HALOZYME REPORTS FULL YEAR 2025 RECORD REVENUE OF $1.4 BILLION AND REITERATES STRONG 2026 FINANCIAL GUIDANCE

Rhea-AI Summary

Halozyme (NASDAQ: HALO) reported record full‑year 2025 total revenue of $1.397 billion, driven by $867.8 million in royalties (+52% YoY). The company completed acquisitions of Elektrofi (Hypercon) and Surf Bio, issued convertible notes, and reiterated 2026 guidance: $1.71–$1.81B revenue, $1.125–$1.205B adjusted EBITDA, and $7.75–$8.25 non‑GAAP EPS.

Net income was $316.9M (includes $284.9M acquired IPR&D); cash and equivalents declined to $145.4M.

Positive

• Total revenue +38% YoY to $1.397B
• Royalty revenue +52% YoY to $867.8M
• Reiterated 2026 guidance: total revenue $1.71–$1.81B
• Completed acquisitions of Elektrofi (Hypercon) and Surf Bio
• $1.125–$1.205B 2026 adjusted EBITDA guidance

Negative

• Net income declined to $316.9M from $444.1M in 2024
• Acquired IPR&D expense of $284.9M drove a Q4 net loss
• Cash and marketable securities fell to $145.4M from $596.1M

Key Figures

2025 Total Revenue: $1,396.6M 2025 Royalty Revenue: $867.8M 2025 Net Income: $316.9M +5 more

8 metrics

2025 Total Revenue $1,396.6M Full year 2025, up 38% YoY

2025 Royalty Revenue $867.8M Full year 2025, up 52% YoY

2025 Net Income $316.9M Full year 2025 vs $444.1M in 2024

2025 GAAP EPS $2.56 Full year 2025 vs $3.43 in 2024

2025 Non-GAAP EPS $4.15 Full year 2025 vs $4.23 in 2024

2026 Revenue Guidance $1.710–$1.810B Total revenue guidance for full year 2026

2026 Adj. EBITDA $1.125–$1.205B Adjusted EBITDA guidance for full year 2026

2026 Non-GAAP EPS $7.75–$8.25 Non-GAAP diluted EPS guidance for full year 2026

Market Reality Check

Price: $80.48 Vol: Volume 1,717,711 is sligh...

normal vol

$80.48 Last Close

Volume Volume 1,717,711 is slightly below the 20-day average of 1,841,954, suggesting no unusual trading ahead of the release. normal

Technical Shares at $79.44 are trading above the 200-day MA of $65.53 and sit within 3.38% of the 52-week high at $82.22.

Peers on Argus

HALO gained 3.28% while key biotech peers showed mixed, mostly modest moves (e.g...

HALO gained 3.28% while key biotech peers showed mixed, mostly modest moves (e.g., MRNA +0.91%, VRNA +0.06%, ROIV -0.21%, MDGL -2.02%, RVMD -1.56%). With no peers in the momentum scanner, the move appears stock-specific.

Previous Earnings Reports

5 past events · Latest: Nov 03 (Positive)

Same Type Pattern 5 events

Date	Event	Sentiment	Move	Catalyst
Nov 03	Earnings and guidance	Positive	+1.6%	Record Q3 2025 results and raised full-year 2025 guidance.
Aug 05	Earnings and guidance	Positive	+2.5%	Exceptional Q2 2025 growth and higher 2025 revenue and EBITDA guidance.
May 06	Earnings and guidance	Positive	+18.1%	Strong Q1 2025 results, guidance raise, and new share repurchase plan.
Oct 31	Earnings and guidance	Positive	+13.0%	Strong Q3 2024 results with higher 2024 revenue and EBITDA guidance.
Aug 06	Earnings and guidance	Positive	+4.2%	Solid Q2 2024 growth and maintained increased 2024 guidance ranges.

Pattern Detected

Earnings and guidance updates have historically triggered positive reactions, with all five recent earnings releases showing upward moves and an average move of about 7.87%.

Recent Company History

Over the past 18 months, Halozyme’s earnings reports have consistently highlighted strong royalty-driven growth, with repeated guidance raises in Q1–Q3 2025 and robust Q3 2024 results. Recent updates added sizeable acquisitions (Elektrofi, Surf Bio) and expanding ENHANZE® partnerships. Today’s full-year 2025 report confirms record $1.397B revenue and reiterates elevated 2026 guidance, extending the trajectory outlined in prior quarters and formalizing preliminary figures disclosed in late January 2026.

Historical Comparison

+7.9% avg move · Past earnings/guidance releases for HALO moved the stock by an average of 7.87%. Today’s full-year 2...

earnings

+7.9%

Average Historical Move earnings

Past earnings/guidance releases for HALO moved the stock by an average of 7.87%. Today’s full-year 2025 report, with record revenue and reiterated 2026 outlook, fits this pattern of earnings as a key catalyst.

Earnings releases show a steady progression of rising revenue and royalty streams, repeated guidance increases for 2024–2025, and layering in acquisitions like Elektrofi and Surf Bio alongside expanding ENHANZE® partnerships.

Market Pulse Summary

This announcement delivers confirmed full-year 2025 results with record $1.397B revenue and $867.8M ...

Analysis

This announcement delivers confirmed full-year 2025 results with record $1.397B revenue and $867.8M in royalties, alongside reiterated 2026 guidance for revenue, adjusted EBITDA, and non-GAAP EPS. It also details balance sheet actions such as new convertible notes and a larger revolving credit facility, plus acquisitions of Elektrofi and Surf Bio. Investors may track execution on ENHANZE® launches, integration of new technologies, and whether 2026 guidance is maintained.

Key Terms

convertible notes, capped call transactions, revolving credit facility, non-GAAP, +4 more

8 terms

convertible notes financial

"sale of $750.0 million aggregate principal amount of the 2031 Convertible Notes and $750.0 million aggregate principal amount of the 2032 Convertible Notes"

Convertible notes are a type of short-term loan that a company receives from investors, which can later be turned into company shares instead of being paid back in cash. They matter to investors because they offer a way to support a company early on while giving the potential to own a stake in its success if the company grows and later raises more funding.

capped call transactions financial

"used a portion of the net proceeds to fund the cost of entering into the 2031 Capped Call Transactions and the 2032 Capped Call Transactions"

Capped call transactions are agreements where investors buy options that give them the chance to benefit if a stock's price goes up, but with a limit on how much they can gain. This helps protect them from paying too much if the stock's price rises a lot, similar to having a maximum limit on a reward. They matter because they help investors manage risk while still allowing some upside potential.

revolving credit facility financial

"amendment to the Company's credit agreement that, among other things extended the maturity date and increased the borrowing capacity of the Company's existing revolving credit facility"

A revolving credit facility is a type of loan that a business can borrow from whenever it needs money, up to a set limit. It’s like having a credit card for companies—allowing them to borrow, pay back, and borrow again as needed, providing flexibility for managing cash flow or funding short-term expenses.

non-GAAP financial

"Non-GAAP diluted earnings per share was $4.15, compared to $4.23 in 2024"

Non-GAAP refers to financial measures that companies use to show their earnings or performance without including certain expenses or income that are often added back to give a different picture. It matters because it can make a company's results look better or more favorable, but it may also hide important costs, so investors need to look at both GAAP (official rules) and non-GAAP numbers to get a full understanding.

phase 1 medical

"the ongoing argenx ARGX-121 Phase 1 program was expanded to include an SC-arm"

Phase 1 is the first stage of testing a new drug or medical treatment in people, focused primarily on safety, how the body handles the product, and finding a tolerated dose. Think of it as a short, tightly controlled experiment with a small group to check for dangerous side effects before wider testing; for investors it is an early milestone that reduces some uncertainty but still carries high risk and potential for both big value changes and setbacks.

multiple myeloma medical

"for the treatment of adult patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplant"

A cancer of the blood that starts in plasma cells, the immune system’s antibody-producing cells in bone marrow. It behaves like a factory where the workers go rogue, crowding out healthy cells and causing bone damage, anemia and infections; treatments and trial results can sharply affect drug sales, regulatory approvals and company valuations, so progress or setbacks are closely watched by investors.

non-small cell lung cancer medical

"for the treatment of patients with epidermal growth factor receptor ("EGFR")-mutated locally advanced or metastatic non-small cell lung cancer ("NSCLC")"

A broad category of lung tumors that grow from the cells lining the airways and make up the majority of lung cancer cases; it includes several subtypes that behave and respond to treatment differently, like different models of the same car family. It matters to investors because its large patient population and variety of treatment options — surgery, traditional chemo, targeted drugs and immunotherapies — create major markets where clinical trial results, drug approvals or changing treatment guidelines can quickly affect a company’s revenue and stock value.

adjusted ebitda financial

"Adjusted EBITDA for the full year was $657.6 million, compared to $632.2 million in 2024"

Adjusted EBITDA is a way companies measure how much money they make from their core operations, like running a business, by removing certain costs or income that aren’t part of regular business activities. It helps investors see how well a company is doing without distractions from unusual expenses or gains, making it easier to compare companies or track performance over time.

AI-generated analysis. Not financial advice.

Full Year 2025 Total Revenue Increased 38% YOY to Record $1.397 billion
Full Year 2025 Royalty Revenue Increased 52% YOY to Record $868 million

Completed Acquisitions of Elektrofi's Hypercon™ Technology and 
Surf Bio's Hyperconcentration Technology

Reiterating 2026 Financial Guidance Ranges:
Total Revenue of $1.710 - $1.810 billion, YOY Growth of 22% - 30%
Adjusted EBITDA of $1.125 - $1.205 billion, YOY Growth of 71% - 83%¹
Non-GAAP Diluted EPS of $7.75 - $8.25, YOY Growth of 87% - 99%¹

SAN DIEGO, Feb. 17, 2026 /PRNewswire/ -- Halozyme Therapeutics, Inc. (NASDAQ: HALO) ("Halozyme" or the "Company") today reported its financial and operating results for the full year and fourth quarter ended December 31, 2025, and provided an update on its recent corporate activities.

"2025 was a pivotal year for Halozyme as we delivered record total revenue of $1.4 billion, which was the result of continued growth in our ENHANZE business. In addition, we expanded our drug delivery technology portfolio with two acquisitions. Three ENHANZE‑enabled blockbusters, DARZALEX SC, Phesgo and VYVGART Hytrulo, drove royalty revenue growth of 52%, reaching a record $868 million in 2025. In the year, we also expanded our ENHANZE opportunities, adding three new collaboration and licensing agreements with Takeda, Merus and Skye Bioscience and gained one new target nomination from Roche. Furthermore, Janssen expanded the global reach of ENHANZE with approvals in the U.S., China and Japan for Rybrevant SC and new indication approvals in front line settings for DARZALEX Faspro. In parallel, we broadened our drug delivery portfolio with the acquisitions of the Hypercon technology and Surf Bio's hyperconcentration technology, which meaningfully expand, diversify and extend our long‑term royalty opportunity into the mid-2040s," said Dr. Helen Torley, President and Chief Executive Officer.

Dr. Torley continued, "As we look ahead, our long-term outlook reflects the strong momentum and opportunity we have built through a broader drug delivery portfolio and offering to the biopharma industry. With royalty revenue projected to exceed $1 billion in 2026 and a clear line of sight to more than $2 billion in total revenue by 2028, Halozyme is entering its next phase of growth with strong conviction. Our projected 22% to 30% total revenue growth in 2026, combined with an expanding development pipeline with six projected new ENHANZE and two Hypercon development program starts, plus plans to sign three or more ENHANZE and Hypercon partnerships in 2026, all reinforce the durability of our revenue. With our strong cash generation and a diversified set of high‑value royalty drivers, we remain focused on delivering sustained long‑term value for shareholders."

Fourth Quarter and Recent Corporate Highlights:

• In December 2025, Halozyme completed the acquisition of Surf Bio, Inc. ("Surf Bio"), subsequently renamed Halozyme Surf Bio, Inc., resulting in an expansion of Halozyme's drug delivery technology portfolio and the potential for future growth through new collaboration agreements.
• In December 2025, Halozyme announced that a German court had granted Halozyme's request for a preliminary injunction ordering Merck Sharp & Dohme Corp. ("Merck") to refrain from distributing and offering Keytruda^® SC in Germany.
• In November 2025, Halozyme completed the acquisition of Elektrofi Inc. ("Elektrofi"), subsequently renamed Halozyme Hypercon, Inc., resulting in an expansion of Halozyme's drug delivery technology portfolio and the potential for future growth through new collaboration agreements.
• In November 2025, Halozyme completed the sale of $750.0 million aggregate principal amount of the 2031 Convertible Notes and $750.0 million aggregate principal amount of the 2032 Convertible Notes. The Company used a portion of the net proceeds to fund the cost of entering into the 2031 Capped Call Transactions and the 2032 Capped Call Transactions. The Company also used a portion of the net proceeds to enter into privately negotiated agreements with certain holders of its outstanding 2027 Convertible Notes and 2028 Convertible Notes to repurchase their 2027 Convertible Notes and 2028 Convertible Notes for cash through privately negotiated transactions entered into concurrently with or shortly after the offering.
• In November 2025, Halozyme entered into an amendment to the Company's credit agreement that, among other things extended the maturity date and increased the borrowing capacity of the Company's existing revolving credit facility from $575.0 million to $750.0 million.

Fourth Quarter and Recent Partner Highlights:

• In January 2026, Janssen announced the U.S. Food and Drug Administration ("FDA") approved DARZALEX FASPRO^® (daratumumab and hyaluronidase-fihj) in combination with bortezomib, lenalidomide and dexamethasone ("D-VRd") for the treatment of adult patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplant.
• In December 2025, Halozyme and Skye Bioscience entered into a non-exclusive global collaboration and license agreement that provides Skye Bioscience access to ENHANZE^® for the development and potential commercialization of an SC formulation of nimacimab for the treatment of obesity.
• In December 2025, Halozyme and Takeda entered into a new global collaboration and exclusive license agreement which provides Takeda with access to ENHANZE^® for use with vedolizumab, marketed globally as ENTYVIO^®, for the treatment of adults with moderately to severely active Crohns' disease or ulcerative colitis, which are the two main forms of inflammatory bowel disease.
• In December 2025, Roche nominated a new undisclosed non-exclusive target to be studied using ENHANZE^®.
• In the fourth quarter of 2025, the ongoing argenx ARGX-121 Phase 1 program was expanded to include an SC-arm evaluating ARGX-121 with ENHANZE^® in healthy adults.
• In December 2025, Janssen announced the FDA approved RYBREVANT FASPRO™ (amivantamab and hyaluronidase-lpuj) for the treatment of patients with epidermal growth factor receptor ("EGFR")-mutated locally advanced or metastatic non-small cell lung cancer ("NSCLC").
• In December 2025, Janssen received approval from the National Medical Products Administration in China for RYBREVANT™ FASPRO for the first-line treatment of adult patients with advanced NSCLC.
• In December 2025, Janssen received approval from the Ministry of Health, Labour and Welfare in Japan for RYBROFAZ^® (amivantamab) with ENHANZE^® for the first-line treatment of adult patients with advanced NSCLC.
• In December 2025, Halozyme entered into a commercial license and supply agreement with Viatris under which Halozyme licenses and supplies an auto-injector product for self-administered SC selatogrel for the treatment of acute myocardial infarction in adult patients.
• In November 2025, Janssen announced the FDA approved DARZALEX FASPRO^® (daratumumab and hyaluronidase-fihj) co-formulated with ENHANZE^®, as single treatment of adult patients with high-risk smoldering multiple myeloma.
• In November 2025, Halozyme and Merus entered into a non-exclusive global collaboration and license agreement that provides Merus access to ENHANZE^® technology for a single target. Merus intends to explore development and potential commercialization of SC administration of petosemtamab, an EGFR and leucine-rich repeat-containing G-protein coupled receptor 5 bispecific antibody, for the treatment of head and neck cancer.

Full Year and Fourth Quarter 2025 Financial Highlights:

• Total revenue for the full year was $1,396.6 million, compared to $1,015.3 million in 2024. The 38% year-over-year increase was primarily driven by royalty revenue growth and an increase in product sales. Revenue included $867.8 million in royalties, an increase of 52% compared to $571.0 million in 2024, primarily driven by continued sales uptake of ENHANZE^® partner products that have launched since 2020, predominantly by VYVGART^® Hytrulo by argenx, DARZALEX^® SC by Janssen and Phesgo^® by Roche in all geographies.
• Cost of sales for the full year was $228.8 million, compared to $159.4 million in 2024. The increase in cost of sales was primarily due to an increase in product sales and labor allocation initiatives.
• Amortization of intangibles expense for the full year was $76.7 million, compared to $71.0 million in 2024. The increase in amortization of intangibles expense was due to the acquisition of Elektrofi in November 2025.
• Research and development expense for the full year was $81.5 million, compared to $79.0 million in 2024. The increase was primarily due to the acquisition of Elektrofi and Surf Bio, partially offset by lower compensation expense driven by resource optimization, labor allocation initiatives, and timing of planned investments in ENHANZE^® related to the development of our new high-yield rHuPH20 manufacturing process.
• Selling, general and administrative expense for the full year was $207.1 million, compared to $154.3 million in 2024. The increase was primarily due to an increase in consulting and professional service fees, including litigation costs incurred in connection with a patent infringement litigation case, diligence and transaction-related costs incurred in support of the acquisition of Elektrofi and Surf Bio, and an increase in compensation expense.
• Net income for the full year was $316.9 million, compared to $444.1 million in 2024. Net Income included acquired in-process research and development ("IPR&D") expense of $284.9 million related to the Surf Bio acquisition in the fourth quarter of 2025.
• Adjusted EBITDA for the full year was $657.6 million, compared to $632.2 million in 2024.^1,2
  Adjusted EBITDA included acquired IPR&D expense of $284.9 million related to the Surf Bio acquisition in the fourth quarter of 2025.
• GAAP diluted earnings per share for the full year was $2.56, compared to $3.43 in 2024. Non-GAAP diluted earnings per share was $4.15, compared to $4.23 in 2024.^1,2
  GAAP and non-GAAP diluted earnings per share included an unfavorable impact of approximately $2.30 per share related to acquired IPR&D expense for the Surf Bio acquisition in the fourth quarter of 2025.
• Total revenue in the fourth quarter was $451.8 million, compared to $298.0 million in the fourth quarter of 2024. The 52% year-over-year increase was primarily driven by royalty revenue growth and an increase in product sales. Revenue included $258.0 million in royalties, an increase of 51% compared to $170.4 million in the fourth quarter of 2024, primarily driven by continued sales uptake of ENHANZE^® partner products that have launched since 2020, predominantly by VYVGART^® Hytrulo by argenx, DARZALEX^® SC by Janssen and Phesgo^® by Roche in all geographies.
• Net loss in the fourth quarter was $141.6 million, compared to net income of $137.0 million in the fourth quarter of 2024. Net loss included acquired IPR&D expense of $284.9 million related to the Surf Bio acquisition in the fourth quarter of 2025.
• Adjusted EBITDA in the fourth quarter was $21.9 million, compared to $195.8 million in the fourth quarter of 2024.^1,2
  Adjusted EBITDA included acquired IPR&D expense of $284.9 million related to the Surf Bio acquisition in the fourth quarter of 2025.
• GAAP diluted loss per share in the fourth quarter was $1.20, compared to GAAP diluted earnings per share $1.06 in the fourth quarter of 2024. Non-GAAP diluted loss per share was $0.24 compared to Non-GAAP diluted earnings per share of $1.26 in the fourth quarter of 2024.^1,2
  GAAP and non-GAAP diluted loss per share in the fourth quarter of 2025 included an unfavorable impact of $2.42 per share related to acquired IPR&D expense for the Surf Bio acquisition in the fourth quarter of 2025.
• Cash, cash equivalents, restricted cash and marketable securities were $145.4 million on December 31, 2025, compared to $596.1 million on December 31, 2024. The decrease was primarily driven by cash used for the Elektrofi and Surf Bio acquisitions and share repurchases, partially offset by the net proceeds from issuance of convertible notes and cash generated from operations.

Financial Outlook for 2026

The Company is reiterating its 2026 financial guidance ranges, which were last updated on January 28, 2026.

For the full year 2026, the Company expects:

• Total revenue of $1.710 billion to $1.810 billion, representing growth of 22% to 30% over 2025 total revenue, primarily driven by increases in royalty revenue and product sales from API.
• Revenue from royalties of $1.130 billion to $1.170 billion, representing growth of 30% to 35% over 2025.
• Adjusted EBITDA of $1.125 billion to $1.205 billion, representing growth of 71% to 83% over 2025, including new Hypercon™ and Surf Bio investment of approximately $60 million.
• Non-GAAP diluted earnings per share of $7.75 to $8.25, representing growth of 87% to 99% over 2025. The Company's earnings per share guidance includes new Hypercon™ and Surf Bio investment of approximately $60 million and does not consider the impact of potential future share repurchases.

Table 1. 2026 Financial Guidance

				Guidance Range
Total Revenue				$1.710 to $1.810 billion
Royalty Revenue				$1.130 to $1.170 billion
Adjusted EBITDA1				$1.125 to $1.205 billion
Non-GAAP Diluted EPS1				$7.75 to $8.25

1	EBITDA, Adjusted EBITDA and Non-GAAP Diluted EPS are Non-GAAP financial measures. See "Note Regarding Use of Non-GAAP Financial Measures" below for an explanation of these measures. Reconciliations between GAAP reported and Non-GAAP financial information for actual results are provided at the end of this earnings release.
2	In alignment with SEC guidance around non-GAAP financial measures relating to acquired IPR&D expense, we have not excluded expenses related to acquired IPR&D from our non-GAAP results.

Webcast and Conference Call

Halozyme will host its Quarterly Update Conference Call for the fourth quarter and full year ended December 31, 2025 today, Tuesday, February 17, 2026, at 1:30 p.m. PT/4:30 p.m. ET. The conference call may be accessed live with pre-registration via link: https://events.q4inc.com/analyst/624893800?pwd=q3lpEa6F. The call will also be webcast live through the "Investors" section of Halozyme's corporate website and a recording will be made available following the close of the call. To access the webcast and additional documents related to the call, please visit Halozyme.com.

About Halozyme

Halozyme is a biopharmaceutical company advancing disruptive solutions to improve patient experiences and outcomes for emerging and established therapies. As the innovators of ENHANZE^® drug delivery technology with the proprietary enzyme rHuPH20, Halozyme's commercially-validated solution facilitates the subcutaneous delivery of injected drugs and fluids, reducing treatment burden and improving convenience. ENHANZE^® has touched more than one million patient lives through ten commercialized products across over 100 global markets and is licensed to leading pharmaceutical and biotechnology companies including Roche, Takeda, Pfizer, Janssen, AbbVie, Eli Lilly, Bristol-Myers Squibb, argenx, ViiV Healthcare, Chugai Pharmaceutical, Acumen Pharmaceuticals, Merus N.V. and Skye Bioscience.

Halozyme expanded its drug delivery technology portfolio to develop partner products using Hypercon™ and the Surf Bio hyperconcentration technology. Hypercon™ is an innovative microparticle technology expected to set a new standard in hyperconcentration of drugs and biologics by reducing injection volume for the same dosage and enabling administration in at‑home and healthcare‑provider settings. The development of the Surf Bio polymer‑based hyperconcentration technology further broadens the range of biologics that can be delivered subcutaneously, meaningfully expanding the scope of opportunities across therapeutic modalities. The Hypercon™ technology has been licensed to leading biopharmaceutical partners, including Janssen, Eli Lilly and argenx.

Halozyme also develops, manufactures and commercializes drug-device combination products using advanced auto-injector technologies designed to improve convenience, reliability and tolerability, enhancing patient comfort and adherence. The Company has two proprietary commercial products, Hylenex^® and XYOSTED^®, partnered commercial products and ongoing development programs with Teva Pharmaceuticals and McDermott Laboratories Limited, an affiliate of Viatris Inc.

Halozyme is headquartered in San Diego, CA, with offices in Ewing, NJ; Minnetonka, MN; and Boston, MA. Minnetonka is also the site of its operations facility.

For more information, visit www.halozyme.com and connect with us on LinkedIn.

Note Regarding Use of Non-GAAP Financial Measures

In addition to disclosing financial measures prepared in accordance with U.S. generally accepted accounting principles ("GAAP"), this press release and the accompanying tables contain certain Non-GAAP financial measures. The Company reports earnings before interest, taxes, depreciation, and amortization ("EBITDA"), adjusted EBITDA, Non-GAAP diluted earnings per share, Non-GAAP diluted shares, and guidance with respect to those measures, in addition to, and not as a substitute for, or superior to, financial measures calculated in accordance with GAAP. The Company calculates Non-GAAP diluted earnings per share excluding share-based compensation expense, amortization of debt discounts, intangible asset amortization, one-time items, if any, such as changes in contingent liabilities, inventory adjustments, impairment charges, transaction costs for business combinations, severance and share-based compensation acceleration expenses, intellectual property litigation costs, inducement expenses related to convertible notes, and certain adjustments to income tax expense. The Company calculates Non-GAAP diluted shares excluding the dilutive impact of convertible notes which is used in calculating Non-GAAP diluted earnings. The Company calculates EBITDA excluding interest, taxes, depreciation and amortization. The Company calculates adjusted EBITDA excluding one-time items, if any, such as changes in contingent liabilities, inventory adjustments, impairment charges, transaction costs for business combinations, severance and share-based compensation acceleration expenses and intellectual property litigation costs. Reconciliations between GAAP and Non-GAAP financial measures are included at the end of this press release. The Company does not provide reconciliations of forward-looking adjusted measures to GAAP due to the inherent difficulty in forecasting and quantifying certain amounts that are necessary for such reconciliation, including adjustments that could be made for changes in share-based compensation expense and the effects of any discrete income tax items. For the same reasons, the Company is unable to address the probable significance of the unavailable information. The Company provides Non-GAAP financial measures that it believes will be achieved; however, it cannot accurately predict all of the components of the adjusted calculations and the GAAP measures may be materially different than the Non-GAAP measures.

The Company evaluates other items of income and expense on an individual basis for potential inclusion in the calculation of Non-GAAP financial measures and considers both the quantitative and qualitative aspects of the item, including (i) its size and nature, (ii) whether or not it relates to the Company's ongoing business operations and (iii) whether or not the Company expects it to occur as part of the Company's normal business on a regular basis. Non-GAAP financial measures do not have any standardized meaning and are therefore unlikely to be comparable to similarly titled measures presented by other companies. These Non-GAAP financial measures are not meant to be considered in isolation and should be read in conjunction with the Company's consolidated financial statements prepared in accordance with GAAP, and are not prepared under any comprehensive set of accounting rules or principles. In addition, from time to time in the future there may be other items that the Company may exclude for purposes of its Non-GAAP financial measures, and the Company may in the future cease to exclude items that it has historically excluded for purposes of its Non-GAAP financial measures.

The Company considers these Non-GAAP financial measures to be important because they provide useful measures of the operating performance of the Company, exclusive of factors that do not directly affect what the Company considers to be its core operating performance, as well as unusual events. The Non-GAAP measures also allow investors and analysts to make additional comparisons of the operating activities of the Company's core business over time and with respect to other companies, as well as assessing trends and future expectations. The Company uses Non-GAAP financial information in assessing what it believes is a meaningful and comparable set of financial performance measures to evaluate operating trends, as well as in establishing portions of our performance-based incentive compensation programs.

Safe Harbor Statement

In addition to historical information, the statements set forth in this press release include forward-looking statements including, without limitation, statements concerning the Company's financial performance (including the Company's expected financial outlook for 2026) and expectations for future growth, profitability, revenue durability, total revenue, royalty revenue, royalty revenue duration, EBITDA, Adjusted EBITDA, and non-GAAP diluted earnings-per-share, and shareholder value.  Forward-looking statements also include future plans, objectives, expectations and intentions related to the acquisitions of Elektrofi and Surf Bio, such acquisitions' expected impact and contributions to the Company's and combined group's operations and financial results (including potential development and commercialization of partnered products and timing related to these events), as well as the expected benefits of the acquisitions. Forward-looking statements related to Elektrofi's and Surf Bio's intellectual property include expectations for length of patent terms and patent expirations and the expected impact such patents may have on the duration, durability and amounts of future royalty payments the Company may receive from licensing such intellectual property. Forward-looking statements regarding the Company's ENHANZE^® drug delivery technology may include the possible benefits and attributes of ENHANZE^®, its potential application to aid in the dispersion and absorption of other injected therapeutic drugs and facilitating more rapid delivery and administration of higher volumes of injectable medications through subcutaneous delivery. Forward-looking statements regarding the Company's business may include potential growth and receipt of royalty and milestone payments driven by our partners' development and commercialization efforts, potential new clinical trial study starts and advancement of partnered development programs, regulatory submissions and product launches, the size and growth prospects of our partners' drug franchises, potential new or expanded collaborations and collaborative targets, and potential approvals of new partnered or proprietary products, and the potential timing of these events. These forward-looking statements are typically, but not always, identified through use of the words "expect," "believe," "enable," "may," "will," "could," "intends," "estimate," "anticipate," "plan," "predict," "probable," "potential," "preliminary," "possible," "should," "continue," and other words of similar meaning and involve risk and uncertainties that could cause actual results to differ materially from those in the forward-looking statements. Actual results could differ materially from the expectations contained in these forward-looking statements as a result of several factors, including uncertainties concerning future matters such as market conditions, changes in domestic and foreign business, changes in the competitive environment in which the Company operates,  the expected benefits of its acquisitions of Elektrofi and Surf Bio, unexpected early expiration or termination of the patent terms for the Company's drug delivery technologies, unexpected levels of revenues, expenditures and costs, unexpected results or delays in the growth of the Company's business, or in the development, regulatory review or commercialization of the Company's partnered or proprietary products, regulatory approval requirements, unexpected adverse events or patient outcomes and competitive conditions. These and other factors that may result in differences are discussed in greater detail in the Company's most recent Annual Report on Form 10-K filed with the Securities and Exchange Commission, including under the headings "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operations". Except as required by law, the Company undertakes no duty to update forward-looking statements to reflect events after the date of this release.

Contacts:

Tram Bui
VP, Investor Relations and Corporate Communications
609-333-7668
tbui@halozyme.com

Sydney Charlton
Teneo
917-972-8407
sydney.charlton@teneo.com

 

Halozyme Therapeutics, Inc. Consolidated Statements of Operations (Unaudited) (In thousands, except per share amounts)
		Three Months Ended				Twelve Months Ended
		December 31,				December 31,
		2025		2024		2025		2024
Revenues
Royalties		$     257,971		$     170,419		$     867,840		$     570,991
Product sales, net		122,665		79,364		376,444		303,492
Revenues under collaborative agreements		71,131		48,225		152,327		140,841
Total revenues		451,767		298,008		1,396,611		1,015,324
Operating expenses
Cost of sales		78,770		42,055		228,774		159,417
Amortization of intangibles		23,376		17,762		76,662		71,049
Research and development		31,897		20,441		81,490		79,048
Selling, general and administrative		77,028		42,249		207,092		154,335
Impairment of intangible asset		48,700		—		48,700		—
Acquired in-process research and development expense		284,887		—		284,887		—
Total operating expenses		544,658		122,507		927,605		463,849
Operating (loss) income		(92,891)		175,501		469,006		551,475
Other income (expense)
Investment and other income, net		2,430		7,253		21,472		23,752
Inducement expense related to convertible notes		(5,477)		—		(5,477)		—
Contingent liability fair value measurement gain		—		—		—		—
Interest expense		(4,911)		(4,540)		(18,126)		(18,095)
(Loss) income before income tax expense		(100,849)		178,214		466,875		557,132
Income tax expense		40,742		41,202		149,986		113,041
Net (loss) income		$   (141,591)		$     137,012		$     316,889		$     444,091
(Loss) earnings per share
Basic		$          (1.20)		$           1.08		$           2.64		$           3.50
Diluted		$          (1.20)		$           1.06		$           2.56		$           3.43
Weighted average common shares outstanding
Basic		117,672		126,406		119,840		126,827
Diluted		117,672		128,980		123,904		129,424

 

Halozyme Therapeutics, Inc. Consolidated Balance Sheets (Unaudited) (In thousands)
		December 31, 2025		December 31, 2024
ASSETS
Current assets
Cash and cash equivalents		$          133,820		$          115,850
Marketable securities, available-for-sale		9,000		480,224
Accounts receivable, net and contract assets		441,273		308,455
Inventories		176,475		141,860
Prepaid expenses and other current assets		64,639		38,951
Total current assets		825,207		1,085,340
Property and equipment, net		82,137		75,035
Prepaid expenses and other assets		53,551		80,596
Goodwill		580,360		416,821
Intangible assets, net		981,467		401,830
Deferred tax assets, net		—		3,855
Restricted cash		2,601		—
Total assets		$       2,525,323		$       2,063,477
LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities
Accounts payable		$            20,899		$            10,249
Accrued expenses		156,193		128,851
Total current liabilities		177,092		139,100
Long-term debt, net		2,142,630		1,505,798
Other long-term liabilities		113,863		54,758
Deferred tax liabilities, net		42,924		—
Total liabilities		2,476,509		1,699,656
Stockholders' equity
Common stock		118		123
Additional paid-in capital		12,002		—
Accumulated other comprehensive (loss) income		(18,092)		3,829
Retained earnings		54,786		359,869
Total stockholders' equity		48,814		363,821
Total liabilities and stockholders' equity		$       2,525,323		$       2,063,477

 

Halozyme Therapeutics, Inc. GAAP to Non-GAAP Reconciliations EBITDA (Unaudited) (In thousands)
		Three Months Ended				Twelve Months Ended
		December 31,				December 31,
		2025		2024		2025		2024
GAAP Net (Loss) Income		$   (141,591)		$     137,012		$     316,889		$     444,091
Adjustments
Investment and other income, net		(2,430)		(7,320)		(21,474)		(24,356)
Interest expense		4,911		4,540		18,126		18,095
Income tax expense		40,742		41,202		149,986		113,041
Depreciation and amortization		26,680		20,415		88,051		81,312
EBITDA		(71,688)		195,849		551,578		632,183
Adjustments
Transaction costs for business combinations(1)		10,733		—		14,604		—
Intellectual property litigation costs(2)		8,084		—		16,683		—
Severance and share-based compensation acceleration expense(3)		24,628		—		24,628		—
Impairment of intangible asset		48,700		—		48,700		—
Other one time items		1,447		—		1,447		—
Adjusted EBITDA		$     21,904		$     195,849		$    657,640		$     632,183

(1)	Amount represents incremental costs including legal and advisory fees incurred in association with the acquisition of Elektrofi, Inc. ("Elektrofi").
(2)	Adjustment relates to litigation costs incurred by Halozyme in connection with Halozyme's patent infringement litigation against Merck Sharp & Dohme Corp. ("Merck"). These charges are excluded because the Company does not believe they are reflective of the Company's ongoing business and operating results.
(3)	Amount represents severance costs and acceleration of unvested equity awards incurred in the Elektrofi acquisition.

 

Halozyme Therapeutics, Inc. GAAP to Non-GAAP Reconciliations Net Income and Diluted EPS (Unaudited) (In thousands, except per share amounts)
		Three Months Ended				Twelve Months Ended
		December 31,				December 31,
		2025		2024		2025		2024
GAAP Net (Loss) Income		$   (141,591)		$     137,012		$     316,889		$     444,091
Adjustments
Inducement expense related to convertible notes		5,477		—		5,477		—
Share-based compensation		16,571		11,462		51,565		43,385
Amortization of debt discount		1,951		1,845		7,506		7,350
Amortization of intangible assets		23,376		17,762		76,662		71,049
Transaction costs for business combinations(1)		10,733		—		14,604		—
Intellectual property litigation costs(2)		8,084		—		16,683		—
Severance and share-based compensation acceleration expense(3)		24,628		—		24,628		—
Impairment of intangible asset		48,700		—		48,700		—
Other one time items		1,447		—		1,447		—
Income tax effect of above adjustments(4)		(27,473)		(5,169)		(54,624)		(18,577)
Non-GAAP Net (Loss) Income		$     (28,097)		$     162,912		$     509,537		$    547,298
GAAP Diluted (LPS) EPS		$          (1.20)		$           1.06		$           2.56		$           3.43
Adjustments
Inducement expense related to convertible notes		0.05		—		0.04		—
Share-based compensation		0.14		0.09		0.42		0.34
Amortization of debt discount		0.02		0.01		0.06		0.06
Amortization of intangible assets		0.20		0.14		0.62		0.55
Transaction costs for business combinations(1)		0.09		—		0.12		—
Intellectual property litigation costs(2)		0.07		—		0.13		—
Severance and share-based compensation acceleration expense(3)		0.21		—		0.20		—
Impairment of intangible asset		0.41		—		0.40		—
Other one time items		0.01		—		0.01		—
Income tax effect of above adjustments(4)		(0.23)		(0.04)		(0.44)		(0.14)
Non-GAAP Diluted (LPS) EPS		$          (0.24)		$           1.26		$           4.15		$           4.23
GAAP Diluted Shares		117,672		128,980		123,904		129,424
Adjustments
Adjustment for dilutive impact of Senior 2028 Convertible Notes(5)		—		—		(1,018)		(74)
Non-GAAP Diluted Shares		117,672		128,980		122,886		129,350

Dollar amounts, as presented, are rounded. Consequently, totals may not add up.
(1)	Amount represents incremental costs including legal and advisory fees incurred in association with the Elektrofi acquisition.
(2)	Adjustment relates to litigation costs incurred by Halozyme in connection with Halozyme's patent infringement litigation against Merck. These charges are excluded because the Company does not believe they are reflective of the Company's ongoing business and operating results.
(3)	Amount represents severance cost and acceleration of unvested equity awards incurred in the Elektrofi acquisition.
(4)	Adjustments relate to taxes for the reconciling items, as well as excess benefits or tax deficiencies from share-based compensation, and the quarterly impact of other discrete items. Non-GAAP tax rate is impacted by the Acquired IPR&D expense, which is non-tax deductible.
(5)	Adjustment made for the dilutive effect of our Convertible Senior Notes due 2028 when the effect is not the same on a GAAP and Non-GAAP basis for the reporting period.

 

 

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SOURCE Halozyme Therapeutics, Inc.

FAQ

What were Halozyme (HALO) full‑year 2025 revenue and royalty totals?

Halozyme reported $1.397 billion in total 2025 revenue and $867.8 million in royalties. According to Halozyme, growth was driven by ENHANZE‑enabled partner product sales and product sales increases across geographies.

What 2026 financial guidance did Halozyme (HALO) reiterate on February 17, 2026?

Halozyme reiterated 2026 guidance of $1.71–$1.81B total revenue and $7.75–$8.25 non‑GAAP EPS. According to Halozyme, guidance assumes investments in Hypercon and Surf Bio of about $60 million.

How do the Elektrofi and Surf Bio acquisitions affect Halozyme (HALO)?

The acquisitions expand Halozyme's drug delivery portfolio with Hypercon and hyperconcentration technologies. According to Halozyme, the deals diversify royalty opportunities and extend potential royalties into the mid‑2040s.

Why did Halozyme (HALO) report a fourth‑quarter net loss in 2025?

Halozyme reported a Q4 net loss primarily due to $284.9 million acquired IPR&D expense related to the Surf Bio acquisition. According to Halozyme, this non‑recurring charge materially reduced quarterly GAAP earnings.

What is Halozyme's (HALO) cash position and recent financing activity as of Dec 31, 2025?

Halozyme held $145.4 million in cash and equivalents on Dec 31, 2025 and issued $750M 2031 and $750M 2032 convertible notes. According to Halozyme, proceeds funded capped calls and repurchases of certain 2027/2028 notes.