Rock Springs Group Files 13G/A for INZY Reporting Zero Beneficial Ownership

Rhea-AI Filing Summary

Inozyme Pharma, Inc. has a Schedule 13G/A filed on behalf of a reporting group that includes Rock Springs Capital Management LP, Rock Springs Capital LLC, Rock Springs Capital Master Fund LP, Mark Bussard and Kris Jenner. The filing identifies the reporting structure: Rock Springs Capital Management LP acts as investment manager, Rock Springs Capital LLC is the general partner, and Mark Bussard and Kris Jenner each own 50% of the management company.

The filing discloses an aggregate beneficial ownership of 0 shares, representing 0% of the class; sole and shared voting and dispositive powers are all reported as 0. Signatories certify the securities were not acquired to change or influence control, and a joint filing statement commits the parties to file amendments on behalf of all undersigned.

Positive

• Explicit identification of reporting persons and their relationships, including investment manager and general partner roles.
• Clear disclosure that aggregate beneficial ownership is 0 shares (0%) and that voting and dispositive powers are reported as 0.
• Joint filing statement and certification commit the undersigned to file future amendments and attest to intent.

Negative

• No material holdings disclosed, so the filing contains no investor-impacting position.
• Four Pines Master Fund LP is referenced as holding shares in Item 2 but there is no separate reporting entry for Four Pines in the schedules provided.

Insights

Financial Analyst

TL;DR: The Rock Springs group reports no beneficial stake in INZY, so there is no immediate financial or control impact.

The filing documents the identities and relationships among fund entities and individuals but reports 0 shares and 0% ownership, with no voting or dispositive power. From a market-impact perspective, this disclosure is procedural and provides transparency about who would file future amendments, but it does not reflect an economic position that would affect valuation or control.

Corporate Governance Expert

TL;DR: Joint filing and certification are in order; reported ownership and voting power are nil, so governance influence is absent.

The document clearly lists the reporting persons and their internal relationships, including the 50/50 ownership of the management company by Mark Bussard and Kris Jenner, and contains a joint filing agreement and certification stating no intent to influence control. Because the reported beneficial ownership and all voting/dispositive powers are 0, there is no change to issuer governance from these filings.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 3)

Inozyme Pharma, Inc.

(Name of Issuer)

Common stock, par value $0.0001 per share

(Title of Class of Securities)

45790W108

(CUSIP Number)

06/30/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No. 45790W108

1

Names of Reporting Persons

Rock Springs Capital Management LP

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

0.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

0 %

12

Type of Reporting Person (See Instructions)

IA

SCHEDULE 13G

CUSIP No. 45790W108

1

Names of Reporting Persons

Rock Springs Capital LLC

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

CAYMAN ISLANDS

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

0.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

0 %

12

Type of Reporting Person (See Instructions)

HC, OO

SCHEDULE 13G

CUSIP No. 45790W108

1

Names of Reporting Persons

Rock Springs Capital Master Fund LP

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

CAYMAN ISLANDS

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

0.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

0 %

12

Type of Reporting Person (See Instructions)

IA

SCHEDULE 13G

CUSIP No. 45790W108

1

Names of Reporting Persons

Mark Bussard

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

0.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

0 %

12

Type of Reporting Person (See Instructions)

HC, IN

SCHEDULE 13G

CUSIP No. 45790W108

1

Names of Reporting Persons

Kris Jenner

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

0.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

0 %

12

Type of Reporting Person (See Instructions)

HC, IN

SCHEDULE 13G

Item 1.
(a)	Name of issuer: Inozyme Pharma, Inc.
(b)	Address of issuer's principal executive offices: 321 Summer Street, Suite 400, Boston, MA 02210
Item 2.
(a)	Name of person filing: This Statement is filed on behalf of each of the following persons (collectively, the "Reporting Persons"): i. Rock Springs Capital Management LP ("RSCM"); ii. Rock Springs Capital Master Fund LP ("Master Fund"); and iii. Rock Springs Capital LLC ("RSC"); iv. Mark Bussard; and v. Kris Jenner This Statement relates to shares (as defined herein) held directly by the Master Fund, which is a Cayman Island exempted limited partnership, and Four Pines Master Fund LP ("Four Pines"), which is a Cayman Islands exempted limited partnership, and indirectly held by RSCM, a Delaware limited partnership, and RSC, a Delaware limited liability company. RSCM serves as the investment manager to each of the Master Fund and Four Pines. RSC is the general partner of RSCM. Mark Bussard and Kris Jenner each own 50% of the management company.
(b)	Address or principal business office or, if none, residence: Rock Springs Capital Management LP, Rock Springs Capital LLC, Rock Springs Capital Master Fund LP, Mark Bussard, and Kris Jenner: 650 South Exeter, Suite 1070 Baltimore, MD 21202
(c)	Citizenship: Rock Springs Capital Management LP - Delaware Rock Springs Capital Master Fund LP - Cayman Islands Rock Springs Capital LLC - Delaware Mark Bussard - United States Kris Jenner - United States
(d)	Title of class of securities: Common stock, par value $0.0001 per share
(e)	CUSIP No.: 45790W108
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 0
(b)	Percent of class: 0%
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 0
	(ii) Shared power to vote or to direct the vote: 0
	(iii) Sole power to dispose or to direct the disposition of: 0
	(iv) Shared power to dispose or to direct the disposition of: 0
Item 5.	Ownership of 5 Percent or Less of a Class.
	Ownership of 5 percent or less of a class
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. See disclosure in Items 2 and 4 hereof. Certain funds listed in Item 2(a) are known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the shares covered by this Statement that may be deemed to be beneficially owned by the Reporting Persons.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. Please see response to Item 2.
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Rock Springs Capital Management LP

Signature:	Mark Bussard
Name/Title:	Mark Bussard | Member
Date:	08/13/2025

Rock Springs Capital LLC

Signature:	Mark Bussard
Name/Title:	Mark Bussard | Member
Date:	08/13/2025

Rock Springs Capital Master Fund LP

Signature:	Mark Bussard
Name/Title:	Mark Bussard | Member
Date:	08/13/2025

Mark Bussard

Signature:	Mark Bussard
Name/Title:	Mark Bussard
Date:	08/13/2025

Kris Jenner

Signature:	Kris Jenner
Name/Title:	Kris Jenner
Date:	08/13/2025

Exhibit Information

JOINT FILING STATEMENT PURSUANT TO RULE 13d-1(k) The undersigned acknowledge and agree that the foregoing statement on SCHEDULE 13G/A, is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on SCHEDULE 13G/A, shall be filed on behalf of each of the undersigned without the necessity of filing additional joint acquisition statements. The undersigned acknowledge that each shall be responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning him or it contained therein, but shall not be responsible for the completeness and accuracy of the information concerning the others, except to the extent that he or it knows or has reason to believe that such information is inaccurate. Dated: August 13, 2025 Rock Springs Capital Management LP By: Rock Springs Capital LLC, General Partner By: Mark Bussard Name: Mark Bussard Title: Member Rock Springs Capital LLC By: Mark Bussard Name: Mark Bussard Title: Member Rock Springs Capital Master Fund LP By: Rock Springs Capital Management LP, Investment Manager By: Rock Springs Capital LLC, General Partner By: Mark Bussard Name: Mark Bussard Title: Member Mark Bussard By: Mark Bussard Name: Mark Bussard Kris Jenner By: Kris Jenner Name: Kris Jenne

FAQ

Who filed the Schedule 13G/A for Inozyme (INZY)?

The filing is made on behalf of Rock Springs Capital Management LP, Rock Springs Capital LLC, Rock Springs Capital Master Fund LP, Mark Bussard and Kris Jenner.

How many Inozyme (INZY) shares do the reporting persons beneficially own?

The filing reports an aggregate beneficial ownership of 0 shares, representing 0% of the class.

Do the reporting persons have voting or dispositive power over INZY shares?

No; the filing lists sole and shared voting power and sole and shared dispositive power as 0 for each reporting person.

Do the filers state any intent to influence control of Inozyme (INZY)?

The signatories certify that the securities were not acquired and are not held for the purpose of changing or influencing control.

What ownership of the management company is disclosed?

The filing states that Mark Bussard and Kris Jenner each own 50% of the management company.