Immatics Q3 2026 earnings: net loss widens to €76M

BMS's collaboration ended in August 2026; Moderna was Immatics' only revenue-generating strategic collaboration as of September 30.

Available on EDGAR 11/10/2026 - 07:05 AM EST Accepted by SEC EDGAR 11/10/2026 - 07:04 AM EST Learn about SEC filing dates

Rhea-AI Filing Summary

Immatics N.V. reported third-quarter and nine-month 2026 results for periods ended September 30. Collaboration revenue for the quarter was €6.9 million, compared with €5.2 million a year earlier, while nine-month revenue was €23.7 million versus €28.5 million. Net loss was €76.0 million for the quarter and €196.3 million for nine months, compared with €50.5 million and €160.7 million in 2025. Research and development expenses were €70.3 million for the quarter and €191.9 million for nine months.

Cash and cash equivalents were €276.6 million and other financial assets were €195.7 million as of September 30, 2026. Management believes these resources are sufficient to fund operating expenses and capital expenditure requirements through at least the next 12 months. Nine-month operating cash outflow was €163.2 million, versus €118.0 million in 2025. On August 26, 2026, the company closed an offering of 15,535,100 ordinary shares and issued 4,315,304 pre-funded warrants; gross proceeds were €115.7 million from shares and €32.1 million from warrants.

The Phase 3 SUPRAME trial is ongoing, with required randomizations on track to be completed by year-end. Immatics expects topline data from the final progression-free survival analysis in the first half of 2027, followed by a BLA submission in 2027.

1 point · 0 major

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0 major · 4 points

How the balance works

Positive

• Minor pointThird-quarter collaboration revenue increased to €6.9 million from €5.2 million.

Negative

• Moderate pointThird-quarter net loss widened to €76.0 million from €50.5 million.
• Moderate pointNine-month net loss widened to €196.3 million from €160.7 million.
• Moderate pointNine-month operating cash outflow reached €163.2 million, versus €118.0 million.
• Minor pointNine-month collaboration revenue declined to €23.7 million from €28.5 million.

Filing Explained

The issued pre-funded warrants can add ordinary shares at a $0.001 exercise price, reducing existing holders’ ownership percentages if exercised.

Immatics’ interim report says the BMS collaboration ended in August 2026; as of September 30, 2026, Moderna was its only revenue-generating collaboration.

The issued pre-funded warrants have a $0.001 exercise price, no expiration date, and may be exercised in whole or in part at holders’ discretion; exercise converts them into ordinary shares. If exercised, those additional shares increase the total share count and reduce existing holders’ percentage ownership, absent offsetting changes.

Key Figures

Quarterly collaboration revenue: €6.9 million Nine-month collaboration revenue: €23.7 million Quarterly net loss: €76.0 million loss +5 more

8 metrics

Quarterly collaboration revenue €6.9 million Three months ended September 30, 2026; €5.2 million in 2025

Nine-month collaboration revenue €23.7 million Nine months ended September 30, 2026; €28.5 million in 2025

Quarterly net loss €76.0 million loss Three months ended September 30, 2026; €50.5 million loss in 2025

Nine-month net loss €196.3 million loss Nine months ended September 30, 2026; €160.7 million loss in 2025

Cash and cash equivalents €276.6 million As of September 30, 2026

Other financial assets €195.7 million As of September 30, 2026

Net cash used in operating activities €163.2 million Nine months ended September 30, 2026; €118.0 million in 2025

Pre-funded warrants issued 4,315,304 warrants August 26, 2026 offering

Key Terms

cost-to-cost basis, pre-funded warrants, blinded independent central review, RMAT designation

4 terms

cost-to-cost basis financial

"revenue is recognized over time on a cost-to-cost basis"

pre-funded warrants financial

"issued 4,315,304 pre-funded warrants to purchase ordinary shares"

Pre-funded warrants are financial instruments that give investors the right to purchase a company's stock at a set price, but with most or all of the purchase price paid upfront. They function like a coupon or gift card for stock, allowing investors to buy shares later at a fixed price, which can be beneficial if they want to avoid future price increases. This makes them important for investors seeking flexibility and certainty in their investment plans.

blinded independent central review medical

"blinded independent central review (BICR)-assessed"

Blinded independent central review is a quality-control step in clinical trials where outside medical experts, who do not know which patients received the experimental therapy, re-examine key measurements (like scans or lab results) to prevent bias. Think of it as neutral referees watching game footage without knowing the teams, which gives investors greater confidence that the trial results are fair, more reliable for regulators, and less likely to be overturned or disputed.

RMAT designation regulatory

"FDA RMAT designation"

A Regenerative Medicine Advanced Therapy (RMAT) designation is a US regulatory status granted by the Food and Drug Administration to experimental cell, gene or tissue-based therapies that treat serious conditions. It gives the developer extra access to regulators and opportunities for faster review, similar to getting a fast-track lane at a government agency; for investors, RMAT can shorten time to market and reduce regulatory risk, which may increase a program’s commercial value and stock impact.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What were IMTX's third-quarter 2026 revenue and net loss?

IMTX reported third-quarter collaboration revenue of €6.9 million and a net loss of €76.0 million. Revenue compared with €5.2 million in the third quarter of 2025, while net loss compared with €50.5 million. For the nine months ended September 30, 2026, revenue was €23.7 million and net loss was €196.3 million.

What cash resources did IMTX report at September 30, 2026?

Immatics reported €276.6 million in cash and cash equivalents and €195.7 million in other financial assets as of September 30, 2026. Management believes these resources are sufficient to fund operating expenses and capital expenditure requirements through at least the next 12 months.

What did IMTX's August 2026 offering include?

Immatics closed the offering on August 26, 2026, with 15,535,100 ordinary shares and 4,315,304 pre-funded warrants. The public offering prices were €7.45 per ordinary share and €7.446 per warrant share. Gross proceeds were €115.7 million from the ordinary shares and €32.1 million from the warrants.

What is the expected timing for IMTX's SUPRAME trial update?

Immatics said enrollment in the Phase 3 SUPRAME trial remains on track to complete required randomizations by year-end. The company expects to disclose topline data from the final progression-free survival analysis in the first half of 2027, followed by a BLA submission in 2027.

Why did IMTX's collaboration revenue decline during the first nine months of 2026?

Nine-month collaboration revenue was €23.7 million, compared with €28.5 million in 2025. Immatics attributed lower Moderna revenue primarily to a lower proportion of costs incurred relative to the overall project budget, partially offset by €1.6 million in milestone payments. BMS revenue also declined, and that collaboration ended in August 2026.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 6-K

REPORT OF FOREIGN PRIVATE ISSUER

Pursuant to Rule 13a-16 or 15d-16

of the Securities Exchange Act of 1934

November 10, 2026

Commission File Number: 001-39363

IMMATICS N.V.

Paul-Ehrlich-Straße 15

72076 Tübingen, Federal Republic of Germany

(Address of Principal Executive Office)

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form 20-F ☒ Form 40-F ☐

INFORMATION CONTAINED IN THIS REPORT ON FORM 6-K

On November 10, 2026, Immatics N.V. (the “Company”) issued an interim report for the three- and nine-month period ended September 30, 2026, which is attached hereto as Exhibit 99.1, and issued a press release announcing the third quarter 2026 financial results and business update for the Company, which is attached hereto as Exhibit 99.2.

INCORPORATION BY REFERENCE

This Report on Form 6-K (other than Exhibit 99.2 hereto) including Exhibit 99.1 hereto, shall be deemed to be incorporated by reference into the registration statements on Form S-8 (Registration Nos. 333-249408, 333-265820, 333-280935, 333-288466 and 333-297029) and the registration statements on Form F-3 (Registration Nos. 333-240260, 333-274218 and 333-286151) of Immatics N.V. and to be a part thereof from the date on which this report is filed, to the extent not superseded by documents or reports subsequently filed or furnished.

EXHIBITS

Exhibit Number	Description
99.1	Immatics N.V. interim report for the three- and nine-month period ended September 30, 2026.
99.2	Press release dated November 10, 2026.

2

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

		IMMATICS N.V.
Date: November 10, 2026		by:	/s/ Harpreet Singh
			Harpreet Singh
			Chief Executive Officer

3

Exhibit 99.1

PRELIMINARY NOTE

The unaudited interim condensed Consolidated Financial Statements for the three- and nine-month period ended September 30, 2026, included herein, have been prepared in accordance with International Accounting Standard 34 (“Interim Financial Reporting”), as issued by the International Accounting Standards Board (“IASB”). The Consolidated Financial Statements are presented in euros. All references in this interim report to “$,” and “U.S. dollars” mean U.S. dollars and all references to “€” and “euros” mean euros, unless otherwise noted.

This interim report, including “Management’s Discussion and Analysis of Financial Condition and Results of Operations,” contains statements that constitute forward-looking statements within the meaning of Section 21E of the Exchange Act and Section 27A of the Securities Act of 1933, as amended (the “Securities Act”). All statements other than statements of historical facts, including statements regarding our future results of operations and financial position, business and commercial strategy, potential market opportunities, products and product candidates, research pipeline, ongoing and planned preclinical studies and clinical trials, regulatory submissions and approvals, research and development costs, the nature of clinical trials (including whether such clinical trials will be registration-enabling), timing and likelihood of success, as well as plans and objectives of management for future operations are forward-looking statements. Many of the forward-looking statements contained in this interim report can be identified by the use of forward-looking words such as “anticipate”, “believe”, “could”, “expect”, “should”, “plan”, “intend”, “estimate”, “will” and “potential” among others. Forward-looking statements are based on our management’s beliefs and assumptions and on information available to our management at the time such statements are made. Such statements are subject to risks and uncertainties, and actual results may differ materially from those expressed or implied in the forward-looking statements due to various factors, including, but not limited to the macro-economic environment; inconclusive clinical trial results or clinical trials failing to achieve one or more endpoints, early data not being repeated in ongoing or future clinical trials, failures to secure required regulatory approvals, disruptions from failures by third-parties on whom we rely in connection with our clinical trials, delays or negative determinations by regulatory authorities, changes or increases in oversight and regulation; increased competition; manufacturing delays or problems, inability to achieve enrollment targets, disagreements with our collaboration partners or failures of collaboration partners to pursue product candidates, legal challenges, including product liability claims or intellectual property disputes, commercialization factors, including regulatory approval and pricing determinations, disruptions to access to raw materials or starting material, proliferation and continuous evolution of new technologies; disruptions to Immatics’ business; management changes, our ability to maintain effective internal controls over financial reporting and disclosure controls and procedures; dislocations in the capital markets; and other important factors described under “Risk Factors” in our Annual Report on Form 20-F for the year ended December 31, 2025, filed with the Securities and Exchange Commission on March 05, 2026 and those described in our other filings with the Securities and Exchange Commission. Forward-looking statements speak only as of the date on which they were made. Because forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified and some of which are beyond our control, you should not rely on these forward-looking statements as predictions of future events. Moreover, we operate in an evolving environment. New risk factors and uncertainties may emerge from time to time, and it is not possible for management to predict all risk factors and uncertainties. Except as required by applicable law, we do not plan to publicly update or revise any forward-looking statements, whether as a result of any new information, future events, changed circumstances or otherwise.

We own various trademark registrations and applications, and unregistered trademarks, including Immatics®, XPRESIDENT®, ACTengine®, ACTallo®, ACTolog®, XCEPTOR®, TCER®, AbsQuant®, IMADetect® and our corporate logo. All other trade names, trademarks and service marks of other companies appearing in this interim report are the property of their respective owners. Solely for convenience, the trademarks and trade names in this interim report may be referred to without the ® and ™ symbols, but such references should not be construed as any indicator that their respective owners will not assert, to the fullest extent under applicable law, their rights thereto. We do not intend to use or display other companies’ trademarks and trade names to imply a relationship with, or endorsement or sponsorship of us by, any other companies.

As used in this interim report, the terms “Immatics”, “we”, “our”, “us”, “the Group” and “the Company” refer to Immatics N.V. and its subsidiaries, taken as a whole, unless the context otherwise requires. The unaudited interim condensed consolidated financial statements and Management’s Discussion & Analysis of Financial Condition and Results of Operations in this interim report are related to Immatics N.V. and its German subsidiary Immatics Biotechnologies GmbH as well as its U.S. subsidiary Immatics US Inc.

1

Unaudited Interim Condensed Consolidated Statement of Loss of Immatics N.V.

				Three months ended September 30,									Nine months ended September 30,
		Notes		2026				2025					2026				2025
				(Euros in thousands, except per share data)									(Euros in thousands, except per share data)
Revenue from collaboration agreements		4			6,923				5,187					23,679				28,505
Research and development expenses					(70,270	)			(47,176	)				(191,867	)			(134,190	)
General and administrative expenses					(15,810	)			(12,673	)				(44,260	)			(37,520	)
Other income					615				29					639				70
Operating result					(78,542	)			(54,633	)				(211,809	)			(143,135	)
Change in liabilities for warrants		5			(3,263	)			—					(3,263	)			1,730
Other financial income		5			5,816				4,250					18,973				14,684
Other financial expenses		5			(440	)			(289	)				(858	)			(36,151	)
Financial result					2,113				3,961					14,852				(19,737	)
Loss before taxes					(76,429	)			(50,672	)				(196,957	)			(162,872	)
Taxes on income		6			407				127					629				2,123
Net loss					(76,022	)			(50,545	)				(196,328	)			(160,749	)
Net loss per share:		16
Basic					(0.50	)			(0.42	)				(1.39	)			(1.32	)
Diluted					(0.50	)			(0.42	)				(1.39	)			(1.32	)

The accompanying notes are an integral part of these unaudited interim condensed consolidated financial statements.

2

Unaudited Interim Condensed Consolidated Statement of Comprehensive Loss of Immatics N.V.

				Three months ended September 30,									Nine months ended September 30,
		Notes		2026				2025					2026				2025
				(Euros in thousands)									(Euros in thousands)
Net loss					(76,022	)			(50,545	)				(196,328	)			(160,749	)
Other comprehensive income/(loss)
Items that may be reclassified subsequently to profit or loss
Currency translation differences from foreign operations					352				(594	)				3,419				(9,138	)
Total comprehensive loss for the period					(75,670	)			(51,139	)				(192,909	)			(169,887	)

The accompanying notes are an integral part of these unaudited interim condensed consolidated financial statements.

3

Unaudited Interim Condensed Consolidated Statement of Financial Position of Immatics N.V.

				As of
		Notes		September 30, 2026				December 31, 2025
				(Euros in thousands)
Assets
Current assets
Cash and cash equivalents		15			276,614				345,918
Other financial assets		15			195,655				123,419
Accounts receivables		15			7,401				6,099
Income tax receivables*		6			7,866				8,393
Other current assets*		8			23,406				20,179
Total current assets					510,942				504,008
Non-current assets
Property, plant and equipment		9			38,572				42,111
Intangible assets		9			1,662				1,582
Right-of-use assets		9			11,093				12,786
Other non-current assets		8			3,454				1,850
Total non-current assets					54,781				58,329
Total assets					565,723				562,337
Liabilities and shareholders’ equity
Current liabilities
Provisions		10			8,402				—
Accounts payables		11			40,275				18,832
Deferred revenue		4			11,113				15,816
Liabilities for warrants		15			33,363				—
Lease liabilities		15			2,498				2,757
Other current liabilities		12			6,021				5,607
Total current liabilities					101,672				43,012
Non-current liabilities
Deferred revenue		4			10,922				18,541
Lease liabilities		15			11,452				12,878
Deferred tax liabilities		6			3,178				3,807
Total non-current liabilities					25,552				35,226
Shareholders’ equity
Share capital		13			1,523				1,341
Share premium		13			1,424,465				1,277,338
Accumulated deficit		13			(982,316	)			(785,988	)
Other reserves		13			(5,173	)			(8,592	)
Total shareholders’ equity					438,499				484,099
Total liabilities and shareholders’ equity					565,723				562,337

*Income tax receivables previously presented under other current assets are presented separately as a new line item to enhance transparency.

The accompanying notes are an integral part of these unaudited interim condensed consolidated financial statements.

4

Unaudited Interim Condensed Consolidated Statement of Cash Flows of Immatics N.V.

				Nine months ended September 30,
				2026				2025
				(Euros in thousands)
Cash flows from operating activities
Net loss					(196,328	)			(160,749	)
Taxes on income		6			(629	)			(2,123	)
Loss before tax					(196,957	)			(162,872	)
Adjustments for:
Interest income		5			(10,207	)			(13,629	)
Depreciation and amortization					8,655				9,231
Interest expenses		5			615				724
Equity-settled share-based payment		7			16,946				11,712
Net foreign exchange differences and expected credit losses					(8,840	)			33,911
Change in liabilities for warrants		5			3,263				(1,730	)
Loss from disposal of fixed assets					48				157
Changes in:
(Increase)/decrease in accounts receivables					(1,163	)			2,658
(Increase) in other assets					(4,288	)			(1,555	)
Increase/(decrease) in deferred revenue, accounts payables and other liabilities					18,731				(15,028	)
Interest received					10,086				22,558
Interest paid					(615	)			(724	)
Income tax paid		6			(1,776	)			(8,107	)
Income tax refunded		6			2,298				4,733
Net cash used in operating activities					(163,204	)			(117,961	)
Cash flows from investing activities
Payments for property, plant and equipment					(2,307	)			(5,588	)
Payments for intangible assets					(129	)			(190	)
Proceeds from disposal of property, plant and equipment					35				47
Payments for investments classified in Other financial assets					(241,787	)			(280,651	)
Proceeds from maturity of investments classified in Other financial assets					173,285				520,089
Net cash provided by/(used in) investing activities					(70,903	)			233,707
Cash flows from financing activities
Proceeds from issuance of shares and warrants		13			170,355				13
Transaction costs from issuance of shares and warrants		13			(9,892	)			—
Payments of lease liabilities					(2,267	)			(2,211	)
Net cash provided by/(used in) financing activities					158,196				(2,198	)
Net increase/(decrease) in cash and cash equivalents					(75,911	)			113,548
Cash and cash equivalents at the beginning of the period					345,918				236,748
Effects of exchange rate changes and expected credit losses on cash and cash equivalents					6,607				(15,374	)
Cash and cash equivalents at the end of the period					276,614				334,922

The accompanying notes are an integral part of these unaudited interim condensed consolidated financial statements.

5

Unaudited Interim Condensed Consolidated Statement of Changes in Shareholders’ equity of Immatics N.V.

(Euros in thousands)		Notes		Share capital				Share premium				Accumulated deficit				Other reserves				Total share- holders’ equity
Balance as of January 1, 2025					1,216				1,162,136				(589,541	)			1,031				574,842
Other comprehensive loss					—				—				—				(9,138	)			(9,138	)
Net loss					—				—				(160,750	)			—				(160,750	)
Comprehensive loss for the period					—				—				(160,750	)			(9,138	)			(169,888	)
Equity-settled share-based compensation		7			—				11,712				—				—				11,712
Share options exercised		13			—				13				—				—				13
Balance as of September 30, 2025					1,216				1,173,861				(750,291	)			(8,107	)			416,679
Balance as of January 1, 2026					1,341				1,277,338				(785,988	)			(8,592	)			484,099
Other comprehensive income					—				—				—				3,419				3,419
Net loss					—				—				(196,328	)			—				(196,328	)
Comprehensive income/(loss) for the period					—				—				(196,328	)			3,419				(192,909	)
Equity-settled share-based payment		7			—				16,946				—				—				16,946
Share options exercised		13			2				836				—				—				838
Issue of share capital – net of transaction costs		13			180				129,345				—				—				129,525
Balance as of September 30, 2026					1,523				1,424,465				(982,316	)			(5,173	)			438,499

The accompanying notes are an integral part of these unaudited interim condensed consolidated financial statements.

6

Notes to the Unaudited Interim Condensed Consolidated Financial Statements of Immatics N.V.

1. Group information

Immatics N.V., together with its German subsidiary Immatics Biotechnologies GmbH (“Immatics GmbH”) and its U.S. subsidiary, Immatics US Inc., (“Immatics” or “the Group”) is a biotechnology company that is primarily engaged in the research and development of PRAME-directed immunotherapies that harness the power of T cells for the treatment of cancer patients.

Immatics N.V. is registered with the commercial register at the Netherlands Chamber of Commerce under RSIN 861058926 with a corporate seat in Amsterdam and is located at Paul-Ehrlich Str. 15 in 72076 Tübingen, Germany.

These unaudited interim condensed consolidated financial statements of the Group for the three and nine month period ended September 30, 2026, were authorized for issue by the Audit Committee of Immatics N.V. on November 10, 2026.

2. Material accounting policies

Basis of presentation

The unaudited interim condensed consolidated financial statements of the Group as of September 30, 2026 and for the three and nine months ended September 30, 2026 and 2025 have been prepared on a going concern basis in accordance with International Accounting Standard 34 (“Interim Financial Reporting”), as issued by the International Accounting Standards Board (“IASB”).

In accordance with IAS 34, the unaudited interim condensed consolidated financial statements do not include all the information and disclosures required in the annual financial statements and should be read in conjunction with the Group’s annual financial statements for the year ended December 31, 2025, which have been prepared in accordance with IFRS® Accounting Standards as issued by the International Accounting Standards Board (“IASB”), taking into account the recommendations of the IFRS Interpretations Committee (“IFRIC® Interpretations”). In these notes to the unaudited interim condensed consolidated financial statements, information is provided primarily on the items for which there have been significant changes compared with the consolidated financial statements of the Group for the year ended December 31, 2025.

The functional currency of Immatics N.V. and Immatics GmbH is the Euro and the functional currency of Immatics US, Inc. is the U.S. dollar. Transactions in foreign currencies are initially recorded by the Group’s entities at the spot exchange rate on the date the transaction first qualifies for recognition. Monetary assets and liabilities denominated in foreign currencies are translated into the respective functional currency at the closing rate at the reporting date. Non‑monetary items measured at historical cost are translated using the exchange rate at the date of the transaction. Non‑monetary items measured at fair value are translated using the exchange rate at the date when the fair value was determined. Exchange differences arising on the settlement or translation of monetary items are recognized in profit or loss. For purpose of translating the results and financial position of Immatics US, Inc. into Euro, assets and liabilities are translated at the closing rate at the reporting date, income and expenses are translated at average exchange rates for the period and equity components are translated at historical exchange rates. Resulting exchange differences are recognized in other comprehensive income. The information presented in these financial statements may contain rounding differences. Therefore, columns and rows within tables may not add due to rounding. Percentages have been calculated using actual, non-rounded figures.

The following exchange rates from the European Central Bank are used for the unaudited interim condensed consolidated financial statements of the Group as of September 30 and for the three and nine months ended September 30:

	Euros per U.S. Dollar
	2026			2025
Spot rate as of September 30,		0.8807			0.8517
Spot rate as of June 30,		0.8777			0.8532
Spot rate as of December 31,		—			0.8511
Average rate three months ended September 30,		0.8692			0.8561
Average rate nine months ended September 30,		0.8613			0.8938
Average rate three months ended June 30,		0.8599			0.8820

The accounting policies adopted in the preparation of the unaudited interim condensed consolidated financial statements are consistent with those followed in the preparation of the Group’s annual consolidated financial statements for the year ended December 31, 2025, with the addition of the policy for pre-funded warrants described in Note 5. The new and amended standards and interpretations applicable for the first time as of January 1, 2026, as disclosed in the notes to the consolidated financial statements for the year ended

7

December 31, 2025, had no impact on the unaudited interim condensed consolidated financial statements of the Group for the three and nine months ended September 30, 2026.

Estimates and assumptions have to be made in the unaudited interim condensed consolidated financial statements as of September 30, 2026. These have an impact on the amounts and disclosures of the recognized assets and liabilities, income and expenses, and contingent liabilities. Except for the judgments relating to the classification and measurement of pre-funded warrants and their treatment in the calculation of earnings per share, as described in Notes 5 and 16, the estimates and judgments are substantially consistent with those described in the Group’s consolidated financial statements for the year ended December 31, 2025. New developments may result in amounts deviating from the original estimates. These possible developments are outside the sphere of influence of the management.

New Standards

In April 2024, IFRS 18, “Presentation and Disclosure in Financial Statements” (hereinafter ”IFRS 18“) was issued to achieve comparability of the financial performance of similar entities. In the first nine months of fiscal year 2026, the Group continued its project to implement IFRS 18. IFRS 18 replaces the previous standard, IAS 1, ”Presentation of Financial Statements“ (hereinafter ”IAS 1"). The standard is effective for annual reporting periods beginning on or after January 1, 2027, including interim financial statements and requires retrospective application. The Group does not intend to early adopt IFRS 18 and will apply the standard for the first time in its consolidated financial statements for the fiscal year beginning January 1, 2027.

With the introduction of IFRS 18, the future structure of the Group’s Consolidated Statement of Loss and related notes will change significantly – while the classification of expenses according to their function within the Group will remain fundamentally unchanged. In the future, the Group’s revenues and expenses will be categorized based on new definitional requirements, including the three main categories: “operating category,” “investing category,” and “financing category.”

Due to the definitional requirements of the relevant main categories under IFRS 18, there will be shifts within the categories compared to the previous breakdown of the income statement into “Operating result” and “Financial result”. This applies, for example, to foreign currency effects and income from cash and cash equivalents. In addition to the resulting reclassifications within the categories, the Group’s Consolidated Statement of Loss must report the two subtotals defined in IFRS 18 – “Operating profit or loss” and “Profit or loss before financing and income taxes” – beginning with the fiscal year 2027.

In addition to the structural changes in the Group’s Consolidated Statement of Loss, current estimates indicate that there may also be minor changes regarding the presentation of the Consolidated Statement of Financial Position and the Consolidated Statement of Cash Flows. In the Consolidated Statement of Cash Flows the Group expects to present interest received in the investing category and interest paid in the financing category.

The Group has assessed the requirements of IFRS 18 regarding management-defined performance measures (MPMs) and concluded that it does not currently disclose any financial measures that meet the definition of an MPM under IFRS 18. Accordingly, no additional MPM-related disclosures are required. Furthermore, the Group does not expect the adoption of IFRS 18 to have a material impact on its operating results, although changes to the presentation and classification of certain items in the financial statements will be required.

3. Segment information

The Group manages its operations as a single segment for the purposes of assessing performance and making operating decisions. The Group’s focus is on the research and development of PRAME-directed immunotherapies that harness the power of T cells for the treatment of cancer. The Chief Executive Officer is the chief operating decision maker who regularly reviews the consolidated operating results and makes decisions about the allocation of the Group’s resources.

4. Revenue from collaboration agreements

The Group currently earns revenue through strategic collaboration agreements with third party pharmaceutical and biotechnology companies. As of September 30, 2026, the Group had one revenue-generating strategic collaboration with ModernaTX, Inc. (“Moderna”). The collaboration agreement with Bristol-Myers-Squibb (“BMS”) ended in August 2026.

Under IFRS 15, the Group applies significant judgement when evaluating whether the obligations under the collaboration agreements represent one or more combined performance obligations, the determination of the transaction price and the allocation of the transaction price to identified performance obligations.

8

Revenue from collaboration agreements was realized with the following partners:

		Three months ended September 30,								Nine months ended September 30,
		2026				2025				2026				2025
		(Euros in thousands)								(Euros in thousands)
Revenue from collaboration agreements:
Moderna, United States			6,923				4,231				20,836				22,428
BMS, United States			—				956				2,843				6,077
Total			6,923				5,187				23,679				28,505

The Group achieved and recognized a €4.3 million ($5.0 million) milestone for Advanced TCER Activities in December 2025, a €0.5 million ($0.6 million) milestone for Database Activities in June 2026 and a €1.1 million ($1.2 million) milestone for Database Activities in July 2026 related to the Moderna agreement. Other than the milestones described above, the Group did not achieve any additional milestones during the nine months ended September 30, 2026 and did not recognize any royalty revenue under the collaboration agreements. The Group plans to recognize the remaining deferred revenue balance into revenue as it performs the related performance obligations under the Moderna collaboration agreement.

The revenue from the collaboration agreement with Moderna is recognized over time on a cost-to-cost basis. During the three months ended September 30, 2026 and September 30, 2025, €6.9 million and €4.2 million revenue was recognized for the Moderna collaboration agreement, respectively. During the nine months ended September 30, 2026 and September 30, 2025, €20.8 million and €22.4 million revenue was recognized for the Moderna collaboration agreement, respectively.

For the collaboration agreement with BMS revenue was recognized over time on a cost-to-cost basis. During the three months ended September 30, 2026, the collaboration agreement with BMS ended. No revenue was recognized during the three months ended September 30, 2026, as the remaining deferred revenue was recognized in the second quarter of 2026 based on the progress of the collaboration activities. During the three months ended September 30, 2025, revenue of €1.0 million was recognized. During the nine months ended September 30, 2026 and September 30, 2025, €2.8 million and €6.1 million was recognized for the BMS collaboration agreement, respectively.

Deferred revenue related to the collaboration agreements consists of the following:

		As of
		September 30, 2026				December 31, 2025
		(Euros in thousands)
Current			11,113				15,816
Non-current			10,922				18,541
Total			22,035				34,357

Deferred revenues are contract liabilities within the scope of IFRS 15.

9

5. Financial result

Financial income and financial expenses consist of the following:

		Three months ended September 30,								Nine months ended September 30,
		2026				2025				2026				2025
		(Euros in thousands)								(Euros in thousands)
Change in liabilities for warrants			(3,263	)			—				(3,263	)			1,730
Interest income			3,340				3,910				10,207				13,629
Foreign currency gains			2,476				263				8,766				179
Gains on other financial instruments			—				77				—				876
Other financial income			5,816				4,250				18,973				14,684
Interest expenses			(200	)			(231	)			(615	)			(724	)
Foreign currency losses			(73	)			(58	)			(100	)			(35,427	)
Losses on other financial instruments			(167	)			—				(143	)			—
Other financial expenses			(440	)			(289	)			(858	)			(36,151	)
Financial result			2,113				3,961				14,852				(19,737	)

On August 26, 2026, the Group issued 4,315,304 pre-funded warrants to purchase ordinary shares with a public offering price of €7.446 ($8.689) per warrant share. The pre-funded warrants are accounted for as a non-derivative financial liability at amortized cost. Changes in the valuation of the pre-funded warrants are recognized in the Company’s Consolidated Statement of Loss as Change in liabilities for warrants. The pre-funded warrants have no expiration date and may be exercised in whole or in part at any time at the holders’ discretion. The liabilities for pre-funded warrants were recognized at fair value less underwriting discount resulting in a carrying amount of €32.1 million.

Since inception the value of the liabilities for pre-funded warrants increased by €1.3 million and resulted in a corresponding expense for the three and nine months ended September 30, 2026. The Change in liabilities for warrants of €3.3 million also includes €2.0 million of underwriting discount fully amortized in accordance with the estimated expected life of the instruments, resulting in a carrying amount of €33.4 million as of September 30, 2026.

The Company’s public warrants expired on July 1, 2025, without any being exercised during their lifetime. As a result, the related liabilities for warrants were derecognized from the Consolidated Statement of Financial Position on that date, with no impact on the Consolidated Statement of Loss for the three months ended September 30, 2025, since the fair value of the warrants was €0.00 as of June 30, 2025. For the nine months ended September 30, 2025, changes in liabilities for warrants resulted in a decrease of €1.7 million, recognized as income, as the fair value declined from €0.24 ($0.25) per warrant as of December 31, 2024, to €0.00 ($0.00) per warrant as of June 30, 2025, prior to their expiration.

Interest income mainly results from short-term deposits as well as cash and cash equivalents. Interest expenses mainly result from leases.

Foreign currency gains and losses mainly consist of gains and losses in connection with our USD holdings of cash and cash equivalents as well as short-term deposits in Immatics N.V. and Immatics GmbH.

Gains and losses on other financial instruments include expected credit loss expenses and reversals of previously recognized expected credit losses relating to cash and cash equivalents and other financial assets for the three and nine months ended September 30, 2026 and 2025, respectively.

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6. Income Tax

The following table illustrates the current and deferred taxes for the periods indicated:

		Three months ended September 30,								Nine months ended September 30,
		2026				2025				2026				2025
		(Euros in thousands)								(Euros in thousands)
Current income tax			—				(4	)			—				(4	)
Deferred income tax			407				131				629				2,127
Taxes on income			407				127				629				2,123

The following table illustrates the income tax receivables for the periods indicated per entity:

		As of
		September 30, 2026				December 31, 2025
		(Euros in thousands)
Immatics N.V.			6,236				7,251
Immatics GmbH			1,630				1,142
Immatics US Inc.			—				—
Total			7,866				8,393

Income tax receivables previously included within other current assets are presented as a separate line item in the statement of financial position to enhance transparency. Income tax receivables mainly consist of withholding taxes on interest income.

During the three and nine months ended September 30, 2026 and 2025, the Group generated a net loss. Therefore, the Group did not recognize a current income tax expense and no equivalent current tax liability for the three and nine months ended September 30, 2026 and 2025.

During the three months ended September 30, 2026 and 2025, the deferred tax liability decreased by €0.4 million and €0.1 million and during the nine months ended September 30, 2026 and 2025 by €0.6 million and €2.1 million, respectively, due to a decrease in temporary differences and correspondingly the Group recognized a deferred income tax benefit.

Immatics paid income tax of €1.8 million during the nine months ended September 30, 2026, for income tax prepayments that the Group expects to claim back in full.

Immatics received an income tax refund of €2.3 million during the nine months ended September 30, 2026, related to income tax prepayments made in prior periods.

The Group calculated the current income tax expense based on the taxable income for the respective period. The Group took into account the tax losses carried forward that can be used to offset the taxable income generated for the purpose of income tax calculation for each entity. In accordance with §10d para 2 EStG (German income tax code), 70% (corporate tax) / 60% (trade tax) of income of a given year can be offset with tax losses carried forward. Accordingly, 30% / 40% of the income before tax is subject to income tax. Due to the limitations on ability to offset deferred tax liabilities with tax losses carried forward in accordance with §10d para 2 EStG, Immatics N.V. and Immatics GmbH need to account for all deferred tax liabilities for taxable temporary differences whereas deferred tax assets on losses carried forward can only be recognized to a certain percentage.

Since Immatics N.V., Immatics GmbH and Immatics US, Inc. did not generate taxable income during the three and nine months ended September 30, 2026 and 2025, no current income tax expense is recognized, respectively.

During the three and nine months ended September 30, 2026 and 2025, the Group’s German operations were subject to a statutory tax rate of 30.6% and 30.2%, respectively, and the Group’s U.S. operations were subject to a federal corporate income tax rate of 21%.

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Due to changes in ownership in prior periods, there are certain limitations on tax losses carried forward for net operating losses incurred by Immatics US, Inc., under Section 382 of the U.S. Internal Revenue Code.

7. Share-based payments

Immatics N.V. has five share-based payment plans. In June 2020, Immatics N.V. established an initial equity incentive plan (“2020 Equity Plan”). This plan was complemented by the Company’s 2022 stock option and incentive plan (“2022 Equity Plan”) which was approved by the Immatics shareholders at the Annual General Meeting on June 13, 2022. At the Annual General Meeting on June 20, 2024, Immatics shareholders approved the Company’s 2024 stock option and incentive plan (“2024 Equity Plan”). At the Annual General Meeting on June 18, 2025, Immatics shareholders approved the Company’s 2025 stock option and incentive plan (“2025 Equity Plan”). At the Annual General Meeting on June 18, 2026, Immatics shareholders approved the Company’s 2026 stock option and incentive plan (“2026 Equity Plan”). The 2026 Equity Plan allows the Company to grant additional options and restricted stock units.

Under the 2020 Equity Plan, the 2022 Equity Plan, the 2024 Equity Plan and the 2025 Equity Plan, directors, management and employees have been granted different types of options, all of which are equity-settled transactions. As of September 30, 2026, no awards were granted under the 2026 Equity Plan.

Under the plans, the Company has the settlement choice for all options granted and has no present obligation to settle in cash, therefore, all options are treated as equity-settled share-based payment transactions.

Subject to meeting performance restrictions, granted options shall accelerate and become vested and exercisable in full immediately prior to and subject to the consummation of a sale event, which was not deemed probable as of September 30, 2026 and 2025, respectively.

Service Options

Under the 2020 Equity Plan, the 2022 Equity Plan, the 2024 Equity Plan, and the 2025 Equity Plan, Immatics issues employee stock options with a service requirement (“Service Options”) to acquire shares of Immatics N.V. The service-based options for employees will vest on a four-year time-based quarterly vesting schedule with a one-year cliff period. Under the 2022 Equity Plan, the 2024 Equity Plan and the 2025 Equity Plan, service options granted based on initial election to the Board will vest on a three-year time-based quarterly vesting schedule and annual service options for members of the Board will vest entirely after one year. Service Options are granted on a recurring basis. The Company granted Service Options, which were accounted for using the respective grant date fair value.

Immatics applied a Black-Scholes pricing model to determine the fair value of the Service Options, with a weighted average fair value of $6.62 per Service Option granted during the nine months ended September 30, 2026 and used the following weighted average assumptions:

		Three months ended September 30, 2026				Nine months ended September 30, 2026
Exercise price in USD		$	9.38			$	9.35
Underlying share price in USD		$	9.38			$	9.35
Volatility			67.71	%			79.35	%
Time period (years)			6.11				6.05
Risk-free rate			4.41	%			3.91	%
Dividend yield			0.00	%			0.00	%

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Service Options outstanding as of September 30, 2026:

		2026
		Weighted average exercise price in USD				Number
Service Options outstanding on January 1, 2026			9.35				11,889,848
Service Options granted in 2026			9.35				3,960,600
Service Options forfeited in 2026			8.72				481,656
Service Options exercised in 2026			6.71				141,597
Service Options expired in 2026			10.88				31,206
Service Options outstanding on September 30, 2026			9.39				15,195,989
Service Options exercisable on September 30, 2026			9.70				8,622,347
Weighted average remaining contract life (years)			7.30

Performance-Based Options (“PSUs”)

In addition, at the initial listing on Nasdaq, certain executive officers and key personnel of the Group received under the 2020 Equity Plan performance-based options (“PSUs”), vesting based on both the achievement of market capitalization milestones and satisfaction of a four-year time-based vesting schedule. The PSUs are split into three equal tranches. The performance criteria for each of the three respective tranches requires Immatics to achieve a market capitalization of at least $1.5 billion, $2 billion and $3 billion, respectively.

The Company did not grant PSUs during the three and nine months ended September 30, 2026.

PSUs outstanding as of September 30, 2026:

		2026
		Weighted average exercise price in USD				Number
PSUs outstanding on January 1, 2026			10.10				3,668,000
PSUs granted in 2026			—				—
PSUs forfeited in 2026			12.15				90,666
PSUs outstanding on September 30, 2026			10.04				3,577,334
PSUs exercisable on September 30, 2026			10.09				1,216,419
Weighted average remaining contract life (years)			3.83

Restricted Stock Units ("RSUs")

Under the 2025 Equity Plan, Immatics issues employee RSUs with a service requirement to obtain shares of Immatics N.V. The RSUs for all employees will vest in four equal annual installments upon satisfaction of service requirements.

During the three and nine months ended September 30, 2026, Immatics granted 196,620 and 1,429,700 RSUs, which are accounted for using the respective grant date fair value.

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RSUs outstanding as of September 30, 2026:

		2026
		Weighted average grant date fair value in USD				Number
RSUs outstanding on January 1, 2026			—				—
RSUs granted in 2026			9.41				1,429,700
RSUs forfeited in 2026			9.32				60,000
RSUs outstanding on September 30, 2026			9.41				1,369,700
Weighted average remaining contract life (years)			3.40

Total share-based compensation expenses:

The Group recognized total employee-related share-based compensation expenses from all plans, during the three and nine months ended September 30, 2026 and 2025 as set out below:

		Three months ended September 30,								Nine months ended September 30,
		2026				2025				2026				2025
		(Euros in thousands)
Research and development expenses			(2,855	)			(1,792	)			(9,046	)			(6,012	)
General and administrative expenses			(3,113	)			(1,450	)			(7,900	)			(5,700	)
Total share-based compensation expenses			(5,968	)			(3,242	)			(16,946	)			(11,712	)

Additional fully vested outstanding awards

Immatics GmbH previously issued share-based awards to employees under former Equity plans. As part of the initial listing on Nasdaq, all outstanding awards were replaced by a combination of cash payments and share-based awards under the 2020 Equity Plan in Immatics N.V. These awards are fully vested and no additional expense is recognized.

Matching Stock Options outstanding as of September 30, 2026:

		2026
		Weighted average exercise price in USD				Number
Matching Stock Options outstanding on January 1, 2026			10.00				1,290,682
Matching Stock Options forfeited in 2026			—				—
Matching Stock Options exercised in 2026			—				—
Matching Stock Options expired in 2026			10.00				140
Matching Stock Options outstanding on September 30, 2026			10.00				1,290,542
Matching Stock Options exercisable on September 30, 2026			10.00				1,290,542
Weighted average remaining contract life (years)			3.75

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Converted Options outstanding as of September 30, 2026:

		2026
		Weighted average exercise price in USD				Number
Converted Options outstanding on January 1, 2026			2.97				457,715
Converted Options forfeited in 2026			—				—
Converted Options exercised in 2026			1.11				18,644
Converted Options expired in 2026			—				—
Converted Options outstanding on September 30, 2026			3.05				439,071
Converted Options exercisable on September 30, 2026			3.05				439,071
Weighted average remaining contract life (years)			1.25

8. Other current and non-current assets

Other current assets consist of the following:

		As of
		September 30, 2026				December 31, 2025
		(Euros in thousands)
Prepaid expenses			13,833				12,920
Value added tax receivables			826				782
Government grant receivables			6,546				4,615
Other assets			2,201				1,862
Total			23,406				20,179

Prepaid expenses include expenses for licenses and software of €5.1 million as of September 30, 2026 and €3.4 million as of December 31, 2025 and prepaid maintenance expenses of €1.4 million as of September 30, 2026 and €1.0 million as of December 31, 2025. The remaining prepaid expenses of €7.3 million as of September 30, 2026 and €8.5 million as of December 31, 2025 are mainly prepayments to clinical research organizations and for insurance and other services.

Other non-current assets consist of the following:

		As of
		September 30, 2026				December 31, 2025
		(Euros in thousands)
Prepaid expenses			2,754				1,081
Other assets			700				769
Total			3,454				1,850

9. Property, plant and equipment, intangible assets and Right-of-use assets

During the nine months ended September 30, 2026 and September 30, 2025, the Group acquired property, plant and equipment and intangible assets in the amount of €1.9 million and €6.0 million, respectively.

The Group’s additions include leasehold improvements, lab equipment, office equipment and computer equipment for the research and commercial GMP manufacturing facility construction in Houston, Texas of €1.1 million and €4.6 million for the nine months ended September 30, 2026 and September 30, 2025, respectively.

During the nine months ended September 30, 2026 and September 30, 2025, there were no material additions to right-of-use assets and corresponding lease liabilities.

The unpaid investments decreased from €0.5 million as of December 31, 2025 to €0.0 million as of September 30, 2026 which is accounted for in accounts payables.

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10. Provisions

Provisions consist of the following:

		As of
		September 30, 2026				December 31, 2025
		(Euros in thousands)
Provision for bonuses			8,402				—
Total			8,402				—

This balance sheet item relates to provisions for the Group’s annual employee bonuses, which were paid at year end.

11. Accounts payables

Accounts payables consist of the following:

		As of
		September 30, 2026				December 31, 2025
		(Euros in thousands)
Trade payables			9,188				340
Accrued liabilities			31,087				18,492
Total			40,275				18,832

Accounts payables are non-interest-bearing and are due within one year. The carrying amounts of accounts payables represent fair values due to their short-term nature.

12. Other current liabilities

Other current liabilities consist of the following:

		As of
		September 30, 2026				December 31, 2025
		(Euros in thousands)
Accrual for vacation and overtime			2,497				1,707
Payroll tax			898				2,318
Income tax liability			32				32
Other liabilities			2,594				1,550
Total			6,021				5,607

Other current liabilities are non-interest-bearing and are due within one year. The carrying amounts of financial liabilities included in other current liabilities approximate their fair values due to their short-term nature.

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13. Shareholders’ equity

As of September 30, 2026 and December 31, 2025, the total number of ordinary shares of Immatics N.V. outstanding is 152,266,773 and 134,071,432 with a par value of €0.01, respectively.

On August 26, 2026, the Group closed an offering of 15,535,100 ordinary shares with a public offering price of €7.45 ($8.69) per ordinary share, and issued 4,315,304 pre-funded warrants to purchase ordinary shares with a public offering price of €7.446 ($8.689) per warrant share. For the issued ordinary shares, the Group received gross proceeds of €115.7 million ($135.0 million) less transaction costs of €7.3 million ($8.5 million), resulting in an increase in share capital of €155.4 thousand and share premium of €108.2 million. The pre-funded warrants are classified as a financial liability.

On March 12, 2026, the Group issued 2,500,000 ordinary shares within the At-the-Market Offering Program ("ATM") with Leerink Partners LLC with a price of €8.68 ($10.02) per ordinary share. The Group received gross proceeds of €21.6 million ($25.0 million) less transaction costs of €0.5 million ($0.6 million), resulting in an increase in share capital of €25.0 thousand and share premium of €21.1 million.

Additionally, the number of ordinary shares increased during the nine months ended September 30, 2026, due to exercised share options from the Group’s equity incentive plan, resulting in an increase in share capital of €2 thousand and share premium of €0.8 million.

The number of ordinary shares increased during the nine months ended September 30, 2025, due to exercised share options from the Group’s equity incentive plan, resulting in an increase in share capital of €0.1 thousand and share premium of €12.6 thousand.

Other reserves are related to accumulated foreign currency translation amounts associated with the Group’s U.S. operations.

14. Related party disclosures

During the nine months ended September 30, 2026, the Group did not enter into any new related-party transactions with its key management personnel or with related entities other than the granting of a total of 384,000 service options to its Board, the granting of 2,174,950 service options to purchase ordinary shares, the granting of 521,300 RSUs to Immatics’ key management personnel, who are members of the Executive Committee but not Directors and the settlement of a termination benefit of €0.3 million to key management personnel.

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15. Financial Instruments

Set out below are the carrying amounts and fair values of the Group’s financial instruments that are carried in the unaudited interim condensed consolidated financial statements.

		Carrying amount per measurement category
		Financial assets as of September 30, 2026								Financial liabilities as of September 30, 2026
(Euros in thousands)		At fair value through profit or loss				At amortized cost				At fair value through profit or loss				At amortized cost				IFRS 7 not applicable and IFRS 16				September 30, 2026
Current/non-current assets
Cash and cash equivalents			—				276,614				—				—				—				276,614
Short-term deposits*			—				195,655				—				—				—				195,655
Accounts receivables			—				7,401				—				—				—				7,401
Other current/non-current assets*			—				2,895				—				—				23,965				26,860
Current/non-current liabilities
Accounts payables			—				—				—				40,275				—				40,275
Other current liabilities			—				—				—				50				5,971				6,021
Liabilities for warrants			—				—				—				33,363				—				33,363
Lease liabilities			—				—				—				—				13,950				13,950
Total			—				482,565				—				73,688				43,886

		Carrying amount per measurement category
		Financial assets as of December 31, 2025								Financial liabilities as of December 31, 2025
(Euros in thousands)		At fair value through profit or loss				At amortized cost				At fair value through profit or loss				At amortized cost				IFRS 7 not applicable and IFRS 16				December 31, 2025
Current/non-current assets
Cash and cash equivalents			—				345,918				—				—				—				345,918
Short-term deposits*			—				123,419				—				—				—				123,419
Accounts receivables			—				6,099				—				—				—				6,099
Other current/non-current assets*			—				2,388				—				—				19,641				22,029
Current/non-current liabilities
Accounts payables			—				—				—				18,832				—				18,832
Other current liabilities			—				—				—				50				5,557				5,607
Lease liabilities			—				—				—				—				15,635				15,635
Total			—				477,824				—				18,882				40,833

*“Short-term deposits” are classified within the line item “other financial assets”. Other current/non-current assets classified as financial instruments comprise mainly of deposits.

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16. Earnings and Loss per Share

The Group reported basic and diluted loss per share during the three and nine months ended September 30, 2026 and 2025.

Basic earnings and loss per share are calculated by dividing the net profit or loss adjusted for the change in liabilities for pre-funded warrants by the weighted-average number of ordinary shares outstanding, including shares issuable upon exercise of pre-funded warrants.

Diluted earnings and loss per share for the three and nine months ended September 30, 2026, are calculated by adjusting the weighted-average number of ordinary shares outstanding for any dilutive effects resulting from equity awards granted to the Board and employees of the Group. The Group’s equity awards for which the exercise price exceeds the Group’s weighted average share price for the three and nine months ended September 30, 2026, are excluded from the calculation of diluted weighted average number of ordinary shares.

The Group was loss-making during the three and nine months ended September 30, 2026 and September 30, 2025, respectively, therefore all instruments under the 2020, 2022, 2024 and 2025 Equity Plan are anti-dilutive instruments and are excluded in the calculation of diluted weighted average number of ordinary shares outstanding.

The 7,187,500 Immatics Warrants issued in 2020 expired on July 1, 2025.

		Three months ended September 30,								Nine months ended September 30,
		2026				2025				2026				2025
		(Euros in thousands, except share and per share data)								(Euros in thousands, except share and per share data)
Numerator:
Net loss			(76,022	)			(50,545	)			(196,328	)			(160,749	)
Adjustments of net loss			3,263				—				3,263				—
Net loss available to common shareholders			(72,759	)			(50,545	)			(193,065	)			(160,749	)
Denominator:
Weighted average shares outstanding - Basic			144,262,289				121,562,940				138,578,738				121,555,415
Effect of potentially dilutive warrants / share options			—				—				—				—
Weighted average shares outstanding - Diluted			144,262,289				121,562,940				138,578,738				121,555,415
Loss per share - Basic			(0.50	)			(0.42	)			(1.39	)			(1.32	)
Loss per share - Diluted			(0.50	)			(0.42	)			(1.39	)			(1.32	)

17. Commitments and contingencies

The statements regarding contingent liabilities and other financial liabilities described in the consolidated financial statements of the Group for the year ended December 31, 2025 have not materially changed.

18. Events occurring after the interim reporting period

The Company evaluated subsequent events for recognition or disclosure through November 10, 2026 and did not identify additional material subsequent events.

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MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

The following discussion and analysis is based on the financial information of Immatics N.V., together with its German subsidiary Immatics Biotechnologies GmbH and its U.S. subsidiary, Immatics US, Inc. (“Immatics”, the “Company”, the “Group”, “we”, “our”). You should read the following discussion and analysis of our financial condition and results of operations together with our unaudited interim condensed consolidated financial statements for the three and nine month period ended September 30, 2026 and 2025 included in this interim report. You should also read our operating and financial review and prospects and our Consolidated Financial Statements for the year ended December 31, 2025, and the notes thereto, in our Annual Report on Form 20-F for the year ended December 31, 2025, filed with the SEC on March 05, 2026 (the “Annual Report”). The following discussion is based on the financial information of Immatics prepared in accordance with International Financial Reporting Standards (“IFRS”), which may differ in material respects from generally accepted accounting principles in other jurisdictions, including U.S. generally accepted accounting principles.

Overview

We are a clinical-stage biotechnology company and the global leader in precision targeting of PRAME, a target expressed in
more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most
PRAME indications and modalities. Our mission is to make a meaningful impact on the lives of patients with cancer and high unmet
medical needs by producing novel, PRAME-directed immunotherapies that provide tangible clinical benefits. We strive to become an
industry-leading, fully integrated global biopharmaceutical company engaged in developing, manufacturing and commercializing
PRAME immunotherapies for the benefit of cancer patients, our shareholders, our employees and our partners.

PRAME is an intracellular protein presented as a peptide on the surface of tumor cells by HLA molecules. The PRAME peptide
can be targeted by T-cell receptors (“TCRs”) engineered by Immatics, thus overcoming the limitations of classical antibodies and
CAR T-cell therapies not able to access intracellular targets. Our PRAME franchise includes multiple product candidates, therapeutic modalities, indications and combination approaches: anzu-cel (anzutresgene autoleucel; IMA203) and IMA203CD8, both PRAME-directed cell therapies, and IMA402, a PRAME-directed bispecific. Combination approaches include IMA402 with immune checkpoint inhibitors, IMA402 with the MAGEA4/8-directed bispecific IMA401, and anzu-cel in combination with Moderna’s PRAME mRNA therapy designed to enhance the cell therapy response. Each modality targeting PRAME, cell therapy and bispecific, is designed with distinct attributes and mechanisms of action to produce the desired therapeutic effect for the targeted cancer patient populations.

We are also driving innovation beyond PRAME with several proprietary and partnered preclinical product candidates targeting multiple indications.

Since our inception, we have focused on developing our technologies and executing our preclinical and clinical research
programs with the aim of making a meaningful impact on the lives of patients with cancer. We do not have any products approved for
sale. We have funded our operations primarily through equity financing and through payments from our collaboration partners.

We have assembled a team of 721 full-time equivalent employees (FTEs) and 656 FTEs as of September 30, 2026 and December 31, 2025, respectively.

Through September 30, 2026 we have raised €1.7 billion cash and cash equivalents through licensing payments from our collaborators and through private placements and public offerings of securities. We hold cash and cash equivalents and other financial assets of €472.3 million as of September 30, 2026. We believe that we have sufficient capital resources to fund our operations through at least the next 12 months.

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Our Strategy

Our mission is to deliver a meaningful impact on the lives of patients with cancer and unmet medical needs by producing novel, PRAME-directed immunotherapies that provide tangible clinical benefits. We seek to execute the following strategy to further this mission, reinforce our position as the global PRAME leader and maximize the value of our PRAME franchise:

•Anzu-cel (IMA203) PRAME Cell Therapy: First Market Entry in Advanced Melanoma

Anzu-cel (anzutresgene autoleucel), previously called IMA203, is our lead PRAME cell therapy and is expected to be our first PRAME therapy to enter the market in advanced melanoma. The estimated addressable patient population for anzu-cel in second-line or later (2L) advanced melanoma includes ~10,000 patients1. Immatics’ global, randomized, controlled, multi-center Phase 3 clinical trial, SUPRAME, is currently ongoing to evaluate the efficacy, safety and tolerability of anzu-cel PRAME cell therapy as monotherapy vs. investigator's choice in patients with unresectable or metastatic melanoma who have received prior treatment with a PD-1 immune checkpoint inhibitor. Anzu-cel received FDA Orphan Drug Designation and FDA RMAT designation, which includes all the benefits of FDA Breakthrough Therapy Designation. SUPRAME is designed to be an adequate and well-controlled clinical trial to generate the data supporting full regulatory approval of anzu-cel. The primary endpoint for SUPRAME is blinded independent central review (“BICR”)-assessed (RECIST v1.1) progression-free survival (PFS). Key secondary endpoints include overall survival (OS), objective response rate (ORR), safety and patient-reported outcomes measuring quality of life. Enrollment in SUPRAME, currently ongoing in North America and Europe, remains on track to complete required randomizations by year-end to support final analysis for the primary endpoint. The Company expects to disclose topline data from the final PFS analysis in the first half of 2027, followed by a BLA submission in 2027. A Phase 2 cohort to treat approximately 30 additional patients with metastatic uveal melanoma is ongoing and being conducted at select centers in the U.S. and Germany with expertise in uveal melanoma. Data from the ongoing single-arm Phase 1b trial as well as the Phase 2 cohort in metastatic uveal melanoma are intended to support a potential label expansion for anzu-cel following expected initial approval in unresectable or metastatic melanoma.

•IMA203CD8 PRAME Cell Therapy: Expansion to all Advanced PRAME Cancers

IMA203CD8 is our PRAME cell therapy product candidate being developed with the goal of expanding into all advanced PRAME cancers. Given its pharmacology profile, we intend to pursue the clinical development of this product candidate through targeted cohorts in selected tumor types to build the clinical evidence for a broader, tumor-agnostic application.

•IMA402 PRAME Bispecific: Expansion to Earlier-Line PRAME Cancers

To expand the PRAME opportunity to earlier-line PRAME cancers, we are developing our off-the-shelf, next-generation, half-life extended TCR bispecific, IMA402, as a monotherapy or in combination with standard of care. In addition, we are exploring the combination of IMA402 PRAME bispecific with IMA401 MAGEA4/8 bispecific in squamous non-small cell lung cancer (sqNSCLC), and potentially other solid tumor indications.

•Unlock the full potential of strategic collaborations.

We have entered strategic collaborations with key industry partners to maintain and expand our global PRAME leadership position and actively seek to enter additional partnerships. These collaborations enable us to develop transformative therapeutics through the combination of synergistic capabilities and technologies, while providing non-dilutive capital through upfront and potential milestone payments, as well as royalties.

(1) Refers to PRAME+/HLA-A*02:01+ patients per year in the U.S. and EU5 in 2028; Source: Company Forecast 2026.

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Components of Operating Results

Revenue from Collaboration Agreements

To date, we have not generated any revenue from the sale of pharmaceutical products. Our revenue has been solely derived from our collaboration agreements, such as with BMS and Moderna. Our revenue from collaboration agreements to date consists of upfront payments, milestone payments and reimbursement of research and development expenses.

Upfront payments allocated to the obligation to perform research and development services are initially recorded on our Consolidated Statement of Financial Position as deferred revenue and are subsequently recognized as revenue on a cost-to-cost measurement basis, in accordance with our accounting policy as described further under “Critical Accounting Estimates.”

As part of the collaboration arrangements, we grant exclusive licensing rights for the development and commercialization of future product candidates, developed for specified targets defined in the respective collaboration agreement. We carry out our research activities using our proprietary technology and know-how, participate in joint steering committees, and prepare data packages. For the collaboration signed with Moderna in September 2023, the Group identified the following distinct performance obligations: initial early pre-clinical TCER targets (“Early TCER Activities”), one initial advanced pre-clinical TCER target from the TCER part (“Advanced TCER Activities”) and four distinct performance obligations which, due to their identical accounting treatment as license accesses, are jointly accounted for as if they were one performance obligation (“Database Activities”). During the year ended December 31, 2025, Immatics entered into an amendment to the Moderna master agreement to conduct a clinical trial for the Advanced TCER Activities, which is accounted for as a separate distinct performance obligation.

All collaboration agreements resulted in a total of €531.6 million of payments through September 30, 2026.

During the three and nine months ended September 30, 2026, we received milestone payments of €1.1 million and €1.6 million from our collaboration partner Moderna. During the year 2025, we achieved a €4.3 million ($5.0 million) milestone from our collaboration partner Moderna in December 2025, related to a contract modification.

Under our revenue generating collaboration agreements, we are entitled to receive payments for certain development and commercial milestone events, in addition to royalty payments upon successful commercialization of a product. Since the achievement of such milestone events is subject to certain conditions outside the influence of the Company and other risk factors, future milestone revenue is considered a variable consideration that is currently uncertain.

Our ability to generate revenue from sales of pharmaceutical products and to become profitable depends on the successful
commercialization of product candidates by us and/or by our collaboration partners, following successful clinical trials and approval
for sale. To the extent that existing or potential future collaborations generate revenue, our revenue may vary due to many
uncertainties in the development of our product candidates and other factors.

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Research and Development Expenses

Research and development expenses consist primarily of personnel-related costs (including share-based compensation) for the various research and development departments, intellectual property (“IP”) expenses, facility-related costs and amortization as well as direct expenses for clinical and preclinical programs.

Our core business is focused on the following initiatives with the goal of providing novel PRAME-directed immunotherapies to
patients with cancer:

•Anzu-cel (IMA203) PRAME Cell Therapy: First Market Entry in Advanced Melanoma;

•IMA203CD8 PRAME Cell Therapy: Expansion to all Advanced PRAME Cancers;

•IMA402 PRAME bispecific: Expansion to Earlier-Line PRAME Cancers; and

•Unlock the full potential of strategic collaborations.

Research expenses are defined as costs incurred for current or planned investigations undertaken with the prospect of gaining new scientific or technical knowledge and understanding. All research and development costs are expensed as incurred due to scientific uncertainty.

We expect our research and development expenses may increase in the future as we advance existing and future proprietary
product candidates into and through clinical studies and pursue regulatory approval. The process of conducting the necessary clinical
studies to obtain regulatory approval is costly and time-consuming. We expect our headcount may increase to support our continued
research activities and to advance the development of our product candidates. Clinical studies generally become larger and more costly to conduct as they advance into later stages and, in the future, we will be required to make estimates for expense accruals related to clinical study expenses. At this time, we cannot reasonably estimate or know the nature, timing and estimated costs of the efforts that will be necessary to complete the development of any product candidates that we develop. We must demonstrate our products’ safety and efficacy through extensive clinical testing. We may experience numerous unforeseen events during, or as a result of, the testing process that could delay or prevent commercialization of our products, including but not limited to the following:

•after reviewing trial results, we or our collaborators may abandon projects previously believed to be promising;

•we, our collaborators, or regulators may suspend or terminate clinical trials if the participating subjects or patients are being exposed to unacceptable health risks;

•our potential products may not achieve the desired effects or may include undesirable side effects or other characteristics that preclude regulatory approval or limit their commercial use if approved;

•contract manufacturing may not meet the necessary standards for the production of the product candidates or may not be able to supply the product candidates in a sufficient quantity;

•regulatory authorities may find that our clinical trial design or conduct do not meet the applicable approval requirements; and

•safety and efficacy results in various human clinical trials reported in scientific and medical literature may not be indicative of results we obtain in our clinical trials.

Clinical testing is very expensive, can take many years, and the outcome is uncertain. The data collected from our clinical trials
of our TCR T-cell therapy or TCR bispecific candidates may not be sufficient to support approval by the FDA, the EMA or comparable regulatory authorities of our TCR T-cell therapy or TCR bispecific product candidates for the treatment of solid tumors.
The clinical trials for our products under development may not be completed on schedule, the FDA, EMA or regulatory authorities in
other countries may not view data generated from clinical trials that we designate as “pivotal” or “registration-enabling” as sufficient
to support regulatory approval, and the FDA, EMA or regulatory authorities in other countries may not ultimately approve any of our
product candidates for commercial sale. If we fail to adequately demonstrate the safety and effectiveness of any product candidate
under development, we may not receive regulatory approval for those product candidates, which would prevent us from generating
revenues or achieving profitability.

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General and Administrative Expenses

General and administrative expenses consist primarily of personnel-related costs (including share-based compensation) for
finance, legal, human resources, business development and the early stages of our commercial activities and other administrative and
operational functions, professional fees, accounting and legal services, information technology and facility-related costs. These costs
relate to the operation of the business, unrelated to the research and development function or any individual program.

Due to the possible planned increase in research and development activities as explained above, we also expect that our general
and administrative expenses might increase. We might incur increased accounting, audit, legal, regulatory, compliance, director and
officer insurance costs. Additionally, if and when a regulatory approval of a product candidate appears likely, we anticipate an
increase in personnel-related expenses and other expenses as a result of our preparation for commercial operations.

Financial Result

The financial result comprises income and expenses arising from changes in liabilities for warrants, as well as other financial income and other financial expenses. The publicly traded warrants were classified as financial liabilities measured at fair value through profit or loss and the pre-funded warrants are accounted for as a non-derivative financial liability at amortized cost. Changes in the valuation of the pre-funded warrants are recognized in the Company’s Consolidated Statement of Loss as Change in liabilities for warrants. The publicly traded warrants expired on July 1, 2025, without being exercised during their term. The pre-funded warrants were issued on August 26, 2026, have no expiration date and may be exercised in whole or in part at any time at the holders’ discretion.

Other financial income results primarily from interest income and foreign exchange gains. Other financial expenses consist of interest expenses related to lease liabilities and foreign exchange losses.

Results of Operations

Comparison of the Three and Nine Months Ended September 30, 2026 and September 30, 2025

The following table summarizes our consolidated statements of operations for each period presented:

		Three months ended September 30,								Nine months ended September 30,
		2026				2025				2026				2025
		(Euros in thousands, except per share data)								(Euros in thousands, except per share data)
Revenue from collaboration agreements			6,923				5,187				23,679				28,505
Research and development expenses			(70,270	)			(47,176	)			(191,867	)			(134,190	)
General and administrative expenses			(15,810	)			(12,673	)			(44,260	)			(37,520	)
Other income			615				29				639				70
Operating result			(78,542	)			(54,633	)			(211,809	)			(143,135	)
Change in liabilities for warrants			(3,263	)			—				(3,263	)			1,730
Other financial income			5,816				4,250				18,973				14,684
Other financial expenses			(440	)			(289	)			(858	)			(36,151	)
Financial result			2,113				3,961				14,852				(19,737	)
Loss before taxes			(76,429	)			(50,672	)			(196,957	)			(162,872	)
Taxes on income			407				127				629				2,123
Net loss			(76,022	)			(50,545	)			(196,328	)			(160,749	)
Net loss per share:
Basic			(0.50	)			(0.42	)			(1.39	)			(1.32	)
Diluted			(0.50	)			(0.42	)			(1.39	)			(1.32	)

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Revenue from Collaboration Agreements

The following table summarizes our collaboration revenue for the periods indicated:

		Three months ended September 30,								Nine months ended September 30,
		2026				2025				2026				2025
		(Euros in thousands)								(Euros in thousands)
Moderna, United States			6,923				4,231				20,836				22,428
BMS, United States			—				956				2,843				6,077
Total			6,923				5,187				23,679				28,505

Our revenue from collaboration agreements increased by €1.7 million from €5.2 million for the three months ended September 30, 2025 to €6.9 million for the three months ended September 30, 2026. Under our collaboration agreement with Moderna revenue increased from €4.2 million for the three months ended September 30, 2025 to €6.9 million for the three months ended September 30, 2026. For our collaboration with BMS revenue decreased from €1.0 million for the three months ended September 30, 2025 to €0.0 million for the three months ended September 30, 2026. During the three months ended September 30, 2026, the collaboration agreement with BMS ended and no revenue was recognized during this period, as the remaining deferred revenue was fully recognized in the second quarter of 2026. The increase for Moderna is primarily attributable to a received milestone payment of €1.1 million and to a higher proportion of costs incurred relative to the overall project budget within the quarter.

Our revenue from collaboration agreements decreased by €4.8 million from €28.5 million for the nine months ended September 30, 2025 to €23.7 million for the nine months ended September 30, 2026. Under our collaboration agreement with Moderna revenue decreased from €22.4 million during the nine months ended September 30, 2025 to €20.8 million during the nine months ended September 30, 2026. Revenue decreased for our collaboration with BMS from €6.1 million during the nine months ended September 30, 2025 to €2.8 million during the nine months ended September 30, 2026. The collaboration agreement with BMS ended in August 2026 and the remaining deferred revenue was fully recognized during the nine months ended September 30, 2026. The decrease for Moderna is primarily attributable to a lower proportion of costs incurred relative to the overall project budget during the nine months ended September 30, 2026, partially offset by received milestone payments of €1.6 million.

We achieved and recognized a €0.5 million ($0.6 million) milestone for Database Activities in June 2026 and a €1.1 million ($1.2 million) milestone for Database Activities in July 2026 related to the Moderna agreement. We did not achieve any additional milestones or receive any royalty payments in connection with our collaboration agreements during the presented periods.

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Research and Development Expenses

The following table summarizes our research and development expenses for the periods indicated:

		Three months ended September 30,								Nine months ended September 30,
		2026				2025				2026				2025
		(Euros in thousands)								(Euros in thousands)
Direct external research and development expenses by program:
TCR T-cell therapy Programs			(30,026	)			(13,971	)			(77,957	)			(34,947	)
TCR Bispecific Programs			(7,333	)			(5,970	)			(15,570	)			(13,749	)
Other programs			(752	)			(555	)			(1,896	)			(2,016	)
Sub-total direct external expenses			(38,111	)			(20,496	)			(95,423	)			(50,712	)
Indirect research and development expenses:
Personnel related (excluding share-based compensation)			(21,811	)			(16,628	)			(63,049	)			(51,430	)
Share-based compensation expenses			(2,855	)			(1,792	)			(9,046	)			(6,013	)
IP expenses			(529	)			(411	)			(1,474	)			(1,782	)
Facility and depreciation			(3,410	)			(3,044	)			(10,799	)			(8,934	)
Other indirect expenses			(3,554	)			(4,805	)			(12,076	)			(15,319	)
Sub-total indirect expenses			(32,159	)			(26,680	)			(96,444	)			(83,478	)
Total			(70,270	)			(47,176	)			(191,867	)			(134,190	)

Direct external research and development expenses for our TCR T-cell therapy Programs increased from €14.0 million for the three months ended September 30, 2025 to €30.0 million for the three months ended September 30, 2026. This increase mainly resulted from increased activities in our clinical trials for anzu-cel (IMA203), predominantly for SUPRAME. Direct external research and development expenses for our TCR bispecific programs increased from €6.0 million for the three months ended September 30, 2025 to €7.3 million for the three months ended September 30, 2026. This increase mainly resulted from increased clinical trial activities related to our development of IMA402.

Direct external research and development expenses for our other programs such as technology platforms and collaboration agreements increased from €0.6 million for the three months ended September 30, 2025 to €0.8 million for the three months ended September 30, 2026.

Direct external research and development expenses for our TCR T-cell therapy Programs increased from €34.9 million for the nine months ended September 30, 2025 to €78.0 million for the nine months ended September 30, 2026. This increase mainly resulted from increased activities in our clinical trials for anzu-cel (IMA203), predominantly for SUPRAME. Direct external research and development expenses for our TCR bispecific programs increased from €13.7 million for the nine months ended September 30, 2025 to €15.6 million for the nine months ended September 30, 2026. This increase mainly resulted from increased clinical trial activities related to our development of IMA402.

Direct external research and development expenses for our other programs such as technology platforms and collaboration agreements decreased from €2.0 million for the nine months ended September 30, 2025 to €1.9 million for the nine months ended September 30, 2026.

We do not allocate indirect research and development expenses by program, as our research and development personnel work across programs. Our intellectual property expenses are incurred for the protection of cancer antigen targets, T cell receptors, antibodies, bispecific molecules, and antigen discovery platforms which are beneficial to the whole research and development group rather than for specific programs. Our programs use common research and development facilities and laboratory equipment, and we also incur other costs such as general laboratory material or maintenance expenses that are incurred for commonly used activities within the whole research and development group.

Personnel-related expenses increased from €16.6 million for the three months ended September 30, 2025 to €21.8 million for the three months ended September 30, 2026. This increase resulted from our headcount growth due to our increased research and development activities particularly clinical trials. Share-based compensation expenses increased from €1.8 million for the three

26

months ended September 30, 2025 to €2.9 million for the three months ended September 30, 2026. The increase is mainly related to the expense recognized for service options and RSUs granted during the first and second quarter. IP expenses increased from €0.4 million for the three months ended September 30, 2025 to €0.5 million for the three months ended September 30, 2026. Facility and depreciation expenses increased from €3.0 million for the three months ended September 30, 2025 to €3.4 million for the three months ended September 30, 2026. This increase is mainly related to increased maintenance on our manufacturing facility. Other indirect expenses decreased from €4.8 million for the three months ended September 30, 2025 to €3.6 million for the three months ended September 30, 2026.

Personnel-related expenses increased from €51.4 million for the nine months ended September 30, 2025 to €63.0 million for the nine months ended September 30, 2026. This increase resulted from our headcount growth due to our increased research and development activities particularly clinical trials. Share-based compensation expenses increased from €6.0 million for the nine months ended September 30, 2025 to €9.0 million for the nine months ended September 30, 2026. The increase is mainly related to the expense recognized for service options and RSUs granted during the nine months ended September 30, 2026. IP expenses decreased from €1.8 million for the nine months ended September 30, 2025 to €1.5 million for the nine months ended September 30, 2026. Facility and depreciation expenses increased from €8.9 million for the nine months ended September 30, 2025 to €10.8 million for the nine months ended September 30, 2026. This increase is mainly related to increased maintenance on our manufacturing facility. Other indirect expenses decreased from €15.3 million for the nine months ended September 30, 2025 to €12.1 million for the nine months ended September 30, 2026.

General and Administrative Expenses

The following table summarizes our general and administrative expenses for the periods indicated:

		Three months ended September 30,								Nine months ended September 30,
		2026				2025				2026				2025
		(Euros in thousands)								(Euros in thousands)
Personnel related (excluding share-based compensation)			(6,473	)			(5,109	)			(16,633	)			(14,099	)
Share-based compensation expenses			(3,113	)			(1,450	)			(7,900	)			(5,700	)
Professional and consulting fees			(4,005	)			(2,420	)			(9,926	)			(6,647	)
Other external general and administrative expenses			(2,219	)			(3,694	)			(9,801	)			(11,074	)
Total			(15,810	)			(12,673	)			(44,260	)			(37,520	)

Personnel related general and administrative expenses, excluding share-based compensation, increased from €5.1 million for the three months ended September 30, 2025 to €6.5 million for the three months ended September 30, 2026. The increase primarily reflects increased engagement in commercialization preparation activities for anzu-cel (IMA203).

Share-based compensation expenses increased from €1.5 million for the three months ended September 30, 2025 to €3.1 million for the three months ended September 30, 2026. The increase is mainly related to the expense recognized for service options and RSUs granted during the first and second quarter.

Professional and consulting fees increased from €2.4 million for the three months ended September 30, 2025 to €4.0 million for the three months ended September 30, 2026. The increase primarily reflects increased engagement in commercialization preparation activities for anzu-cel (IMA203).

Other external expenses decreased from €3.7 million for the three months ended September 30, 2025 to €2.2 million for the three months ended September 30, 2026.

Personnel related general and administrative expenses, excluding share-based compensation, increased from €14.1 million for the nine months ended September 30, 2025 to €16.6 million for the nine months ended September 30, 2026. The increase primarily reflects increased engagement in commercialization preparation activities for anzu-cel (IMA203).

Share-based compensation expenses increased from €5.7 million for the nine months ended September 30, 2025 to €7.9 million for the nine months ended September 30, 2026. The increase is mainly related to the expense recognized for service options and RSUs granted during the nine months ended September 30, 2026.

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Professional and consulting fees increased from €6.6 million for the nine months ended September 30, 2025 to €9.9 million for the nine months ended September 30, 2026. The increase primarily reflects increased engagement in commercialization preparation activities for anzu-cel (IMA203).

Other external expenses decreased from €11.1 million for the nine months ended September 30, 2025 to €9.8 million for the nine months ended September 30, 2026.

Change in Liabilities for Warrants

On August 26, 2026, Immatics issued 4,315,304 pre-funded warrants under its public offering. The pre-funded warrants have an exercise price of $0.001 per share. The pre-funded warrants are classified as financial liabilities measured at amortized cost.

Since inception the value of the liabilities for pre-funded warrants increased by €1.3 million and resulted in a corresponding expense for the three and nine months ended September 30, 2026. The Change in liabilities for warrants of €3.3 million also includes €2.0 million of underwriting discount fully amortized in accordance with the estimated expected life of the instruments, resulting in a carrying amount of €33.4 million as of September 30, 2026.

On July 1, 2025, the 7,187,500 outstanding publicly traded warrants expired and were derecognized without impact on the Consolidated Statement of Loss at that date. The fair value of the publicly traded warrants decreased from €0.24 ($0.25) per warrant as of December 31, 2024 to €0.00 ($0.00) as of June 30, 2025. During the nine months ended September 30, 2025, a decrease in Liabilities for warrants of €1.7 million and a corresponding income was recognized.

Other Financial Income and Other Financial Expenses

Other financial income increased from €4.3 million for the three months ended September 30, 2025 to €5.8 million for the three months ended September 30, 2026. The increase mainly resulted from higher foreign exchange gains partially offset by lower interest income mainly due to lower interest rates and lower balances of cash and cash equivalents and other financial assets.

Other financial expenses increased from €0.3 million for the three months ended September 30, 2025 to €0.4 million for the three months ended September 30, 2026.

Other financial income increased from €14.7 million for the nine months ended September 30, 2025 to €19.0 million for the nine months ended September 30, 2026. The increase mainly resulted from higher foreign exchange gains partially offset by lower interest income mainly due to lower interest rates and lower balances of cash and cash equivalents and other financial assets.

Other financial expenses decreased from €36.2 million for the nine months ended September 30, 2025 to €0.9 million for the nine months ended September 30, 2026. The decrease mainly resulted from lower foreign exchange losses.

Taxes on income

Taxes on income changed from a benefit of €0.1 million for the three months ended September 30, 2025 to a benefit of €0.4 million for the three months ended September 30, 2026. The income tax benefit during the three months ended September 30, 2026 and September 30, 2025, is mainly related to a decrease in temporary differences resulting in a decrease in deferred tax liability with a corresponding income. Immatics did not generate a taxable profit for the three months ended September 30, 2026 or for the three months ended September 30, 2025, correspondingly, no current income tax was recognized.

Taxes on income changed from a benefit of €2.1 million for the nine months ended September 30, 2025 to a benefit of €0.6 million for the nine months ended September 30, 2026. The income tax benefit during the nine months ended September 30, 2026 and September 30, 2025, is mainly related to a decrease in temporary differences resulting in a decrease in deferred tax liability with a corresponding income. Immatics did not generate a taxable profit for the nine months ended September 30, 2026 or for the nine months ended September 30, 2025, correspondingly, no current income tax was recognized.

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Liquidity and Capital Resources

Cash and cash equivalents decreased from €345.9 million as of December 31, 2025 to €276.6 million as of September 30, 2026.

We believe our existing Cash, cash equivalents and Other financial assets will be sufficient to fund our operating expenses and capital expenditure requirements through at least the next 12 months. We may consider raising additional capital to pursue strategic investments, to take advantage of financing opportunities or for other reasons.

Sources and Uses of Liquidity

We have incurred losses since inception, with the exception of the year ended December 31, 2022 and the year ended December 31, 2024. As of September 30, 2026, we had an accumulated deficit of €982.3 million.

We have funded our operations primarily from public offerings and private placements of our equity securities as well as upfront and other payments from collaboration agreements.

On August 26, 2026, the Group closed an offering of 15,535,100 ordinary shares with a public offering price of €7.45 ($8.69) per ordinary share, and issued 4,315,304 pre-funded warrants to purchase ordinary shares with a public offering price of €7.446 ($8.689) per warrant share. For the issued ordinary shares, the Group received gross proceeds of €115.7 million ($135.0 million) less transaction costs of €7.3 million ($8.5 million), resulting in an increase in share capital of €155.4 thousand and share premium of €108.2 million. For the issued pre-funded warrants the Group received gross proceeds of €32.1 million ($37.5 million) less transaction costs of €2.0 million ($2.2 million). The pre-funded warrants are classified as financial liabilities measured at amortized cost.

We have established an at-the-market (“ATM”) offering program with Leerink Partners LLC pursuant to which we may, from time to time, issue and sell shares. We filed a prospectus supplement and accompanying prospectus on March 27, 2025, relating to the ATM offering program with an aggregate offering price of $150 million. There were no sales under the ATM program during the three months ended September 30, 2026.

On March 12, 2026, the Group issued 2,500,000 ordinary shares according to the ATM offering program with Leerink Partners LLC with a price of €8.68 ($10.02) per ordinary share. The Group received gross proceeds of €21.6 million ($25.0 million) less transaction costs of €0.5 million ($0.6 million), resulting in an increase in share capital of €25.0 thousand and share premium of €21.1 million.

In the year ended December 31, 2025, we received €107.2 million ($125.0 million) gross proceeds less transaction costs of €7.0 million ($8.0 million) in connection with our public offering of 12,500,000 ordinary shares on December 8, 2025.

We plan to utilize the existing Cash, cash equivalents and Other financial assets on hand primarily to fund our operating activities associated with our research and development initiatives to continue or commence clinical trials and seek regulatory approval for our product candidates. We also expect to continue investing in laboratory and manufacturing equipment and operations to support our anticipated development. Cash in excess of immediate requirements is invested in accordance with our investment policy with an emphasis on liquidity and capital preservation and consists primarily of cash in banks and short-term deposits.

Cash Flows

The following table summarizes our cash flows for each period presented:

		Nine months ended September 30,
		2026				2025
		(Euros in thousands)
Net cash provided by / (used in):
Operating activities			(163,204	)			(117,961	)
Investing activities			(70,903	)			233,707
Financing activities			158,196				(2,198	)
Total			(75,911	)			113,548

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Operating Activities

We primarily currently derive cash from our collaboration agreements. Our cash used in operating activities is significantly influenced by our use of cash for operating expenses and working capital to support the business. Historically we experienced negative cash flows from operating activities as we have invested in the development of our technologies and in the clinical and preclinical development of our product candidates.

Our net cash outflow from operating activities for the nine months ended September 30, 2026 was €163.2 million. This was comprised of a loss before tax of €197.0 million and net foreign exchange differences and expected credit losses of €8.8 million, partially offset by non-cash charges from equity-settled share-based compensation expenses for employees of €16.9 million, a decrease in working capital of €13.2 million, depreciation and amortization charge of €8.7 million, a non-cash expense of €3.3 million related to the change in liabilities of warrants and other effects of €0.5 million. The decrease in working capital mainly resulted from an increase in deferred revenue, accounts payables and other liabilities of €18.7 million due to timing of payments, partially offset by an increase in other assets and prepayments of €4.3 million and an increase in accounts receivables of €1.2 million.

Our net cash outflow from operating activities for the nine months ended September 30, 2025 was €118.0 million. This was comprised of a loss before tax of €162.8 million, an increase in working capital of €13.9 million, a non-cash income of €1.7 million related to the change in liabilities of warrants, partially offset by net foreign exchange differences and expected credit losses of €33.9 million, non-cash charges from equity-settled share-based compensation expenses for employees of €11.7 million, depreciation and amortization charge of €9.2 million and other effects of €5.6 million. The increase in working capital mainly resulted from a decrease in deferred revenue, accounts payable and other liabilities of €15.0 million and an increase in other assets and prepayments of €1.6 million, partly offset by a decrease in accounts receivables of €2.7 million.

Investing Activities

Our net outflow of cash from investing activities for the nine months ended September 30, 2026 was €70.9 million. This consisted primarily of cash paid in the amount of €241.8 million for short-term deposit investments that are classified as Other financial assets and held with financial institutions to finance the company and €2.4 million cash paid for new equipment and intangible assets, partially offset by cash received from maturity of short-term deposits of €173.3 million.

Our net inflow of cash from investing activities for the nine months ended September 30, 2025 was €233.7 million. This consisted primarily of cash received from maturity of short-term deposits of €520.1 million, partially offset by cash paid in the amount of €280.7 million for short-term deposit investments that are classified as Other financial assets and held with financial institutions to finance the company and €5.7 million cash paid for new equipment and intangible assets.

Financing Activities

For the nine months ended September 30, 2026, net cash received from financing activities amounted to €158.2 million.

On August 26, 2026, the Group closed an offering of 15,535,100 ordinary shares with a public offering price of €7.45 ($8.69) per ordinary share and issued 4,315,304 pre-funded warrants to purchase ordinary shares with a public offering price of €7.446 ($8.689) per warrant share. For the issued ordinary shares, the Group received gross proceeds of €115.7 million ($135.0 million) less transaction costs of €7.3 million ($8.5 million) resulting in an increase in share capital of €155.4 thousand and share premium of €108.2 million. For the issued pre-funded warrants the Group received gross proceeds of €32.1 million ($37.5 million) less transaction costs of €2.0 million ($2.2 million).

On March 12, 2026, the Group issued 2,500,000 ordinary shares according to the ATM program with Leerink Partners LLC with a price of €8.68 ($10.02) per ordinary share. The Group received gross proceeds of €21.6 million ($25.0 million) less transaction costs of €0.5 million ($0.6 million), resulting in an increase in share capital of €25.0 thousand and share premium of €21.1 million.

The Group intends to use the net proceeds from these offerings to fund the continued research and development of the Group’s pipeline, the manufacturing and production of product candidates and for working capital.

Additionally, the number of ordinary shares increased due to exercised share options from the Group’s equity incentive plan, resulting in an increase in share capital of €2 thousand and share premium of €0.8 million.

For the nine months ended September 30, 2026 the Group paid €2.3 million for lease agreements.

For the nine months ended September 30, 2025, the Group paid €2.2 million for lease agreements.

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Operation and Funding Requirements

Historically, we have incurred significant losses due to our substantial research and development expenses. We have an accumulated deficit of €982.3 million as of September 30, 2026. We expect our expenses to increase in connection with our ongoing activities, particularly as we continue the research and development of, continue or commence clinical trials including GMP manufacturing of, and seek regulatory approval for and, if approved, commercialize our product candidates. We believe that we have sufficient financial resources available to fund our projected operating requirements for at least the next twelve months. Because the outcome of our current and planned clinical trials is highly uncertain, we cannot reasonably estimate the actual amounts necessary to successfully complete the development and commercialization of our product candidates. For example, our costs will increase if we experience any delays in our current and planned clinical trials. Our future funding requirements will depend on many factors, including, but not limited to:

•progress, timing, scope and costs of our clinical trials, including the ability to timely initiate clinical sites, enroll patients and manufacture TCR T-cell therapy and TCR bispecific product candidates for our ongoing, planned and potential future clinical trials;

•time and cost to conduct IND- or CTA-enabling studies for our preclinical programs;

•time and costs required to perform research and development to identify and characterize new product candidates from our research programs;

•the sufficiency of our clinical trials and data to secure regulatory approval;

•time and cost necessary to obtain regulatory authorizations and approvals that may be required by regulatory authorities to execute clinical trials or commercialize our products;

•our ability to successfully commercialize our product candidates, if approved;

•our ability to have clinical and commercial products successfully manufactured consistent with FDA, the EMA and comparable regulatory authorities’ regulations;

•amount of sales and other revenues from product candidates that we may commercialize, any royalty or other payment obligations we have with respect to such sales (such as our tiered low single digit percentage to less than one percentage royalty obligation for certain of our product candidates), the selling prices for such potential products, and the availability of adequate third party coverage and reimbursement for patients;

•sales and marketing costs associated with commercializing our products, if approved, including the cost and timing of building our marketing and sales capabilities;

•cost of building, staffing and validating our manufacturing processes, which may include capital expenditure;

•terms and timing of our current and any potential future collaborations, licensing or other arrangements that we have established or may establish;

•cash requirements of any future acquisitions or the development of other product candidates;

•costs of operating as a public company;

•time and cost necessary to respond to technological, regulatory, political and market developments;

•costs of filing, prosecuting, defending and enforcing any patent claims and other IP rights; and

•costs associated with any potential business or product acquisitions, strategic collaborations, licensing agreements or other arrangements that we may establish.

Identifying potential product candidates and conducting preclinical studies and clinical trials is a time-consuming, expensive and uncertain process that takes many years to complete, and we may never generate the necessary data or results required to obtain regulatory approval and commercialize our product candidates. In addition, our product candidates, if approved, may not achieve commercial success. Our commercial revenues, if any, will be derived from sales of products that we do not expect to be commercially available for a number of years, if at all. Accordingly, we will need to continue to rely on additional financing to achieve our business objectives. Adequate additional financing may not be available to us on acceptable terms, or at all.

Unless and until we can generate sufficient revenue to finance our cash requirements, which may never happen, we will seek additional capital, which may be through a variety of means, including through public and private equity offerings and debt financings, credit and loan facilities and additional collaborations. If we raise additional capital through the sale of equity or convertible debt securities, our existing shareholders’ ownership interest will be diluted, and the terms of such equity or convertible debt securities may include liquidation or other preferences that are senior to or otherwise adversely affect the rights of our existing shareholders. If we raise additional capital through the sale of debt securities or through entering into credit or loan facilities, we may

31

be restricted in our ability to take certain actions, such as incurring additional debt, making capital expenditures, acquiring or licensing IP rights, declaring dividends or encumbering our assets to secure future indebtedness. Such restrictions could adversely impact our ability to conduct our operations and execute our business plan. If we raise additional capital through collaborations with third parties, we may be required to relinquish valuable rights to our IP or product candidates or we may be required to grant licenses for our IP or product candidates on unfavorable terms. If we are unable to raise additional capital when needed, we may be required to delay, limit, reduce or terminate our product development efforts or we may be required to grant rights to third parties to develop and market our product candidates that we would otherwise prefer to develop and market ourselves. For more information as to the risks associated with our future funding needs, see “Risk Factors—Risks Related to Our Financial Position.”

Critical Accounting Estimates

Our unaudited interim condensed consolidated financial statements for the three and nine month period ended September 30, 2026 and 2025, respectively, have been prepared in accordance with International Accounting Standard 34 (Interim Financial Reporting), as issued by the International Accounting Standards Board.

The preparation of the consolidated financial statements in accordance with IFRS for the year ended December 31, 2025 and for the three and nine month period ended September 30, 2026, respectively, required the use of estimates and assumptions by the management that affect the value of assets and liabilities – as well as contingent assets and liabilities – as reported on the balance sheet date, and revenues and expenses arising during the year. The main areas in which assumptions, estimates and the exercising of a degree of discretion are appropriate relate to the determination of revenue recognition, research and development expenses, and share-based compensations as well as income taxes.

Our estimates are based on historical experience and other assumptions that are considered appropriate in the circumstances, and parameters available when the consolidated financial statements were prepared. Existing circumstances and assumptions about future developments, however, may change due to market changes or circumstances arising that are beyond our control. Hence, our estimates may vary from the actual values.

Our material accounting policies are more fully discussed in our unaudited interim condensed consolidated financial statements as of September 30, 2026, and in our consolidated financial statements included in our Annual Report filed with the Securities and Exchange Commission on March 5, 2026.

Recently Issued and Adopted Accounting Pronouncement

For information on the standards applied for the first time as of January 1, 2026 and 2025 please refer to our unaudited interim condensed consolidated financial statements as of September 30, 2026.

Quantitative and Qualitative Disclosures about Market Risk

We are exposed to various risks in relation to financial instruments. Our principal financial instruments comprise cash and cash equivalents, short-term deposits and accounts receivables. The main purpose of these financial instruments is to invest the proceeds of capital contributions and upfront payments from collaboration agreements. We have various other financial instruments such as other receivables and trade accounts payables, which arise directly from our operations.

The main risks arising from the Group’s financial instruments are market risk and liquidity risk. The Board reviews and agrees on policies for managing these risks as summarized below. The Group also monitors the market price risk arising from all financial instruments.

Interest rate risk

Our exposure of the Group to changes in interest rates relates to investments in deposits and to changes in the interest for overnight deposits.

Regarding the assets and liabilities shown in the Consolidated Statement of Financial Position, the Group is currently not subject to interest rate risks.

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Credit risk

Financial instruments that potentially subject us to concentrations of credit and liquidity risk consist primarily of cash and cash equivalents, accounts receivables and short-term deposits. Our cash and cash equivalents and short-term deposits are denominated in euros and U.S. dollars and maintained with six financial institutions in Germany and two in the United States. Our accounts receivables are denominated in U.S. dollars.

We continually monitor our positions with, and the credit quality of, the financial institutions and corporation, which are counterparts to our financial instruments and we are not anticipating non-performance. The maximum default risk corresponds to the carrying amount of the financial assets shown in the Consolidated Statement of Financial Position. We monitor the risk of a liquidity shortage. The main factors considered here are the maturities of financial assets, as well as expected cash flows from equity measures.

Currency risk

Currency risk is the risk that the value of a financial instrument will fluctuate due to changes in foreign exchange rates. In particular, it poses a threat if the value of the currency in which liabilities are priced appreciates relative to the currency of the assets. Our business transactions are generally conducted in Euros and U.S. Dollars. We aim to match Euro cash inflows with Euro cash outflows and U.S. Dollar cash inflows with U.S. Dollar cash outflows where possible. Our objective of currency risk management is to identify, manage and control currency risk exposures within acceptable parameters.

Our cash and cash equivalents were €276.6 million as of September 30, 2026. Approximately 88% of our cash and cash equivalents were held in Germany, of which approximately 32% were denominated in Euros and 68% were denominated in U.S. Dollars. The remainder of our cash and cash equivalents are held in the United States and denominated in U.S. Dollars. Additionally, we have short-term deposits classified as Other financial assets denominated in Euros in the amount of €85.5 million and U.S. Dollars in the amount of €110.2 million as of September 30, 2026.

Market risk and currency risk of warrants

Our activities expose us to financial risks arising from fluctuations in the market price of Immatics’ ordinary shares, which affect the value of the pre-funded warrants. The pre-funded warrants are measured based on the closing market price of Immatics’ ordinary shares on Nasdaq, adjusted for the exercise price of $0.001 per warrant. As of September 30, 2026, a 10% increase (decrease) in the quoted market price of Immatics’ ordinary shares, with all other variables held constant, would have resulted in a loss (gain) before tax of €3.3 million, with a corresponding decrease (increase) in equity.

Currency risk refers to the risk that the value of a financial instrument will fluctuate as a result of changes in foreign exchange rates. As the pre-funded warrants are denominated in U.S. dollars, while the functional currency of Immatics N.V. is the euro, the pre-funded warrants are exposed to foreign currency risk arising from fluctuations in the EUR/USD exchange rate. If the Euro had weakened/strengthened by 10% against U.S. Dollars, with all other variables held constant, the Group’s gain/loss before tax would be €3.7 million/(€3.0 million) with a corresponding effect in the equity as of September 30, 2026.

The risks associated with our warrants result in non-cash, non-operating financial statement effects and have no impact on the Company’s cash position, operating expenses or cash flows.

OTHER INFORMATION

Legal Proceedings

From time to time, we may be subject to various legal proceedings and claims that arise in the ordinary course of our business activities. As of the date of this Report, we do not believe that we are party to any claim or litigation, the outcome of which would, individually or in the aggregate, be reasonably expected to have a material adverse effect on our business.

Risk Factors

There have been no material changes from the risk factors described in the section titled “Risk Factors” in our Annual Report.

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Exhibit 99.2

PRESS RELEASE

Immatics Announces Third Quarter 2026

Financial Results and Business Update

•Enrollment in the SUPRAME Phase 3 trial of anzu-cel (anzutresgene autoleucel, IMA203) is on track to complete the required randomizations by year-end to support final analysis for the primary PFS endpoint

•SUPRAME topline data disclosure remains expected in H1 2027, followed by BLA submission in 2027

•IMA203CD8 PRAME Cell Therapy: Updated Phase 1 data presented at ESMO Congress 2026 showed deep and durable anti-tumor activity across multiple tumor types and a manageable safety profile; in gynecologic cancers at clinically relevant doses, cORR was 55% and mDOR was 8.4 months

•IMA402 PRAME Bispecific: Phase 1b data presented at ESMO Congress 2026 continue to demonstrate encouraging anti-tumor activity in multiple indications, alongside a favorable safety profile, within the recommended Phase 2 dose (RP2D) range. In patients with PRAME-high advanced melanoma cORR was 32%, mDOR was 12.5 months and 1-year OS rate was 91%

•Cash and cash equivalents as well as other financial assets of $536.3 million1 (€472.3 million) as of September 30, 2026; cash reach now projected into Q4 2028

1 All amounts converted using the exchange rate published by the European Central Bank in effect as of September 30, 2026 (1 EUR = 1.1355 USD).

Immatics Press Release November 10, 2026 1 | 14

Houston, Texas and Tuebingen, Germany, November 10, 2026 – Immatics N.V. (NASDAQ: IMTX, “Immatics” or the “Company”), the global leader in precision targeting of PRAME with multiple clinical-stage programs spanning cell therapies and bispecifics, today provided a business update and reported financial results for the quarter ended September 30, 2026.

“Our focus is clear: completing enrollment in the Phase 3 SUPRAME trial and preparing for the BLA filing for anzu-cel in melanoma. In addition, we continue to advance our Phase 1/2 bispecific and cell therapy programs across multiple cancer types,” said Harpreet Singh, Ph.D., Chief Executive Officer and Co-Founder of Immatics. “Everything we do is guided by patients with cancer who urgently need new treatment options. This commitment drives our continued work across the PRAME franchise and our preparations for the anticipated launch of anzu-cel, positioning us well as we enter what we expect to be the defining year for Immatics.”

Third Quarter 2026 and Subsequent Company Progress

PRAME Franchise – Cell Therapy

Anzu-cel (IMA203) PRAME Cell Therapy – First Market Entry in Advanced Melanoma

Anzu-cel (anzutresgene autoleucel), previously called IMA203, is Immatics’ lead PRAME cell therapy and is expected to be the Company’s first PRAME therapy to enter the market in advanced melanoma. The estimated addressable patient population for anzu-cel in second-line or later (2L) advanced melanoma includes ~10,000 patients2.

Phase 3 trial, SUPRAME, for anzu-cel (IMA203) in previously treated, advanced melanoma

•Immatics’ global, randomized, controlled, multi-center Phase 3 clinical trial, SUPRAME, is currently ongoing to evaluate the efficacy, safety and tolerability of anzu-cel PRAME cell therapy as monotherapy vs. investigator's choice in patients with unresectable or metastatic melanoma who have received prior treatment with a PD-1 immune checkpoint inhibitor. Anzu-cel received FDA Orphan Drug Designation and FDA RMAT designation, which includes all the benefits of FDA Breakthrough Therapy Designation.

•SUPRAME is designed to be an adequate and well-controlled clinical trial to generate the data supporting full regulatory approval of anzu-cel.

•The primary endpoint for SUPRAME is blinded independent central review (“BICR”)-assessed (RECIST v1.1) progression-free survival (PFS). Key secondary endpoints include overall survival (OS), objective response rate (ORR), safety and patient-reported outcomes measuring quality of life.

2 Refers to PRAME+/HLA-A*02:01+ patients per year in the U.S. and EU5 in 2028; Source: Company Forecast 2026.

Immatics Press Release November 10, 2026 2 | 14

•Enrollment in SUPRAME, currently ongoing in North America and Europe, remains on track to complete required randomizations by year-end to support final analysis for the primary endpoint.

•The Company expects to disclose topline data from the final PFS analysis in the first half of 2027, followed by a BLA submission in 2027.

Phase 1/2 trial for anzu-cel (IMA203) in previously treated, metastatic melanoma

•Updated Phase 1b clinical data presented at the 2026 ASCO Annual Meeting showed durable anti-tumor activity at longer follow-up in metastatic melanoma, including 56% confirmed objective response rate (cORR), 14.6 months median duration of response (mDOR), 6.1 months median PFS (mPFS) and 16.2 months median OS (mOS). The OS rate was 70% at 12 months and 46% at 24 months. Anzu-cel maintained an expected and manageable tolerability profile. Exploratory analyses, presented at ESMO Congress 2026, further characterized durable clinical benefit and hematologic recovery following one-time treatment with anzu-cel, strengthening its clinical profile.

Phase 2 cohort for anzu-cel (IMA203) PRAME cell therapy in patients with metastatic uveal melanoma

•A Phase 2 cohort to treat approximately 30 additional patients with metastatic uveal melanoma is ongoing and being conducted at select centers in the U.S. and Germany with expertise in uveal melanoma.

•Data from the ongoing single-arm Phase 1b trial as well as the Phase 2 cohort in metastatic uveal melanoma are intended to support a potential label expansion for anzu-cel following expected initial approval in unresectable or metastatic melanoma.

Commercial and Cell Product Manufacturing Update

•The Company continues to build the commercial infrastructure for the anticipated launch of anzu-cel, subject to FDA approval.

•Effective September 28, 2026, Jason Braun was appointed Chief Commercial Officer. Mr. Braun joined Immatics in January 2024 and has led the development of the Company’s commercial strategy and the build-out of its commercial team in preparation for the anticipated launch of anzu-cel. He previously led the marketing launch of Yescarta® and held commercial leadership roles at Kite, Pharmacyclics, Dendreon and Amgen.

•Key leadership positions across the commercial and medical affairs teams have been filled with seasoned leaders from the U.S. biotech and pharmaceutical industry, bringing extensive expertise in commercial cell therapy.

Immatics Press Release November 10, 2026 3 | 14

•The Company operates a fully functional 100,000-square-foot R&D and cell therapy manufacturing facility in the Houston metropolitan area, with capacity to support ongoing clinical trials and commercial supply.

IMA203CD8 PRAME Cell Therapy – Expansion to All Advanced PRAME Cancers

IMA203CD8 is the Company’s PRAME cell therapy product candidate being developed with the goal of expanding into all advanced PRAME cancers. Given its pharmacology profile, the Company intends to pursue the clinical development of this product candidate through targeted cohorts in selected tumor types to build the clinical evidence base for a broader, tumor-agnostic application.

•On October 23, 2026, updated Phase 1 data were presented at ESMO Congress 2026. IMA203CD8 PRAME cell therapy demonstrated deep and durable anti-tumor activity across multiple tumor types with a consistent and manageable safety profile, supporting its tumor-agnostic potential. Among patients with advanced, heavily pretreated gynecologic cancers treated at clinically relevant doses, the cORR was 55% and mDOR was 8.4 months.

•Phase 1a dose escalation is complete. Immatics is currently enrolling patients with uterine cancer at clinically relevant doses to further expand the clinical dataset in this indication.

•In addition, a Phase 1/2 investigator-initiated trial (IIT) in patients with PRAME-positive pediatric cancers is planned to start in H1 2027.

•The clinical activity of IMA203CD8 observed across tumor types with distinct biology and differing levels of PRAME expression, including ovarian cancer, uterine cancer, melanoma and synovial sarcoma, supports the broad applicability of IMA203CD8 across PRAME-positive cancers. The development approach for IMA203CD8 will leverage targeted cohorts of selected tumor types, such as ovarian cancer, uterine cancer, rare cancers and pediatric cancers to build the clinical evidence base for broader, tumor-agnostic application.

Immatics Press Release November 10, 2026 4 | 14

PRAME Franchise - Bispecifics

IMA402 PRAME Bispecific – Expansion to Earlier-Line PRAME Cancers

To expand the PRAME opportunity to earlier-line PRAME cancers, the Company is developing its off-the-shelf, next-generation, half-life extended TCR bispecific, IMA402, as a monotherapy or in combination with standard of care. In addition, Immatics is exploring the combination of IMA402 PRAME bispecific with IMA401 MAGEA4/8 bispecific in squamous non-small cell lung cancer (sqNSCLC) and potentially other solid tumor indications.

•On October 24, 2026, updated Phase 1b data were presented at ESMO Congress 2026. IMA402 demonstrated favorable tolerability as monotherapy and in combination with an immune checkpoint inhibitor (ICI). In the efficacy population treated within the RP2D range, IMA402 demonstrated deep and durable responses, with a cORR of 25% across all tumor types and PRAME expression levels. Among patients with PRAME-high tumors a cORR of 32% was observed. In patients with PRAME-high advanced melanoma, cORR was 32%, mDOR was 12.5 months and 1-year OS was 91%.

•The promising clinical profile of IMA402 supports a development path across various solid tumors in earlier and later treatment lines. These include combination approaches with ICIs in melanoma and in gynecologic cancers, as well as IMA402 in combination with the Company’s MAGEA4/8-directed bispecific, IMA401, in lung cancer with first data expected in 2027.

•Furthermore, the use of Immatics’ proprietary rapid, sensitive and reliable liquid biopsy-based PRAME testing enables precise patient selection and could support potential fast-to-market strategies, subject to regulatory approval, in PRAME-high melanoma and beyond.

Immatics Press Release November 10, 2026 5 | 14

Third Quarter 2026 Financial Results

Cash Position: Cash and cash equivalents, as well as other financial assets, total $536.3 million1 (€472.3 million) as of September 30, 2026, compared to $532.9 million1 (€469.3 million) as of December 31, 2025. The change is primarily the result of gross proceeds of a public offering of $172.5 million and an at-the-market offering of $25 million, offset by ongoing research and development activities.

Revenue: Total revenue, consisting of revenue from collaboration agreements, was $7.8 million1 (€6.9 million) for the three months ended September 30, 2026, compared to $5.9 million1 (€5.2 million) for the three months ended September 30, 2025. The increase is mainly due to a higher milestone as well as higher level of activity and proportion of costs incurred relative to the overall plan in our collaboration programs within the quarter.

Research and Development Expenses: R&D expenses were $79.8 million1 (€70.3 million) for the three months ended September 30, 2026, compared to $53.6 million1 (€47.2 million) for the three months ended September 30, 2025. The increase mainly resulted from costs associated with advancing the product candidates in clinical trials, particularly the SUPRAME trial.

General and Administrative Expenses: G&A expenses were $17.9 million1 (€15.8 million) for the three months ended September 30, 2026, compared to $14.4 million1 (€12.7 million) for the three months ended September 30, 2025. The increase mainly resulted from activities in preparation for commercialization of anzu-cel.

Net Loss: Net loss was $86.3 million1 (€76.0 million) for the three months ended September 30, 2026, compared to a net loss of $57.3 million1 (€50.5 million) for the three months ended September 30, 2025. The increase is mainly driven by higher costs associated with the SUPRAME trial in the three months ended September 30, 2026.

Full financial statements can be found in our Report on Form 6-K filed with the Securities and Exchange Commission (SEC) on November 10, 2026, and published on the SEC website under www.sec.gov.

Upcoming Investor Conferences

•Jefferies Global Healthcare Conference, London, United Kingdom – November 16 - 19, 2026

•J.P. Morgan Healthcare Conference, San Francisco, US – January 11 - 14, 2027

To see the full list of events and presentations, visit: https://investors.immatics.com/events-presentations.

Immatics Press Release November 10, 2026 6 | 14

About PRAME

PRAME is a tumor-associated target expressed in more than 50 cancers. Immatics’ PRAME franchise includes multiple product candidates, therapeutic modalities, indications and combination approaches: anzu-cel (anzutresgene autoleucel; IMA203) and IMA203CD8, both PRAME-directed cell therapies, and IMA402, a PRAME-directed bispecific. Combination approaches include IMA402 with immune checkpoint inhibitors, IMA402 with the MAGEA4/8-directed bispecific IMA401, and anzu-cel in combination with Moderna’s PRAME mRNA therapy designed to enhance the cell therapy response.

About Immatics

Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.

Immatics intends to use its website www.immatics.com as a means of disclosing material non-public information. For regular updates, you can also follow us on LinkedIn and Instagram.

Forward-Looking Statements

Certain statements in this press release may be considered forward-looking statements. Forward-looking statements generally relate to future events or the Company’s future financial or operating performance. For example, statements concerning timing of data read-outs, the timing, outcome and design of clinical trials, the nature of clinical trials (including whether such clinical trials will be registration-enabling), the timing and outcomes of IND, CTA, BLA and other regulatory filings, the timing of commercial launches, estimated market opportunities, manufacturing timetables, capacity and success rates, the potential benefits of product candidates, the Company’s intended strategy, and other metrics are forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as “may”, “should”, “expect”, “plan”, “target”, “intend”, “will”, “estimate”, “anticipate”, “believe”, “predict”, “potential” or “continue”, or the negatives of these terms or variations of them or similar terminology. Such forward-looking statements are subject to risks, uncertainties, and other factors which could cause actual results to differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon estimates and assumptions that, while considered reasonable by Immatics and its management, are inherently uncertain. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. Factors that may cause actual results to differ materially from current expectations include, but are not limited to, various factors beyond management's control including general economic conditions and other risks, uncertainties and factors set forth in the Company’s Annual Report on Form 20-F and other filings with the Securities and Exchange Commission (SEC). Nothing in this press release should be regarded as a

Immatics Press Release November 10, 2026 7 | 14

representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved. You should not place undue reliance on forward-looking statements, which speak only as of the date they are made. The Company undertakes no duty to update these forward-looking statements. All the scientific and clinical data presented within this press release are – by definition prior to completion of the clinical trial and a clinical study report – preliminary in nature and subject to further quality checks including customary source data verification.

Immatics Press Release November 10, 2026 8 | 14

For more information, please contact:

Media

Trophic Communications

Phone: +49 151 74416179

immatics@trophic.eu

Immatics N.V.

Jordan Silverstein

Head of Strategy

Phone: +1 346 319-3325

InvestorRelations@immatics.com

Immatics Press Release November 10, 2026 9 | 14

Immatics N.V. and subsidiaries

Condensed Consolidated Statement of Loss of Immatics N.V.

		Three months ended September 30,									Nine months ended September 30,
		2026				2025					2026				2025
		(Euros in thousands, except per share data)									(Euros in thousands, except per share data)
Revenue from collaboration agreements			6,923				5,187					23,679				28,505
Research and development expenses			(70,270	)			(47,176	)				(191,867	)			(134,190	)
General and administrative expenses			(15,810	)			(12,673	)				(44,260	)			(37,520	)
Other income			615				29					639				70
Operating result			(78,542	)			(54,633	)				(211,809	)			(143,135	)
Change in liabilities for warrants			(3,263	)			—					(3,263	)			1,730
Other financial income			5,816				4,250					18,973				14,684
Other financial expenses			(440	)			(289	)				(858	)			(36,151	)
Financial result			2,113				3,961					14,852				(19,737	)
Loss before taxes			(76,429	)			(50,672	)				(196,957	)			(162,872	)
Taxes on income			407				127					629				2,123
Net loss			(76,022	)			(50,545	)				(196,328	)			(160,749	)
Net loss per share:
Basic			(0.50	)			(0.42	)				(1.39	)			(1.32	)
Diluted			(0.50	)			(0.42	)				(1.39	)			(1.32	)

Immatics Press Release November 10, 2026 10 | 14

Immatics N.V. and subsidiaries

Condensed Consolidated Statement of Comprehensive Loss of Immatics N.V.

		Three months ended September 30,									Nine months ended September 30,
		2026				2025					2026				2025
		(Euros in thousands)									(Euros in thousands)
Net loss			(76,022	)			(50,545	)				(196,328	)			(160,749	)
Other comprehensive income/(loss)
Items that may be reclassified subsequently to profit or loss
Currency translation differences from foreign operations			352				(594	)				3,419				(9,138	)
Total comprehensive loss for the period			(75,670	)			(51,139	)				(192,909	)			(169,887	)

Immatics Press Release November 10, 2026 11 | 14

Immatics N.V. and subsidiaries

Condensed Consolidated Statement of Financial Position of Immatics N.V.

		As of
		September 30, 2026				December 31, 2025
		(Euros in thousands)
Assets
Current assets
Cash and cash equivalents			276,614				345,918
Other financial assets			195,655				123,419
Accounts receivables			7,401				6,099
Income tax receivables			7,866				8,393
Other current assets			23,406				20,179
Total current assets			510,942				504,008
Non-current assets
Property, plant and equipment			38,572				42,111
Intangible assets			1,662				1,582
Right-of-use assets			11,093				12,786
Other non-current assets			3,454				1,850
Total non-current assets			54,781				58,329
Total assets			565,723				562,337
Liabilities and shareholders’ equity
Current liabilities
Provisions			8,402				—
Accounts payables			40,275				18,832
Deferred revenue			11,113				15,816
Liabilities for warrants			33,363				—
Lease liabilities			2,498				2,757
Other current liabilities			6,021				5,607
Total current liabilities			101,672				43,012
Non-current liabilities
Deferred revenue			10,922				18,541
Lease liabilities			11,452				12,878
Deferred tax liabilities			3,178				3,807
Total non-current liabilities			25,552				35,226
Shareholders’ equity
Share capital			1,523				1,341
Share premium			1,424,465				1,277,338
Accumulated deficit			(982,316	)			(785,988	)
Other reserves			(5,173	)			(8,592	)
Total shareholders’ equity			438,499				484,099
Total liabilities and shareholders’ equity			565,723				562,337

Immatics Press Release November 10, 2026 12 | 14

Immatics N.V. and subsidiaries

Condensed Consolidated Statement of Cash Flows of Immatics N.V.

		Nine months ended September 30,
		2026				2025
		(Euros in thousands)
Cash flows from operating activities
Net loss			(196,328	)			(160,749	)
Taxes on income			(629	)			(2,123	)
Loss before tax			(196,957	)			(162,872	)
Adjustments for:
Interest income			(10,207	)			(13,629	)
Depreciation and amortization			8,655				9,231
Interest expenses			615				724
Equity-settled share-based payment			16,946				11,712
Net foreign exchange differences and expected credit losses			(8,840	)			33,911
Change in liabilities for warrants			3,263				(1,730	)
Loss from disposal of fixed assets			48				157
Changes in:
(Increase)/decrease in accounts receivables			(1,163	)			2,658
(Increase) in other assets			(4,288	)			(1,555	)
Increase/(decrease) in deferred revenue, accounts payables and other liabilities			18,731				(15,028	)
Interest received			10,086				22,558
Interest paid			(615	)			(724	)
Income tax paid			(1,776	)			(8,107	)
Income tax refunded			2,298				4,733
Net cash used in operating activities			(163,204	)			(117,961	)
Cash flows from investing activities
Payments for property, plant and equipment			(2,307	)			(5,588	)
Payments for intangible assets			(129	)			(190	)
Proceeds from disposal of property, plant and equipment			35				47
Payments for investments classified in Other financial assets			(241,787	)			(280,651	)
Proceeds from maturity of investments classified in Other financial assets			173,285				520,089
Net cash provided by/(used in) investing activities			(70,903	)			233,707
Cash flows from financing activities
Proceeds from issuance of shares and warrants			170,355				13
Transaction costs from issuance of shares and warrants			(9,892	)			—
Payments of lease liabilities			(2,267	)			(2,211	)
Net cash provided by/(used in) financing activities			158,196				(2,198	)
Net increase/(decrease) in cash and cash equivalents			(75,911	)			113,548
Cash and cash equivalents at the beginning of the period			345,918				236,748
Effects of exchange rate changes and expected credit losses on cash and cash equivalents			6,607				(15,374	)
Cash and cash equivalents at the end of the period			276,614				334,922

Immatics Press Release November 10, 2026 13 | 14

Immatics N.V. and subsidiaries

Condensed Consolidated Statement of Changes in Shareholders’ Equity of Immatics N.V.

(Euros in thousands)		Share capital				Share premium				Accumulated deficit				Other reserves				Total share- holders’ equity
Balance as of January 1, 2025			1,216				1,162,136				(589,541	)			1,031				574,842
Other comprehensive loss			—				—				—				(9,138	)			(9,138	)
Net loss			—				—				(160,750	)			—				(160,750	)
Comprehensive loss for the period			—				—				(160,750	)			(9,138	)			(169,888	)
Equity-settled share-based compensation			—				11,712				—				—				11,712
Share options exercised			—				13				—				—				13
Balance as of September 30, 2025			1,216				1,173,861				(750,291	)			(8,107	)			416,679
Balance as of January 1, 2026			1,341				1,277,338				(785,988	)			(8,592	)			484,099
Other comprehensive income			—				—				—				3,419				3,419
Net loss			—				—				(196,328	)			—				(196,328	)
Comprehensive income/(loss) for the period			—				—				(196,328	)			3,419				(192,909	)
Equity-settled share-based payment			—				16,946				—				—				16,946
Share options exercised			2				836				—				—				838
Issue of share capital – net of transaction costs			180				129,345				—				—				129,525
Balance as of September 30, 2026			1,523				1,424,465				(982,316	)			(5,173	)			438,499

Immatics Press Release November 10, 2026 14 | 14

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