[SCHEDULE 13G] Immunome, Inc. SEC Filing

Rhea-AI Filing Summary

The Vanguard Group filed a Schedule 13G disclosing a passive ownership stake in Immunome Inc. (IMNM) as of 30 Jun 2025.

• Beneficial ownership: 4,524,952 common shares, representing 5.2 % of outstanding stock, triggering the 5 % reporting threshold.
• Voting vs. dispositive power: Vanguard holds 0 shares with sole voting power and 89,119 shares with shared voting power. It has 4,353,438 shares with sole dispositive power and 171,514 shares with shared dispositive power, underscoring a largely passive position focused on investment management rather than influence.
• The filer qualifies as an investment adviser (IA) under Rule 13d-1(b)(1)(ii)(E) and certifies the shares were acquired in the ordinary course of business, not to influence control.
• No other persons hold more than 5 % indirectly through Vanguard-managed accounts, and no group or subsidiary disclosure is required.
• Certification signed by Ashley Grim, Head of Global Fund Administration, on 29 Jul 2025.

For investors, the filing signals increasing institutional ownership from a major index manager, which can enhance liquidity and visibility but is not indicative of activist intent.

Positive

• Institutional validation: A 5.2 % stake by one of the world’s largest asset managers can increase market confidence and trading liquidity.

Negative

• Limited influence: Vanguard reports zero sole voting power, indicating the position provides little immediate governance support or activist potential.

Insights

Portfolio Manager

TL;DR – Vanguard now holds 5.2 % of IMNM, passive stake improves liquidity but offers no activist catalyst.

Crossing the 5 % threshold brings Immunome into prominent index portfolios, likely boosting daily trading volumes and index-fund demand. Vanguard’s zero sole voting power suggests its governance team will vote per internal guidelines, limiting direct influence on strategy. While passive funds rarely drive valuation re-ratings, the increased institutional base can lower volatility and broaden analyst coverage over time. Overall impact: modestly positive for liquidity, neutral for fundamental outlook.

Corporate Governance Expert

TL;DR – Filing is routine; no control intent, governance impact minimal.

Schedule 13G—rather than 13D—confirms Vanguard’s intent to remain passive. The absence of sole voting power and limited shared voting authority (≈0.1 % of shares) translates to negligible sway over board matters. Management should not expect policy pressure beyond standard stewardship themes (ESG, compensation alignment). Investors seeking strategic activism should look elsewhere.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

Immunome Inc

(Name of Issuer)

Common Stock

(Title of Class of Securities)

45257U108

(CUSIP Number)

06/30/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No. 45257U108

1

Names of Reporting Persons

The Vanguard Group

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

PENNSYLVANIA

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 89,119.00
7	Sole Dispositive Power 4,353,438.00
8	Shared Dispositive Power 171,514.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

4,524,952.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.20 %

12

Type of Reporting Person (See Instructions)

IA

SCHEDULE 13G

Item 1.
(a)	Name of issuer: Immunome Inc
(b)	Address of issuer's principal executive offices: 18702 North Creek Parkway, Suite 100, Bothell, WA, 98011
Item 2.
(a)	Name of person filing: The Vanguard Group
(b)	Address or principal business office or, if none, residence: 100 Vanguard Blvd., Malvern, PA 19355
(c)	Citizenship: PA
(d)	Title of class of securities: Common Stock
(e)	CUSIP No.: 45257U108
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 4524952
(b)	Percent of class: 5.2 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 0
	(ii) Shared power to vote or to direct the vote: 89119
	(iii) Sole power to dispose or to direct the disposition of: 4353438
	(iv) Shared power to dispose or to direct the disposition of: 171514
Item 5.	Ownership of 5 Percent or Less of a Class.
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. The Vanguard Group, Inc.'s clients, including investment companies registered under the Investment Company Act of 1940 and other managed accounts, have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the securities reported herein. No one other person's interest in the securities reported herein is more than 5%.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

The Vanguard Group

Signature:	Ashley Grim
Name/Title:	Head of Global Fund Administration
Date:	07/29/2025

FAQ

How many Immunome (IMNM) shares does Vanguard now own?

Vanguard reports 4,524,952 IMNM common shares.

What percentage of Immunome’s outstanding stock does this represent?

The filing states the stake equals 5.2 % of the class.

Is Vanguard’s position activist or passive?

It is passive; the Schedule 13G and certification confirm no intent to influence control.

Does Vanguard have voting power over the IMNM shares?

Vanguard has 0 sole voting power and 89,119 shares with shared voting power.

When was the ownership threshold crossed?

The event date triggering the filing is 30 Jun 2025.