IONS Form 144: 225,200 Shares Proposed Resale

IONS notice of proposed resale of 225,200 shares of Common Stock.

Rhea-AI Filing Summary

IONS notice of proposed resale of 225,200 shares of Common Stock. The form lists 225,200 shares to be sold pursuant to an option exercise with cash proceeds and identifies Stifel Nicolaus & Company Inc as a broker. The filing also records two prior dispositions by Elizabeth Hougen of 6,988 and 12,922 shares on 01/30/2026 and 01/16/2026, respectively, with their cash amounts.

Insights

Securities Compliance Attorney

Form 144 reports a proposed resale tied to an option exercise and recent insider dispositions.

The notice lists 225,200 shares offered following an option exercise and names Stifel Nicolaus & Company Inc as the broker. The filing format and figures align with a Rule 144 notice of proposed sale rather than an issuer registration.

Timing and exact settlement mechanics are not specified in the excerpt; subsequent Form 4/Form 144 updates or broker confirmations would show completion.

FAQ

What does the IONS Form 144 disclose about shares to be sold?

It discloses a proposed resale of 225,200 shares of Common Stock tied to an option exercise. The form lists the sale method as cash and names Stifel Nicolaus & Company Inc as broker.

Who is the broker listed on the IONS Form 144?

The filing names Stifel Nicolaus & Company Inc at 501 N Broadway, St. Louis. This broker is listed in connection with the proposed resale of shares.

Did any insider share dispositions occur recently for IONS?

Yes. The filing records Elizabeth Hougen disposing of 6,988 shares on 01/30/2026 and 12,922 shares on 01/16/2026, with cash amounts shown alongside each transaction.

Is the Form 144 an issuer registration for new shares for IONS?

No. The form lists a proposed resale following an option exercise, indicating a notice of intended sale under Rule 144 rather than a registration of new issuer shares.

What sale proceeds are shown for Elizabeth Hougen's past dispositions?

The excerpt shows proceeds of $580,049.00 for 6,988 shares on 01/30/2026 and $985,109.00 for 12,922 shares on 01/16/2026.

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Accepted by SEC EDGAR 03/16/2026 - 04:32 PM Learn about SEC filing dates

Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK	0001074773
Filer CCC	XXXXXXXX
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer	IONIS PHARMACEUTICALS INC
SEC File Number	000-19125
Address of Issuer	2855 GAZELLE COURT CARLSBAD CALIFORNIA 92010
Phone	7609319200
Name of Person for Whose Account the Securities are To Be Sold	HOUGEN ELIZABETH L
See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.
Relationship to Issuer	Officer

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common Stock	Stifel Nicolaus & Company Inc 501 N Broadway St. Louis MO 63102	225200	16284212.00	159391229	03/16/2026	Nasdaq

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common Stock	01/02/2019	Option Exercise	Issuer			225200	03/16/2026	Cash

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Name and Address of Seller	Title of Securities Sold	Date of Sale	Amount of Securities Sold	Gross Proceeds
Elizabeth Hougen 2855 Gazelle Court Carlsbad CA 92010	Common Stock	01/30/2026	6988	580049.00
Elizabeth Hougen 2855 Gazelle Court Carlsbad CA 92010	Common Stock	01/16/2026	12922	985109.00

144: Remarks and Signature

Remarks
Date of Notice	03/16/2026
Date of Plan Adoption or Giving of Instruction, If Relying on Rule 10b5-1	12/09/2025
ATTENTION:
The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.
Signature	/s/ Luca Lotito, as a duly authorized representative of STIFEL, as attorney-in-fact for Elizabeth Hougen
ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)