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GNI group takes 69.1% Gyre (NASDAQ: GYRE) stake after $300M Cullgen deal

Filing Impact
(Moderate)
Filing Sentiment
(Neutral)
Form Type
SCHEDULE 13D/A

Rhea-AI Filing Summary

GNI USA, Inc. and GNI Group Ltd. report beneficial ownership of 86,323,015 shares of Gyre Therapeutics common stock, representing 69.1% of the company’s equity on an as-converted basis. This stake includes issued common shares plus stock underlying Series X and Series B preferred shares.

The filing reflects Gyre’s all-stock acquisition of Cullgen Inc., which valued Cullgen at approximately $300 million and closed on May 4, 2026. Cullgen shareholders received a mix of Gyre common stock and Series B Preferred Stock, each Series B share being convertible into five common shares once stockholders approve a Conversion Proposal.

The Series B Preferred Stock carries dividend and voting rights aligned with common stock, but key corporate actions affecting these preferred shares require approval from their holders until conversion is approved. Certain executives, directors and stockholders are subject to lock-up agreements that restrict transfers of portions of their holdings for 180 days, 12 months and 18 months after closing, and a registration rights agreement requires Gyre to file a resale registration statement for Cullgen holders.

Positive

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Insights

GNI now controls about 69% of Gyre after a $300M all-stock Cullgen deal.

GNI USA and GNI Group Ltd. disclose beneficial ownership of 86,323,015 Gyre Therapeutics shares, or 69.1% of the company on an as-converted basis. This consolidates effective control with a single shareholder group and reflects the share issuance structure tied to the Cullgen acquisition.

The Cullgen transaction, valued at about $300 million, was paid entirely in Gyre equity, using both common stock and Series B Preferred Stock. Each Series B share is convertible into five common shares after stockholders approve the Conversion Proposal, but issuance is capped at 19.99% of pre-approval common stock and voting power, consistent with Nasdaq rules.

Series B holders gain meaningful governance influence: until the Conversion Proposal is approved, adverse changes to their rights, further issuances, or major transactions require majority Series B consent. Lock-up agreements stagger potential selling pressure over 180 days, 12 months and 18 months from the May 4, 2026 closing, while a registration rights agreement commits Gyre to register resale of common and as-converted Series B shares within specified post-closing timelines.

Beneficial ownership 86,323,015 shares Shares beneficially owned by GNI USA and GNI Group on an as-converted basis
Ownership percentage 69.1% of class Percent of Gyre common stock represented by 86,323,015 shares
Cullgen transaction value $300 million Approximate value of all-stock acquisition of Cullgen Inc.
Gyre shares outstanding 96,994,001 shares Common stock outstanding as of April 16, 2026 per proxy statement
Merger issuance 14,450,527 shares Gyre common stock issued in the Cullgen merger
Series B conversion ratio 5 common per preferred Each Series B Preferred share convertible into five Gyre common shares
Nasdaq issuance cap 19.99% Maximum common stock or voting power issued before Conversion Proposal approval
Series B from GNI USA 2,143,706 shares Series B Preferred Stock received by GNI USA in exchange for Cullgen capital stock
Series B Preferred Stock financial
"The Certificate of Designation provides for the issuance of shares of Series B Preferred Stock."
Series B preferred stock is a type of ownership share issued by a company that offers certain advantages over common stock, such as priority in receiving dividends or assets if the company is sold or liquidated. It is typically issued after an initial round of funding, making it a way for investors to support a company's growth while gaining some protections and benefits. This stock matters to investors because it often provides a more secure investment position with potential for future growth.
Exchange Ratio financial
"for each share of Cullgen common stock held by such holders, a number of shares of the Series B Preferred Stock, equal to (x) 0.4753 (the "Exchange Ratio")"
The exchange ratio is the number used to decide how many shares of one company you get for each share you own in another company during a merger or acquisition. It’s like a recipe that tells you how to swap shares fairly, ensuring both companies’ values are balanced. This ratio matters because it determines how ownership divides between the companies' shareholders.
Conversion Proposal regulatory
"Pursuant to the Merger Agreement, the Company agreed to convene a meeting of its stockholders to submit ... the Conversion Proposal."
Lock-Up Agreements financial
"certain executive officers, directors and stockholders of the Company and Cullgen have entered into lock-up agreements (the "Lock-Up Agreements")"
A lock-up agreement is a contract that prevents company insiders—founders, employees, and early investors—from selling their shares for a set period after a public stock offering. It matters to investors because it keeps a large block of shares off the market temporarily; when the lock-up ends, those holders can sell and this increased supply can cause the stock price to fall, similar to a timed release that suddenly opens a valve.
Registration Rights Agreement financial
"the Company entered into a Registration Rights Agreement (the "Registration Rights Agreement") with Cullgen and certain holders"
A registration rights agreement is a contract that gives investors the option to have their ownership stakes officially registered with the government, making it easier to sell their shares later. This agreement matters because it provides investors with a clearer path to cash out their investments if they choose, offering more liquidity and confidence in their ability to sell their holdings when desired.
Fundamental Transaction financial
"the Company will not, without the affirmative vote of the holders ... consummate a Fundamental Transaction (as defined in the Certificate of Designation)"
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403783103

(CUSIP Number)
Ying Luo, Ph.D.
Nihonbashi-Honcho YS Bldg. 3rd Floor, 2-2-2 Nihonbashi-Honcho, Chuo-ku
Tokyo, M0, 103-0023
81-3-6214-3600

(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)
05/04/2026

(Date of Event Which Requires Filing of This Statement)


If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box.

The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).




schemaVersion:


SCHEDULE 13D




Comment for Type of Reporting Person:
Consists of (i) 72,773,219 shares of common stock, par value $0.001 per share ("Company Common Stock"), of Gyre Therapeutics, Inc., a Delaware corporation (the "Company" or "Gyre"), held by GNI USA, Inc., a Delaware corporation ("GNI USA"), (ii) 540,666 shares of Company Common Stock issuable upon conversion of 811 shares of Series X Convertible Preferred Stock, par value $0.001 per share ("Series X Preferred Stock"), underlying warrants held by GNI USA, (iii) 10,718,530 shares of Company Common Stock issuable upon the conversion of 2,143,706 shares of Series B Preferred Stock, par value $0.001 per share ("Series B Preferred Stock"), held by GNI USA and (iv) 2,290,600 shares of Company Common Stock issuable upon the conversion of 458,120 shares of Series B Preferred Stock held by GNI Group Ltd., a company incorporated under the laws of Japan with limited liability ("GNI Japan" and, together with GNI USA, the "Reporting Persons"). All percentage calculations herein are based on 124,994,324 shares of Company Common Stock, consisting of (i) 96,994,001 shares of Company Common Stock outstanding as of April 16, 2026, as disclosed in the Issuer's Definitive Proxy Statement on DEF 14A filed with the U.S. Securities and Exchange Commission (the "SEC") on April 27, 2026 (the "Proxy Statement"), (ii) 14,450,527 shares of Company Common Stock issued in the Merger (as defined below), (iii) 540,666 shares of Company Common Stock issuable upon conversion of 811 shares of Series X Preferred Stock underlying warrants held by GNI USA, (iv) 10,718,530 shares of Company Common Stock issuable upon the conversion of 2,143,706 shares of Series B Preferred Stock held by GNI USA and (v) 2,290,600 shares of Company Common Stock issuable upon the conversion of 458,120 shares of Series B Preferred Stock held by GNI Japan.


SCHEDULE 13D




Comment for Type of Reporting Person:
Consists of (i) 72,773,219 shares of Company Common Stock held by GNI USA, (ii) 540,666 shares of Company Common Stock issuable upon conversion of 811 shares of Series X Preferred Stock underlying warrants held by GNI USA, (iii) 10,718,530 shares of Company Common Stock issuable upon the conversion of 2,143,706 shares of Series B Preferred Stock held by GNI USA and (iv) 2,290,600 shares of Company Common Stock issuable upon the conversion of 458,120 shares of Series B Preferred Stock held by GNI Japan. All percentage calculations herein are based on 124,994,324 shares of Company Common Stock, consisting of (i) 96,994,001 shares of Company Common Stock outstanding as of April 16, 2026, as disclosed in the Proxy Statement, (ii) 14,450,527 shares of Company Common Stock issued in the Merger, (iii) 540,666 shares of Company Common Stock issuable upon conversion of 811 shares of Series X Preferred Stock underlying warrants held by GNI USA, (iv) 10,718,530 shares of Company Common Stock issuable upon the conversion of 2,143,706 shares of Series B Preferred Stock held by GNI USA and (v) 2,290,600 shares of Company Common Stock issuable upon the conversion of 458,120 shares of Series B Preferred Stock held by GNI Japan.


SCHEDULE 13D


GNI USA, Inc.
Signature:/s/ Thomas Eastling
Name/Title:Thomas Eastling, Attorney-in-fact
Date:05/06/2026
GNI Group Ltd.
Signature:/s/ Thomas Eastling
Name/Title:Thomas Eastling, Attorney-in-fact
Date:05/06/2026

FAQ

How much of Gyre Therapeutics (GYRE) do GNI USA and GNI Group now own?

GNI USA and GNI Group together report beneficial ownership of 86,323,015 shares of Gyre Therapeutics common stock, representing 69.1% of the class on an as-converted basis. This includes issued common shares plus stock underlying Series X and Series B preferred shares.

What deal led to the updated ownership disclosure for Gyre Therapeutics (GYRE)?

The disclosure follows Gyre’s completion of an all-stock acquisition of Cullgen Inc. on May 4, 2026. The transaction valued Cullgen at approximately $300 million, with Cullgen shareholders receiving Gyre common stock and Series B Preferred Stock instead of cash.

How does Gyre Therapeutics’ Series B Preferred Stock work after the Cullgen merger?

Each share of Series B Preferred Stock is convertible into five shares of Gyre common stock after stockholders approve a Conversion Proposal. The stock carries dividends and voting rights aligned with common stock, with important protective voting rights for Series B holders until conversion is approved.

What is the Conversion Proposal mentioned for Gyre Therapeutics (GYRE)?

The Conversion Proposal seeks stockholder approval to allow conversion of Series B Preferred Stock into common stock under Nasdaq rules. Before approval, Gyre cannot issue more than 19.99% of its pre-approval common stock or voting power in connection with these conversions.

Are Cullgen and Gyre insiders restricted from selling Gyre Therapeutics (GYRE) shares?

Yes. Certain executive officers, directors and stockholders entered lock-up agreements. Subject to exceptions, one-third of their Gyre shares are restricted for 180 days, another third for 12 months, and the final third for 18 months after the May 4, 2026 merger closing.

What registration rights were granted to Cullgen holders in the Gyre Therapeutics merger?

Gyre agreed in a Registration Rights Agreement to file a resale registration statement for Cullgen holders’ Gyre common shares, including shares issuable from Series B conversions, within 45 days after closing. It will seek effectiveness within 90 business days, or 120 days if subject to full SEC review.