Record 2025 revenue as Halozyme (NASDAQ: HALO) reiterates strong 2026 outlook

Rhea-AI Filing Summary

Halozyme Therapeutics reported another year of strong top-line growth in 2025, with total revenue of $1.3966 billion, up 38% from 2024. Royalty revenue rose 52% to a record $867.8 million, driven mainly by ENHANZE-enabled products such as VYVGART Hytrulo, DARZALEX SC and Phesgo.

Despite this, full-year net income declined to $316.9 million from $444.1 million, as results absorbed $284.9 million of acquired in-process R&D expense tied to the Surf Bio acquisition and higher operating costs. The company posted a fourth-quarter net loss of $141.6 million after these charges.

Halozyme expanded its drug-delivery portfolio by acquiring Elektrofi and Surf Bio and completed $1.5 billion of new convertible notes while increasing its revolving credit facility to $750 million. For 2026, it reiterates guidance for total revenue of $1.710–$1.810 billion, adjusted EBITDA of $1.125–$1.205 billion and non-GAAP diluted EPS of $7.75–$8.25, all implying robust double-digit growth over 2025.

Positive

• Record 2025 revenue with strong royalty growth – Total revenue reached $1.3966 billion, up 38% year over year, while royalty revenue grew 52% to a record $867.8 million, underscoring the strength of Halozyme’s ENHANZE-based partnership model.
• Ambitious 2026 growth guidance – The company reiterates 2026 guidance for total revenue of $1.710–$1.810 billion, adjusted EBITDA of $1.125–$1.205 billion and non-GAAP diluted EPS of $7.75–$8.25, all implying robust double-digit increases over 2025.
• Strategic expansion of drug-delivery portfolio – Acquisitions of Elektrofi and Surf Bio add Hypercon and hyperconcentration technologies, which management states can expand and extend royalty opportunities and have already led to additional licensing relationships.

Negative

• GAAP profitability pressured by acquisition-related charges – Full-year net income declined to $316.9 million from $444.1 million, and Q4 showed a $141.6 million net loss, both heavily impacted by $284.9 million of acquired in-process R&D expense and other one-time costs.
• Higher leverage and lower liquidity – Long-term debt increased to $2.1426 billion from $1.5058 billion after issuing 2031 and 2032 convertible notes, while cash, cash equivalents, restricted cash and marketable securities fell to $145.4 million from $596.1 million.

Insights

Biopharma earnings analyst

Record 2025 revenue, portfolio expansion and aggressive 2026 guidance signal a broadly positive setup.

Halozyme delivered total 2025 revenue of $1.3966 billion, up 38%, with royalties up 52% to $867.8 million. Growth is concentrated in ENHANZE-enabled blockbusters and supported by new collaboration deals with Takeda, Merus, Skye Bioscience and Viatris.

Profitability optics are weaker: GAAP net income fell to $316.9 million from $444.1 million, and Q4 showed a net loss of $141.6 million, largely due to $284.9 million of acquired IPR&D from the Surf Bio acquisition plus higher SG&A and an intangible impairment. Cash and securities dropped to $145.4 million while long-term debt climbed to $2.1426 billion after issuing 2031 and 2032 convertible notes.

Management reiterates an ambitious 2026 outlook: total revenue of $1.710–$1.810 billion (22–30% growth), royalty revenue of $1.130–$1.170 billion (30–35% growth), adjusted EBITDA of $1.125–$1.205 billion (71–83% growth) and non-GAAP diluted EPS of $7.75–$8.25 (87–99% growth). These targets lean on continued ENHANZE uptake, new ENHANZE and Hypercon program starts, and integration of Elektrofi and Surf Bio investments.

FALSE000115903600011590362026-02-172026-02-17

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

____________________________________________

FORM 8-K

_____________________________________________

CURRENT REPORT

Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934

Date of Report (Date of Earliest Event Reported): February 17, 2026

HALOZYME THERAPEUTICS, INC.

(Exact name of registrant as specified in its charter)

________________________

Commission File Number 001-32335

Delaware						88-0488686
(State or other jurisdiction of incorporation)						(I.R.S. Employer Identification No.)
12390 El Camino Real						92130
San Diego						(Zip Code)
California
(Address of principal executive offices)

(858) 794-8889

(Registrant’s telephone number, including area code)

Not Applicable

(Former name or former address, if changed since last report)

________________________

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐  Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐  Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐  Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

Title of each class

Trading Symbol(s)

Name of each exchange on which registered

Common Stock, $0.001 par value

HALO

The Nasdaq Stock Market LLC

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).         

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 2.02 Results of Operations and Financial Condition.

On February 17, 2026, Halozyme Therapeutics, Inc. issued a press release to report its financial results for the fourth quarter ended December 31, 2025. A copy of the press release is attached as Exhibit 99.1, which is furnished under Item 2.02 of this report and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, (the “Exchange Act”) or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, regardless of any general incorporation language in such filing.

Item 9.01 Financial Statements and Exhibits.

Exhibit No.			Description
99.1			Press release dated February 17, 2026
104			Cover Page Interactive Data File (formatted as inline XBRL and contained in Exhibit 101)

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Halozyme Therapeutics, Inc (Registrant)

Dated:

February 17, 2026

By:

/s/ Nicole LaBrosse

Nicole LaBrosse

Senior Vice President, Chief Financial Officer

Exhibit 99.1

HALOZYME REPORTS FULL YEAR 2025 RECORD REVENUE OF $1.4 BILLION AND REITERATES STRONG 2026 FINANCIAL GUIDANCE

Full Year 2025 Total Revenue Increased 38% YOY to Record $1.397 billion

Full Year 2025 Royalty Revenue Increased 52% YOY to Record $868 million

Completed Acquisitions of Elektrofi’s Hypercon™ Technology and

Surf Bio’s Hyperconcentration Technology

Reiterating 2026 Financial Guidance Ranges:

Total Revenue of $1.710 - $1.810 billion, YOY Growth of 22% - 30%

Adjusted EBITDA of $1.125 - $1.205 billion, YOY Growth of 71% - 83%1

Non-GAAP Diluted EPS of $7.75 - $8.25, YOY Growth of 87% - 99%1

SAN DIEGO, February 17, 2026 -- Halozyme Therapeutics, Inc. (NASDAQ: HALO) (“Halozyme” or the “Company”) today reported its financial and operating results for the full year and fourth quarter ended December 31, 2025, and provided an update on its recent corporate activities.

“2025 was a pivotal year for Halozyme as we delivered record total revenue of $1.4 billion, which was the result of continued growth in our ENHANZE business. In addition, we expanded our drug delivery technology portfolio with two acquisitions. Three ENHANZE‑enabled blockbusters, DARZALEX SC, Phesgo and VYVGART Hytrulo, drove royalty revenue growth of 52%, reaching a record $868 million in 2025. In the year, we also expanded our ENHANZE opportunities, adding three new collaboration and licensing agreements with Takeda, Merus and Skye Bioscience and gained one new target nomination from Roche. Furthermore, Janssen expanded the global reach of ENHANZE with approvals in the U.S., China and Japan for Rybrevant SC and new indication approvals in front line settings for DARZALEX Faspro. In parallel, we broadened our drug delivery portfolio with the acquisitions of the Hypercon technology and Surf Bio’s hyperconcentration technology, which meaningfully expand, diversify and extend our long‑term royalty opportunity into the mid-2040s,” said Dr. Helen Torley, President and Chief Executive Officer.

Dr. Torley continued, “As we look ahead, our long-term outlook reflects the strong momentum and opportunity we have built through a broader drug delivery portfolio and offering to the biopharma industry. With royalty revenue projected to exceed $1 billion in 2026 and a clear line of sight to more than $2 billion in total revenue by 2028, Halozyme is entering its next phase of growth with strong conviction. Our projected 22% to 30% total revenue growth in 2026, combined with an expanding development pipeline with six projected new ENHANZE and two Hypercon development program starts, plus plans to sign three or more ENHANZE and Hypercon partnerships in 2026, all reinforce the durability of our revenue. With our strong cash generation and a diversified set of high‑value royalty drivers, we remain focused on delivering sustained long‑term value for shareholders.”

Fourth Quarter and Recent Corporate Highlights:

•In December 2025, Halozyme completed the acquisition of Surf Bio, Inc. (“Surf Bio”), subsequently renamed Halozyme Surf Bio, Inc., resulting in an expansion of Halozyme’s drug delivery technology portfolio and the potential for future growth through new collaboration agreements.

•In December 2025, Halozyme announced that a German court had granted Halozyme’s request for a preliminary injunction ordering Merck Sharp & Dohme Corp. (“Merck”) to refrain from distributing and offering Keytruda® SC in Germany.

•In November 2025, Halozyme completed the acquisition of Elektrofi Inc. (“Elektrofi”), subsequently renamed Halozyme Hypercon, Inc., resulting in an expansion of Halozyme’s drug delivery technology portfolio and the potential for future growth through new collaboration agreements.

•In November 2025, Halozyme completed the sale of $750.0 million aggregate principal amount of the 2031 Convertible Notes and $750.0 million aggregate principal amount of the 2032 Convertible Notes. The Company used a portion of the net proceeds to fund the cost of entering into the 2031 Capped Call Transactions and the 2032 Capped Call Transactions. The Company also used a portion of the net proceeds to enter into privately negotiated agreements with certain holders of its outstanding 2027 Convertible Notes and 2028 Convertible Notes to repurchase their 2027 Convertible Notes and 2028 Convertible Notes for cash through privately negotiated transactions entered into concurrently with or shortly after the offering.

•In November 2025, Halozyme entered into an amendment to the Company’s credit agreement that, among other things extended the maturity date and increased the borrowing capacity of the Company’s existing revolving credit facility from $575.0 million to $750.0 million.

Fourth Quarter and Recent Partner Highlights:

•In January 2026, Janssen announced the U.S. Food and Drug Administration (“FDA”) approved DARZALEX FASPRO® (daratumumab and hyaluronidase-fihj) in combination with bortezomib, lenalidomide and dexamethasone (“D-VRd”) for the treatment of adult patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplant.

•In December 2025, Halozyme and Skye Bioscience entered into a non-exclusive global collaboration and license agreement that provides Skye Bioscience access to ENHANZE® for the development and potential commercialization of an SC formulation of nimacimab for the treatment of obesity.

•In December 2025, Halozyme and Takeda entered into a new global collaboration and exclusive license agreement which provides Takeda with access to ENHANZE® for use with vedolizumab, marketed globally as ENTYVIO®, for the treatment of adults with moderately to severely active Crohns’ disease or ulcerative colitis, which are the two main forms of inflammatory bowel disease.

•In December 2025, Roche nominated a new undisclosed non-exclusive target to be studied using ENHANZE®.

•In the fourth quarter of 2025, the ongoing argenx ARGX-121 Phase 1 program was expanded to include an SC-arm evaluating ARGX-121 with ENHANZE® in healthy adults.

•In December 2025, Janssen announced the FDA approved RYBREVANT FASPRO™ (amivantamab and hyaluronidase-lpuj) for the treatment of patients with epidermal growth factor receptor (“EGFR”)-mutated locally advanced or metastatic non-small cell lung cancer (“NSCLC”).

•In December 2025, Janssen received approval from the National Medical Products Administration in China for RYBREVANT™ FASPRO for the first-line treatment of adult patients with advanced NSCLC.

•In December 2025, Janssen received approval from the Ministry of Health, Labour and Welfare in Japan for RYBROFAZ® (amivantamab) with ENHANZE® for the first-line treatment of adult patients with advanced NSCLC.

•In December 2025, Halozyme entered into a commercial license and supply agreement with Viatris under which Halozyme licenses and supplies an auto-injector product for self-administered SC selatogrel for the treatment of acute myocardial infarction in adult patients.

•In November 2025, Janssen announced the FDA approved DARZALEX FASPRO® (daratumumab and hyaluronidase-fihj) co-formulated with ENHANZE®, as single treatment of adult patients with high-risk smoldering multiple myeloma.

•In November 2025, Halozyme and Merus entered into a non-exclusive global collaboration and license agreement that provides Merus access to ENHANZE® technology for a single target. Merus intends to explore development and potential commercialization of SC administration of petosemtamab, an EGFR and leucine-rich repeat-containing G-protein coupled receptor 5 bispecific antibody, for the treatment of head and neck cancer.

Full Year and Fourth Quarter 2025 Financial Highlights:

•Total revenue for the full year was $1,396.6 million, compared to $1,015.3 million in 2024. The 38% year-over-year increase was primarily driven by royalty revenue growth and an increase in product sales. Revenue included $867.8 million in royalties, an increase of 52% compared to $571.0 million in 2024, primarily driven by continued sales uptake of ENHANZE® partner products that have launched since 2020, predominantly by VYVGART® Hytrulo by argenx, DARZALEX® SC by Janssen and Phesgo® by Roche in all geographies.

•Cost of sales for the full year was $228.8 million, compared to $159.4 million in 2024. The increase in cost of sales was primarily due to an increase in product sales and labor allocation initiatives.

•Amortization of intangibles expense for the full year was $76.7 million, compared to $71.0 million in 2024. The increase in amortization of intangibles expense was due to the acquisition of Elektrofi in November 2025.

•Research and development expense for the full year was $81.5 million, compared to $79.0 million in 2024. The increase was primarily due to the acquisition of Elektrofi and Surf Bio, partially offset by lower compensation expense driven by resource optimization, labor allocation initiatives, and timing of planned investments in ENHANZE® related to the development of our new high-yield rHuPH20 manufacturing process.

•Selling, general and administrative expense for the full year was $207.1 million, compared to $154.3 million in 2024. The increase was primarily due to an increase in consulting and professional service fees, including litigation costs incurred in connection with a patent infringement litigation case, diligence and transaction-related costs incurred in support of the acquisition of Elektrofi and Surf Bio, and an increase in compensation expense.

•Net income for the full year was $316.9 million, compared to $444.1 million in 2024. Net income included acquired in-process research and development (“IPR&D”) expense of $284.9 million related to the Surf Bio acquisition in the fourth quarter of 2025.

•Adjusted EBITDA for the full year was $657.6 million, compared to $632.2 million in 2024.1,2

Adjusted EBITDA included acquired IPR&D expense of $284.9 million related to the Surf Bio acquisition in the fourth quarter of 2025.

•GAAP diluted earnings per share for the full year was $2.56, compared to $3.43 in 2024. Non-GAAP diluted earnings per share was $4.15, compared to $4.23 in 2024.1,2

GAAP and non-GAAP diluted earnings per share included an unfavorable impact of approximately $2.30 per share related to acquired IPR&D expense for the Surf Bio acquisition in the fourth quarter of 2025.

•Total revenue in the fourth quarter was $451.8 million, compared to $298.0 million in the fourth quarter of 2024. The 52% year-over-year increase was primarily driven by royalty revenue growth and an increase in product sales. Revenue included $258.0 million in royalties, an increase of 51% compared to $170.4 million in the fourth quarter of 2024, primarily driven by continued sales uptake of ENHANZE® partner products that have launched since 2020, predominantly by VYVGART® Hytrulo by argenx, DARZALEX® SC by Janssen and Phesgo® by Roche in all geographies.

•Net loss in the fourth quarter was $141.6 million, compared to net income of $137.0 million in the fourth quarter of 2024. Net loss included acquired IPR&D expense of $284.9 million related to the Surf Bio acquisition in the fourth quarter of 2025.

•Adjusted EBITDA in the fourth quarter was $21.9 million, compared to $195.8 million in the fourth quarter of 2024.1,2

Adjusted EBITDA included acquired IPR&D expense of $284.9 million related to the Surf Bio acquisition in the fourth quarter of 2025.

•GAAP diluted loss per share in the fourth quarter was $1.20, compared to GAAP diluted earnings per share $1.06 in the fourth quarter of 2024. Non-GAAP diluted loss per share was $0.24, compared to Non-GAAP diluted earnings per share of $1.26 in the fourth quarter of 2024.1,2

GAAP and non-GAAP diluted loss per share in the fourth quarter of 2025 included an unfavorable impact of $2.42 per share related to acquired IPR&D expense for the Surf Bio acquisition in the fourth quarter of 2025.

•Cash, cash equivalents, restricted cash and marketable securities were $145.4 million on December 31, 2025, compared to $596.1 million on December 31, 2024. The decrease was primarily driven by cash used for the Elektrofi and Surf Bio acquisitions and share repurchases, partially offset by the net proceeds from issuance of convertible notes and cash generated from operations.

Financial Outlook for 2026

The Company is reiterating its 2026 financial guidance ranges, which were last updated on January 28, 2026.

For the full year 2026, the Company expects:

•Total revenue of $1.710 billion to $1.810 billion, representing growth of 22% to 30% over 2025 total revenue, primarily driven by increases in royalty revenue and product sales from API.

•Revenue from royalties of $1.130 billion to $1.170 billion, representing growth of 30% to 35% over 2025.

•Adjusted EBITDA of $1.125 billion to $1.205 billion, representing growth of 71% to 83% over 2025, including new Hypercon™ and Surf Bio investment of approximately $60 million.

•Non-GAAP diluted earnings per share of $7.75 to $8.25, representing growth of 87% to 99% over 2025. The Company’s earnings per share guidance includes new Hypercon™ and Surf Bio investment of approximately $60 million and does not consider the impact of potential future share repurchases.

Table 1. 2026 Financial Guidance

Guidance Range

Total Revenue

$1.710 to $1.810 billion

Royalty Revenue

$1.130 to $1.170 billion

Adjusted EBITDA1

$1.125 to $1.205 billion

Non-GAAP Diluted EPS1

$7.75 to $8.25

1    EBITDA, Adjusted EBITDA and Non-GAAP Diluted EPS are Non-GAAP financial measures. See “Note Regarding Use of Non-GAAP Financial Measures” below for an explanation of these measures. Reconciliations between GAAP reported and Non-GAAP financial information for actual results are provided at the end of this earnings release.

2    In alignment with SEC guidance around non-GAAP financial measures relating to acquired IPR&D expense, we have not excluded expenses related to acquired IPR&D from our non-GAAP results.

Webcast and Conference Call

Halozyme will host its Quarterly Update Conference Call for the fourth quarter and full year ended December 31, 2025 today, Tuesday, February 17, 2026, at 1:30 p.m. PT/4:30 p.m. ET. The conference call may be accessed live with pre-registration via link: https://events.q4inc.com/analyst/624893800?pwd=q3lpEa6F. The call will also be webcast live through the “Investors” section of Halozyme’s corporate website and a recording will be made available following the close of the call. To access the webcast and additional documents related to the call, please visit Halozyme.com.

About Halozyme

Halozyme is a biopharmaceutical company advancing disruptive solutions to improve patient experiences and outcomes for emerging and established therapies. As the innovators of ENHANZE® drug delivery technology with the proprietary enzyme rHuPH20, Halozyme’s commercially-validated solution facilitates the subcutaneous delivery of injected drugs and fluids, reducing treatment burden and improving convenience. ENHANZE® has touched more than one million patient lives through ten commercialized products across over 100 global markets and is licensed to leading pharmaceutical and biotechnology companies including Roche, Takeda, Pfizer, Janssen, AbbVie, Eli Lilly, Bristol-Myers Squibb, argenx, ViiV Healthcare, Chugai Pharmaceutical, Acumen Pharmaceuticals, Merus N.V. and Skye Bioscience.

Halozyme expanded its drug delivery technology portfolio to develop partner products using Hypercon™ and the Surf Bio hyperconcentration technology. Hypercon™ is an innovative microparticle technology expected to set a new standard in hyperconcentration of drugs and biologics by reducing injection volume for the same dosage and enabling administration in at-home and healthcare-provider settings. The development of the Surf Bio polymer-based hyperconcentration technology further broadens the range of biologics that can be delivered subcutaneously, meaningfully expanding the scope of opportunities across therapeutic modalities. The Hypercon™ technology has been licensed to leading biopharmaceutical partners, including Janssen, Eli Lilly and argenx.

Halozyme also develops, manufactures and commercializes drug-device combination products using advanced auto-injector technologies designed to improve convenience, reliability and tolerability, enhancing patient comfort and adherence. The Company has two proprietary commercial products, Hylenex® and XYOSTED®, partnered commercial products and ongoing development programs with Teva Pharmaceuticals and McDermott Laboratories Limited, an affiliate of Viatris Inc.

Halozyme is headquartered in San Diego, CA, with offices in Ewing, NJ; Minnetonka, MN; and Boston, MA. Minnetonka is also the site of its operations facility.

For more information, visit www.halozyme.com and connect with us on LinkedIn.

Note Regarding Use of Non-GAAP Financial Measures

In addition to disclosing financial measures prepared in accordance with U.S. generally accepted accounting principles (“GAAP”), this press release and the accompanying tables contain certain Non-GAAP financial measures. The Company reports earnings before interest, taxes, depreciation, and

amortization (“EBITDA”), adjusted EBITDA, Non-GAAP diluted earnings per share, Non-GAAP diluted shares, and guidance with respect to those measures, in addition to, and not as a substitute for, or superior to, financial measures calculated in accordance with GAAP. The Company calculates Non-GAAP diluted earnings per share excluding share-based compensation expense, amortization of debt discounts, intangible asset amortization, one-time items, if any, such as changes in contingent liabilities, inventory adjustments, impairment charges, transaction costs for business combinations, severance and share-based compensation acceleration expenses, intellectual property litigation costs, inducement expenses related to convertible notes, and certain adjustments to income tax expense. The Company calculates Non-GAAP diluted shares excluding the dilutive impact of convertible notes which is used in calculating Non-GAAP diluted earnings. The Company calculates EBITDA excluding interest, taxes, depreciation and amortization. The Company calculates adjusted EBITDA excluding one-time items, if any, such as changes in contingent liabilities, inventory adjustments, impairment charges, transaction costs for business combinations, severance and share-based compensation acceleration expenses and intellectual property litigation costs. Reconciliations between GAAP and Non-GAAP financial measures are included at the end of this press release. The Company does not provide reconciliations of forward-looking adjusted measures to GAAP due to the inherent difficulty in forecasting and quantifying certain amounts that are necessary for such reconciliation, including adjustments that could be made for changes in share-based compensation expense and the effects of any discrete income tax items. For the same reasons, the Company is unable to address the probable significance of the unavailable information. The Company provides Non-GAAP financial measures that it believes will be achieved; however, it cannot accurately predict all of the components of the adjusted calculations and the GAAP measures may be materially different than the Non-GAAP measures.

The Company evaluates other items of income and expense on an individual basis for potential inclusion in the calculation of Non-GAAP financial measures and considers both the quantitative and qualitative aspects of the item, including (i) its size and nature, (ii) whether or not it relates to the Company’s ongoing business operations and (iii) whether or not the Company expects it to occur as part of the Company’s normal business on a regular basis. Non-GAAP financial measures do not have any standardized meaning and are therefore unlikely to be comparable to similarly titled measures presented by other companies. These Non-GAAP financial measures are not meant to be considered in isolation and should be read in conjunction with the Company’s consolidated financial statements prepared in accordance with GAAP, and are not prepared under any comprehensive set of accounting rules or principles. In addition, from time to time in the future there may be other items that the Company may exclude for purposes of its Non-GAAP financial measures, and the Company may in the future cease to exclude items that it has historically excluded for purposes of its Non-GAAP financial measures.

The Company considers these Non-GAAP financial measures to be important because they provide useful measures of the operating performance of the Company, exclusive of factors that do not directly affect what the Company considers to be its core operating performance, as well as unusual events. The Non-GAAP measures also allow investors and analysts to make additional comparisons of the operating activities of the Company’s core business over time and with respect to other companies, as well as assessing trends and future expectations. The Company uses Non-GAAP financial information in assessing what it believes is a meaningful and comparable set of financial performance measures to evaluate operating trends, as well as in establishing portions of our performance-based incentive compensation programs.

Safe Harbor Statement

In addition to historical information, the statements set forth in this press release include forward-looking statements including, without limitation, statements concerning the Company’s financial performance (including the Company’s expected financial outlook for 2026) and expectations for future growth, profitability, revenue durability, total revenue, royalty revenue, royalty revenue duration, EBITDA, Adjusted EBITDA, and non-GAAP diluted earnings-per-share, and shareholder value. Forward-looking statements also include future plans, objectives, expectations and intentions related to the acquisitions of Elektrofi and Surf Bio, such acquisitions’ expected impact and contributions to the Company’s and combined group’s operations and financial results (including potential development

and commercialization of partnered products and timing related to these events), as well as the expected benefits of the acquisitions. Forward-looking statements related to Elektrofi’s and Surf Bio’s intellectual property include expectations for length of patent terms and patent expirations and the expected impact such patents may have on the duration, durability and amounts of future royalty payments the Company may receive from licensing such intellectual property. Forward-looking statements regarding the Company’s ENHANZE® drug delivery technology may include the possible benefits and attributes of ENHANZE®, its potential application to aid in the dispersion and absorption of other injected therapeutic drugs and facilitating more rapid delivery and administration of higher volumes of injectable medications through subcutaneous delivery. Forward-looking statements regarding the Company’s business may include potential growth and receipt of royalty and milestone payments driven by our partners’ development and commercialization efforts, potential new clinical trial study starts and advancement of partnered development programs, regulatory submissions and product launches, the size and growth prospects of our partners’ drug franchises, potential new or expanded collaborations and collaborative targets, and potential approvals of new partnered or proprietary products, and the potential timing of these events. These forward-looking statements are typically, but not always, identified through use of the words “expect,” “believe,” “enable,” “may,” “will,” “could,” “intends,” “estimate,” “anticipate,” “plan,” “predict,” “probable,” “potential,” “preliminary,” “possible,” “should,” “continue,” and other words of similar meaning and involve risk and uncertainties that could cause actual results to differ materially from those in the forward-looking statements. Actual results could differ materially from the expectations contained in these forward-looking statements as a result of several factors, including uncertainties concerning future matters such as market conditions, changes in domestic and foreign business, changes in the competitive environment in which the Company operates, the expected benefits of its acquisitions of Elektrofi and Surf Bio, unexpected early expiration or termination of the patent terms for the Company’s drug delivery technologies, unexpected levels of revenues, expenditures and costs, unexpected results or delays in the growth of the Company’s business, or in the development, regulatory review or commercialization of the Company’s partnered or proprietary products, regulatory approval requirements, unexpected adverse events or patient outcomes and competitive conditions. These and other factors that may result in differences are discussed in greater detail in the Company’s most recent Annual Report on Form 10-K filed with the Securities and Exchange Commission, including under the headings “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations”. Except as required by law, the Company undertakes no duty to update forward-looking statements to reflect events after the date of this release.

Contacts:

Tram Bui

VP, Investor Relations and Corporate Communications

609-333-7668

tbui@halozyme.com

Sydney Charlton

Teneo

917-972-8407

sydney.charlton@teneo.com

Halozyme Therapeutics, Inc.

Consolidated Statements of Operations

(Unaudited)

(In thousands, except per share amounts)

						Three Months Ended												Twelve Months Ended
						December 31,												December 31,
						2025						2024						2025						2024
Revenues
Royalties						$	257,971					$	170,419					$	867,840					$	570,991
Product sales, net						122,665						79,364						376,444						303,492
Revenues under collaborative agreements						71,131						48,225						152,327						140,841
Total revenues						451,767						298,008						1,396,611						1,015,324
Operating expenses
Cost of sales						78,770						42,055						228,774						159,417
Amortization of intangibles						23,376						17,762						76,662						71,049
Research and development						31,897						20,441						81,490						79,048
Selling, general and administrative						77,028						42,249						207,092						154,335
Impairment of intangible asset						48,700						—						48,700						—
Acquired in-process research and development expense						284,887						—						284,887						—
Total operating expenses						544,658						122,507						927,605						463,849
Operating (loss) income						(92,891)						175,501						469,006						551,475
Other income (expense)
Investment and other income, net						2,430						7,253						21,472						23,752
Inducement expense related to convertible notes						(5,477)						—						(5,477)						—
Contingent liability fair value measurement gain						—						—						—						—
Interest expense						(4,911)						(4,540)						(18,126)						(18,095)
(Loss) income before income tax expense						(100,849)						178,214						466,875						557,132
Income tax expense						40,742						41,202						149,986						113,041
Net (loss) income						$	(141,591)					$	137,012					$	316,889					$	444,091
(Loss) earnings per share
Basic						$	(1.20)					$	1.08					$	2.64					$	3.50
Diluted						$	(1.20)					$	1.06					$	2.56					$	3.43
Weighted average common shares outstanding
Basic						117,672						126,406						119,840						126,827
Diluted						117,672						128,980						123,904						129,424

Halozyme Therapeutics, Inc.

Consolidated Balance Sheets

(Unaudited)

(In thousands)

						December 31, 2025						December 31, 2024
ASSETS
Current assets
Cash and cash equivalents						$	133,820					$	115,850
Marketable securities, available-for-sale						9,000						480,224
Accounts receivable, net and contract assets						441,273						308,455
Inventories						176,475						141,860
Prepaid expenses and other current assets						64,639						38,951
Total current assets						825,207						1,085,340
Property and equipment, net						82,137						75,035
Prepaid expenses and other assets						53,551						80,596
Goodwill						580,360						416,821
Intangible assets, net						981,467						401,830
Deferred tax assets, net						—						3,855
Restricted cash						2,601						—
Total assets						$	2,525,323					$	2,063,477
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities
Accounts payable						$	20,899					$	10,249
Accrued expenses						156,193						128,851
Total current liabilities						177,092						139,100
Long-term debt, net						2,142,630						1,505,798
Other long-term liabilities						113,863						54,758
Deferred tax liabilities, net						42,924						—
Total liabilities						2,476,509						1,699,656
Stockholders’ equity
Common stock						118						123
Additional paid-in capital						12,002						—
Accumulated other comprehensive (loss) income						(18,092)						3,829
Retained earnings						54,786						359,869
Total stockholders’ equity						48,814						363,821
Total liabilities and stockholders’ equity						$	2,525,323					$	2,063,477

Halozyme Therapeutics, Inc.

GAAP to Non-GAAP Reconciliations

EBITDA

(Unaudited)

(In thousands)

						Three Months Ended												Twelve Months Ended
						December 31,												December 31,
						2025						2024						2025						2024
GAAP Net (Loss) Income						$	(141,591)					$	137,012					$	316,889					$	444,091
Adjustments
Investment and other income, net						(2,430)						(7,320)						(21,474)						(24,356)
Interest expense						4,911						4,540						18,126						18,095
Income tax expense						40,742						41,202						149,986						113,041
Depreciation and amortization						26,680						20,415						88,051						81,312
EBITDA						(71,688)						195,849						551,578						632,183
Adjustments
Transaction costs for business combinations(1)						10,733						—						14,604						—
Intellectual property litigation costs(2)						8,084						—						16,683						—
Severance and share-based compensation acceleration expense(3)						24,628						—						24,628						—
Impairment of intangible asset						48,700						—						48,700						—
Other one time items						1,447						—						1,447						—
Adjusted EBITDA						$	21,904					$	195,849					$	657,640					$	632,183

(1)Amount represents incremental costs including legal and advisory fees incurred in association with the acquisition of Elektrofi, Inc. (“Elektrofi”).

(2)Adjustment relates to litigation costs incurred by Halozyme in connection with Halozyme’s patent infringement litigation against Merck Sharp & Dohme Corp. (“Merck”). These charges are excluded because the Company does not believe they are reflective of the Company’s ongoing business and operating results.

(3)Amount represents severance costs and acceleration of unvested equity awards incurred in the Elektrofi acquisition.

Halozyme Therapeutics, Inc.

GAAP to Non-GAAP Reconciliations

Net Income and Diluted EPS

(Unaudited)

(In thousands, except per share amounts)

						Three Months Ended												Twelve Months Ended
						December 31,												December 31,
						2025						2024						2025						2024
GAAP Net (Loss) Income						$	(141,591)					$	137,012					$	316,889					$	444,091
Adjustments
Inducement expense related to convertible notes						5,477						—						5,477						—
Share-based compensation						16,571						11,462						51,565						43,385
Amortization of debt discount						1,951						1,845						7,506						7,350
Amortization of intangible assets						23,376						17,762						76,662						71,049
Transaction costs for business combinations(1)						10,733						—						14,604						—
Intellectual property litigation costs(2)						8,084						—						16,683						—
Severance and share-based compensation acceleration expense(3)						24,628						—						24,628						—
Impairment of intangible asset						48,700						—						48,700						—
Other one time items						1,447						—						1,447						—
Income tax effect of above adjustments(4)						(27,473)						(5,169)						(54,624)						(18,577)
Non-GAAP Net (Loss) Income						$	(28,097)					$	162,912					$	509,537					$	547,298
GAAP Diluted (LPS) EPS						$	(1.20)					$	1.06					$	2.56					$	3.43
Adjustments
Inducement expense related to convertible notes						0.05						—						0.04						—
Share-based compensation						0.14						0.09						0.42						0.34
Amortization of debt discount						0.02						0.01						0.06						0.06
Amortization of intangible assets						0.20						0.14						0.62						0.55
Transaction costs for business combinations(1)						0.09						—						0.12						—
Intellectual property litigation costs(2)						0.07						—						0.13						—
Severance and share-based compensation acceleration expense(3)						0.21						—						0.20						—
Impairment of intangible asset						0.41						—						0.40						—
Other one time items						0.01						—						0.01						—
Income tax effect of above adjustments(4)						(0.23)						(0.04)						(0.44)						(0.14)
Non-GAAP Diluted (LPS) EPS						$	(0.24)					$	1.26					$	4.15					$	4.23
GAAP Diluted Shares						117,672						128,980						123,904						129,424
Adjustments
Adjustment for dilutive impact of Senior 2028 Convertible Notes(5)						—						—						(1,018)						(74)
Non-GAAP Diluted Shares						117,672						128,980						122,886						129,350

Dollar amounts, as presented, are rounded. Consequently, totals may not add up.

(1)Amount represents incremental costs including legal and advisory fees incurred in association with the Elektrofi acquisition.

(2)Adjustment relates to litigation costs incurred by Halozyme in connection with Halozyme’s patent infringement litigation against Merck. These charges are excluded because the Company does not believe they are reflective of the Company’s ongoing business and operating results.

(3)Amount represents severance cost and acceleration of unvested equity awards incurred in the Elektrofi acquisition.

(4)Adjustments relate to taxes for the reconciling items, as well as excess benefits or tax deficiencies from share-based compensation, and the quarterly impact of other discrete items. Non-GAAP tax rate is impacted by the Acquired IPR&D expense, which is non-tax deductible.

(5)Adjustment made for the dilutive effect of our Convertible Senior Notes due 2028 when the effect is not the same on a GAAP and Non-GAAP basis for the reporting period.

FAQ

How did Halozyme (HALO) perform financially in full-year 2025?

Halozyme delivered strong 2025 growth, with total revenue of $1.3966 billion, up 38% from 2024. Royalty revenue rose 52% to $867.8 million, driven by ENHANZE-enabled products. GAAP net income declined to $316.9 million, mainly due to acquisition-related IPR&D charges and higher operating expenses.

What guidance did Halozyme (HALO) give for its 2026 financial outlook?

For 2026, Halozyme expects total revenue of $1.710–$1.810 billion, representing 22–30% growth over 2025. It guides to royalty revenue of $1.130–$1.170 billion, adjusted EBITDA of $1.125–$1.205 billion, and non-GAAP diluted EPS of $7.75–$8.25, all showing strong projected increases.

Why did Halozyme’s GAAP net income decline in 2025 despite record revenue?

Net income fell to $316.9 million from $444.1 million largely because 2025 results included $284.9 million of acquired in-process R&D expense from the Surf Bio acquisition. Additional increases in SG&A and an intangible impairment further weighed on reported profitability.

What major acquisitions did Halozyme (HALO) complete in 2025 and why are they important?

Halozyme acquired Elektrofi and Surf Bio in 2025, adding Hypercon and polymer-based hyperconcentration technologies to its drug-delivery portfolio. These platforms are intended to enable high-concentration subcutaneous formulations, broadening future royalty opportunities and supporting new or expanded collaborations with large biopharma partners.

How is Halozyme’s balance sheet positioned after its 2025 financing activities?

At December 31, 2025, Halozyme held $145.4 million in cash, cash equivalents, restricted cash and marketable securities, down from $596.1 million a year earlier. Long-term debt rose to $2.1426 billion after issuing 2031 and 2032 convertible notes and amending its revolving credit facility.

What drove Halozyme’s royalty revenue growth in 2025?

Royalty revenue increased 52% to $867.8 million in 2025, primarily from continued sales uptake of ENHANZE partner products launched since 2020. Key contributors included VYVGART Hytrulo by argenx, DARZALEX SC by Janssen and Phesgo by Roche across multiple global markets.

How did Halozyme (HALO) perform in the fourth quarter of 2025?

Fourth-quarter 2025 total revenue was $451.8 million, up 52% from the prior year’s quarter, with royalties of $258.0 million. However, the company reported a net loss of $141.6 million, mainly reflecting $284.9 million of acquired IPR&D expense related to the Surf Bio acquisition.

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