[144] IONIS PHARMACEUTICALS INC SEC Filing

Rhea-AI Filing Summary

Insider notice to sell common stock: A Form 144 filing shows proposed sale of 437 shares of common stock on 10/06/2025 via Stifel Nicolaus & Company on Nasdaq with an aggregate market value of $30,268.00. The shares were acquired under an Employee Stock Purchase Plan on 09/03/2024 and paid in cash. The filer represents no undisclosed material adverse information and the filing includes prior sales by the same person totaling 208,648 shares across dates in 2025 with gross proceeds shown (largest single prior sale: $12,228,840.00 on 09/03/2025). The notice states standard Rule 144 and Rule 10b5-1 remarks and signature attestation.

Positive

• Securities were acquired under an Employee Stock Purchase Plan, indicating lawful, compensation-based acquisition
• Broker and exchange identified (Stifel Nicolaus & Company; Nasdaq), providing execution transparency

Negative

• Substantial prior sales in 2025 by the same person (totaling 208,648 shares) could reduce insider ownership
• Current filing discloses planned sale, which may modestly increase public float if executed

Insights

Insider Transactions Analyst

TL;DR: An insider plans a small planned sale; prior large sales occurred earlier in 2025.

The filing documents a proposed sale of 437 shares acquired under an Employee Stock Purchase Plan on 09/03/2024

Prior sales by the same person show materially larger disposals in 2025 (e.g., $12,228,840.00 on 09/03/2025), which is relevant for liquidity and insider ownership trends. Monitor filings for cumulative insider sell volumes over the next 30–90 days to assess change in beneficial ownership.

Securities Compliance Specialist

TL;DR: Form 144 mechanics and attestations are routine but trigger public disclosure obligations.

The notice lists broker details (Stifel Nicolaus & Company) and the Nasdaq execution venue, and includes the required attestation that no undisclosed material adverse information exists. This is a standard compliance step for shares exceeding Rule 144 thresholds or when particular conditions apply.

Key compliance items to watch: whether an announced sale completes on 10/06/2025 and whether a Rule 10b5-1 plan date appears in subsequent filings, which would affect interpretation of trading intent.

Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK
Filer CCC
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer

SEC File Number

Address of Issuer

Phone

Name of Person for Whose Account the Securities are To Be Sold

See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.

Relationship to Issuer

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common Stock	Stifel Nicolaus & Company Inc 501 N Broadway St. Louis MO 63102	437	30268.00	159391229	10/06/2025	Nasdaq

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common Stock	09/03/2024	Employee Stock Purchase Plan	Issuer			437	09/03/2024	Cash

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Name and Address of Seller	Title of Securities Sold	Date of Sale	Amount of Securities Sold	Gross Proceeds
Brett Monia 2855 Gazelle Ct Carlsbad CA 92010	Common Stock	09/03/2025	203814	12228840.00
Brett Monia 2855 Gazelle Ct Carlsbad CA 92010	Common Stock	07/30/2025	2432	109440.00
Brett Monia 2855 Gazelle Ct Carlsbad CA 92010	Common Stock	07/30/2025	2432	109440.00
Brett Monia 2855 Gazelle Ct Carlsbad CA 92010	Common Stock	07/11/2025	1160	48416.00

144: Remarks and Signature

Remarks

Date of Notice

Date of Plan Adoption or Giving of Instruction, If Relying on Rule 10b5-1

ATTENTION:

The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.

Signature

ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)

FAQ

What does the Form 144 for IONS disclose about the proposed sale?

The filing shows a proposed sale of 437 common shares on 10/06/2025 via Stifel Nicolaus & Company on Nasdaq with aggregate market value $30,268.00.

How were the 437 shares acquired according to the filing for IONS?

The shares were acquired on 09/03/2024 under an Employee Stock Purchase Plan and paid for in cash.

Does the Form 144 include prior sales by the same person for IONS?

Yes; prior sales in 2025 total 208,648 shares with listed gross proceeds including $12,228,840.00 on 09/03/2025.

Who is the executing broker named in the IONS Form 144?

The broker listed is Stifel Nicolaus & Company Inc at the St. Louis address provided in the filing.

Does the filer make any attestation in the Form 144 for IONS?

Yes; the filer represents they do not possess undisclosed material adverse information and includes the standard signature attestation required by Rule 144.