State Street (IOVA institutional holder) reports 5.1% passive stake in Iovance

Rhea-AI Filing Summary

State Street Corporation has filed a Schedule 13G reporting beneficial ownership of common stock of IOVANCE BIOTHERAPEUTICS INC as of 12/31/2025. State Street reports beneficial ownership of 20,161,445 shares, representing 5.1% of the company’s common stock.

State Street reports no sole voting or dispositive power, with 19,204,365 shares subject to shared voting power and 20,161,445 shares subject to shared dispositive power. Subsidiaries involved include SSGA Funds Management and various State Street Global Advisors entities. State Street certifies the holdings are in the ordinary course of business and not for changing or influencing control of Iovance.

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Accepted by SEC EDGAR 02/09/2026 - 06:43 AM Learn about SEC filing dates

FAQ

What stake does State Street Corporation report in IOVA common stock?

State Street Corporation reports beneficial ownership of 20,161,445 Iovance Biotherapeutics (IOVA) common shares, representing 5.1% of the class as of 12/31/2025. This reflects a large institutional position disclosed on Schedule 13G as a passive ownership filing.

How much voting power does State Street have over IOVA shares?

State Street reports no sole voting power over IOVA shares and 19,204,365 shares with shared voting power. This means voting decisions are exercised jointly through affiliated entities rather than by State Street alone, consistent with institutional asset management structures.

Does State Street control the disposition of its IOVA holdings?

State Street reports no sole dispositive power and 20,161,445 IOVA shares with shared dispositive power. Dispositive power refers to authority over selling or otherwise disposing of shares, which here is shared among State Street’s asset management subsidiaries.

Is State Street’s IOVA position intended to influence corporate control?

State Street certifies the IOVA securities were acquired and are held in the ordinary course of business and not for the purpose of changing or influencing control. The filing states the holdings are not connected with any control-related transaction, other than certain nomination-related activities allowed under regulations.

Which State Street subsidiaries are associated with the IOVA holdings?

Subsidiaries listed include SSGA Funds Management, Inc., State Street Global Advisors Europe Limited, State Street Global Advisors Limited, State Street Global Advisors Trust Company, and State Street Global Advisors, Ltd.. These entities manage assets that include IOVA shares reported in this filing.

What triggered State Street’s Schedule 13G filing for Iovance Biotherapeutics?

The Schedule 13G is tied to a 12/31/2025 event date, when State Street’s beneficial ownership reached or exceeded the 5% threshold in Iovance Biotherapeutics common stock. Crossing this threshold requires disclosure of ownership, voting power, and dispositive power under SEC rules.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

IOVANCE BIOTHERAPEUTICS INC

(Name of Issuer)

COMMON STOCK

(Title of Class of Securities)

462260100

(CUSIP Number)

12/31/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No. 462260100

1

Names of Reporting Persons

STATE STREET CORPORATION

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

MASSACHUSETTS

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 19,204,365.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 20,161,445.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

20,161,445.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.1 %

12

Type of Reporting Person (See Instructions)

HC

SCHEDULE 13G

Item 1.
(a)	Name of issuer: IOVANCE BIOTHERAPEUTICS INC
(b)	Address of issuer's principal executive offices: 999 SKYWAY ROAD SUITE 150, SAN CARLOS, CALIFORNIA, 94070
Item 2.
(a)	Name of person filing: STATE STREET CORPORATION;
(b)	Address or principal business office or, if none, residence: ONE CONGRESS STREET, SUITE 1, BOSTON MA 02114, UNITED STATES
(c)	Citizenship: MA
(d)	Title of class of securities: COMMON STOCK
(e)	CUSIP No.: 462260100
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 20161445.00
(b)	Percent of class: 5.1 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 0
	(ii) Shared power to vote or to direct the vote: 19,204,365
	(iii) Sole power to dispose or to direct the disposition of: 0
	(iv) Shared power to dispose or to direct the disposition of: 20,161,445
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. NOT APPLICABLE
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. SSGA FUNDS MANAGEMENT, INC. (IA);STATE STREET GLOBAL ADVISORS EUROPE LIMITED (IA);STATE STREET GLOBAL ADVISORS LIMITED (IA);STATE STREET GLOBAL ADVISORS TRUST COMPANY (IA);STATE STREET GLOBAL ADVISORS, LTD. (IA);
Item 8.	Identification and Classification of Members of the Group.
	If a group has filed this schedule pursuant to §240.13d-1(b)(1)(ii)(K), so indicate under Item 3(k) and attach an exhibit stating the identity and Item 3 classification of each member of the group. If a group has filed this schedule pursuant to §240.13d-1(c) or §240.13d-1(d), attach an exhibit stating the identity of each member of the group. NOT APPLICABLE
Item 9.	Notice of Dissolution of Group.
	Notice of dissolution of a group may be furnished as an exhibit stating the date of the dissolution and that all further filings with respect to transactions in the security reported on will be filed, if required, by members of the group, in their individual capacity. See Item 5. NOT APPLICABLE

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

STATE STREET CORPORATION

Signature:	ELIZABETH SCHAEFER
Name/Title:	SENIOR VICE PRESIDENT, CHIEF ACCOUNTING OFFICER
Date:	02/09/2026