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HCW Biologics (HCWB) files exhibits-only S-1 amendment with new exhibits

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(Neutral)
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Form Type
S-1/A

Rhea-AI Filing Summary

HCW Biologics Inc. filed Amendment No. 1 to its Registration Statement on Form S-1 as an exhibits-only update. The amendment adds and organizes legal, governance, financing, warrant, equity incentive, and related agreements as exhibits, along with opinion letters, consents, and Inline XBRL data files.

The company states that the remainder of the S-1 registration statement is unchanged and therefore omitted from this amendment. The filing is signed by Founder and Chief Executive Officer Hing C. Wong and other directors and officers, confirming authorization of this administrative update.

Positive

  • None.

Negative

  • None.
Registration number 333-296577 S-1 registration statement identifier
Amendment date June 18, 2026 Date the S-1 Amendment No. 1 was signed in Miramar, Florida
Exhibit 5.1 Opinion of Clark Hill PLC Legal opinion filed with the S-1 exhibits-only amendment
Registration Statement on Form S-1 regulatory
"HCW Biologics Inc. is filing this Amendment No. 1 to its Registration Statement on Form S-1"
A registration statement on Form S-1 is a detailed filing a company submits to the U.S. securities regulator to register new shares for public sale; it includes a plain-language prospectus, financial statements, business description and risk factors. For investors it matters because it provides the official, comprehensive blueprint of the offering — like an owner’s manual — allowing buyers to assess risks, inspect financial health and compare valuation before deciding to invest.
exhibits-only filing regulatory
"HCW Biologics Inc. is filing this Amendment No. 1 ... as an exhibits-only filing."
Inline XBRL technical
"Inline XBRL Instance Document ... Taxonomy Extension Schema ... Calculation Linkbase Document"
Inline XBRL is a file format for financial filings that embeds machine-readable data tags directly inside the human-readable report, so the same document can be read by people and parsed by software. For investors it makes extracting, comparing and verifying financial numbers faster and more reliable—like a grocery list where each item also has a barcode—reducing manual errors and speeding up analysis.
Equity Incentive Plan financial
"2019 Equity Incentive Plan, as amended, and forms of agreement thereunder ... 2021 Equity Incentive Plan"
An equity incentive plan is a program that gives employees, executives or directors the right to receive company stock or options to buy stock as part of their pay. Think of it as offering slices of future company profit to motivate people to boost long‑term performance; for investors it matters because it can align employee goals with shareholder value but also increases the number of shares outstanding, which can dilute existing ownership.
Indemnification Agreement financial
"Form of Indemnification Agreement between HCW Biologics Inc. and each of its officers and directors."
An indemnification agreement is a contract in which one party promises to cover losses, costs, or legal claims that another party might face, acting like a tailored safety net or private insurance policy. For investors, it matters because such agreements shift potential financial risk away from a company or its officers and onto the indemnifier, which can affect a company’s future liabilities, cash flow and how risky the investment appears during deal-making or litigation.
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As filed with the Securities and Exchange Commission on June 18, 2026

 

Registration No. 333-296577

 

 

 

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

 

Amendment No. 1

to

FORM S-1

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933

 

HCW BIOLOGICS INC.

(Exact name of Registrant as specified in its charter)

 

Delaware   2834   82-5024477
(State or Other Jurisdiction of   Primary Standard Industrial   (I.R.S. Employer
Incorporation or Organization)   Classification Code Number   Identification Number)

 

2929 N Commerce Parkway

Miramar, FL 33025

(954) 842-2024

Address, including zip code, and telephone number, including area code, of Registrant’s principal executive offices

 

Hing C. Wong, Ph.D.

Chief Executive Officer

HCW Biologics Inc.

2929 N Commerce Parkway

Miramar, FL 33025

(954) 842-2024

Name, Address Including Zip Code, and Telephone Number, Including Area Code, of Agent for Service

 

With a copy to:

 

James Groth

Clark Hill PLC

130 E. Randolph St., Ste. 3900

Chicago, IL 60601

(312) 985-5900

 

Yevgeniya (Jeny) Zarmon

Clark Hill PLC

210 Carnegie Center, Suite 102

Princeton, NJ 08540

(609) 785-2918

 

Approximate Date of Commencement of Proposed Sale to the Public: From time to time after the effective date of this registration statement, as determined by market conditions.

 

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box. ☒

 

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

 

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

 

If this Form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

 

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

 

Large accelerated filer Accelerated filer
Non-accelerated filer Smaller reporting company
    Emerging growth company

 

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

 

The registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which specifically states that this registration statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act or until the registration statement shall become effective on such date as the Securities and Exchange Commission, acting pursuant to Section 8(a) of the Securities Act, may determine.

 

 

 

 
 

 

EXPLANATORY NOTE

 

HCW Biologics Inc. is filing this Amendment No. 1 to its Registration Statement on Form S-1 (File No. 333-296577) as an exhibits-only filing. Accordingly, this Amendment consists only of the facing page, this explanatory note, Item 16(a) of Part II of the Registration Statement, the signature page to the Registration Statement and the filed exhibits. The remainder of the Registration Statement is unchanged and has therefore been omitted.

 

 
 

 

PART II

 

Item 16. Exhibits.

 

EXHIBIT INDEX

 

        Incorporated by reference

  Filed or
Exhibit No.   Exhibit title   Form   File No.   Exhibit No.   Filing date  

furnished herewith

3.1   Amended and Restated Certificate of Incorporation   8-K   001-40591   3.1   07/26/2021    
3.1a   Certificate of Amendment of Certificate of Incorporation, filed March 31, 2025   8-K   001-40591   3.1a   04/01/2025    
3.1b   Certificate of Correction of the Certificate of Amendment of Certificate of Incorporation, filed April 1, 2025   8-K   001-40591   3.1b   04/01/2025    
3.2   Amended and Restated Bylaws   8-K   001-40591   3.2   07/26/2021    
4.1   Specimen Stock Certificate   S-1/A   333-256510   4.1   07/09/2021    
4.2   Description of Securities   10-K   001-40591   4.2   03/29/2022    
4.3   Form of New Warrant   8-K   001-40591   4.1   11/20/2025    
4.4   Form of Common Stock Purchase Warrant   8-K   001-40591   4.1   02/19/2026    
4.5   Form of Pre-Funded Common Stock Purchase Warrant   8-K   001-40591   4.2   02/19/2026    
4.6   Form of Common Stock Warrant, dated May 7, 2025, between Company and Holder   10-Q   001-40591   10.13   08/18/2025    
4.7   Form of Pre-Funded Common Stock Purchase Warrant   8-K   001-40591    4.1   5/21/2026    
4.8  

Form of Common Stock Purchase Warrant

  8-K   001-40591    4.2   5/21/2026    
5.1   Opinion of Clark Hill PLC                  

X

10.1   Form of Inducement Agreement between the Company and Armistice Capital Management LLC   8-K   001-40591   10.1   11/20/2025    
10.2   Securities Purchase Agreement, dated February 17, 2026, between Company and Purchaser   8-K   001-40591   10.2   02/19/2026    
10.3   Amendment to Existing Warrants Agreement, dated February 17, 2026, between the Company and Purchaser   8-K   001-40591   10.3   02/19/2026    
10.4   Form of Lock-up Agreement   S-1   333-393396   10.42   02/11/2026    
10.5   Form of Indemnification Agreement between HCW Biologics Inc. and each of its officers and directors.   S-1/A   333-256510   10.1   07/09/2021    
10.6+   2019 Equity Incentive Plan, as amended, and forms of agreement thereunder.   S-1/A   333-256510   10.2   07/09/2021    
10.7+   First Amendment to 2019 Equity Incentive Plan.   S-1/A   333-256510   10.3   07/09/2021    
10.8+   2021 Equity Incentive Plan and forms of agreement thereunder   S-1/A   333-256510   10.4   07/09/2021    
10.9+   Employment Agreement, dated July 6, 2021, between Peter Rhode and HCW Biologics Inc.   S-1/A   333-256510   10.6   07/09/2021    
10.10+   Employment Agreement, dated October 9, 2019, between Rebecca Byam and HCW Biologics Inc.   S-1/A   333-256510   10.7   07/09/2021    

 

II-1
 

 

       

Incorporated by reference

 

Filed or

furnished

herewith

Exhibit No.   Exhibit title   Form   File No.   Exhibit No.   Filing date  
10.11+   Non-Employee Director Compensation Policy.   S-1/A   333-256510   10.8   07/09/2021    
10.12+   Employment Agreement, dated June 18, 2021, between Dr. Hing C. Wong and HCW Biologics Inc.   S-1/A   333-256510   10.13   07/09/2021    
10.13+   Executive Incentive Bonus Plan   S-1/A   333-256510   10.11   07/09/2021    
10.14†   Exclusive License Agreement, dated December 24, 2020, between HCW Biologics Inc. and Wugen, Inc.   S-1/A   333-256510   10.10   07/09/2021    
10.15†   Master Services Agreement, dated March 14, 2019, between HCW Biologics Inc. and EirGenix, Inc.   S-1/A   333-256510   10.12   07/09/2021    
10.16†#   Purchase and Sale Agreement, by and between HCW Biologics Inc. and Wai 3300 Corporate Way, LLC, dated May 27, 2022   10-Q   001-40591   10.1   08/12/2022    
10.17#   Loan Agreement by and between HCW Biologics Inc. and Cogent Bank, dated August 15, 2022   10-Q   001-40591   10.1   11/07/2022    
10.18#   Mortgage and Security Agreement by and between HCW Biologics Inc. and Cogent Bank, dated August 15, 2022   10-Q   001-40591   10.2   11/07/2022    
10.19   Form of Subscription Agreement, dated February 20, 2024, by and between the Company and the Subscribers party thereto   8-K   001-40591   10.1   02/22/2024    
10.20   Form of Amended and Restated Senior Secured Note Purchase Agreement, dated July 2, 2024, by and between the Company and the Purchase party thereto   10-Q   001-40591   10.1   08/14/2024    
10.21   Form of Amended and Restated Pledge Agreement, dated July 2, 2024, by and among the Company, Escrow Agent and Noteholder parties thereto   10-Q   001-40591   10.3   08/14/2024    
10.22   Form of Escrow Agreement, dated May 1, 2025, by and between the Company, Escrow Agent and Noteholder party thereto   10-Q   001-40591   10.4   08/14/2024    
10.23   Form of First Amendment to Amended and Restated Secured Note Purchase Agreement, dated September 30, 2024, by and between the Company and Purchaser party thereto   10-Q   001-40591   10.5   11/14/2024    
10.24   Form of Secured Promissory Note by and between the Company and the Holder party thereof   10-Q   001-40591   10.2   08/14/2024    
10.25   Second Amendment to Amended and Restated Senior Secured Note Purchase Agreement and Related Agreements, dated May 1, 2025, between Company and Holder   10-Q   001-40591   10.12   08/18/2025    
10.26   Equity Purchase Agreement, dated February 20, 2025, between the Company and Square Gate Master Fund - Series 4.   8-K   001-40591   10.1   2/21/2025    
10.27   Registration Rights Agreement, dated February 20, 2025, between the Company and Square Gate Master Fund - Series 4   8-K   001-40591   10.2   2/21/2025    
10.28   First Amendment to the Equity Purchase Agreement, dated August 14, 2025, between the Company and Square Gate Master Fund - Series 4.   8-K   001-40591   10.1   08/15/2025    

 

II-2
 

 

       

Incorporated by reference

 

Filed or

furnished

herewith

Exhibit No.   Exhibit title   Form   File No.   Exhibit No.   Filing date  
10.29   Amended and Restated Amended and Restated License, Research and Co-Development Agreement, dated November 17, 2025, between the Company and Beijing Trimmune Biotech Co., Ltd.   S-1   333-293396   10.40   02/11/2026    
10.30†#   Amendment 1 to Amended and Restated License, Research and Co-Development Agreement, dated January 27, 2026, between the Company and Beijing Trimmune Biotech Co., Ltd.   S-1   333-293396   10.43   02/11/2026    
10.31†#   Shareholder Purchase Agreement, dated October 10, 2025, between co-founders of Beijing Trimmune Biotech Co., Ltd., including the Company   S-1   333-293396   10.44   02/11/2026    
10.32   Exclusive License Agreement 12-Month Suspension, dated May 29, 2025, between the Company and Wugen, Inc.   10-Q   001-40591   10.17   08/18/2025    
10.33   Settlement Agreement and Release, dated July 13, 2024, by and between the Company and Altor BioScience, LLC, NantCell, Inc., and ImmunityBio, Inc.   10-Q   001-40591   10.6   11/14/2024    
10.34   Placement Agency Agreement, dated February 17, 2026, between the Company and Maxim Group LLC   8-K   001-40591   10.1   02/19/2026    
10.35   Form of Securities Purchase Agreement   8-K   001-40591   10.1   5/21/2026    
10.36   Form of Registration Rights Agreement by and between the Company and the Investors   8-K   001-40591   10.2   5/21/2026    
10.37   Form of Placement Agency Agreement, by and between the Company and E.F. Hutton & Co. LLC   8-K   001-40591   10.3   5/21/2026    
10.38*   Form of Lock-Up Agreement                  
23.1*   Consent of Independent Registered Public Accounting Firm                  
23.2   Opinion of Clark Hill PLC (included in Exhibit 5.1)                   X
101.INS   Inline XBRL Instance Document                   X
101.SCH   Inline XBRL Taxonomy Extension Schema Document                   X
101.CAL   Inline XBRL Taxonomy Extension Calculation Linkbase Document                   X
101.DEF   Inline XBRL Taxonomy Extension Definition Linkbase Document                   X
101.LAB   Inline XBRL Taxonomy Extension Label Linkbase Document                   X
101.PRE   Inline XBRL Taxonomy Extension Presentation Linkbase Document                   X
104   Cover Page Interactive Data File (embedded within the Inline XBRL document)                   X
107*   Filing Fee Table                    

 

+ Indicates a management contract or compensatory plan or arrangement.

 

†† Certain information in this document has been excluded pursuant to Item 601(b)(10) of Regulation S-K. Such excluded information is not material and is the type of information the Registrant treats as private and confidential. The Registrant agrees to furnish supplementally such information to the SEC upon request.

 

# Certain information in this document has been excluded pursuant to Item 601(a)(5) or (a)(6) of Regulation S-K. The Registrant agrees to furnish supplementally such information to the SEC upon request.

 

* Previously filed.

 

II-3
 

 

SIGNATURES

 

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this registration statement on Form S-1 to be signed on its behalf by the undersigned, in the city of Miramar, State of Florida, on June 18, 2026.

 

  HCW BIOLOGICS INC.
     
  By: /s/ Hing C. Wong
  Name:  Hing C. Wong
  Title: Founder & Chief Executive Officer

 

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this registration statement on Form S-1 to be signed on its behalf by the undersigned, thereunto duly authorized.

 

Signature   Title   Date
     

*

Scott T. Garrett

  Chairman of the Board of Directors   June 18, 2026
     

*

Rebecca Byam

  Chief Financial Officer   June 18, 2026
     

*

Hing C. Wong

  Chief Executive Officer   June 18, 2026
     

*

Rick S. Greene

  Director   June 18, 2026
     

*

Lisa M. Giles

  Director   June 18, 2026

 

By:  /s/ Hing C. Wong  
  Hing C. Wong, Attorney-in-Fact  

 

II-4

 

FAQ

What did HCWB change in its latest S-1 amendment?

HCW Biologics filed Amendment No. 1 to its Form S-1 as an exhibits-only update, adding legal, financing, warrant, equity plan, and related agreements, plus XBRL data files, without changing the main registration disclosure.

Is HCW Biologics’ core S-1 registration statement being revised in this filing?

No, the company states the amendment consists only of the facing page, explanatory note, Item 16(a), signature page, and exhibits. The remainder of the S-1 registration statement remains unchanged and is therefore omitted from this amendment.

What kinds of agreements are listed as exhibits in HCWB’s S-1 amendment?

The exhibit index includes charter documents, bylaws, multiple warrant forms, equity incentive plans, employment agreements, license and services agreements, loan and mortgage documents, purchase and sale agreements, and placement and purchase agreements tied to the company’s financing activities.

Does HCW Biologics include Inline XBRL data in this S-1 amendment?

Yes, the amendment lists several Inline XBRL exhibits, including instance, schema, calculation, definition, label, and presentation linkbase documents, plus a cover page interactive data file, ensuring structured data availability for the registration statement.

Who signed HCW Biologics’ exhibits-only S-1 amendment?

The amendment is signed on behalf of HCW Biologics by Founder and Chief Executive Officer Hing C. Wong, with additional signatures from the chairman, chief financial officer, and other directors, some executed via attorney-in-fact authority.