Form 144: Proposed option‑sale notices and two insider dispositions

Form 144 notice of proposed sales of Common Stock tied to option exercises and recent open‑market dispositions.

Rhea-AI Filing Summary

Form 144 notice of proposed sales of Common Stock tied to option exercises and recent open‑market dispositions. The filing lists multiple option‑exercise issuances dated 07/01/2021, 07/03/2023, 07/02/2018, 07/01/2020, and 07/01/2019 for 12,000; 10,321; 16,000; 12,000; and 16,000 shares respectively. It also reports that Joseph Loscalzo sold 832 shares on 03/03/2026 for $66,833 and 200 shares on 03/04/2026 for $16,000.

Insights

Equity Capital Markets Analyst

Routine Form 144 report showing option‑related issuances and two recent small insider sales.

The filing lists option exercises by the issuer across five grant dates totaling specified share counts (12,000; 10,321; 16,000; 12,000; 16,000). These entries describe securities to be sold tied to exercises, not company operational results.

Two completed dispositions by Joseph Loscalzo—832 shares for $66,833 and 200 shares for $16,000—are recorded with transaction dates 03/03/2026 and 03/04/2026. Cash proceeds and trade dates are shown directly in the listing.

Key Figures

Option exercise — 07/01/2021: 12,000 shares Option exercise — 07/03/2023: 10,321 shares Option exercise — 07/02/2018: 16,000 shares +2 more

5 metrics

Option exercise — 07/01/2021 12,000 shares listed under Securities To Be Sold

Option exercise — 07/03/2023 10,321 shares listed under Securities To Be Sold

Option exercise — 07/02/2018 16,000 shares listed under Securities To Be Sold

Sale by Joseph Loscalzo — 03/03/2026 832 shares for $66,833 Securities Sold During The Past 3 Months

Sale by Joseph Loscalzo — 03/04/2026 200 shares for $16,000 Securities Sold During The Past 3 Months

Key Terms

Form 144, Option Exercise, Issuer

3 terms

Form 144 regulatory

"144: Securities To Be Sold"

Form 144 is a document that investors must file with the government when they plan to sell a large number of shares of a company's stock. It helps ensure transparency so everyone knows how many shares are being sold and when, which can impact the stock's price.

Option Exercise financial

"Common Stock | 07/01/2021 | Option Exercise"

Issuer financial

"Option Exercise | Issuer | | | 12000"

FAQ

What does IONS Form 144 disclose about proposed sales?

The filing lists proposed sales tied to option exercises for specific grant dates and share counts. It details option exercise issuances of 12,000; 10,321; 16,000; 12,000; and 16,000 shares on the listed grant dates.

Who sold shares recently according to the filing for IONS?

Joseph Loscalzo reported two recent sales: 832 shares sold on 03/03/2026 for $66,833 and 200 shares sold on 03/04/2026 for $16,000. The filing shows trade dates and proceeds.

Are the option exercises reported as issuer transactions or open‑market sales?

The option exercises are listed with the method labeled Issuer, indicating exercises resulting in shares issued by the company. The filing pairs those items with the payment method labeled Cash.

Does the Form 144 show total proceeds expected from the proposed sales?

The filing lists cash proceeds for completed past sales by Joseph Loscalzo but does not present an aggregate expected proceeds figure for the option‑related proposed sales in the excerpt provided.

What dates are associated with the option grants shown in the filing?

Grant or grant‑related dates shown include 07/01/2021, 07/03/2023, 07/02/2018, 07/01/2020, and 07/01/2019, each paired with the respective share counts listed in the filing.

AI-generated analysis. How Rhea-AI works. Not financial advice.

See more from StockTitan in Google Search and AI answers. Adds StockTitan as a preferred source · opens Google

Add on Google Not now

Accepted by SEC EDGAR 05/04/2026 - 06:05 PM Learn about SEC filing dates

Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK	0001276128
Filer CCC	XXXXXXXX
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer	IONIS PHARMACEUTICALS INC
SEC File Number	000-19125
Address of Issuer	2855 GAZELLE COURT CARLSBAD CALIFORNIA 92010
Phone	7609319200
Name of Person for Whose Account the Securities are To Be Sold	LOSCALZO JOSEPH
See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.
Relationship to Issuer	Director

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common Stock	Stifel Nicolaus & Company Inc 501 N Broadway St. Louis MO 63102	54321	4345680.00	165262556	05/04/2026	Nasdaq

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common Stock	07/01/2021	Option Exercise	Issuer			12000	05/04/2026	Cash
Common Stock	07/03/2023	Option Exercise	Issuer			10321	05/04/2026	Cash
Common Stock	07/02/2018	Option Exercise	Issuer			16000	05/04/2026	Cash
Common Stock	07/01/2020	Option Exercise	Issuer			12000	05/04/2026	Cash
Common Stock	07/01/2019	Option Exercise	Issuer			16000	05/04/2026	Cash

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Name and Address of Seller	Title of Securities Sold	Date of Sale	Amount of Securities Sold	Gross Proceeds
Joseph Loscalzo 2855 Gazelle Ct Carlsbad CA 92010	Common Stock	03/03/2026	832	66833.00
Joseph Loscalzo 2855 Gazelle Ct Carlsbad CA 92010	Common Stock	03/04/2026	200	16000.00

144: Remarks and Signature

Remarks
Date of Notice	05/04/2026
Date of Plan Adoption or Giving of Instruction, If Relying on Rule 10b5-1	11/18/2025
ATTENTION:
The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.
Signature	/s/ James Weimer, as a duly authorized representative of STIFEL, as attorney-in-fact for Joseph Loscalzo
ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)