STOCK TITAN

[Form 4] Ionis Pharmaceuticals, Inc. Insider Trading Activity

Filing Impact
(Moderate)
Filing Sentiment
(Negative)
Form Type
4
Rhea-AI Filing Summary

Joseph Klein III, a director of Ionis Pharmaceuticals, reported multiple transactions on 09/03/2025. The filing shows option exercises resulting in receipt of common stock and contemporaneous sales executed under a Rule 10b5-1 trading plan. Specifically, the report lists exercises of options that generated 12,000 and 16,000 shares credited to a trust, and a sale of 28,000 shares at $60 per share pursuant to the 10b5-1 plan. The filing also reports a disposition of 16,346 shares and notes 100 shares held by his son for which he disclaims beneficial ownership. All transactions are reported as indirect holdings through a trust except the 100 shares held by his son.

Joseph Klein III, amministratore di Ionis Pharmaceuticals, ha segnalato più operazioni il 03/09/2025. La comunicazione indica l'esercizio di opzioni che hanno comportato l'acquisizione di azioni ordinarie e vendite effettuate contestualmente ai sensi di un piano di negoziazione Rule 10b5-1. In dettaglio, il rapporto riporta esercizi di opzioni che hanno originato l'accredito di 12.000 e 16.000 azioni a un trust e la vendita di 28.000 azioni a 60 dollari ciascuna in base al piano 10b5-1. La segnalazione indica inoltre la cessione di 16.346 azioni e che 100 azioni sono detenute da suo figlio, sulle quali dichiara di non avere la titolarità effettiva. Tutte le operazioni sono riportate come partecipazioni indirette tramite un trust, fatta eccezione per le 100 azioni del figlio.

Joseph Klein III, director de Ionis Pharmaceuticals, reportó múltiples transacciones el 03/09/2025. La presentación muestra ejercicios de opciones que resultaron en la recepción de acciones ordinarias y ventas simultáneas ejecutadas bajo un plan de negociación Rule 10b5-1. Específicamente, el informe enumera ejercicios de opciones que generaron 12.000 y 16.000 acciones acreditadas a un fideicomiso, y una venta de 28.000 acciones a 60 dólares por acción conforme al plan 10b5-1. El documento también informa una disposición de 16.346 acciones y señala que 100 acciones las posee su hijo, sobre las cuales él niega la propiedad beneficiaria. Todas las transacciones se registran como participaciones indirectas a través de un fideicomiso, excepto las 100 acciones del hijo.

Ionis Pharmaceuticals의 이사 Joseph Klein III는 2025년 9월 3일 여러 건의 거래를 신고했습니다. 제출서류에는 보통주를 취득한 주식매수선택권 행사와 Rule 10b5-1 거래계획에 따라 동시 진행된 매도가 기재되어 있습니다. 구체적으로 보고서에는 신탁으로 입금된 12,000주 및 16,000주를 발생시킨 옵션 행사와 10b5-1 계획에 따라 주당 60달러에 28,000주를 매도한 내용이 나와 있습니다. 또한 16,346주의 처분과 그의 아들이 보유한 100주에 대해 실소유권을 부인한 사실도 보고하고 있습니다. 모든 거래는 100주를 제외하고 신탁을 통한 간접 보유로 신고되었습니다.

Joseph Klein III, administrateur d'Ionis Pharmaceuticals, a déclaré plusieurs opérations le 03/09/2025. Le dossier indique des exercices d'options entraînant la réception d'actions ordinaires et des ventes contemporaines effectuées dans le cadre d'un plan de négociation Rule 10b5-1. Plus précisément, le rapport mentionne des exercices d'options ayant généré 12 000 et 16 000 actions créditées à une fiducie, ainsi qu'une vente de 28 000 actions à 60 $ par action en vertu du plan 10b5-1. Le dossier signale également la cession de 16 346 actions et précise que 100 actions sont détenues par son fils, dont il décline la propriété bénéficiaire. Toutes les opérations sont déclarées comme des détentions indirectes via une fiducie, à l'exception des 100 actions du fils.

Joseph Klein III, Direktor von Ionis Pharmaceuticals, meldete am 03.09.2025 mehrere Transaktionen. Die Einreichung zeigt die Ausübung von Optionen, die zur Erlangung von Stammaktien führten, sowie gleichzeitig erfolgte Verkäufe im Rahmen eines Rule-10b5-1-Handelsplans. Konkret listet der Bericht Ausübungen von Optionen auf, die 12.000 bzw. 16.000 Aktien erzeugten, die einem Trust gutgeschrieben wurden, sowie einen Verkauf von 28.000 Aktien zu je 60 USD gemäß dem 10b5-1-Plan. Die Meldung berichtet außerdem über die Veräußerung von 16.346 Aktien und vermerkt 100 Aktien, die sein Sohn hält, für die er die wirtschaftliche Eigentümerschaft verneint. Alle Transaktionen werden als indirekte Beteiligungen über einen Trust gemeldet, mit Ausnahme der 100 Aktien des Sohnes.

Positive
  • Sale executed under a documented Rule 10b5-1 trading plan, which provides a pre-established framework for insider sales
  • Full disclosure of option exercise details including exercise prices ($42.88 and $52.22) and related option terms
  • Transactions reported as indirect through a trust, showing consistent ownership reporting structure
Negative
  • Large insider sale (28,000 shares) at $60 per share which may be perceived as significant insider liquidity
  • Some dispositions reported (16,346 shares) with limited context in the filing about source or purpose beyond the 10b5-1 sale

Insights

TL;DR: Director executed and exercised equity instruments and sold shares under a pre-established 10b5-1 plan.

The Form 4 shows coordinated activity: two option exercises credited to a trust (12,000 and 16,000 shares) and a matching sale of 28,000 shares at $60 under a Rule 10b5-1 plan adopted Jan 3, 2024. The reported exercises reference two non-qualified stock options with exercise prices of $42.88 and $52.22 and multi-year vest/exercise schedules. Reporting is filed as indirect ownership by trust and includes a disclaimer regarding 100 shares held by the reporting persons son. For investors, this is a routine director liquidity event structured via a trading plan; the filing contains no statements about material company events.

TL;DR: Transactions appear compliant with Section 16 reporting and a documented 10b5-1 plan.

The filing explicitly indicates the sale was made pursuant to a 10b5-1 plan and the form is signed by an attorney-in-fact, showing procedural adherence. Ownership is reported largely through an indirect trust vehicle and the filer disclaims beneficial ownership of shares held by his son. The disclosure is clear on transaction codes, quantities, prices, and option terms, enabling transparent oversight of insider activity without alleging breaches or omissions within the filing's scope.

Joseph Klein III, amministratore di Ionis Pharmaceuticals, ha segnalato più operazioni il 03/09/2025. La comunicazione indica l'esercizio di opzioni che hanno comportato l'acquisizione di azioni ordinarie e vendite effettuate contestualmente ai sensi di un piano di negoziazione Rule 10b5-1. In dettaglio, il rapporto riporta esercizi di opzioni che hanno originato l'accredito di 12.000 e 16.000 azioni a un trust e la vendita di 28.000 azioni a 60 dollari ciascuna in base al piano 10b5-1. La segnalazione indica inoltre la cessione di 16.346 azioni e che 100 azioni sono detenute da suo figlio, sulle quali dichiara di non avere la titolarità effettiva. Tutte le operazioni sono riportate come partecipazioni indirette tramite un trust, fatta eccezione per le 100 azioni del figlio.

Joseph Klein III, director de Ionis Pharmaceuticals, reportó múltiples transacciones el 03/09/2025. La presentación muestra ejercicios de opciones que resultaron en la recepción de acciones ordinarias y ventas simultáneas ejecutadas bajo un plan de negociación Rule 10b5-1. Específicamente, el informe enumera ejercicios de opciones que generaron 12.000 y 16.000 acciones acreditadas a un fideicomiso, y una venta de 28.000 acciones a 60 dólares por acción conforme al plan 10b5-1. El documento también informa una disposición de 16.346 acciones y señala que 100 acciones las posee su hijo, sobre las cuales él niega la propiedad beneficiaria. Todas las transacciones se registran como participaciones indirectas a través de un fideicomiso, excepto las 100 acciones del hijo.

Ionis Pharmaceuticals의 이사 Joseph Klein III는 2025년 9월 3일 여러 건의 거래를 신고했습니다. 제출서류에는 보통주를 취득한 주식매수선택권 행사와 Rule 10b5-1 거래계획에 따라 동시 진행된 매도가 기재되어 있습니다. 구체적으로 보고서에는 신탁으로 입금된 12,000주 및 16,000주를 발생시킨 옵션 행사와 10b5-1 계획에 따라 주당 60달러에 28,000주를 매도한 내용이 나와 있습니다. 또한 16,346주의 처분과 그의 아들이 보유한 100주에 대해 실소유권을 부인한 사실도 보고하고 있습니다. 모든 거래는 100주를 제외하고 신탁을 통한 간접 보유로 신고되었습니다.

Joseph Klein III, administrateur d'Ionis Pharmaceuticals, a déclaré plusieurs opérations le 03/09/2025. Le dossier indique des exercices d'options entraînant la réception d'actions ordinaires et des ventes contemporaines effectuées dans le cadre d'un plan de négociation Rule 10b5-1. Plus précisément, le rapport mentionne des exercices d'options ayant généré 12 000 et 16 000 actions créditées à une fiducie, ainsi qu'une vente de 28 000 actions à 60 $ par action en vertu du plan 10b5-1. Le dossier signale également la cession de 16 346 actions et précise que 100 actions sont détenues par son fils, dont il décline la propriété bénéficiaire. Toutes les opérations sont déclarées comme des détentions indirectes via une fiducie, à l'exception des 100 actions du fils.

Joseph Klein III, Direktor von Ionis Pharmaceuticals, meldete am 03.09.2025 mehrere Transaktionen. Die Einreichung zeigt die Ausübung von Optionen, die zur Erlangung von Stammaktien führten, sowie gleichzeitig erfolgte Verkäufe im Rahmen eines Rule-10b5-1-Handelsplans. Konkret listet der Bericht Ausübungen von Optionen auf, die 12.000 bzw. 16.000 Aktien erzeugten, die einem Trust gutgeschrieben wurden, sowie einen Verkauf von 28.000 Aktien zu je 60 USD gemäß dem 10b5-1-Plan. Die Meldung berichtet außerdem über die Veräußerung von 16.346 Aktien und vermerkt 100 Aktien, die sein Sohn hält, für die er die wirtschaftliche Eigentümerschaft verneint. Alle Transaktionen werden als indirekte Beteiligungen über einen Trust gemeldet, mit Ausnahme der 100 Aktien des Sohnes.

SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Estimated average burden
hours per response: 0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
KLEIN JOSEPH III

(Last) (First) (Middle)
2855 GAZELLE COURT

(Street)
CARLSBAD CA 92010

(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
IONIS PHARMACEUTICALS INC [ IONS ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
X Director 10% Owner
Officer (give title below) Other (specify below)
3. Date of Earliest Transaction (Month/Day/Year)
09/03/2025
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 09/03/2025 M 16,000 A $0.0 16,000 I by Trust
Common Stock 09/03/2025 M 12,000 A $0.0 28,000 I by Trust
Common Stock 09/03/2025 S 28,000(1) D $60 0 I by Trust
Common Stock 16,346 D
Common Stock 100 I by Son(2)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Non-Qualified Stock Option (right to buy) $42.88 09/03/2025 M 12,000 07/02/2019 07/01/2028 Common Stock 12,000 $0.0 0 I by Trust
Non-Qualified Stock Option (right to buy) $52.22 09/03/2025 M 16,000 07/03/2018 07/02/2027 Common Stock 16,000 $0.0 0 I by Trust
Explanation of Responses:
1. Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on January 3, 2024
2. The reporting person disclaims beneficial ownership of all securities held by his son, and this report should not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.
By: Patrick R. O'Neil, attorney-in-fact For: Joseph Klein, III 09/04/2025
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What did Ionis (IONS) director Joseph Klein III report on Form 4 dated 09/03/2025?

The filing reports option exercises resulting in 12,000 and 16,000 shares credited to a trust, a sale of 28,000 shares at $60 per share under a Rule 10b5-1 plan, a disposition of 16,346 shares, and 100 shares held by his son (disclaimed).

Were any insider sales made under a 10b5-1 plan in this Form 4 for IONS?

Yes. The filing explicitly indicates the sale of 28,000 shares was executed pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 3, 2024.

What option exercise prices and expirations are disclosed for Joseph Klein III?

Two non-qualified stock options are disclosed: one with a $42.88 exercise price exercisable from 07/02/2019 and expiring 07/01/2028 (12,000 shares), and one with a $52.22 exercise price exercisable from 07/03/2018 and expiring 07/02/2027 (16,000 shares).

How is beneficial ownership reported in this Form 4?

Most securities are reported as indirect (I) via a trust. The reporting person disclaims beneficial ownership of shares held by his son.

Who signed the Form 4 for Joseph Klein III?

The Form 4 was signed by Patrick R. O'Neil, attorney-in-fact for Joseph Klein, III on 09/04/2025.
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