[144] Ionis Pharmaceuticals, Inc. SEC Filing

Rhea-AI Filing Summary

Relay Therapeutics (RLAY) Form 4 – insider activity. Chief Legal Officer Brian Adams disclosed two automatic sales that occurred solely to satisfy income-tax withholding on recently vested restricted stock units (RSUs).

• 28 Jul 2025: 1,637 shares sold at $3.74.
• 29 Jul 2025: 18,276 shares sold at $3.68.

The transactions were executed under the company’s equity-compensation policy and were not discretionary open-market sales. No option exercises, new grants or other equity movements were reported.

After the sales Adams still beneficially owns 371,472 shares—including 144,611 underlying RSUs—down from 389,748 shares prior to the transactions. The filing contains no operational or financial information and appears to be routine administration rather than a signal of insider sentiment.

Insights

Securities Analyst

TL;DR: Routine tax-withholding sale; negligible impact on RLAY valuation.

The combined sale of ~19.9 k shares (≈US$75 k) is immaterial versus Relay Therapeutics’ market capitalization. Because the trades were automatic and tied to RSU tax obligations, they do not reflect an elective reduction in exposure. Adams’ post-trade holding of more than 370 k shares, including substantial unvested RSUs, maintains alignment with shareholders. No strategic, financial or governance changes are disclosed. I view the filing as neutral and not price-moving.

Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK
Filer CCC
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer

SEC File Number

Address of Issuer

Phone

Name of Person for Whose Account the Securities are To Be Sold

See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.

Relationship to Issuer

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common Stock	Stifel Nicolaus & Company Inc 501 N Broadway St. Louis MO 63102	2432	109440.00	159391229	07/30/2025	Nasdaq

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common Stock	01/03/2022	Option Exercise	Issuer			101489	07/30/2025	Cash

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Name and Address of Seller	Title of Securities Sold	Date of Sale	Amount of Securities Sold	Gross Proceeds
Brett Monia 2855 Gazelle Ct Carlsbad CA 92010	Common Stock	07/30/2025	2432	109440.00

144: Remarks and Signature

Remarks

Date of Notice

Date of Plan Adoption or Giving of Instruction, If Relying on Rule 10b5-1

ATTENTION:

The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.

Signature

ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)

FAQ

How many Relay Therapeutics (RLAY) shares did Brian Adams sell on 28 July 2025?

He sold 1,637 shares at $3.74 each.

What was the second sale reported in the Form 4?

On 29 July 2025 he sold 18,276 shares at $3.68 each.

Why were the shares sold?

Both transactions were automatic sales to cover income-tax withholding from RSU vesting, per company policy.

How many RLAY shares does Brian Adams own after the transactions?

He still beneficially owns 371,472 shares, including 144,611 RSUs.

Do these sales indicate a change in insider sentiment?

The filing states they were non-discretionary; thus they are generally viewed as neutral for sentiment analysis.

Were any new equity awards or option exercises disclosed?

No. The Form 4 reports only the two tax-related sales; no new grants or option exercises were mentioned.