STOCK TITAN

[Form 4] IONIS PHARMACEUTICALS INC Insider Trading Activity

Filing Impact
(Neutral)
Filing Sentiment
(Negative)
Form Type
4

Officer sale under 10b5-1 plan reduced direct holdings. An executive, Eric Swayze, reported the sale of 6,849 shares of Ionis Pharmaceuticals common stock on 10/06/2025 at a weighted-average price of $69.02. The filing states these sales were executed pursuant to a Rule 10b5-1 trading plan adopted on 08/14/2024, meaning they were pre-arranged instructions rather than discretionary trades.

After the transactions, the reporting person beneficially owns 30,453 shares directly and an additional 184 shares indirectly through a family member. The filer offers to provide detailed per-trade price information to the company, shareholders, or the SEC on request.

La vendita di un funzionario secondo un piano 10b5-1 ha ridotto le partecipazioni dirette. Un dirigente, Eric Swayze, ha riportato la vendita di 6,849 azioni ordinarie di Ionis Pharmaceuticals in data 10/06/2025 a un prezzo medio ponderato di $69.02. La pratica indica che queste vendite sono state eseguite ai sensi di un piano di negoziazione 10b5-1 adottato il 14/08/2024, il che significa che erano istruzioni predefinite anziché operazioni discrezionali.

Dopo le transazioni, la persona che segnala detiene direttamente 30,453 azioni e ulteriori 184 azioni indirettamente tramite un familiare. Il dichiarante si offre di fornire informazioni dettagliate per singola operazione di prezzo alla società, agli azionisti o alla SEC su richiesta.

La venta de un funcionario bajo un plan 10b5-1 redujo las participaciones directas. Un ejecutivo, Eric Swayze, informó la venta de 6,849 acciones ordinarias de Ionis Pharmaceuticals el 10/06/2025 a un precio medio ponderado de $69.02. El archivo indica que estas ventas se realizaron conforme a un plan de comercio de la regla 10b5-1 adoptado el 08/14/2024, lo que significa que fueron instrucciones preacordadas en lugar de operaciones discrecionales.

Después de las transacciones, la persona que informa posee directamente 30,453 acciones y, adicionalmente, 184 acciones indirectamente a través de un familiar. El declarante ofrece proporcionar información detallada por cada operación de precio a la empresa, a los accionistas o a la SEC bajo petición.

10b5-1 계획에 따른 임원 매도가 직접 보유를 감소시켰습니다. 임원인 Eric Swayze가 Ionis Pharmaceuticals 주식 일반주 6,849주를 2025년 10월 6일에 가중평균가 $69.02로 매도했다고 보고했습니다. 신청서에 따르면 이 매도는 08/14/2024에 채택된 10b5-1 거래 계획에 따라 실행되었으며, 이는 사전 약정된 지시였지 재량적 거래가 아니었습니다.

거래 이후 보고인은 직접적으로 30,453주, 가족 구성원을 통해 간접적으로 추가로 184주를 보유하게 되었습니다. 제출인은 회사, 주주 또는 SEC에 요청 시 거래별 가격 정보를 상세히 제공하겠다고 밝혔습니다.

Vente d'un cadre sous un plan 10b5-1 réduisant les avoirs directs. Un dirigeant, Eric Swayze, a signalé la vente de 6 849 actions ordinaires d'Ionis Pharmaceuticals le 06/10/2025 à un cours moyen pondéré de 69,02 $. Le dossier indique que ces ventes ont été exécutées conformément à un plan de négociation 10b5-1 adopté le 14/08/2024, ce qui signifie qu'il s'agissait d'instructions préétablies plutôt que de transactions discrétionnaires.

Après les transactions, la personne déclarant détient directement 30 453 actions et indirectement, par l'intermédiaire d'un membre de la famille, 184 actions supplémentaires. Le déclarant se propose de fournir des informations détaillées par opération de prix à la société, aux actionnaires ou à la SEC sur demande.

Verkauf eines Beamten unter einem 10b5-1-Plan senkte direkte Beteiligungen. Ein Manager, Eric Swayze, meldete den Verkauf von 6.849 Aktien von Ionis Pharmaceuticals Stammaktien am 06.10.2025 zu einem gewichteten Durchschnittspreis von 69,02 $. Die Einreichung besagt, dass diese Verkäufe gemäß einem am 14.08.2024 angenommenen 10b5-1-Handelsplan durchgeführt wurden, was bedeutet, dass es sich um vorher festgelegte Anweisungen und nicht um discretionary Trades handelte.

Nach den Transaktionen besitzt die meldende Person direkt 30.453 Aktien und zusätzlich 184 Aktien indirekt durch ein Familienmitglied. Der Einreicher bietet an, auf Anfrage detaillierte Informationen pro Handelspreis dem Unternehmen, den Aktionären oder der SEC zur Verfügung zu stellen.

بيع من قبل موظف بموجب خطة 10b5-1 خفض الحيازات المباشرة. أبلغ التنفيذي Eric Swayze عن بيع 6,849 سهمًا من Ionis Pharmaceuticals العادية في 10/06/2025 بسعر وسط وزني قدره $69.02. يقول الملف أن هذه المبيعات نُفذت وفقًا لخطة تداول 10b5-1 تبنت في 08/14/2024، ما يعني أنها تعليمات مُسبقة وليست صفقات تقديرية.

بعد المعاملات، يمتلك الشخص المُبلغ بشكل فعّال مباشرة 30,453 سهمًا وبشكل غير مباشر من خلال أحد أفراد الأسرة 184 سهمًا إضافيًا. يعرض المبلغ إن يقدم معلومات تفصيلية بسعر كل صفقة للشركة أو للمساهمين أو للجهة SEC عند الطلب.

在 10b5-1 计划下的官员出售降低了直接持股。 一位高管 Eric Swayze 报告于 2025-10-06 以加权平均价格 $69.02 出售了 6,849 股 Ionis Pharmaceuticals 普通股。文件显示这些销售是根据于 2024-08-14 采纳的 10b5-1 交易计划执行的,这意味着它们是事先安排好的指令,而非自由裁量交易。

交易完成后,报告人直接拥有 30,453 股,并通过家庭成员间接持有额外的 184 股。申报人愿意在公司、股东或 SEC 要求时提供每笔交易的详细价格信息。

Positive
  • Sale executed under a Rule 10b5-1 plan adopted on 08/14/2024, indicating pre-arranged, compliant trading
  • Reporting offers transparency by committing to provide per-trade price details on request
Negative
  • Officer sold 6,849 shares, reducing direct ownership to 30,453 shares
  • Sale represents a meaningful partial divestment (single transaction block reported at ~$69.02 weighted average)

Insights

TL;DR: A pre-planned insider sale reduced direct holdings but followed a documented 10b5-1 plan.

The sale of 6,849 shares at a weighted-average price of $69.02 was executed under a Rule 10b5-1 plan adopted on 08/14/2024, which provides an affirmative defense against insider trading claims by showing trades were pre-scheduled. This procedural detail supports compliance with insider-trading rules.

The reporting officer retains 30,453 shares directly and 184 indirectly via a family member, so the sale was a partial reduction of holdings rather than a full exit. Monitor any future filings for additional planned sales or deviations from scheduled trades within the plan's timeframe.

La vendita di un funzionario secondo un piano 10b5-1 ha ridotto le partecipazioni dirette. Un dirigente, Eric Swayze, ha riportato la vendita di 6,849 azioni ordinarie di Ionis Pharmaceuticals in data 10/06/2025 a un prezzo medio ponderato di $69.02. La pratica indica che queste vendite sono state eseguite ai sensi di un piano di negoziazione 10b5-1 adottato il 14/08/2024, il che significa che erano istruzioni predefinite anziché operazioni discrezionali.

Dopo le transazioni, la persona che segnala detiene direttamente 30,453 azioni e ulteriori 184 azioni indirettamente tramite un familiare. Il dichiarante si offre di fornire informazioni dettagliate per singola operazione di prezzo alla società, agli azionisti o alla SEC su richiesta.

La venta de un funcionario bajo un plan 10b5-1 redujo las participaciones directas. Un ejecutivo, Eric Swayze, informó la venta de 6,849 acciones ordinarias de Ionis Pharmaceuticals el 10/06/2025 a un precio medio ponderado de $69.02. El archivo indica que estas ventas se realizaron conforme a un plan de comercio de la regla 10b5-1 adoptado el 08/14/2024, lo que significa que fueron instrucciones preacordadas en lugar de operaciones discrecionales.

Después de las transacciones, la persona que informa posee directamente 30,453 acciones y, adicionalmente, 184 acciones indirectamente a través de un familiar. El declarante ofrece proporcionar información detallada por cada operación de precio a la empresa, a los accionistas o a la SEC bajo petición.

10b5-1 계획에 따른 임원 매도가 직접 보유를 감소시켰습니다. 임원인 Eric Swayze가 Ionis Pharmaceuticals 주식 일반주 6,849주를 2025년 10월 6일에 가중평균가 $69.02로 매도했다고 보고했습니다. 신청서에 따르면 이 매도는 08/14/2024에 채택된 10b5-1 거래 계획에 따라 실행되었으며, 이는 사전 약정된 지시였지 재량적 거래가 아니었습니다.

거래 이후 보고인은 직접적으로 30,453주, 가족 구성원을 통해 간접적으로 추가로 184주를 보유하게 되었습니다. 제출인은 회사, 주주 또는 SEC에 요청 시 거래별 가격 정보를 상세히 제공하겠다고 밝혔습니다.

Vente d'un cadre sous un plan 10b5-1 réduisant les avoirs directs. Un dirigeant, Eric Swayze, a signalé la vente de 6 849 actions ordinaires d'Ionis Pharmaceuticals le 06/10/2025 à un cours moyen pondéré de 69,02 $. Le dossier indique que ces ventes ont été exécutées conformément à un plan de négociation 10b5-1 adopté le 14/08/2024, ce qui signifie qu'il s'agissait d'instructions préétablies plutôt que de transactions discrétionnaires.

Après les transactions, la personne déclarant détient directement 30 453 actions et indirectement, par l'intermédiaire d'un membre de la famille, 184 actions supplémentaires. Le déclarant se propose de fournir des informations détaillées par opération de prix à la société, aux actionnaires ou à la SEC sur demande.

Verkauf eines Beamten unter einem 10b5-1-Plan senkte direkte Beteiligungen. Ein Manager, Eric Swayze, meldete den Verkauf von 6.849 Aktien von Ionis Pharmaceuticals Stammaktien am 06.10.2025 zu einem gewichteten Durchschnittspreis von 69,02 $. Die Einreichung besagt, dass diese Verkäufe gemäß einem am 14.08.2024 angenommenen 10b5-1-Handelsplan durchgeführt wurden, was bedeutet, dass es sich um vorher festgelegte Anweisungen und nicht um discretionary Trades handelte.

Nach den Transaktionen besitzt die meldende Person direkt 30.453 Aktien und zusätzlich 184 Aktien indirekt durch ein Familienmitglied. Der Einreicher bietet an, auf Anfrage detaillierte Informationen pro Handelspreis dem Unternehmen, den Aktionären oder der SEC zur Verfügung zu stellen.

SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Estimated average burden
hours per response: 0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Swayze Eric

(Last) (First) (Middle)
2855 GAZELLE COURT

(Street)
CARLSBAD CA 92010

(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
IONIS PHARMACEUTICALS INC [ IONS ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director 10% Owner
X Officer (give title below) Other (specify below)
EVP Research
3. Date of Earliest Transaction (Month/Day/Year)
10/06/2025
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 10/06/2025 S 6,849(1) D $69.02(2) 30,453 D
Common Stock 184 I by Son
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Explanation of Responses:
1. Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 14, 2024.
2. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $69.02 to $69.03 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.
By: Patrick R. O'Neil, attorney-in-fact For: Eric Swayze 10/08/2025
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What did the IONS Form 4 filed by Eric Swayze report?

The filing reports a sale of 6,849 shares on 10/06/2025 at a weighted-average price of $69.02, executed under a Rule 10b5-1 trading plan.

How many Ionis (IONS) shares does Eric Swayze own after the reported sale?

After the sale, the reporting person beneficially owns 30,453 shares directly and 184 shares indirectly through a family member.

Was the sale discretionary or pre-arranged for IONS insider trades?

The sale was pre-arranged under a Rule 10b5-1 plan adopted on 08/14/2024, indicating it was not a discretionary trade.

What price range did the reported IONS sale cover?

The filing states transactions were executed at prices ranging from $69.02 to $69.03, with a reported weighted-average of $69.02.

Who signed the Form 4 for the reported IONS transaction?

The Form 4 was submitted by an attorney-in-fact, Patrick R. O'Neil, on behalf of Eric Swayze on 10/08/2025.
Ionis Pharmaceuticals

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Biotechnology
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United States
CARLSBAD