Grace Therapeutics: Opaleye buys 60,490 shares

The two weighted-average purchase prices covered multiple transactions, with disclosed price ranges of $2.00 to $2.04 and $2.03 to $2.07.

Rhea-AI Filing Summary

Opaleye Management, Inc., a ten percent owner of Grace Therapeutics, Inc. (GRCE) and investment manager of Opaleye, L.P., reported three purchases by the fund, which directly owns the shares, totaling 60,490 common shares. Opaleye, L.P. purchased 38,796 shares on October 1, 2026, at a weighted-average price of $2.0353 per share, with transaction prices ranging from $2.00 to $2.04; 20,000 shares on October 2, 2026, at a weighted-average price of $2.0684 per share, with transaction prices ranging from $2.03 to $2.07; and 1,694 shares on October 5, 2026, at $2.0600 per share. No Rule 10b5-1 plan is reported. Opaleye Management may be deemed to beneficially own the fund's shares but disclaims beneficial ownership except to the extent of its pecuniary interest.

Insider Trade Summary

Net Buyer: 60,490 shares

Net Buy 3 txns

Insider Opaleye Management Inc.

Role 10% Owner

Bought 60,490 shs ($124K)

Type	Security	Shares	Price	Value
Purchase	Common Stock, par value $0.0001 per share F1, F4	1,694	$2.06	$3K
Purchase	Common Stock, par value $0.0001 per share F3, F1, F4	20,000	$2.0684	$41K
Purchase	Common Stock, par value $0.0001 per share F2, F1, F4	38,796	$2.0353	$79K

Holdings After Transaction: Common Stock, par value $0.0001 per share — 2,858,657 shares (Indirect, By Opaleye, L.P.)

Footnotes (4)

1. F1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund.
2. F2. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.00 to $2.04. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.
3. F3. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.03 to $2.07. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.
4. F4. Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

Key Figures

Shares purchased: 60,490 shares Shares purchased: 38,796 shares Weighted-average purchase price: $2.0353 per share +4 more

7 metrics

Shares purchased 60,490 shares Three purchases by Opaleye, L.P.

Shares purchased 38,796 shares October 1, 2026

Weighted-average purchase price $2.0353 per share October 1, 2026; multiple transactions priced from $2.00 to $2.04

Shares purchased 20,000 shares October 2, 2026

Weighted-average purchase price $2.0684 per share October 2, 2026; multiple transactions priced from $2.03 to $2.07

Shares purchased 1,694 shares October 5, 2026

Purchase price $2.0600 per share October 5, 2026

Key Terms

weighted average price, beneficial ownership, pecuniary interest, Section 16(a)

4 terms

weighted average price financial

"The price reported is a weighted average price."

Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.

beneficial ownership regulatory

"disclaims beneficial ownership of the shares reported herein"

Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.

pecuniary interest financial

"except to the extent of its pecuniary interest therein"

Section 16(a) regulatory

"for purposes of Section 16(a) of the Securities Exchange Act of 1934"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many GRCE shares did Opaleye buy, and at what prices?

Opaleye, L.P. purchased 60,490 GRCE common shares across three transactions. The reported prices were $2.0353 per share on October 1, 2026, and $2.0684 per share on October 2, 2026, both weighted averages; the October 5, 2026, purchase was reported at $2.0600 per share. No Rule 10b5-1 plan is reported.

Who owned the shares in the GRCE purchases reported by Opaleye Management?

The shares were owned directly by Opaleye, L.P. Opaleye Management, Inc., the fund's investment manager, may be deemed to beneficially own those shares but disclaims beneficial ownership except to the extent of its pecuniary interest therein.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 10/05/2026 - 06:46 PM Accepted by SEC EDGAR 10/05/2026 - 06:46 PM Learn about SEC filing dates

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Opaleye Management Inc.

(Last) (First) (Middle)

ONE BOSTON PLACE, 26TH FLOOR

(Street)

BOSTON MASSACHUSETTS 02108

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
Grace Therapeutics, Inc. [ GRCE ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
10/01/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock, par value $0.0001 per share	10/01/2026		P		38,796	A	$2.0353(2)	2,836,963	I	By Opaleye, L.P.(1)(4)
Common Stock, par value $0.0001 per share	10/02/2026		P		20,000	A	$2.0684(3)	2,856,963	I	By Opaleye, L.P.(1)(4)
Common Stock, par value $0.0001 per share	10/05/2026		P		1,694	A	$2.06	2,858,657	I	By Opaleye, L.P.(1)(4)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund.

2. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.00 to $2.04. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.

3. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.03 to $2.07. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.

4. Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

	Opaleye Management, Inc., By: /s/ James Silverman, President	10/05/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)