[Form 4] GRAIL, Inc. Insider Trading Activity

Rhea-AI Filing Summary

Joshua J. Ofman, President of GRAIL, Inc. (GRAL), reported a sale of 9,692 shares of common stock on 10/02/2025 at a reported price of $64.0025 per share. After the transaction he beneficially owns 478,182 shares. The filing notes the sale was executed under a Rule 10b5-1 trading plan adopted on March 13, 2025, and the Form 4 was signed by an attorney-in-fact on 10/03/2025. The report is a routine Section 16 disclosure showing an officer-initiated disposition under an established trading plan.

Positive

• Sale executed under a Rule 10b5-1 plan adopted on March 13, 2025, which provides an affirmative defense
• Complete disclosure of shares sold (9,692), price ($64.0025), and post-transaction ownership (478,182)

Negative

• Officer disposition of 9,692 shares could be viewed negatively by some investors
• No purchases or grants reported in this filing to offset the sale

Insights

Securities Trading Specialist

Insider sale of 9,692 shares executed under a 10b5-1 plan.

The filing shows a single sale of 9,692 shares on 10/02/2025 at $64.0025 per share and residual beneficial ownership of 478,182 shares. The seller is listed as an officer (President), and the transaction is explicitly attributed to a Rule 10b5-1 trading plan adopted on March 13, 2025.

This matters because trades under an active 10b5-1 plan are pre‑planned and provide an affirmative defense against insider trading allegations; the filing therefore signals a pre‑arranged disposition rather than an opportunistic sale.

Corporate Governance Analyst

Officer sale disclosed; quantity and plan date are the key governance facts.

The Form 4 discloses an officer-level sale and records the attorney-in-fact signature dated 10/03/2025. The remaining direct ownership of 478,182 shares is shown on the form, which is material to assessing the officer's ongoing equity stake.

For investor governance review, the presence of a 10b5-1 plan reduces immediate signaling of nonpublic information use; no additional transactions, grants, or derivative activity are reported in this filing.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

X

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Ofman Joshua J.

(Last) (First) (Middle)

C/O GRAIL, INC.

1525 O'BRIEN DRIVE

(Street)

MENLO PARK CA 94025

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
GRAIL, Inc. [ GRAL ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	President

3. Date of Earliest Transaction (Month/Day/Year)
10/02/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	10/02/2025		S		9,692	D(1)	$64.0025	478,182	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. The sale transaction reported in this Form 4 is made pursuant to a Rule 10b5-1 trading plan adopted on March 13, 2025

Remarks:

	/s/Donald Lang, as Attorney-in-Fact for Joshua Ofman	10/03/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What did GRAIL (GRAL) insider Joshua Ofman disclose on the Form 4?

He disclosed a sale of 9,692 shares on 10/02/2025 at $64.0025 per share, leaving him with 478,182 shares beneficially owned.

Was the sale by Joshua Ofman part of a 10b5-1 trading plan?

Yes. The Form 4 states the sale was made pursuant to a Rule 10b5-1 trading plan adopted on March 13, 2025.

Who signed the Form 4 for Joshua Ofman and when?

The form was signed by Donald Lang, as Attorney-in-Fact for Joshua Ofman on 10/03/2025.

Does the filing show any derivative transactions or option activity?

No. Table II shows no derivative securities acquired, disposed of, or beneficially owned in this filing.

How much direct ownership does Joshua Ofman retain after the sale?

The filing reports he beneficially owns 478,182 shares following the reported transaction.