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  4. [Form 4] IONIS PHARMACEUTICALS INC Insider Trading Activity

Ionis (NASDAQ: IONS) EVP exercises RSUs, sells shares for tax withholding

Filing Impact
(Moderate)
Filing Sentiment
(Negative)
Form Type
4

Rhea-AI Filing Summary

Ionis Pharmaceuticals EVP Kyle Jenne reported routine equity compensation activity involving restricted stock units and common shares. On April 15, 2026, Jenne exercised 12,226 Restricted Stock Units, each representing a right to receive one share of Ionis common stock pursuant to a prior award.

In connection with this vesting, on April 16, 2026, Jenne completed an automatic sale of 4,902 common shares to cover required tax withholding obligations under the company’s equity incentive plan, at a weighted average price of $75.171 per share, with individual trades ranging from $75.06 to $75.26. Following these transactions, Jenne directly holds 23,713 shares of common stock and 74,402 Restricted Stock Units, which continue to vest in four equal annual installments.

Positive

  • None.

Negative

  • None.
Insider Jenne Kyle
Role EVP, Chf GL Pdt Str Ofcr
Sold 4,902 shs ($368K)
Type Security Shares Price Value
Sale Common Stock 4,902 $75.171 $368K
Exercise Restricted Stock Unit 12,226 $0.00 --
Exercise Common Stock 12,226 $0.00 --
Holdings After Transaction: Common Stock — 23,713 shares (Direct); Restricted Stock Unit — 74,402 shares (Direct)
Footnotes (1)
  1. Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award. The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $75.06 to $75.26 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4. Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value. Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.
Shares sold for tax withholding 4,902 shares Automatic sale of common stock on April 16, 2026
Weighted average sale price $75.171 per share Common stock sold in multiple trades, $75.06–$75.26 range
RSUs vested and exercised 12,226 units Restricted Stock Units converted into common stock on April 15, 2026
Common shares held after transactions 23,713 shares Direct Ionis common stock ownership following sale
Restricted Stock Units remaining 74,402 units RSU balance after April 15, 2026 vesting event
Restricted Stock Unit financial
"Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award."
A restricted stock unit is a promise from a company to give an employee shares of stock after certain conditions are met, like staying with the company for a set amount of time. It’s like earning a bonus that turns into company stock once you’ve proven your commitment, making it a way to motivate and reward employees.
automatic sale to cover the required tax withholding obligations financial
"The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan"
weighted average price financial
"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions"
Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.
Equity Incentive Plan financial
"pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice."
An equity incentive plan is a program that gives employees, executives or directors the right to receive company stock or options to buy stock as part of their pay. Think of it as offering slices of future company profit to motivate people to boost long‑term performance; for investors it matters because it can align employee goals with shareholder value but also increases the number of shares outstanding, which can dilute existing ownership.
contingent right to receive one share financial
"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."
Form 4 Insider Transactions: What Each Field Means →
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Jenne Kyle
(Last)(First)(Middle)
2855 GAZELLE COURT
(Street)
CARLSBAD CALIFORNIA 92010
(City)(State)(Zip)
UNITED STATES
(Country)		2. Issuer Name and Ticker or Trading Symbol
IONIS PHARMACEUTICALS INC [ IONS ] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director10% Owner
XOfficer (give title below)Other (specify below)
EVP, Chf GL Pdt Str Ofcr
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
04/15/2026		6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock04/15/2026M(1)12,226(1)A$0.028,615D
Common Stock04/16/2026S(2)4,902(2)D$75.171(3)23,713D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Restricted Stock Unit$0.0(4)04/15/2026M12,22604/15/2026(5) (5)Common Stock12,226$0.074,402D
Explanation of Responses:
1. Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award.
2. The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice.
3. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $75.06 to $75.26 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4.
4. Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.
5. Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.
By: Patrick R. O'Neil, attorney-in-fact For: Kyle Jenne04/17/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

Source: View Original Filing on SEC EDGAR

FAQ

What insider transactions did Ionis (IONS) EVP Kyle Jenne report?

Kyle Jenne reported vesting of 12,226 Restricted Stock Units and an automatic sale of 4,902 Ionis common shares to cover tax withholding obligations. These transactions reflect routine equity compensation activity rather than discretionary open-market buying or selling.

How many Ionis (IONS) shares did Kyle Jenne sell and at what price?

Kyle Jenne sold 4,902 Ionis common shares at a weighted average price of $75.171 per share. The shares were sold in multiple trades with prices ranging from $75.06 to $75.26, solely to satisfy required tax withholding.

How many Ionis (IONS) Restricted Stock Units did Kyle Jenne vest?

Kyle Jenne vested 12,226 Restricted Stock Units, each convertible into one Ionis common share or its cash equivalent. These units vest in four equal annual installments under the company’s equity incentive plan and are paid out upon vesting.

What are Kyle Jenne’s Ionis (IONS) holdings after these Form 4 transactions?

After the reported transactions, Kyle Jenne directly holds 23,713 Ionis common shares and 74,402 Restricted Stock Units. The remaining Restricted Stock Units continue to vest in four equal annual installments under the company’s equity incentive plan.

Was Kyle Jenne’s Ionis (IONS) share sale a discretionary market trade?

The sale was not discretionary; it was an automatic sale to cover required tax withholding obligations tied to Restricted Stock Unit vesting. Such tax-cover transactions are mechanical and do not represent a typical open-market investment decision.