Welcome to our dedicated page for Ionis Pharmaceuticals SEC filings (Ticker: IONS), a comprehensive resource for investors and traders seeking official regulatory documents including 10-K annual reports, 10-Q quarterly earnings, 8-K material events, and insider trading forms.
Ionis Pharmaceuticals, Inc. filings document an operating biotechnology company focused on RNA-targeted medicines, marketed products, partnered programs, and clinical-stage pipeline assets. Form 8-K reports cover GAAP and non-GAAP financial results, product-sales updates, Regulation FD disclosures, clinical data releases, and regulatory communications involving programs such as zilganersen in Alexander disease and bepirovirsen in chronic hepatitis B.
Proxy materials describe annual meeting procedures, director matters, board governance, and stockholder voting items. Other filings record capital-structure events and material agreements, including the completed private offering of convertible senior notes due 2030, along with exhibit filings and related corporate disclosures.
Joseph H. Wender, a director of Ionis Pharmaceuticals, Inc. (IONS), reported multiple sales under a Rule 10b5-1 trading plan adopted December 16, 2024. On 09/02/2025 he reported disposing of 11,200 shares at a weighted-average price of $55.0386 (sales priced between $55.000 and $55.180) and disposing of 5,600 shares at a weighted-average price of $57.5311 (prices between $57.500 and $57.575), leaving his beneficial ownership at 120,035 shares after that transaction. On 09/03/2025 he reported disposing of 11,200 shares at a weighted-average price of $60.1383 (prices between $60.00 and $60.53), leaving his beneficial ownership at 108,835 shares. The Form 4 was signed by Patrick R. O'Neil as attorney-in-fact for Mr. Wender on 09/04/2025.
Insider sale reported by Director B. Lynne Parshall of Ionis Pharmaceuticals (IONS). On 09/02/2025 the reporting person sold a total of 20,000 shares of Ionis common stock in two transactions executed under a Rule 10b5-1 trading plan adopted May 6, 2025. The first block of 10,750 shares was sold at a weighted-average price of $50.42 (individual trades ranged $50.0137–$50.92) leaving 75,594 shares beneficially owned after the sale. The second block of 9,250 shares was sold at a weighted-average price of $51.49 (individual trades ranged $51.24–$51.81) leaving 66,344 shares beneficially owned after that sale. The Form 4 was signed by an attorney-in-fact on 09/04/2025.
Brett P. Monia, Chief Executive Officer and Director of Ionis Pharmaceuticals (IONS), reported multiple transactions on 09/03/2025 that offset each other, resulting in no net change to total common shares held. On that date the reporting person acquired 203,814 shares through exercises and market purchases and sold 203,814 shares under a Rule 10b5-1 trading plan adopted August 13, 2024. The filings show weighted-average sale prices in three ranges: $58.57–$59.55, $59.60–$60.57, and $60.61–$61.48. Following the transactions the reporting person beneficially owned 180,009 common shares. The Form 4 also lists exercises of non-qualified stock options at strike prices of $32.60, $37.58, and $53.77, with resulting increases in underlying common shares reported in Table II.
Joseph Klein III, a director of Ionis Pharmaceuticals, reported multiple transactions dated 09/03/2025. The filing shows two non-derivative acquisitions recorded as 16,000 and 12,000 shares of common stock reported with transaction code M and price listed as $0.0, each noted as indirectly owned by a trust. On the same date the form records a sale of 28,000 common shares at $60 per share, with an explanatory note stating the sale was made pursuant to a Rule 10b5-1 trading plan adopted January 3, 2024. The report also lists 16,346 shares held directly and 100 shares held indirectly by his son, with the filer disclaiming beneficial ownership of the son's shares.
Joseph Klein III, a director of Ionis Pharmaceuticals, reported multiple transactions on 09/03/2025. The filing shows option exercises resulting in receipt of common stock and contemporaneous sales executed under a Rule 10b5-1 trading plan. Specifically, the report lists exercises of options that generated 12,000 and 16,000 shares credited to a trust, and a sale of 28,000 shares at $60 per share pursuant to the 10b5-1 plan. The filing also reports a disposition of 16,346 shares and notes 100 shares held by his son for which he disclaims beneficial ownership. All transactions are reported as indirect holdings through a trust except the 100 shares held by his son.
Richard S. Geary, Executive Vice President and Chief Development Officer of Ionis Pharmaceuticals (IONS), reported the sale of 10,000 shares of common stock on 09/02/2025. The shares were sold at a weighted average price of $50.3671 per share (individual trades ranged from $50.01 to $50.92). After the reported disposition, Mr. Geary beneficially owns 79,657 shares. The filing states the sales were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 6, 2025, and the filer offers to provide trade-level detail on request.
Shannon L. Devers, EVP & Chief Human Resources Officer of Ionis Pharmaceuticals (IONS), reported multiple transactions on September 3, 2025. The filing shows sales of 3,162 shares at a weighted average price of $61.0192 reported as executed under a Rule 10b5-1 trading plan adopted September 3, 2024. The reporting person also acquired 2,234 shares and acquired by option exercise 928 shares at stated prices.
The Form 4 lists two non-qualified stock option exercises that vest from 01/03/2023 and 01/03/2024 with expiration dates in 2032 and 2033 and shows 15,009 shares held after the sale.
Joseph H. Wender, a director of Ionis Pharmaceuticals, Inc. (IONS), reported sales of company common stock under a Rule 10b5-1 trading plan. On 09/02/2025 he sold 11,200 shares at a weighted average price of $55.0386 and 5,600 shares at a weighted average price of $57.5311, and on 09/03/2025 he sold 11,200 shares at a weighted average price of $60.1383. Following those transactions, the filing reports beneficial ownership levels of 125,635, 120,035 and 108,835 shares respectively, each listed as held indirectly by trust. The Form 4 states the trades were made pursuant to a 10b5-1 plan adopted December 16, 2024, and provides price ranges for the multiple executions behind each weighted average.
Joseph T. Baroldi, Executive Vice President and Chief Business Officer of Ionis Pharmaceuticals (IONS), reported multiple transactions dated 09/03/2025. The filing shows purchases/issuances of non-qualified stock options with a $31.80 exercise price totaling 32,800 options (three grants/exercises of 2,800, 15,000 and 15,000) that underlie common stock. On the same date the reporting person sold 32,800 common shares in multiple transactions at weighted average prices of $62.0101 and $59.0864 as noted. The Form 4 states the sales were made pursuant to a Rule 10b5-1 trading plan adopted May 2, 2025. Following the reported transactions, the filing lists various beneficial ownership totals and discloses 3,071 shares indirectly owned by spouse.
Patrick O'Neil, EVP, CLO & General Counsel of Ionis Pharmaceuticals (IONS), filed a Form 4 reporting multiple transactions on September 2–3, 2025. The filing shows exercises of non-qualified stock options and contemporaneous sales executed under a Rule 10b5-1 trading plan adopted May 2, 2025. Reported option exercises include 13,050 shares at a $32.60 strike, 14,000 at $37.58, and 49,800 at $53.77. Reported sales under the 10b5-1 plan include 13,050 shares at a weighted average $54.5148, 65,475 shares at a weighted average $60.89, and 11,375 shares at a weighted average $61.42. The Form discloses the number of shares beneficially owned following each transaction line as reported in the filing.