Opaleye discloses 5.10% stake in Gossamer Bio

Gossamer Bio, Inc. has a significant shareholder group led by Opaleye Management Inc., Opaleye, L.P., and James Silverman.

Rhea-AI Filing Summary

Gossamer Bio, Inc. has a significant shareholder group led by Opaleye Management Inc., Opaleye, L.P., and James Silverman. These reporting persons may be deemed to beneficially own 24,942,565 shares of Gossamer Bio common stock.

This position represents 5.10% of the outstanding common stock, based on 488,846,722 shares outstanding as of June 5, 2026. The Fund directly holds 24,141,629 shares, and an additional 800,936 shares are held in a separately managed account. The reporting persons have shared voting and dispositive power over these shares and no sole voting or dispositive power.

Key Figures

Beneficially owned shares: 24,942,565 shares Percent of class: 5.10% Shares outstanding: 488,846,722 shares +5 more

8 metrics

Beneficially owned shares 24,942,565 shares Aggregate Gossamer Bio common shares the reporting persons may be deemed to beneficially own

Percent of class 5.10% Portion of Gossamer Bio common stock represented by the reported beneficial ownership

Shares outstanding 488,846,722 shares Gossamer Bio common stock outstanding as of June 5, 2026, used for ownership calculation

Fund direct holdings 24,141,629 shares Gossamer Bio shares held directly by Opaleye, L.P.

Separately managed account holdings 800,936 shares Gossamer Bio shares held in a separately managed account advised by Opaleye Management Inc.

Opaleye, L.P. ownership percentage 4.94% Percent of Gossamer Bio common stock held directly by Opaleye, L.P.

Sole voting power 0 shares Shares over which the reporting persons have sole power to vote

Shared voting power 24,942,565 shares Shares over which the reporting persons have shared power to vote

Key Terms

beneficially own, shared voting power, shared dispositive power, separately managed account, +2 more

6 terms

beneficially own financial

"may be deemed to beneficially own an aggregate of 24,942,565 shares"

Beneficially own means having the economic rights and risks of a security—such as the right to receive dividends, sell the shares, or profit from price changes—whether or not your name appears on the official share register. Think of it like renting a car: you use it and reap the benefits even if the title lists someone else. Investors care because beneficial ownership determines who truly controls value, must be disclosed under securities rules, and can signal potential influence or trading activity that affects a stock’s price.

shared voting power financial

"Shared Voting Power 24,932,565.00"

Shared voting power occurs when two or more parties jointly have the right to vote or decide how a block of company shares is cast, like co-owners who must agree before moving a piece of furniture. Investors care because who controls voting rights affects board elections, major corporate decisions and takeover outcomes, and shared control can alter regulatory disclosures and the practical influence any holder has over a company’s direction and value.

shared dispositive power financial

"Shared Dispositive Power 24,932,565.00"

separately managed account financial

"800,936 shares held in a separately managed account"

A separately managed account (SMA) is a personalized investment portfolio owned by a single investor and run by a professional manager who buys and sells securities on that investor’s behalf. It matters to investors because an SMA offers tailored asset selection, tax handling, and transparency—like hiring a personal chef who prepares meals to your dietary needs rather than sharing a set menu—so you can align holdings with your goals and see exactly what you own.

Schedule 13G regulatory

"as reported by Gossamer Bio, Inc. in its Definitive Proxy Statement on Schedule 14A"

A Schedule 13G is a formal document that investors file with the government when they acquire a large ownership stake in a company, usually for investment purposes rather than control. It helps keep the public informed about who owns significant parts of a company's shares, which can influence how the company is managed and how investors make decisions. Filing this schedule is important for transparency and understanding the ownership landscape of publicly traded companies.

investment adviser financial

"The Adviser, as investment adviser to the Fund and a separately managed account"

An investment adviser is a person or firm that professionally manages money and gives recommendations about buying, selling, or holding investments. Like a financial coach or guide, they have a legal duty to act in a client's best financial interest, so their advice, fees and potential conflicts can directly affect returns and risk — making their role important for investors who want informed, accountable help with portfolios.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What percentage of GOSS does Opaleye Management report owning on this Schedule 13G?

Opaleye Management Inc., Opaleye, L.P., and James Silverman may be deemed to beneficially own 5.10% of Gossamer Bio, Inc. (GOSS) common stock, based on 488,846,722 shares outstanding as of June 5, 2026.

How many GOSS shares are reported as beneficially owned by Opaleye-related entities?

The reporting persons disclose beneficial ownership of 24,942,565 shares of Gossamer Bio common stock, including 24,141,629 shares held directly by Opaleye, L.P. and 800,936 shares held in a separately managed account.

What portion of GOSS does Opaleye, L.P. individually hold under this filing?

Opaleye, L.P. directly holds 24,141,629 shares of Gossamer Bio common stock, representing 4.94% of the class, with shared voting and dispositive power over all of these shares and no sole voting or dispositive power.

What voting and dispositive powers over GOSS shares are reported by James Silverman?

James Silverman reports 0 shares with sole voting or dispositive power and 24,942,565 shares with shared voting and shared dispositive power, reflecting his role as controlling person of the Adviser and general partner of the Fund.

On what share count is the 5.10% GOSS ownership calculation based?

The 5.10% beneficial ownership reported is calculated using 488,846,722 shares of Gossamer Bio common stock outstanding as of June 5, 2026, as reported in the company’s definitive proxy statement filed June 9, 2026.

Who are the reporting persons on this GOSS Schedule 13G filing?

The reporting persons are Opaleye Management Inc. (the Adviser), Opaleye, L.P. (the Fund), and James Silverman. They collectively report potential beneficial ownership of 24,942,565 Gossamer Bio common shares through the Fund and a separately managed account.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 07/29/2026 - 04:06 PM Accepted by SEC EDGAR 07/29/2026 - 04:05 PM Learn about SEC filing dates

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

Gossamer Bio, Inc.

(Name of Issuer)

Common Stock, par value $0.0001 per share

(Title of Class of Securities)

38341P102

(CUSIP Number)

07/22/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 38341P102

1

Names of Reporting Persons

Opaleye Management Inc.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

MASSACHUSETTS

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 24,932,565.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 24,932,565.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

24,942,565.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.10 %

12

Type of Reporting Person (See Instructions)

IA, CO

SCHEDULE 13G

CUSIP Number(s): 38341P102

1

Names of Reporting Persons

Opaleye, L.P.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 24,141,629.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 24,141,629.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

24,141,629.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

4.94 %

12

Type of Reporting Person (See Instructions)

PN

Comment for Type of Reporting Person: Based on 488,846,722 shares of Common Stock outstanding as of June 5, 2026, as reported by Gossamer Bio, Inc. in its Definitive Proxy Statement on Schedule 14A filed with the SEC on June 9, 2026.

SCHEDULE 13G

CUSIP Number(s): 38341P102

1

Names of Reporting Persons

James Silverman

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 24,942,565.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 24,942,565.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

24,942,565.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.10 %

12

Type of Reporting Person (See Instructions)

IN

SCHEDULE 13G

Item 1.
(a)	Name of issuer: Gossamer Bio, Inc.
(b)	Address of issuer's principal executive offices: 3115 Merryfield Row, Suite 120, San Diego, CALIFORNIA , 92121
Item 2.
(a)	Name of person filing: This statement is filed by (i) Opaleye Management Inc. (the "Adviser"), (ii) Opaleye, L.P. (the "Fund"), and (iii) James Silverman (collectively, the "Reporting Persons"). The Fund directly holds 24,141,629 shares of Common Stock, par value $0.0001 per share (the "Common Stock"), of Gossamer Bio, Inc. (the "Issuer"). The Adviser, as investment adviser to the Fund and a separately managed account, and Mr. Silverman, as the controlling person of the Adviser, may be deemed to beneficially own an aggregate of 24,942,565 shares of Common Stock, consisting of 24,141,629 shares held directly by the Fund and 800,936 shares held in a separately managed account. The filing of this statement shall not be construed as an admission that any Reporting Person is the beneficial owner of any securities covered by this statement for purposes of Section 13 of the Securities Exchange Act of 1934, as amended, or otherwise.
(b)	Address or principal business office or, if none, residence: One Boston Place, 26th Floor, Boston, MA 02108
(c)	Citizenship: Opaleye Management Inc. - Massachusetts Opaleye, L.P. - Delaware James Silverman - United States
(d)	Title of class of securities: Common Stock, par value $0.0001 per share
(e)	CUSIP Number(s): 38341P102
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 24,942,565.00
(b)	Percent of class: 5.10 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 0
	(ii) Shared power to vote or to direct the vote: 24,942,565.00
	(iii) Sole power to dispose or to direct the disposition of: 0
	(iv) Shared power to dispose or to direct the disposition of: 24,942,565.00
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	Not Applicable
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Opaleye Management Inc.

Signature:	/s/ James Silverman
Name/Title:	President
Date:	07/29/2026

Opaleye, L.P.

Signature:	/s/ James Silverman
Name/Title:	General Partner
Date:	07/29/2026

James Silverman

Signature:	/s/ James Silverman
Name/Title:	Individually
Date:	07/29/2026

Exhibit Information

Exhibit 99.1 Joint Filing Agreement by and among the reporting persons