Schedule 13G/A: AWM discloses passive 2.8% in InfuSystem

Rhea-AI Filing Summary

InfuSystem Holdings (INFU): AWM Investment Company filed Amendment No. 11 to Schedule 13G reporting beneficial ownership of 561,656 shares of InfuSystem common stock, representing 2.8% of the class.

AWM reports sole voting and sole dispositive power over these shares. The filing states AWM acts as investment adviser to Special Situations Life Sciences Fund, L.P., which holds the shares. The certification indicates the securities were acquired and are held in the ordinary course of business and not to change or influence control. Item 5 confirms ownership of 5 percent or less of the class. The date of the event requiring the filing is 09/30/2025.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 11)

InfuSystem Holdings, Inc

(Name of Issuer)

Common Stock

(Title of Class of Securities)

45685K102

(CUSIP Number)

09/30/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No. 45685K102

1

Names of Reporting Persons

AWM Investment Company, Inc.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 561,656.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 561,656.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

561,656.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

2.8 %

12

Type of Reporting Person (See Instructions)

IA

Comment for Type of Reporting Person: AWM Investment Company, Inc., a Delaware corporation (AWM), is the investment adviser to Special Situations Life Sciences Fund, L.P. (SSLS) (SSLS will hereafter be referred to as the Fund). As the investment adviser to the Fund, AWM holds sole voting and investment power over 561,656 Shares.

SCHEDULE 13G

Item 1.
(a)	Name of issuer: InfuSystem Holdings, Inc
(b)	Address of issuer's principal executive offices: 3851 WEST HAMLIN ROAD, ROCHESTER HILLS, MICHIGAN, 48309
Item 2.
(a)	Name of person filing: The person filing this report is AWM Investment Company, Inc., a Delaware corporation (AWM), which is the investment adviser to Special Situations Life Sciences Fund, L.P. a Delaware limited partnership (SSLS), (SSLS, will hereafter be referred to as the Fund). The principal business of the Fund is to invest in equity and equity-related securities and other securities of any kind or nature. David M. Greenhouse (Greenhouse) and Adam C. Stettner (Stettner) are members of LS Advisers, L.LC., a New York limited liability company (LS). Greenhouse and Stettner are also controlling principals of AWM.
(b)	Address or principal business office or, if none, residence: 527 Madison Avenue, Suite 2600 New York, NY 10022
(c)	Citizenship: AWM is a Delaware Corporation
(d)	Title of class of securities: Common Stock
(e)	CUSIP No.: 45685K102
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 561,656
(b)	Percent of class: 2.8 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: AWM is the investment adviser to the Fund. As the investment adviser to the Fund, AWM holds sole voting power over 561,656 shares of Common Stock of the Issuer (the Shares) held by SSLS. Greenhouse and Stettner are members of LS, the general partner of SSLS. Greenhouse and Stettner are also controlling principals of AWM.
	(ii) Shared power to vote or to direct the vote: 0
	(iii) Sole power to dispose or to direct the disposition of: AWM is the investment adviser to the Fund. As the investment adviser to the Fund, AWM holds sole investment power over 561,656 shares of Common Stock of the Issuer (the Shares) held by SSLS. Greenhouse and Stettner are members of LS, the general partner of SSLS. Greenhouse and Stettner are also controlling principals of AWM.
	(iv) Shared power to dispose or to direct the disposition of: 0
Item 5.	Ownership of 5 Percent or Less of a Class.
	Ownership of 5 percent or less of a class
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	Not Applicable
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

AWM Investment Company, Inc.

Signature:	Adam Stettner
Name/Title:	Executive Vice President
Date:	11/13/2025

FAQ

What stake in INFU does AWM Investment Company report?

AWM reports beneficial ownership of 561,656 shares of InfuSystem common stock, equal to 2.8% of the class.

Is AWM’s INFU stake passive or active?

It is filed on Schedule 13G/A with a certification of ordinary-course ownership, indicating a passive stake.

Who holds the INFU shares and who has voting power?

The shares are held by Special Situations Life Sciences Fund, L.P.; AWM has sole voting and sole dispositive power over 561,656 shares.

What is the date of the reportable event for AWM’s INFU filing?

The date of the event requiring the filing is 09/30/2025.

What is AWM’s filer classification in this 13G/A?

AWM is classified as an Investment Adviser (IA).

Does AWM own more than 5% of INFU?

No. Item 5 confirms ownership of 5 percent or less of the class.

Who signed the filing and when?

The filing was signed by Adam Stettner, Executive Vice President, on 11/13/2025.