Insider stock sale planned under Rule 144 (NASDAQ: IONS)

Rhea-AI Filing Summary

An affiliate of the issuer has filed a notice under Rule 144 to sell 9,390 shares of common stock through broker Stifel Nicolaus & Company on the Nasdaq market, with an aggregate market value of $795,117. The filing notes that 161,974,393 shares of the issuer’s common stock were outstanding at the time of the notice.

The shares to be sold were acquired from the issuer through stock option exercises on three dates in 2022, 2023, and 2024, all paid in cash. The person filing the notice previously sold 16,777 shares on 11/25/2025 for gross proceeds of $1,342,160 and 3,162 shares on 09/03/2025 for gross proceeds of $192,882. By signing, the seller represents they are not aware of undisclosed material adverse information about the issuer.

Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK
Filer CCC
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer

SEC File Number

Address of Issuer

Phone

Name of Person for Whose Account the Securities are To Be Sold

See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.

Relationship to Issuer

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common Stock	Stifel Nicolaus & Company Inc 501 N Broadway St. Louis MO 63102	9390	795117.00	161974393	01/07/2026	Nasdaq

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common Stock	01/02/2024	Option Exercise	Issuer			9264	01/07/2026	Cash
Common Stock	01/03/2023	Option Exercise	Issuer			3829	01/07/2026	Cash
Common Stock	01/03/2022	Option Exercise	Issuer			5561	01/07/2026	Cash

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Name and Address of Seller	Title of Securities Sold	Date of Sale	Amount of Securities Sold	Gross Proceeds
Shannon Devers 1367 Gazelle Ct Carlsbad CA 92010	Common Stock	11/25/2025	16777	1342160.00
Shannon Devers 1367 Gazelle Ct Carlsbad CA 92010	Common Stock	09/03/2025	3162	192882.00

144: Remarks and Signature

Remarks

Date of Notice

Date of Plan Adoption or Giving of Instruction, If Relying on Rule 10b5-1

ATTENTION:

The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.

Signature

ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)

FAQ

How many IONS common shares are planned to be sold under this Form 144?

The notice covers a proposed sale of 9,390 shares of common stock, with an aggregate market value of $795,117, to be sold through Stifel Nicolaus & Company on Nasdaq.

When is the proposed sale of IONS shares expected to occur?

The filing lists an approximate date of sale of 01/07/2026 for the 9,390 shares of common stock to be sold on Nasdaq.

How were the IONS shares being sold under Rule 144 originally acquired?

The shares were acquired from the issuer via stock option exercises on 01/03/2022, 01/03/2023, and 01/02/2024, with payment described as cash in each case.

What recent IONS share sales has the seller already completed?

The seller previously sold 16,777 shares of common stock on 11/25/2025 for gross proceeds of $1,342,160, and 3,162 shares on 09/03/2025 for gross proceeds of $192,882.

How many IONS shares were outstanding when this Form 144 was filed?

The notice states that 161,974,393 shares of common stock were outstanding at the time of the filing.

Which broker is handling the planned sale of IONS shares?

The proposed sale of 9,390 common shares is to be executed through Stifel Nicolaus & Company Inc., located at 501 N Broadway, St. Louis, MO 63102.

What representation does the seller make about information on the issuer?

By signing the notice, the seller represents that they do not know any material adverse information about the issuer’s current or prospective operations that has not been publicly disclosed.