Welcome to our dedicated page for Ionis Pharmaceuticals SEC filings (Ticker: IONS), a comprehensive resource for investors and traders seeking official regulatory documents including 10-K annual reports, 10-Q quarterly earnings, 8-K material events, and insider trading forms.
Ionis Pharmaceuticals, Inc. filings document an operating biotechnology company focused on RNA-targeted medicines, marketed products, partnered programs, and clinical-stage pipeline assets. Form 8-K reports cover GAAP and non-GAAP financial results, product-sales updates, Regulation FD disclosures, clinical data releases, and regulatory communications involving programs such as zilganersen in Alexander disease and bepirovirsen in chronic hepatitis B.
Proxy materials describe annual meeting procedures, director matters, board governance, and stockholder voting items. Other filings record capital-structure events and material agreements, including the completed private offering of convertible senior notes due 2030, along with exhibit filings and related corporate disclosures.
C. Frank Bennett, EVP and Chief Scientific Officer of Ionis Pharmaceuticals (IONS), reported multiple transactions in early September 2025. He sold shares under a Rule 10b5-1 trading plan adopted May 13, 2025, and reported sales on 09/02/2025 and 09/03/2025 at weighted-average prices of $49.14 and ranges around $60.25–$61.995 and $61.26–$61.995 as disclosed. On 09/03/2025 he also acquired 46,800 shares by exercise/conversion of non-qualified stock options with a $53.77 exercise price. Following the reported activity, his beneficial ownership is reported as 88,679 shares.
Joseph Loscalzo, a director of Ionis Pharmaceuticals (IONS), reported paired transactions on 09/03/2025. He exercised 16,000 non-qualified stock options with an exercise price of $24.42 (options originally granted 07/01/2017, expiring 06/30/2026) and thereby acquired 16,000 shares. The same day he sold 16,000 shares under a Rule 10b5-1 trading plan adopted August 13, 2024, at a weighted-average price of $60.1482 (sales ranged from $60.00 to $60.57). The Form 4 shows 36,330 shares beneficially owned following these transactions.
Eugene Schneider, EVP and Chief Clinical Development Officer of Ionis Pharmaceuticals (IONS), reported option exercise and subsequent share sales executed on 09/03/2025. Schneider exercised a non-qualified stock option to acquire 19,658 shares at an exercise price of $53.77, which increased his beneficial ownership to 71,165 shares. He then sold 12,455 shares at a weighted average price of $60.4608, reducing ownership to 58,710, and sold an additional 7,203 shares at a weighted average price of $61.4163, bringing beneficial ownership to 51,507 shares. The sales were made pursuant to a Rule 10b5-1 trading plan adopted on May 2, 2025. The Form 4 includes weighted-average price ranges for the sales and an undertaking to provide transaction price breakdowns on request.
Patrick R. O'Neil, EVP, CLO & General Counsel of Ionis Pharmaceuticals (IONS), reported a non-derivative purchase of 331 shares of Ionis common stock on 08/29/2025 at a price of $27.71 per share under the company's Amended and Restated 2000 Employee Stock Purchase Plan. After the purchase O'Neil beneficially owned 57,130 shares. The filing notes these ESPP-acquired shares may not be sold until 03/02/2026. The Form 4 is a single-person filing and reflects a routine employee-plan purchase rather than a sale or option exercise.
Brett Monia, who is listed as both a director and the Chief Executive Officer of Ionis Pharmaceuticals, purchased 189 shares of Ionis Pharmaceuticals, Inc. common stock on 08/29/2025 under the company’s Amended and Restated 2000 Employee Stock Purchase Plan at a per-share price of $27.71. Following the transaction the filing reports 180,009 shares beneficially owned. The purchased shares are subject to a sale restriction and may not be sold until 03/02/2026. The Form 4 was signed by an attorney-in-fact on behalf of Brett Monia on 09/03/2025.
Richard S. Geary, Executive Vice President and Chief Development Officer of Ionis Pharmaceuticals (IONS), reported a purchase of 165 shares of Ionis common stock on 08/29/2025 at a price of $27.71 per share under the company’s Amended and Restated 2000 Employee Stock Purchase Plan. After this transaction, he beneficially owns 89,657 shares directly. The reporting disclosure notes these purchased shares may not be sold until March 2, 2026, indicating a holding restriction tied to the plan.
C. Frank Bennett, EVP and Chief Scientific Officer of Ionis Pharmaceuticals (IONS), reported an employee stock purchase on 08/29/2025. The filing shows 213 shares of Ionis common stock were acquired at a price of $27.71 under the company’s Amended and Restated 2000 Employee Stock Purchase Plan. Following the transaction the filing lists 93,679 shares beneficially owned (direct). The purchased shares are subject to a sale restriction and may not be sold until March 2, 2026. The Form 4 was signed by an attorney-in-fact on behalf of Mr. Bennett on 09/03/2025.
Brian Birchler, EVP of Corporate and Development Operations at Ionis Pharmaceuticals (IONS), reported an insider purchase of 56,826 shares of Ionis common stock on 08/29/2025 at a price of $27.71 per share. The filing indicates these shares were acquired under the company’s Amended and Restated 2000 Employee Stock Purchase Plan and may not be sold until March 2, 2026. The Form 4 was executed by an attorney-in-fact and reflects that the shares are directly beneficially owned following the transaction.
Form 144 filed for Ionis Pharmaceuticals (IONS) reports a proposed sale of 16,000 shares of common stock via Stifel Nicolaus with an aggregate market value of $962,371.00. The filing lists approximately 159,391,229 shares outstanding and an approximate sale date of 09/03/2025 on Nasdaq. The shares were acquired by option exercise on 07/01/2016 and the proposed payment method is cash. The filer reports no securities sold in the past three months.
Ionis Pharmaceuticals (IONS) reported a Form 144 notice for a proposed sale of 124,850 shares of common stock to be handled by Stifel Nicolaus & Company, Inc. on 09/03/2025 on Nasdaq with an aggregate market value of $7,634,553.00. The shares were acquired on 01/04/2021 through an option exercise from the issuer and the planned consideration is cash. The filing also discloses a recent sale by Patrick O'Neil of 13,050 shares on 09/02/2025 for gross proceeds of $711,418.00. The filing includes the statutorily required declaration that the seller is not aware of undisclosed material adverse information.