the agreements for these medicines Genmab is entitled to certain potential milestones and royalties.


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Interim Report for the Nine Months of 2026

Approved Medicines


Approved Product	Discovered and/or Developed/Marketed By	Disease Indication(s)2
DARZALEX (daratumumab)/DARZALEX FASPRO (daratumumab and hyaluronidase-fihj)	Johnson & Johnson (J&J) (Royalties to Genmab on global net sales)	Multiple myeloma
		Light-chain (AL) Amyloidosis
Kesimpta (ofatumumab)	Novartis Pharma AG (Novartis) (Royalties to Genmab on global net sales)	Relapsing multiple sclerosis (RMS)
TEPEZZA (teprotumumab-trbw)	Amgen Inc. (Amgen) (under sublicense from Roche Holding AG (Roche), royalties to Genmab on global net sales)	Thyroid eye disease (TED)
RYBREVANT (amivantamab/amivantamab-vmjw)/RYBREVANT FASPROTM (amivantamab and hyaluronidase-lpuj)	J&J (Royalties to Genmab on global net sales)	Advanced NSCLC with certain EGFR mutations
TECVAYLI (teclistamab/teclistamab cqyv)	J&J (Royalties to Genmab on global net sales)	Relapsed and refractory multiple myeloma
TALVEY (talquetamab/talquetamab-tgvs)	J&J (Royalties to Genmab on global net sales)	Relapsed and refractory multiple myeloma
BIZENGRI (zenocutuzumab-zbco)	Partner Therapeutics, Inc. (part of Genmab’s acquisition of Merus, royalties to Genmab on U.S. net sales)	Pancreatic adenocarcinoma, NSCLC and cholangiocarcinoma that are advanced, unresectable or metastatic and harbor NRG1 gene fusions

1 Approved and investigational medicines under development, and, where relevant, commercialized by a company other than Genmab for which we receive royalties.
2 See local prescribing information for precise indication and safety information.

DARZALEX (daratumumab) – Redefining the treatment of multiple myeloma

•First-in-class human CD38 monoclonal antibody

•Developed and commercialized by J&J under an exclusive worldwide license from Genmab

•Intravenous (IV) formulation approved in combination with other therapies and as monotherapy for certain multiple myeloma indications

•First SC CD38-directed antibody approved for the treatment of certain multiple myeloma indications, known as DARZALEX FASPRO in the U.S., and DARZALEX SC in Europe

•First licensed treatment for patients with high-risk smoldering multiple myeloma (SMM), approved in the U.S. and Europe

•SC daratumumab is the first approved therapy for AL amyloidosis in the U.S., Europe, and Japan

Daratumumab is a human monoclonal antibody that binds with high affinity to the CD38 molecule, which is highly expressed on the surface of multiple myeloma cells and is also expressed by AL amyloidosis plasma cells. Genmab used technology licensed from Medarex to generate the CD38 antibody. Daratumumab is being developed and commercialized by J&J under an exclusive worldwide license from Genmab. Under the terms of


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the agreement, Genmab receives royalties between 12% and 20% with J&J reducing such royalty payments for Genmab’s share of J&J’s royalty payments made to Halozyme; payments are further reduced in countries and territories where there are no relevant patents. Daratumumab (marketed as DARZALEX for IV administration and as DARZALEX FASPRO in the U.S. and as DARZALEX SC in Europe for SC administration) is approved in a large number of territories for the treatment of adult patients with certain multiple myeloma indications and is the only approved therapy for the treatment of patients with high-risk SMM, approved in Europe. It is also the only approved therapy in the U.S., Europe and Japan for the treatment of adult patients with AL amyloidosis.

Please consult the European Summary of Product Characteristics for DARZALEX and DARZALEX SC and the U.S. Prescribing Information for DARZALEX and DARZALEX FASPRO for the labeled indication and safety information.

Kesimpta (ofatumumab) – Approved for the treatment of RMS

•Human CD20 monoclonal antibody developed and commercialized by Novartis under a license agreement with Genmab

•Approved in multiple territories including the U.S., Europe and Japan for the treatment of RMS in adults

•First B-cell therapy that can be self-administered by patients using the Sensoready® autoinjector pen

Ofatumumab is a human monoclonal antibody that targets an epitope on the CD20 molecule encompassing parts of the small and large extracellular loops. Genmab used technology licensed from Medarex to generate the CD20 antibody. Ofatumumab, marketed as Kesimpta, is approved in territories including the U.S., Europe, and Japan for the treatment of certain adult patients with RMS. Kesimpta is the first B-cell therapy that can be self-administered by patients using the Sensoready autoinjector pen, once monthly after starting therapy. Ofatumumab is being developed and marketed worldwide by Novartis under a license agreement between Genmab and Novartis. Under the terms of the agreement, Genmab receives a 10% royalty on net sales of Kesimpta, and Genmab pays a low-single digit royalty to Medarex based on Kesimpta sales. Please consult the U.S. Prescribing Information and the European Summary of Product Characteristics for the labeled indication and safety information for Kesimpta.

TEPEZZA (teprotumumab) – First FDA-approved medicine for the treatment of TED

•Developed and commercialized by Amgen for the treatment of TED

•First and only approved medicine for the treatment of TED in the U.S., Japan and Europe

Teprotumumab, approved in the U.S., Japan and Europe under the trade name TEPEZZA, is a human monoclonal antibody that targets the Insulin-like Growth Factor 1 Receptor (IGF-1R), a validated target. It is the first and only medicine approved for the treatment of TED. Genmab used technology licensed from Medarex to generate the IGF-1R antibody. The antibody was created by Genmab under a collaboration with Roche. Development and commercialization of the product is currently being conducted by Amgen. Under the terms of Genmab’s original agreement with Roche, Genmab receives a mid-single digit royalty on net sales (as defined) of TEPEZZA. Please consult the U.S. Prescribing Information and the European Summary of Product Characteristics for the labeled indication and safety information for TEPEZZA.

Bispecific antibodies created under Genmab and J&J DuoBody research and license agreement

•Under the agreement with J&J, Genmab is eligible to receive milestones and receives royalties on net sales of RYBREVANT, TECVAYLI and TALVEY

In July 2012, and as amended in December 2013, Genmab entered into a collaboration with J&J to create and develop bispecific antibodies using Genmab’s DuoBody technology platform. Three approved therapies were generated from this agreement, RYBREVANT (amivantamab), TECVAYLI (teclistamab) and TALVEY (talquetamab).


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RYBREVANT is approved for the treatment of certain adult patients with NSCLC in certain territories including the U.S., Europe, Japan and other territories. In December 2025, an SC formulation was approved, marketed as RYBREVANT FASPRO. TECVAYLI and TALVEY are approved for the treatment of certain adult patients with relapsed or refractory multiple myeloma in certain territories including the U.S., Europe, Japan and other territories. J&J is responsible for the development and commercialization of these medicines.

Under the terms of the agreement, for RYBREVANT, Genmab receives royalties between 8% and 10% on net sales with J&J reducing such royalty payments for Genmab’s share of J&J’s royalty payments made to Halozyme; payments are further reduced in countries and territories where there are no relevant patents. Genmab also pays a royalty to Medarex based on RYBREVANT net sales. For TECVAYLI and TALVEY, Genmab is eligible to receive milestones and receives mid-single digit royalty on net sales of TECVAYLI subject to a reduction of such royalty payments in countries and territories where there are no relevant patents, among other reductions. Please consult the U.S. Prescribing Information and the European Summary of Product Characteristics for each product for the labeled indication and safety information.

SIGNIFICANT RISKS AND UNCERTAINTIES

As a biotech company, Genmab faces a number of risks and uncertainties. These are common for the industry and relate to operations, intellectual property, research and development, commercialization, and financial activities.

For further information about risks and uncertainties that Genmab faces, refer to the 2025 Annual Report filed with the Nasdaq Copenhagen and the Form 20-F filed with the U.S. SEC, both of which were filed in February 2026. At the date of this interim report, there have been no significant changes to Genmab’s overall risk profile since the publication of these reports. See Genmab’s Form 20-F for a detailed summary of risks related to our collaborations.


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 15/45 CVR no. 2102 3884

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FINANCIAL REVIEW

The interim report is prepared on a consolidated basis for Genmab A/S (parent company) and its subsidiaries. The symbol “$” is used throughout this interim report to refer to the U.S. dollar. The Genmab consolidated Group is referenced herein as “Genmab” or the “Company.”

On December 12, 2025, Genmab closed the acquisition of Merus, including its late-stage breakthrough therapy asset petosemtamab. In order to finance the acquisition, Genmab borrowed $5.5 billion and utilized cash on hand. Genmab’s financial results for the first nine months of 2026 reflect the impact of these transactions.

Revenue
Genmab’s revenue was $3,238 million for the first nine months of 2026 compared to $2,662 million for the first nine months of 2025. The increase of $576 million, or 22%, was primarily driven by higher DARZALEX and Kesimpta royalties achieved under our collaborations with J&J and Novartis, respectively, and increased EPKINLY net product sales. This increase was partly offset by $35 million of reduced milestone revenue achieved under our collaborations, primarily AbbVie and J&J.


	Three Months Ended September 30,				Nine Months Ended September 30,
	2026		2025		2026		2025
Royalties	$	991	$	841	$	2,699	$	2,219
Net product sales	149		104		410		280
Reimbursement revenue	15		7		35		43
Milestone revenue	5		53		31		66
Collaboration revenue	17		17		53		54
License revenue	10		—		10		—
Total revenue	$	1,187	$	1,022	$	3,238	$	2,662

Royalties

Royalty revenue amounted to $2,699 million in the first nine months of 2026 compared to $2,219 million in the first nine months of 2025. The increase of $480 million, or 22%, was primarily driven by higher DARZALEX and Kesimpta royalties achieved under our collaborations with J&J and Novartis, respectively. The table below summarizes Genmab’s royalty revenue by product.


	Three Months Ended September 30,				Nine Months Ended September 30,
	2026		2025		2026		2025
DARZALEX	$	751	$	656	$	2,057	$	1,744
Kesimpta	149		122		408		320
TEPEZZA	36		30		93		75
Other	55		33		141		80
Total royalties	$	991	$	841	$	2,699	$	2,219

J&J’s net sales of DARZALEX were $12,410 million in the first nine months of 2026 compared to $10,448 million in the first nine months of 2025. The increase of $1,962 million, or 19%, was driven by market share gains and market growth in all regions. Royalty revenue on net sales of DARZALEX was $2,057 million in the first nine months of 2026 compared to $1,744 million in the first nine months of 2025, an increase of $313 million, or 18%. The percentage increase in royalties is lower than the percentage increase in the underlying net sales primarily due to Genmab’s Halozyme royalty reductions in connection with the increase in SC product net sales and royalty reductions on net sales in countries and territories where there is no Genmab patent


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coverage. Under our license agreement with Janssen for DARZALEX, for purposes of calculating royalties due to Genmab, DARZALEX net sales for non-U.S. dollar denominated currencies are translated to U.S. dollar at a specified annual Currency Hedge Rate.

Novartis’ net sales of Kesimpta were $4,072 million in the first nine months of 2026 compared to $3,198 million in the first nine months of 2025. The increase of $874 million, or 27%, was primarily driven by increased demand and strong access. Royalty revenue on net sales of Kesimpta was $408 million in the first nine months of 2026 compared to $320 million in the first nine months of 2025, an increase of $88 million, or 28%.

Amgen’s net sales of TEPEZZA were $1,592 million in the first nine months of 2026 compared to $1,446 million in the first nine months of 2025, an increase of $146 million, or 10%. Royalty revenue on net sales of TEPEZZA was $93 million in the first nine months of 2026 compared to $75 million in the first nine months of 2025, an increase of $18 million, or 24%. The percentage increase in royalties is higher than the percentage increase in underlying net sales primarily due to the timing of adjustments recognized during the respective periods.

Other royalties consist of royalties from net sales of RYBREVANT, TECVAYLI, TALVEY, TEPKINLY and BIZENGRI. These royalties were not material for the first nine months of 2026 or 2025.

Royalty revenue fluctuations from period to period are driven by the level of product net sales, foreign currency exchange rate movements and more specifically to DARZALEX, the contractual arrangement related to annual Currency Hedge Rate, Genmab’s share of J&J’s royalty payments to Halozyme in connection with SC product net sales and the level of royalty reductions on net sales in countries and territories where there is no patent protection.

Net Product Sales

Global net product sales include sales of EPKINLY in the U.S. and Japan and Tivdak in Japan and Europe.

EPKINLY/TEPKINLY

Global net sales of EPKINLY/TEPKINLY were $491 million in the first nine months of 2026 compared to $333 million in the first nine months of 2025, an increase of $158 million or 47%, driven by strong growth in both 3L+ DLBCL and 3L+ FL, as well as 2L FL, which was approved in the U.S. in November 2025. Net product sales of EPKINLY in the U.S. and Japan recorded by Genmab were $381 million in the first nine months of 2026 compared to $272 million in the first nine months of 2025.

Net sales of TEPKINLY in territories where Genmab receives royalty revenue were $110 million in the first nine months of 2026 compared to $61 million in the first nine months of 2025.

Tivdak

Global net product sales of Tivdak were $131 million in the first nine months of 2026 compared to $120 million in the first nine months of 2025, an increase of $11 million or 9%. Net product sales of Tivdak in Japan and Europe recorded by Genmab were $29 million in the first nine months of 2026 compared to $8 million in the first nine months of 2025. Tivdak was approved in Japan in May 2025 and became available for prescribing in Europe starting in September 2025.

Genmab records 50% of gross profit from net sales of Tivdak by Pfizer in the U.S. Net sales of Tivdak in the U.S. were $102 million in the first nine months of 2026 compared to $112 million in the first nine months of 2025, a decrease of $10 million or 9%.

Reimbursement Revenue

Reimbursement revenue, mainly comprised of the reimbursement of certain research and development costs related to the development work under Genmab’s collaboration agreements, amounted to $35 million in the nine months of 2026 compared to $43 million in the first nine months of 2025. The decrease of $8 million, or 19%,


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was driven primarily by the acasunlimab program, partly offset by reimbursement revenue recognized related to the AbbVie and Gilead agreements.

Milestone Revenue

Milestone revenue was $31 million in the first nine months of 2026 compared to $66 million in the first nine months of 2025, a decrease of $35 million, or 53%. Milestone revenue in the first nine months of 2026 was primarily driven by $28 million of milestones received from collaboration partners acquired as part of the Merus acquisition compared to milestones achieved under our collaborations with AbbVie for $30 million, J&J for $20 million and Novo Nordisk for $13 million in the first nine months of 2025.

Milestone revenue may fluctuate significantly from period to period due to both the timing of achievements and the varying amount of each individual milestone under our license and collaboration agreements.

Collaboration Revenue

Collaboration revenue, which primarily reflects 50% of gross profit from net sales of Tivdak in the U.S. by Pfizer, was $53 million in the first nine months of 2026 compared to $54 million in the first nine months of 2025, a decrease of $1 million, or 2%. The decrease was primarily driven by lower Tivdak net sales, partially offset by Genmab's 50% share of a $10 million milestone received by Pfizer following regulatory approval of Tivdak in China during the second quarter of 2026.

Key Developments to Revenue – Third Quarter of 2026

Genmab’s revenue was $1,187 million for the third quarter of 2026 compared to $1,022 million for the third quarter of 2025. The increase of $165 million, or 16%, was primarily driven by higher DARZALEX and Kesimpta royalties achieved under our collaborations with J&J and Novartis, respectively, and increased EPKINLY net product sales. These increases were partly offset by decreased milestones received from collaboration partners.

Royalties

Royalty revenue on net sales of DARZALEX was $751 million in the third quarter of 2026 compared to $656 million in the third quarter of 2025, an increase of $95 million, or 14%. Royalty revenue on net sales of Kesimpta was $149 million in the third quarter of 2026 compared to $122 million million in the third quarter of 2025, an increase of $27 million, or 22%.

Net Product Sales

EPKINLY/TEPKINLY

Global net sales of EPKINLY/TEPKINLY were $179 million in the third quarter of 2026, compared to $122 million in the third quarter of 2025, an increase of $57 million or 47%.

Tivdak

Global net product sales of Tivdak were $47 million in the third quarter of 2026 and $42 million in the third quarter of 2025.

Genmab records 50% of gross profit from net sales of Tivdak by Pfizer in the U.S. Net sales of Tivdak in the U.S. were $37 million in the third quarter of 2026 compared to $35 million in the third quarter of 2025.

Milestone Revenue

Milestone revenue was $5 million in the third quarter of 2026 compared to $53 million in the third quarter of 2025, a decrease of $48 million, or 91%. Milestone revenue in the in the third quarter of 2025 was driven by milestones achieved under our collaborations with AbbVie for $30 million, Novo Nordisk for $13 million and J&J for $10 million.

Refer to Financial Statement Note 3 in this interim report for further details about revenue.


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 18/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

Cost of Product Sales
Genmab recognized cost of product sales of $234 million in the first nine months of 2026 compared to $157 million in the first nine months of 2025. Cost of product sales includes profit-sharing amounts payable to AbbVie, royalty expense and product costs. The profit-sharing amount paid to AbbVie related to EPKINLY was $184 million in the first nine months of 2026 compared to $128 million in the first nine months of 2025. Royalty expense was $29 million in the first nine months of 2026 compared to $17 million in the first nine months of 2025.

Key Developments to Cost of Product Sales – Third Quarter of 2026

Cost of product sales were $88 million for the third quarter of 2026 compared to $58 million for the third quarter of 2025. The profit-sharing amount paid to AbbVie related to EPKINLY was $68 million in the third quarter of 2026 compared to $46 million in the third quarter of 2025.

Research and Development Expenses
Research and development expenses amounted to $1,329 million in the first nine months of 2026 compared to $1,071 million in the first nine months of 2025. The increase of $258 million, or 24%, was primarily driven by higher clinical development costs to support ongoing Phase 2 and Phase 3 clinical trials for petosemtamab, following its acquisition in December 2025, and Rina-S, as well as the increase in employees to support the continued expansion of Genmab’s overall product portfolio. These increases were partly offset by decreased research and development expenses related to the acasunlimab program, as well as epcoritamab under our collaboration with AbbVie, primarily due to lower clinical costs in the first nine months of 2026 compared to the first nine months of 2025.

Research and development expenses accounted for 70% of total research and development expenses & selling, general and administrative expenses in the first nine months of 2026 compared to 72% in the first nine months of 2025.

Key Developments to Research and Development Expenses – Third Quarter of 2026

Research and development expenses were $451 million for the third quarter of 2026 compared to $354 million for the third quarter of 2025, an increase of $97 million, or 27%. The increase was primarily driven by higher clinical development costs to support ongoing Phase 2 and Phase 3 clinical trials for petosemtamab, following its acquisition in December 2025, and Rina-S, as well as the increase in employees to support the continued expansion of Genmab’s overall product portfolio. These increases were partly offset by decreased research and development expenses related to the acasunlimab program as well as epcoritamab under our collaboration with AbbVie, primarily due to lower clinical costs in the third quarter of 2026 compared to the third quarter of 2025.

Selling, General and Administrative Expenses
Selling, general and administrative expenses were $567 million in the first nine months of 2026 compared to $418 million in the first nine months of 2025. The increase of $149 million, or 36%, was driven primarily by the expansion of Genmab’s global commercialization capabilities, primarily associated with the investment in commercialization related activities for Rina-S and petosemtamab to prepare for the upcoming projected launches, including an increase in employees to support commercialization related efforts, general and administrative expenses associated with the acquisition of Merus which occurred in December 2025, as well as increased litigation expenses related to ongoing legal matters.

Selling, general and administrative expenses accounted for 30% of total research and development expenses & selling, general and administrative expenses in the first nine months of 2026 compared to 28% for the first nine months of 2025.

Key Developments to Selling, General and Administrative Expenses – Third Quarter of 2026

Selling, general and administrative expenses were $196 million for the third quarter of 2026 compared to $148 million for the third quarter of 2025. The increase of $48 million, or 32%, was driven primarily by the expansion of Genmab’s global commercialization capabilities, including an increase in employees to support


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 19/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

commercialization related efforts, and additional selling, general and administrative expenses associated with the acquisition of Merus which occurred in December 2025.

Acquisition and Integration Related Charges
Acquisition and integration related charges, which related primarily to severance, retention and professional fees incurred in connection with the integration of Merus following its acquisition in December 2025, were $87 million in the first nine months of 2026. There were no acquisition and integration related charges in the first nine months of 2025.

Key Developments to Acquisition and Integration Related Charges – Third Quarter of 2026

Acquisition and integration related charges, which related primarily to severance, retention and professional fees incurred in connection with the integration of Merus following its acquisition in December 2025, were $10 million for the third quarter of 2026. There were no acquisition and integration related charges for the third quarter of 2025.

Amortization of Acquired Intangible Assets
Amortization of acquired intangible assets, which includes amortization of technology platform and commercialized intangible assets acquired through acquisitions, was $35 million for the first nine months of 2026 compared to $9 million for the first nine months of 2025. The increase of $26 million was primarily driven by the amortization of the Merus technology platform and commercialized intangible asset acquired in December 2025.

Key Developments to Amortization of Acquired Intangible Assets – Third Quarter of 2026

Amortization of acquired intangible assets was $11 million for the third quarter of 2026 compared to $3 million for the third quarter of 2025. The increase of $8 million, was primarily driven by the amortization of the Merus technology platform acquired in December 2025.

Operating Profit
Operating profit was $986 million in the first nine months of 2026 compared to $1,007 million in the first nine months of 2025. The decrease was driven by the items described above. Adjusted operating profit excluding Acquisition and integration related charges and Amortization of acquired intangible assets, was $1,108 million in the first nine months of 2026 compared to $1,016 million in the first nine months of 2025.

Key Developments to Operating Profit - Third Quarter of 2026
Operating profit was $431 million for the third quarter of 2026 compared to $459 million for the third quarter of 2025. The decrease was driven by the items described above. Adjusted operating profit excluding Acquisition and integration related charges and Amortization of acquired intangible assets, was $452 million in the third quarter of 2026 compared to $462 million in the third quarter of 2025.


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 20/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

Net Financial Items
Financial income and expense was comprised of the following:


	Three Months Ended September 30,				Nine Months Ended September 30,
	2026		2025		2026		2025
Interest and other financial income	$	25	$	32	$	75	$	90

Gain on marketable securities	—		18		—		87
Gain on other investments, net	5		—		5		—
Foreign exchange rate gain	(13)		10		40		135
Total financial income	$	17	$	60	$	120	$	312

Interest and other financial expenses	(4)		(3)		$	(9)	$	(17)
Interest expense on borrowings	(82)		—		(256)		—
Amortization expense on borrowings	(25)		—		(68)		—
Loss on marketable securities	—		(12)		—		(24)
Loss on other investments, net	—		(2)		—		(1)
Foreign exchange rate loss	17		(20)		(50)		(128)
Total financial expenses	$	(94)	$	(37)	$	(383)	$	(170)
Net financial items	$	(77)	$	23	$	(263)	$	142

Interest and Other Financial Income

Interest and Other Financial Income is comprised of interest income on cash and marketable securities and other financial gains. The decrease of $15 million for the first nine months of 2026 compared to the first nine months of 2025, was primarily driven by a $49 million decrease in interest income on marketable securities due to the liquidation of all marketable securities to contribute to the funding of the Merus acquisition completed in December 2025. This decrease was partially offset by an increase of $23 million due to a modification gain related to the Term B Loans Amended Credit Agreement entered into in June 2026 and other financial gains related to the term loans.

Refer to Financial Statement Note 8 in this interim report for further details about borrowings.

Interest and Amortization Expense on Borrowings

The increase of $324 million for the first nine months of 2026 compared to the first nine months of 2025, was due to $256 million of interest expense and $68 million of amortization of fees associated with the debt issued in December 2025 in connection with the financing of the Merus acquisition as well as the Term B Loans Amended Credit Agreement in June 2026. There was no interest expense or amortization of fees on borrowings for the first nine months of 2025 as Genmab did not have any borrowings prior to December 2025.

Refer to Financial Statement Note 8 in this interim report for further details about borrowings.

Gain on Marketable Securities, Net
Gain on marketable securities, net, which includes the impact of foreign exchange rate movements, decreased $63 million in the first nine months of 2026 compared to the first nine months of 2025. There were no gains or losses on marketable securities for the first nine months of 2026 due to the liquidation of all marketable securities to contribute to the funding of the Merus acquisition in December 2025.


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 21/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

Foreign Exchange Rate Loss/Gain, Net

Foreign exchange rate loss, net, was $10 million in the first nine months of 2026 compared to foreign exchange rate gain, net of $7 million in the first nine months of 2025. The decrease was primarily driven by foreign exchange rate movements impacting Genmab’s EUR and DKK denominated assets and liabilities. The EUR and DKK weakened against the USD in the first nine months of 2026 compared to strengthening against the USD in the first nine months of 2025.

Key Developments to Net Financial Items – Third Quarter of 2026

Interest and Other Financial Income

Interest and Other Financial Income is comprised of interest income on cash and marketable securities and other financial gains. The decrease of $7 million for the third quarter of 2026 compared to the third quarter of 2025, was primarily driven by the decrease in interest income on marketable securities due to the liquidation of all marketable securities to contribute to the funding of the Merus acquisition completed in December 2025.

Refer to Financial Statement Note 8 in this interim report for further details about borrowings.

Interest and Amortization Expense on Borrowings

The increase of $107 million for the third quarter of 2026 compared to the third quarter of 2025, was due to $82 million of interest expense and $25 million of amortization of fees associated with the debt issued in December 2025 in connection with the financing of the Merus acquisition as well as the Term B Loans Amended Credit Agreement in June 2026. There was no interest expense or amortization of fees on borrowings for the third quarter of 2025 as Genmab did not have any borrowings prior to December 2025.

Refer to Financial Statement Note 8 in this interim report for further details about borrowings.

Gain on Marketable Securities, Net

Gain on marketable securities, net, which includes the impact of foreign exchange rate movements, decreased $6 million in the third quarter of 2026 compared to the third quarter of 2025. There were no gains or losses on marketable securities for the third quarter of 2026 due to the liquidation of all marketable securities to contribute to the funding of the Merus acquisition in December 2025.

Foreign Exchange Rate Loss/Gain, Net

Foreign exchange rate gain, net, was $4 million in the third quarter of 2026 compared to foreign exchange rate loss, net of $10 million in the third quarter of 2025. The increase was primarily driven by reduced foreign currency exposure on Genmab’s foreign denominated assets and liabilities in the third quarter of 2026 compared to the third quarter of 2025, partly offset by negative foreign exchange rate movements impacting Genmab’s foreign denominated assets and liabilities.

The third quarter result included reductions of $13 million in foreign exchange gains and $17 million in foreign exchange losses, presented within financial income and financial expenses, respectively, consistent with their year-to-date classification.

Corporate Tax
Corporate tax expense for the first nine months of 2026 was $25 million compared to $217 million for the first nine months of 2025. The decrease in corporate tax expense is the result of Genmab’s lower net profit before tax and decrease in the estimated annual effective tax rate in the first nine months ended 2026 to 3.4%, compared to 18.9% in the first nine months of 2025. The lower estimated annual effective tax rate was primarily attributable to the Merus integration that allows for the partial recognition of previously unrecognized tax benefits. Accordingly, the estimated annual effective tax rate for the first nine months ended 2026 is not indicative of the Company's expected annual effective tax rate in future periods. The annual effective tax rate may experience further volatility from the statutory rate as Merus integration continues.


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 22/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

Key Developments to Corporate Tax – Third Quarter of 2026

Corporate tax expense for the third quarter of 2026 was $12 million compared to $81 million for the third quarter of 2025. The decrease in corporate tax expense is the result of Genmab’s lower net profit before tax and decrease in the estimated annual effective tax rate to 3.4% in the third quarter of 2026 compared to 18.9% in the third quarter of 2025. The lower estimated annual effective tax rate was primarily attributable to the Merus integration that allows for the partial recognition of previously unrecognized tax benefits. Accordingly, the estimated annual effective tax rate for the third quarter of 2026 is not indicative of the Company's expected annual effective tax rate in future periods. The annual effective tax rate may experience further volatility from the statutory rate as Merus integration continues.

Net Profit
Net profit for the first nine months of 2026 was $698 million compared to $932 million in the first nine months of 2025. The decrease was driven by the items described above. Net profit for the third quarter of 2026 was $342 million compared to $401 million in the third quarter of 2025. The decrease was driven by the items described above.

Liquidity and Capital Resources


	September 30,		December 31,
	2026		2025

Cash and cash equivalents	$	1,860	$	1,715
Shareholders' equity	$	6,333	$	5,847
Non-current borrowings	$	4,674	$	5,001
Current borrowings	$	318	$	273


	Nine Months Ended September 30,
	2026		2025		Change
Net cash provided by operating activities	$	574	$	885	$	(311)
Net cash (used in) investing activities	$	(16)	$	(71)	$	55
Net cash (used in) financing activities	$	(403)	$	(440)	$	37
Net increase in cash and cash equivalents	$	155	$	374	$	(219)

Exchange Rate adjustments	$	(10)	$	7	$	(17)

Net cash provided by operating activities is primarily related to our operating profit, changes in operating assets and liabilities, reversal of net financial items, adjustments related to non-cash transactions, interest received and paid and corporate taxes paid. Net cash provided by operating activities was $574 million for the first nine months of 2026. This was primarily driven by Genmab’s operating profit generated during the period of $986 million, adjustments for non-cash transactions of $233 million, and interest received of $42 million. These increases were partly offset by $354 million of unfavorable changes in working capital, interest paid of $231 million, primarily related to borrowings, and taxes paid of $97 million. Net cash provided by operating activities was $885 million for the first nine months of 2025. This was primarily driven by Genmab’s operating profit generated during the period of $1,007 million, adjustments for non-cash transactions of $143 million, and interest received of $84 million. These increases were partly offset by taxes paid of $317 million and unfavorable working capital changes of $28 million. The $311 million decrease in net cash provided by operating activities in the first nine months of 2026 compared to the first nine months of 2025 is primarily driven by higher working capital outflows and interest payments, partly offset by lower corporate taxes paid.


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 23/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

Net cash used in investing activities primarily reflects differences between the proceeds received from the sale and maturity of our investments and amounts invested, and the cash paid for investments in tangible and intangible assets. The $55 million decrease in net cash used in investing activities was primarily driven by the absence of marketable securities activity during the first nine months of 2026 following the liquidation of all marketable securities to contribute to the funding of the Merus acquisition completed in December 2025, compared to net marketable securities purchased of $26 million in the first nine months of 2025, lower investments in intangible and tangible assets of $23 million, as well as distributions from our fund investments of $8 million during the first nine months of 2026 compared to the first nine months of 2025.

Net cash used in financing activities is primarily related to the repayments of borrowings, purchase of treasury shares, exercise of warrants, lease payments, and payment of withholding taxes on behalf of employees on net settled Restricted Stock Units (RSUs). The $37 million decrease in net cash used in financing activities between the periods was primarily driven by $334 million of higher cash paid for the purchase of treasury shares during the first nine months of 2025 compared to the first nine months of 2026 due to the timing of share repurchases, partially offset by $288 million of cash principal repayments on borrowings during the first nine months of 2026 compared to none in the first nine months of 2025 as Genmab did not have any borrowings prior to December 2025.

Balance Sheet
As of September 30, 2026, total assets were $12,936 million compared to $12,873 million on December 31, 2025. The increase of $63 million was primarily driven by an increase in cash and cash equivalents, receivables and other current assets and right-of-use assets, partly offset by a decrease in other intangible assets. Cash and cash equivalents increased by $145 million due to the operating profit generated during the period, partly offset by working capital movements, repayments of principal and interest related to borrowings and corporate taxes paid. Receivables and other current assets increased $129 million due to higher DARZALEX and Kesimpta royalties achieved under our collaborations with J&J and Novartis, driven by higher net sales in the third quarter of 2026 as compared to the fourth quarter of 2025, as well as higher trade receivables resulting from increased EPKINLY sales during the same period. Right-of-use assets increased $58 million, primarily related to the commencement of a lease for a manufacturing facility in the U.S. These increases were partly offset by a decrease of $281 million related to other intangible assets due to negative foreign exchange rate impacts from the weakening of the EUR against the USD on our EUR denominated intangible assets.

As of September 30, 2026, total liabilities were $6,603 million compared to $7,026 million on December 31, 2025. The decrease in total liabilities of $423 million was primarily driven by a decrease in current other payables, non-current and current borrowings and taxes payable, partly offset by an increase in non-current and current lease liabilities. The decrease in current other payables of $137 million, was primarily driven by higher accruals recorded at year-end 2025 related to accrued termination costs associated with the discontinuance of the acasunlimab and other programs during the fourth quarter of 2025, accrued compensation and bonuses and accrued withholding tax on Merus related option payments paid in the first nine months of 2026. Non-current and current borrowings decreased $282 million, primarily driven by principal repayments on term loans A and B, as well as a decrease in corporate tax payable of $43 million. These decreases were partly offset by an increase in non-current and current lease liabilities of $54 million related to the commencement of a lease for a manufacturing facility in the U.S.

Shareholders’ equity as of September 30, 2026, was $6,333 million compared to $5,847 million on December 31, 2025. The increase of $486 million, or 8%, was primarily driven by Genmab’s net profit for the period and share-based compensation expenses, partly offset by negative foreign exchange rate impacts affecting the translation of our subsidiaries into USD, mainly the EUR based subsidiaries as a result of the weakening of the EUR against the USD and the purchase of treasury shares.

Employees
Employees comprise individuals who are employed by Genmab and excludes contractors and consultants. As of September 30, 2026, the total number of employees was 3,244 compared to 2,681 as of September 30,


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 24/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

2025. The increase was primarily driven by the continued investment and expansion of our R&D product portfolio and global commercialization capabilities, primarily related to Rina-S and petosemtamab. Also contributing to the increase in employees was the acquisition of Merus, which occurred during the fourth quarter of 2025.


	Nine Months Ended September 30,
Employees	2026		2025
Research and development employees	$	2,081	$	1,841
Selling, general and administrative employees	1,163		840
Total employees	$	3,244	$	2,681

Legal Matters

Genmab is involved in pending legal proceedings arising out of the normal conduct of its business, the most significant of which are described below. These matters involve highly complex issues which are often subject to substantial uncertainties and, therefore, the probability of a loss, if any, being sustained and/or an estimate of the amount of any loss is difficult to ascertain. In cases that have been settled or adjudicated, or where quantifiable fines and penalties have been assessed and which, in each case, are not subject to appeal, or where a loss is probable and we are able to make a reasonable estimate of the loss, Genmab records the loss absorbed or makes a provision for its best estimate of the expected loss. Management has assessed the claims below on that basis and no provisions have been recorded.

Chugai Patent Infringement Complaint

In 2024, Chugai filed a lawsuit in the Tokyo District Court in Japan against AbbVie’s and Genmab’s Japanese subsidiaries asserting that their activities related to EPKINLY (epcoritamab) in Japan infringe two Japanese patents held by Chugai and claiming damages and injunctive relief. In September 2025, Chugai filed two further lawsuits in the same court, against the same parties and with similar assertions, based on two newly granted Japanese patents held by Chugai which are similar to the patents from the original lawsuit.

Genmab and AbbVie believe that all four of the patents are invalid and/or not infringed and intend to vigorously defend the claims.

AbbVie Rina-S Trade Secret Complaint

During the first quarter of 2025, AbbVie filed a complaint in the U.S. District Court for the Western District of Washington (Seattle) naming Genmab A/S; ProfoundBio U.S. Co.; ProfoundBio (Suzhou) Co., Ltd.; and former AbbVie employees as defendants. AbbVie alleges that the defendants have misappropriated AbbVie’s alleged trade secrets relating to the use of disaccharides to improve the hydrophilicity of drug-linkers in ADCs in connection with Rina-S and other ADC pipeline products of ProfoundBio. AbbVie is seeking damages and broad injunctive relief. AbbVie is not asserting or enforcing any patent rights against the defendants, and to Genmab’s knowledge, AbbVie has not pursued any development of products incorporating their alleged trade secrets. During the fourth quarter of 2025, AbbVie filed a complaint with the U.S. International Trade Commission (ITC) under Section 337 of the Tariff Act against ProfoundBio US Co.; ProfoundBio (Suzhou) Co., Ltd.; Genmab A/S; Genmab B.V.; and Genmab US, Inc., seeking to exclude certain antibody drug conjugate products from importation into the United States. The ITC complaint was based on allegations substantially similar to those asserted in the Washington district court action. During the second quarter of 2026, AbbVie withdrew its ITC complaint and filed an unopposed motion to terminate the investigation and in July 2026, the ITC issued a Final Determination which ended the investigation. AbbVie has now resumed its case in the district court which had been stayed during the ITC investigation.

Genmab categorically refutes these allegations and will vigorously defend the company against AbbVie’s claims.


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 25/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME


		Three Months Ended September 30,				Nine Months Ended September 30,
(USD million)	Note	2026		2025		2026		2025
Revenue	3	$	1,187	$	1,022	$	3,238	$	2,662

Cost of product sales*		(88)		(58)		(234)		(157)
Research and development expenses*	1	(451)		(354)		(1,329)		(1,071)
Selling, general and administrative expenses		(196)		(148)		(567)		(418)
Acquisition and integration related charges		(10)		—		(87)		—
Amortization of acquired intangible assets	1	(11)		(3)		(35)		(9)
Total costs and operating expenses		$	(756)	$	(563)	$	(2,252)	$	(1,655)

Operating profit		$	431	$	459	$	986	$	1,007

Financial income	6	17		60		120		312
Financial expenses	6	(94)		(37)		(383)		(170)

Net profit before tax		$	354	$	482	$	723	$	1,149

Corporate tax expense		(12)		(81)		(25)		(217)

Net profit		$	342	$	401	$	698	$	932

Other comprehensive income:

Amounts which may be re-classified to the income statement:
Exchange differences on translation of foreign operations		(22)		6		(248)		22
Cash flow hedges:
Gross deferred gains on cash flow hedges	9	6		—		16		—
Deferred tax expense on cash flow hedges	9	(1)		—		(1)		—
Deferred gains on cash flow hedges, net of tax	9	$	5	$	—	$	15	$	—
Total comprehensive income		$	325	$	407	$	465	$	954

Basic net profit per share		$	5.58	$	6.51	$	11.36	$	14.95
Diluted net profit per share		$	5.51	$	6.46	$	11.23	$	14.90

*Excludes amortization of acquired intangible assets. Refer to Note 1 for details of prior year reclassifications.


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 26/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

CONDENSED CONSOLIDATED BALANCE SHEETS


		September 30, 2026		December 31, 2025
(USD million)	Note

ASSETS

Goodwill	4	$	355	$	355
Other intangible assets	4	8,842		9,123
Property and equipment		129		153
Right-of-use assets	12	185		127
Receivables & other non-current assets	9,10	25		22
Deferred tax assets		173		171
Other investments	5	39		37

Total non-current assets		$	9,748	$	9,988

Corporate tax receivable		57		40
Inventories		30		18

Receivables & other current assets	9,10	1,241		1,112

Cash and cash equivalents		1,860		1,715

Total current assets		$	3,188	$	2,885

Total assets		$	12,936	$	12,873

SHAREHOLDERS’ EQUITY AND LIABILITIES

Share capital		10		10
Share premium		1,936		1,920
Other reserves		(414)		(181)
Retained earnings		4,801		4,098

Total shareholders' equity		$	6,333	$	5,847

Borrowings	8	4,674		5,001
Lease liabilities	12	176		134
Contract liabilities	3	82		95
Deferred tax liabilities		365		364
Other payables	11	7		5

Total non-current liabilities		$	5,304	$	5,599

Borrowings	8	318		273
Corporate tax payable		—		43
Lease liabilities	12	30		18
Contract liabilities	3	19		24
Other payables	11	932		1,069

Total current liabilities		$	1,299	$	1,427

Total liabilities		$	6,603	$	7,026

Total shareholders' equity and liabilities		$	12,936	$	12,873

Share-based payments	7
Related parties	13
Contingencies	14
Subsequent events to the balance sheet date	15


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 27/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS


		Nine Months Ended September 30,
(USD million)	Note	2026		2025


Net profit before tax		$	723	$	1,149

Financial income	6	(120)		(312)
Financial expenses	6	383		170
Adjustments for non-cash transactions
Share-based compensation expense	7	124		92
Depreciation		45		39
Amortization	4	37		11
Impairment charges		27		1
Change in operating assets and liabilities:
Receivables	10	(113)		(124)
Inventories		(38)		(5)
Contract Liabilities	3	(18)		—
Other payables	11	(185)		101
Cash flows from operating activities before financial items		$	865	$	1,122

Interest received		42		84
Interest elements of lease payments	12	(5)		(4)
Other interest paid		(2)		—
Interest paid on borrowings	8	(229)		—
Corporate taxes paid		(97)		(317)
Net cash provided by operating activities		$	574	$	885




Investment in intangible assets	4	(8)		(18)
Investment in tangible assets		(11)		(24)
Marketable securities bought		—		(956)
Marketable securities sold		—		930
Other investments bought	5	(5)		(3)
Other investments sold	5	8		—
Net cash (used in) investing activities		$	(16)	$	(71)

Warrants exercised	7	16		16
Principal elements of lease payments		(10)		(11)
Purchase of treasury shares	7	(96)		(430)
Payment of withholding taxes on behalf of employees on net settled RSUs		(23)		(15)
Principal repayments on borrowings	8	(288)		—
Debt Issuance costs paid	8	(2)		—
Net cash (used in) financing activities		$	(403)	$	(440)

Change in cash and cash equivalents		$	155	$	374

Cash and cash equivalents at the beginning of the period		1,715		1,380
Exchange rate adjustments		(10)		7
Cash and cash equivalents at the end of the period		$	1,860	$	1,761

Cash and cash equivalents include:
Bank deposits		1,860		1,621
Short-term marketable securities		—		140
Cash and cash equivalents at the end of the period		$	1,860	$	1,761


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 28/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN EQUITY


		Share		Share		Other		Retained		Shareholders'
(USD million)	Note	capital		premium		reserves		earnings		equity


Balance at December 31, 2024		$	10	$	1,961	$	(226)	$	3,392	$	5,137

Net profit		—		—		—		932		932
Other comprehensive income		—		—		22		—		22
Total comprehensive income		$	—	$	—	$	22	$	932	$	954

Transactions with owners:
Exercise of warrants	7	—		16		—		—		16
Purchase of treasury shares	7	—		—		—		(430)		(430)
Share-based compensation expenses	7	—		—		—		89		89
Share-based reduction		—		(64)				64		—
Withholding taxes on behalf of employees on net settled RSUs		—		—		—		(15)		(15)

Balance at September 30, 2025		$	10	$	1,913	$	(204)	$	4,032	$	5,751

Balance at December 31, 2025		$	10	$	1,920	$	(181)	$	4,098	$	5,847

Net profit		—		—		—		698		698
Other comprehensive income		—		—		(233)		—		(233)
Total comprehensive income		—		—		(233)		698		465

Transactions with owners:
Exercise of warrants	7	—		16		—		—		16
Purchase of treasury shares	7	—		—		—		(96)		(96)
Share-based compensation expenses	7	—		—		—		124		124

Withholding taxes on behalf of employees on net settled RSUs		—		—		—		(23)		(23)

Balance at September 30, 2026		$	10	$	1,936	$	(414)	$	4,801	$	6,333


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 29/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

NOTES TO THE CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

Note 1 - Basis of Presentation

Accounting Policies

These interim financial statements of the Genmab Group (Genmab or the Company) have been prepared in accordance with IAS 34 (Interim Financial Reporting) as issued by the International Accounting Standards Board (IASB) and in accordance with IAS 34 as endorsed by the European Union (EU) and additional Danish disclosure requirements for interim reports of listed companies. The interim report has not been audited or reviewed by Genmab’s external auditors.

The interim report has been prepared using the same accounting policies as outlined in Section 1 – Basis of Presentation in the financial statements in the Genmab 2025 Annual Report (Annual Report), except as noted below. A number of amended standards became applicable for the current reporting period. There was no impact to Genmab’s financial statements as a result of adopting these amended standards. These interim financial statements should be read in conjunction with the Annual Report.

(In all accompanying tables, amounts of U.S. dollars are expressed in millions, except per share amounts, unless otherwise noted).

Derivative Financial Instruments

The Company is exposed to certain risks relating to its ongoing financial arrangements. The risk managed using derivative instruments is to reduce variability in interest cash flows on its floating-rate debt. Interest rate swaps are entered into to manage interest rate risk associated with the Company’s floating-rate debt. The use of financial derivatives is governed by the Company’s policies approved by the Board of Directors, which provide written principles on the use of financial derivatives consistent with the Company’s risk management strategy. As a matter of policy, Genmab does not use highly leveraged derivative instruments, nor does Genmab use financial instruments for speculative purposes.

IFRS 9 “Financial Instruments” requires entities to recognize all derivative instruments as either assets or liabilities in the Condensed Consolidated Balance Sheets at fair value. The accounting for changes in the fair value (i.e., gains or losses) of a derivative instrument depends on whether it has been designated and qualifies as part of a hedging relationship and, further, on the type of hedging relationship.

The derivatives are designated as cash flow hedges and qualify for hedge accounting treatment. Changes in the fair value of derivative hedging instruments are initially recognized in Other Comprehensive Income (“OCI”) to the extent that the hedge is effective, and accumulated in Other reserves (net of taxes), a component of equity. Amounts accumulated in equity are subsequently reclassified to net profit in the period(s) in which the hedged item affects net profit, and are presented in the same line item in the Condensed Consolidated Statements of Comprehensive Income as the underlying hedged item (i.e., in “interest expense on borrowings” when the hedged transactions are interest cash flows associated with floating-rate debt).To the extent that the hedge is ineffective, changes in fair value are recognized in the Condensed Consolidated Statements of Comprehensive Income within Financial Income/Financial Expense.

Hedge effectiveness is determined at the inception of the hedge relationship and through periodic prospective effectiveness assessments to ensure that an economic relationship exists between the hedged item and hedging instrument at inception of and throughout the hedged term.

The hedge ratio for each designation will be established by comparing the quantity of the hedging instrument and the quantity of the hedged item to determine their relative weighting. For all of the Company’s existing hedge relationships the hedge ratio has been determined as 1:1. Designated hedges are expected to be effective and therefore the impact of ineffectiveness on profit and loss is not expected to be material.

Hedge accounting is discontinued prospectively when the hedging instrument expires or is sold, terminated, exercised or no longer qualifies for hedge accounting. When hedge accounting is discontinued, any gain or loss


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 30/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

recognized in Other Comprehensive Income at that time remains in equity and is recognized in the Condensed Consolidated Statements of Comprehensive Income when the hedged transaction is ultimately recognized in profit or loss.

If it becomes probable that a forecasted transaction will not occur, previously deferred gains and losses related to those forecasted transactions would be recognized in profit or loss in the Condensed Consolidated Statements of Comprehensive Income in the current period.

Genmab’s designated derivative contracts consist of interest rate swap agreements, which effectively modify the Company’s exposure to interest rate risk by converting a portion of the Company’s floating-rate debt to a fixed-rate basis (for interest rate swap arrangements) for approximately two years, thus reducing the impact of interest-rate changes on future interest expense. These agreements involve the receipt of floating-rate amounts in exchange for fixed-rate interest payments without an exchange of the underlying notional amount.

Information about Geographical Areas

Genmab is managed and operated as one business unit, which is reflected in the organizational structure and internal reporting. Resources are allocated and performance is assessed on a consolidated basis. No separate lines of business or separate business entities have been identified with respect to any licensed products, product candidates, product sales or geographical markets. Refer to Note 2.2 in the Annual Report for further details.

Reclassifications

Beginning in the third quarter of 2026, Genmab presents Amortization of acquired intangible assets as a separate line item in the Condensed Consolidated Statements of Comprehensive Income to provide greater transparency regarding these expenses. Comparative amounts have been reclassified to conform to the current period presentation. For the three and nine months ended September 30, 2025, $3 million and $9 million, respectively, were reclassified from Research and development expenses to Amortization of acquired intangible assets. These reclassifications had no effect on operating profit, net profit or earnings per share.

Note 2 - Acquisitions

Merus

During the fourth quarter of 2025, Genmab completed the acquisition of Merus, a clinical-stage biotechnology company developing petosemtamab, for $97 per share in an all-cash transaction representing a transaction value of approximately $8.0 billion. The transaction was accounted for as an asset acquisition, as substantially all of the fair value of the acquired gross assets was concentrated in a single identifiable asset, petosemtamab.

Refer to Note 5.5 of the 2025 Annual Report for further details regarding the acquisition and the related accounting.


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 31/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

Note 3 - Revenue

The table below summarizes Genmab’s revenue by type and collaboration partner, and royalties by product, under Genmab’s agreements.


	Three Months Ended September 30,				Nine Months Ended September 30,
	2026		2025		2026		2025

Revenue by type:
Royalties	$	991	$	841	$	2,699	$	2,219
Net product sales	149		104		410		280
Reimbursement revenue	15		7		35		43
Milestone revenue	5		53		31		66
Collaboration revenue	17		17		53		54
License revenue	10		—		10		—
Total	$	1,187	$	1,022	$	3,238	$	2,662

Revenue by collaboration partner:
J&J	$	794	$	694	$	2,169	$	1,831
Roche	36		30		93		76
Novartis	149		122		410		322
BioNTech	2		4		6		34
Pfizer	20		19		59		60
AbbVie	10		36		26		44
Other**	27		13		65		15
Total*	$	1,038	$	918	$	2,828	$	2,382

Royalties by product:
DARZALEX	$	751	$	656	$	2,057	$	1,744
Kesimpta	149		122		408		320
TEPEZZA	36		30		93		75
Other**	55		33		141		80
Total	$	991	$	841	$	2,699	$	2,219

*Excludes Genmab’s Net product sales

**Other consists of royalties from net sales of RYBREVANT, TECVAYLI, TALVEY, TEPKINLY and BIZENGRI as well as milestones from collaboration partners

Net Product Sales

Genmab recognized net product sales of $410 million during the first nine months of 2026 compared to $280 million in the first nine months of 2025. The increase in net products sales was primarily driven by sales of EPKINLY in the U.S. and Japan of $381 million in the first nine months of 2026 compared to $272 million in the first nine months of 2025.


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 32/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

Contract Liabilities

Genmab has contract liabilities primarily associated with the AbbVie Agreement and Gilead Agreement (assumed through the acquisition of Merus in the fourth quarter of 2025). As part of the continued evaluation of these contract liabilities during the first nine months of 2026, Genmab’s classification of contract liabilities reflects the current estimate of research and development activities as of September 30, 2026. Contract liabilities, primarily related to AbbVie and Gilead, have been recognized as reimbursement revenue in the Condensed Consolidated Statements of Comprehensive Income as the performance obligations have been satisfied. Reimbursement revenue recognized related to the AbbVie and Gilead agreements was $18 million in the first nine months of 2026. Reimbursement revenue recognized in the first nine months of 2025 was immaterial.

Refer to Note 2.1 in the Annual Report for further details regarding revenue.


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 33/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

Note 4 - Other Intangible Assets and Goodwill


	Goodwill		Licenses and Patents		Technology Platforms		Acquired IPR&D		Total Intangible Assets

September 30, 2026
Cost at the beginning of the year	$	355	$	268	$	550	$	8,474	$	9,647
Additions during the period	—		1		7		—		8
Effect of exchange rate adjustment	—		(4)		(12)		(237)		(253)
Cost at the end of the period	$	355	$	265	$	545	$	8,237	$	9,402

Amortization and impairment losses at the beginning of the period	—		(148)		(21)		—		(169)
Amortization for the period	—		(7)		(30)		—		(37)

Effect of exchange rate adjustment	—		1		—		—		1
Amortization and impairment losses at the end of the period	—		(154)		(51)		—		(205)
Carrying amount at the end of the period	$	355	$	111	$	494	$	8,237	$	9,197

December 31, 2025
Cost at the beginning of the year	$	355	$	149	$	180	$	1,532	$	2,216
Additions during the year	—		115		369		6,927		7,411
Effect of exchange rate adjustment	—		4		1		15		20
Cost at the end of the year	$	355	$	268	$	550	$	8,474	$	9,647

Amortization and impairment losses at the beginning of the year	—		(126)		(7)		—		(133)
Amortization for the year	—		(2)		(14)		—		(16)
Impairment losses for the year	—		(18)		—		—		(18)
Effect of exchange rate adjustment	—		(2)		—		—		(2)
Amortization and impairment losses at the end of the year	—		(148)		(21)		—		(169)
Carrying amount at the end of the year	$	355	$	120	$	529	$	8,474	$	9,478

Other Intangible Assets

The decrease in the gross carrying value of other intangible assets during the first nine months of 2026 was primarily driven by negative foreign exchange rate movements resulting from the weakening of the EUR against the USD, mainly related to petosemtamab (acquired IPR&D) and the technology platform acquired as part of the Merus acquisition completed in December 2025.

Amortization expense was $37 million for the first nine months of 2026 and $11 million for the first nine months of 2025.

For the first nine months of 2026, $35 million was recorded in Amortization of acquired intangible assets in the Condensed Consolidated Statements of Comprehensive Income. Of the $35 million of amortization, $30 million


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related to technology platforms and $5 million related to commercialized intangible assets, acquired through the Merus and ProfoundBio acquisitions. The remaining $2 million was recorded in Research and development expenses in the Condensed Consolidated Statements of Comprehensive Income.

In the first nine months of 2025, $9 million was recorded in Amortization of acquired intangible assets in the Condensed Consolidated Statements of Comprehensive Income, which entirely related to the technology platform acquired through the ProfoundBio acquisition. The remaining $2 million was recorded in Research and development expenses in the Condensed Consolidated Statements of Comprehensive Income.

Goodwill

The carrying amount of goodwill, which relates to the acquisition of ProfoundBio during the second quarter of 2024, was $355 million as of both September 30, 2026 and December 31, 2025.

Note 5 - Financial Instruments

The table below shows the fair value measurements by level for Genmab’s financial assets measured at fair value through profit or loss:


	Note	September 30, 2026								December 31, 2025
Assets Measured at Fair Value		Level 1		Level 2		Level 3		Total		Level 1		Level 2		Level 3		Total
Interest rate swaps	1,9	$	—	$	16	$	—	$	16	$	—	$	—	$	—	$	—
Other investments		$	9	$	2	$	28	$	39	$	9	$	2	$	26	$	37

Derivative Financial Instruments

Derivative financial instruments consists exclusively of interest rate swaps and are based on quotes from the market makers that derive fair values from market data and are classified as Level 2. The non-current portion of $5 million and the current portion of $11 million are recorded in the Condensed Consolidated Balances sheets in Receivables & other non-current assets and Receivables & other current assets, respectively. Refer to Note 1 and Note 9 in this interim report for further details regarding Genmab’s derivative financial instruments.

Other Investments

Other investments primarily consist of investments in certain strategic investment funds. Genmab’s share of the fair value of these fund investments is determined based on the valuation of the underlying investments included in the fund. Investments in publicly traded equity securities included in these strategic investment funds are valued based on the most recent sale price or official closing price reported on the exchange or over-the-counter market on which they trade, while investments in non-publicly traded equity securities are based on other factors, including but not limited to, type of the security, the size of the holding, the initial cost of the security, the price and extent of public trading in similar securities of the comparable companies, an analysis of the company's or issuer's financial statements and with respect to debt securities, the maturity and creditworthiness. As such, these fund investments have been characterized as Level 3 investments as fair values are based on significant unobservable inputs.

There were no transfers into or out of Level 3 during the first nine months of 2026 or 2025. Acquisitions (capital calls), distributions and fair value changes on Level 3 investments in 2026 and 2025 were as follows:


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 35/45 CVR no. 2102 3884

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			Other Investments
Fair value at December 31, 2024			$25
Acquisitions			3
Fair value changes			(2)
Fair value at September 30, 2025			$26
Acquisitions			1
Fair value changes			(1)
Fair value at December 31, 2025			$26
Acquisitions			5
Distributions			(8)
Fair value changes			5
Fair value at September 30, 2026			$28

Refer to Note 4.3 and Note 4.4 in the Annual Report for further details regarding Genmab’s marketable securities and other investments.

Note 6 - Financial Income and Expenses


	Three Months Ended September 30,				Nine Months Ended September 30,
	2026		2025		2026		2025


Financial income:
Interest and other financial income	$	25	$	32	$	75	$	90
Gain on marketable securities	—		18		—		87
Gain on other investments, net	5		—		5		—
Foreign exchange rate gain	(13)		10		40		135

Total financial income	$	17	$	60	$	120	$	312

Financial expenses:
Interest and other financial expenses	$	(4)	$	(3)	$	(9)	$	(17)
Interest expense on borrowings	(82)		—		(256)		—
Amortization expense on borrowings	(25)		—		(68)		—
Loss on marketable securities	—		(12)		—		(24)
Loss on other investments, net	—		(2)		—		(1)
Foreign exchange rate loss	17		(20)		(50)		(128)

Total financial expenses	$	(94)	$	(37)	$	(383)	$	(170)

Net financial items	$	(77)	$	23	$	(263)	$	142


Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark			Tel: +45 7020 2728 www.genmab.com			Company Announcement no. 45 Page 36/45 CVR no. 2102 3884

Interim Report for the Nine Months of 2026

Note 7 - Share-Based Payments

Restricted Stock Unit Program

Genmab has established an RSU program (equity-settled share-based payment transactions) as an incentive for Genmab’s employees, members of the Executive Management, and members of the Board of Directors. RSUs granted to Executive Management are performance-based (PSUs).


	Nine Months Ended
	September 30,
	2026	2025
RSUs granted	655,202	651,178
Weighted average fair value per RSU granted (DKK)	1,861.03	1,607.47

RSUs vested	230,227	198,918

Refer to Note 4.6 in the Annual Report for details on the RSU program.

Warrant Program

Genmab has established a warrant program (equity-settled share-based payment transactions) as an incentive for Genmab employees.


	Nine Months Ended
	September 30,
	2026		2025
Warrants granted	522,621		540,011
Weighted average exercise price per warrant granted (DKK)	1,864.92		1,609.25
Weighted average Black-Scholes fair value per warrant granted (DKK)	600.80		501.60

Warrants exercised	67,447		96,016
Weighted average exercise price on date of grant per warrant exercised (DKK)	1,518.41		1,069.78
% change in share capital - warrants exercised	0.11	%	0.15	%

Refer to Note 4.6 in the Annual Report for details on the warrant program.

Share-Based Compensation Expense

Share-based compensation expenses related to Genmab’s RSU and warrant programs for the first nine months of 2026 were $124 million compared to $92 million for the first nine months of 2025.

Share Repurchases

At Genmab’s Annual General Meeting on March 12, 2025, the Board of Directors was authorized to allow Genmab to acquire treasury shares with a total nominal value of up to 10% of the share capital in the period until and including March 11, 2030. The purchase price for the relevant shares may not deviate by more than 10% from the price quoted on Nasdaq Copenhagen at the time of the acquisition. Such shares may only be acquired to the extent that the Company’s total holding of treasury shares does not at any time exceed a nominal value of 10% of the share capital. The authorization replaced existing previously provided authorizations to purchase treasury shares.

As announced on February 17, 2026, Genmab initiated a share buy-back program to honor our commitments under the RSU program. During the first nine months of 2026, Genmab acquired 342,130 of its own shares under the program, representing approximately 0.5% of share capital as of December 31, 2025. The total amount incurred to acquire the shares, including directly attributable costs, was $96 million and was recognized as a deduction to shareholders’ equity. These shares are classified as treasury shares and are


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presented within retained earnings on the Condensed Consolidated Balance Sheets as of September 30, 2026. As of September 30, 2026, 5,329,268 shares were available for repurchase, and 911,318 treasury shares were held by Genmab.

As announced on March 25, 2025, Genmab initiated a share buy-back program to reduce capital and to honor our commitments under the RSU program. During the first nine months of 2025, Genmab acquired 2,200,000 of its own shares under the program, representing approximately 3.3% of share capital as of December 31, 2024. The total amount incurred to acquire the shares, including directly attributable costs, was $430 million and was recognized as a deduction to shareholders’ equity. These shares are classified as treasury shares and are presented within retained earnings on the Condensed Consolidated Balance Sheets as of September 30, 2025. As of September 30, 2025, 3,781,534 shares were available for repurchase, and 2,639,101 treasury shares were held by Genmab.

Share Capital Reduction

At Genmab’s Annual General Meeting on March 19, 2026, shareholders approved the cancellation of 1,900,000 treasury shares, each with a nominal value of DKK 1, reducing the Company’s nominal share capital by DKK 1,900,000. The Board of Directors resolved to complete the capital reduction on April 17, 2026, after which it was registered with the Danish Business Authority. The cancellation resulted in immaterial reductions in share capital and share premium. The corresponding reclassifications within retained earnings offset each other, with no net impact on retained earnings or total equity.

Note 8 - Borrowings


	Current				Non-Current
	September 30,		December 31,		September 30,		December 31,
	2026		2025		2026		2025
Term A Loans (Secured)	$	50	$	53	$	876	$	909
Term B Loans (Secured)	268		207		1,406		1,707
Secured Notes	—		7		1,439		1,434
Unsecured Notes	—		6		953		951
Total Borrowings	$	318	$	273	$	4,674	$	5,001


	Term A Loans (Secured)		Term B Loans (Secured)		Secured Notes		Unsecured Notes		Total
Beginning Balance as of 12/31/2025	$	962	$	1,914	$	1,441	$	957	$	5,274
Loan modification and other adjustments	(6)		(28)		(2)		(1)		(37)
Accrued interest	(2)		(7)		(7)		(6)		(22)
Principal repayments	(38)		(250)		—		—		(288)
Amortization of deferred financing fees	10		45		7		3		65
Ending Balance as of 9/30/2026	$	926	$	1,674	$	1,439	$	953	$	4,992

In June 2026, Genmab entered into an amendment to the Credit Agreement executed in December 2025 (the “Amended Credit Agreement”), modifying the interest terms of the Term B Loans. The Amended Credit Agreement reduced the applicable interest margin from 3.00% to 2.00%. At the time of the Amended Credit Agreement, the nominal value on the Term B Loans was $1,950 million, which represented the initial nominal value less life to date principal repayments. Subsequent to the Amended Credit Agreement, the nominal value was $1,900 million. All other terms of the Amended Credit Agreement remain materially consistent with the Credit Agreement. The amendment did not result in derecognition of the financial liability. A modification adjustment of $23 million was made to the carrying amount of the Term B Loans, with the corresponding gain


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recognized in other finance income. Other adjustments during the period pertain to capitalized deferred financing fees.

The Term A Loans are subject to financial covenants. As of September 30, 2026, Genmab was in compliance with these covenants.

Refer to Note 4.8 in the Annual Report for further details.

Note 9 - Derivative Financial Instruments

The Company uses derivative instruments to manage its exposure to floating-rate debt indexed to 3-month Term Secured Overnight Financing Rate (SOFR). The Company has entered into interest rate swap agreements designated as cash flow hedges. These agreements are used to manage interest rate risk associated with a portion of the Company’s floating-rate debt. The Company follows established risk management policies, including the use of derivatives to hedge interest rates. The counterparties in these derivative instruments are banks which the Company considers the risk of non-performance as minimal.

If the hedge ratio for risk management purposes is no longer optimal but the risk management objective remains unchanged and the hedge continues to qualify for hedge accounting, the hedge relationship will be rebalanced by adjusting either the volume of the hedging instrument or the volume of the hedged item so that the hedge ratio aligns with the ratio used for risk management purposes. Hedge ineffectiveness is measured each reporting date and recognized immediately in profit or loss in the Condensed Consolidated Statements of Comprehensive Income. Rebalancing the hedge relationship may give rise to additional hedge ineffectiveness.

Derivative:

Certain information related to our derivative financial instruments is presented below:

Effective Date

Nominal Amount

Fixed Rate

Index

Actual Termination Date

Location of Financial Instrument in Condensed Consolidated Balance Sheets

Interest rate swap

1/16/2026

406

3.3960

3 Month SOFR rate

6/30/2028

Receivables & other non-current assets and Receivables & other current assets

Interest rate swap

1/27/2026

406

3.4885

3 Month SOFR rate

6/30/2028

Receivables & other non-current assets and Receivables & other current assets

Interest rate swap

2/9/2026

406

3.3625

3 Month SOFR rate

6/30/2028

Receivables & other non-current assets and Receivables & other current assets

Interest rate swap

2/12/2026

406

3.3355

3 Month SOFR rate

6/30/2028

Receivables & other non-current assets and Receivables & other current assets

Deferred Hedging Gains and Losses on Cash Flow Hedges:

Based on valuation at September 30, 2026, and assuming market rates remain constant through contract maturities, it is expected that transfers to earnings of the existing gain or losses reported in Other Comprehensive Income on interest rate cash flow hedges during the next twelve months will correspond to the


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current assets portion of the derivative as disclosed in Note 5 in this interim report. No hedge ineffectiveness was recognized in profit or loss during the period.

Derivative Impact on the Statements of Cash Flow Hedge Reserve:

The following table presents the pre-tax amounts of derivative gains or losses and the line item in the Condensed Consolidated Statements of Comprehensive Income that may be affected when reclassified to profit or loss:


	Carrying Value in Condensed Consolidated Balance Sheet Asset/(Liability)		Opening Balance January 1, 2026		Fair Value (Gain)/Loss Deferred to OCI		Amount Reclassified to Profit or Loss		Closing Balance September 30, 2026		Location When Reclassified to Profit or Loss
Cash flow hedges - Interest rate risk
Interest rate swaps	$	16	$	—	$	(19)	$	3	$	(16)	Financial Expense

The fair value gain reclassified to profit or loss was $3 million for the nine months ended September 30, 2026.

Note 10 - Receivables and Other Assets


	September 30,		December 31.
	2026		2025

Receivables related to collaboration agreements	$	992	$	907
Trade receivables related to product sales	119		96
Prepayments	77		65
Interest receivables	4		4
Interest rate swaps	16		—
Other receivables and assets	58		62
Total	$	1,266	$	1,134

Receivables and other assets - non-current	$	25	$	22
Receivables and other assets - current	1,241		1,112
Total	$	1,266	$	1,134

The $132 million increase in receivables and other assets was primarily due to higher DARZALEX and Kesimpta royalties achieved under our collaborations with J&J and Novartis, driven by higher net sales in the third quarter of 2026 as compared to the fourth quarter of 2025, as well as higher trade receivables resulting from increased EPKINLY sales during the same period. Receivables related to DARZALEX and Kesimpta were $899 million at September 30, 2026 compared to $822 million at December 31, 2025, an increase of $77 million or 9%.

Refer to Note 3.6 in the Annual Report for further details regarding Receivables and other assets.


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Note 11 - Other Payables


	September 30,		December 31,
	2026		2025

Liabilities related to collaboration agreements	$	90	$	79
Staff cost liabilities	141		171
Accounts payable	224		145
Accrued R&D	300		410
Accrued interest on borrowings	48		—
Other liabilities	136		269
Total	$	939	$	1,074

Non-current other payables	$	7	$	5
Current other payables	932		1,069
Total	$	939	$	1,074

The $135 million decrease in other payables was primarily attributable to higher R&D accruals recorded at year-end 2025 related to accrued termination costs associated with the discontinuance of the acasunlimab and other programs during the fourth quarter of 2025, accrued compensation and bonuses and accrued withholding tax on Merus related option payments paid in the first nine months of 2026. These decreases were partly offset by accrued interest on borrowings associated with the debt issued in December 2025 in connection with the financing of the Merus acquisition as well as the Term B Loans Amended Credit Agreement in June 2026.

Refer to Note 3.8 in the Annual Report for further details regarding Other payables.

Note 12 - Leases

Amounts recognized in the Condensed Consolidated Balance Sheets

The Condensed Consolidated Balance Sheets show the following amounts relating to leases:


	September 30, 2026		December 31, 2025

Right-of-use assets
Properties	$	185	$	127

Total right-of-use assets	$	185	$	127

Lease liabilities
Current	$	30	$	18
Non-current	176		134

Total lease liabilities	$	206	$	152

During the first nine months of 2026, there was an addition to Genmab’s right-of-use assets and lease liabilities related to the commencement of a lease for a manufacturing facility in the U.S. The lease for a manufacturing


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facility has a non-cancelable lease period of approximately 21 years and an option to extend for an additional 10 years. During the first nine months of 2025, there were no material additions to Genmab’s right-of-use assets and lease liabilities.

Amounts recognized in the Condensed Consolidated Statements of Comprehensive Income

The Condensed Consolidated Statements of Comprehensive Income show the following amounts relating to leases:


	Three Months Ended September 30,				Nine Months Ended September 30,
	2026		2025		2026		2025

Depreciation charge of right-of-use assets
Properties	$	5	$	4	$	14	$	12

Total depreciation charge of right-of-use assets	$	5	$	4	$	14	$	12
Interest Expense	$	2	$	1	$	5	$	4

Depreciation charges for right-of-use assets is included in Research and development expenses and Selling, general, and administrative expenses within the Condensed Consolidated Statements of Comprehensive Income. Interest expense is included in Financial expenses within the Condensed Consolidated Statements of Comprehensive Income.

In the first nine months of 2026, depreciation charges for right-of-use assets of $8 million and $6 million are included in Research and development expenses and Selling, general, and administrative expenses, respectively. In the first nine months of 2025, depreciation charges for right-of-use assets of $8 million and $4 million are included in Research and development expenses and Selling, general, and administrative expenses, respectively.

Variable lease payments, short-term lease expense and low-value leases are not material.

Note 13 - Related Parties

Genmab’s related parties are its Board of Directors, Executive Management, and close members of the family of these persons.

Genmab has not granted any loans, guarantees or other commitments to or on behalf of any of the members of the Board of Directors or members of the Executive Management.

Related party transactions include remuneration relating to the Board of Directors and the Executive Management as described in Note 5.1 in the Annual Report. There were no material related party transactions during the first nine months of 2026 or 2025.

Changes to the Executive Management and the Board of Directors

Following Genmab’s Annual General Meeting on March 19, 2026, the Board of Directors is comprised of five independent board members, one non-independent board member, and three employee-elected board members. Deirdre P. Connelly (Chair), Pernille Erenbjerg (Deputy Chair), Rolf Hoffmann, Elizabeth O’Farrell, Paolo Paoletti and Anders Gersel Pedersen were re-elected to the Board of Directors for a one-year period. Mijke Zachariasse and Martin Schultz currently serve as employee-elected board members for three-year terms expiring in 2028. Michael Kavanagh, who was also serving as an employee-elected board member, has


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stepped down from the Board of Directors upon his departure from Genmab on August 14, 2026. Gina Schweizer, who was elected as his alternate, has succeeded him as an employee-elected board member effective August 15, 2026.

Note 14 - Contingencies

Chugai Patent Infringement Complaint

Genmab and AbbVie believe that all four of the patents are invalid and/or not infringed and intend to vigorously defend the claims.

AbbVie Rina-S Trade Secret Complaint

Genmab categorically refutes these allegations and will vigorously defend the company against AbbVie’s claims.

Note 15 - Subsequent Events to the Balance Sheet Date

No events have occurred subsequent to the balance sheet date that could significantly affect the condensed consolidated financial statements as of September 30, 2026.


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ABOUT GENMAB

Genmab is an international biotechnology company dedicated to improving the lives of people with cancer and other serious diseases through innovative antibody medicines. For over 25 years, its passionate, innovative and collaborative team has advanced a broad range of antibody-based therapeutic formats, including bispecific antibodies, antibody-drug conjugates (ADCs), immune-modulating antibodies and other next-generation modalities. Genmab’s science powers eight approved antibody medicines, and the company is advancing a strong late-stage clinical pipeline, including wholly owned programs, with the goal of delivering transformative medicines to patients.

Established in 1999, Genmab is headquartered in Copenhagen, Denmark, with international presence across North America, Europe and Asia Pacific. For more information, please visit Genmab.com or follow us on LinkedIn, X, Facebook and Instagram.

This Interim Report contains forward looking statements. The words “believe,” “expect,” “anticipate,” “intend” and “plan” and similar expressions identify forward looking statements. Actual results or performance may differ materially from any future results or performance expressed or implied by such statements. The important factors that could cause our actual results or performance to differ materially include, among others, risks associated with preclinical and clinical development of products, uncertainties related to the outcome and conduct of clinical trials including unforeseen safety issues, uncertainties related to product manufacturing, the lack of market acceptance of our products, our inability to manage growth, the competitive environment in relation to our business area and markets, our inability to attract and retain suitably qualified personnel, the unenforceability or lack of protection of our patents and proprietary rights, our relationships with affiliated entities, changes and developments in technology which may render our products or technologies obsolete, and other factors. For a further discussion of these risks, please refer to the risk management sections in Genmab’s most recent financial reports, which are available on www.genmab.com and the risk factors included in Genmab’s most recent Annual Report on Form 20-F and other filings with the U.S. Securities and Exchange Commission (SEC), which are available at www.sec.gov. Genmab does not undertake any obligation to update or revise forward looking statements in this Interim Report nor to confirm such statements to reflect subsequent events or circumstances after the date made or in relation to actual results, unless required by law.

Genmab A/S and/or its subsidiaries own the following trademarks: Genmab®; the Y-shaped Genmab logo®; Genmab in combination with the Y-shaped Genmab logo®; HuMax®; DuoBody®; HexaBody®; DuoHexaBody®; HexElect®; KYSO®, RAINFOL™, ProfoundBio™ and Rina-S® are trademarks of ProfoundBio, U.S., Co. and Genmab (Suzhou) Co., Ltd. Tivdak® is a trademark of Seagen Inc.; EPCORE®, EPKINLY®, TEPKINLY® and their designs are trademarks of AbbVie Biotechnology Ltd.; Biclonics® and BIZENGRI® are registered trademarks of Merus N.V. Kesimpta® and Sensoready® are trademarks of Novartis AG or its affiliates; DARZALEX®, DARZALEX FASPRO®, RYBREVANT®, RYBREVANT FASPRO™,TECVAYLI® and TALVEY® are trademarks of Johnson & Johnson; TEPEZZA® is a trademark of Horizon Therapeutics Ireland DAC.


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DIRECTORS’ AND MANAGEMENT’S STATEMENT ON THE INTERIM REPORT

The Board of Directors and the registered members of Executive Management have today considered and adopted the interim report of the Genmab Group for the nine months ended September 30, 2026.

The interim report has not been audited or reviewed by Genmab’s external auditors. The interim report is prepared in accordance with IAS 34, “Interim Financial Reporting,” as issued by the IASB and in accordance with IAS 34 as endorsed by the EU, and additional Danish disclosure requirements for interim reports of listed companies.

We consider the applied accounting policies to be appropriate and, in our opinion, the interim report gives a true and fair view of the assets and liabilities, financial position, results of operation and cash flows of the Group.

Furthermore, we consider the Management’s Review to give a true and fair account of the development in the Group’s activities and financial affairs, results of operations and the Group’s financial position as a whole as well as a description of the significant risks and uncertainties which the Group faces, as further described in this report, our 2025 Annual Report and the Form 20-F filed with the U.S. Securities and Exchange Commission in February 2026.

Copenhagen, November 5, 2026

Registered Members of Executive Management



Jan van de Winkel (President & CEO)			Anthony Pagano (Executive Vice President & CFO)

Board of Directors



Deirdre P. Connelly (Chair)	Pernille Erenbjerg (Deputy Chair)	Anders Gersel Pedersen


Rolf Hoffmann	Paolo Paoletti	Elizabeth O’Farrell


Mijke Zachariasse (Employee elected)	Gina Schweizer (Employee elected)	Martin Schultz (Employee elected)