Larimar Therapeutics Inc SEC Filings

Larimar Therapeutics (LRMR) filed an 8-K announcing an updated corporate presentation posted to its website and furnished as Exhibit 99.1, dated November 10, 2025. The company plans to use the slide deck in meetings with investors, analysts, and other stakeholders.

This is an informational update intended to support outreach and communication. The filing also lists the company’s common stock on the Nasdaq Global Market under the symbol LRMR.

Larimar Therapeutics (LRMR) reported Q3 2025 results highlighted by increased R&D investment as it advances nomlabofusp for Friedreich’s ataxia. The company posted a net loss of $47.7 million, driven by research and development expense of $44.9 million and general and administrative expense of $4.6 million. Cash, cash equivalents and marketable securities totaled $175.4 million as of September 30, 2025, supported by $65.0 million of net proceeds from a July 31 underwritten offering.

Management reiterated its regulatory path: participation in FDA’s START pilot, FDA feedback that skin frataxin (FXN) concentration may be considered a reasonably likely surrogate endpoint subject to future review, and BLA safety database parameters. The company targets a BLA submission for accelerated approval in Q2 2026 and plans a regulatory and study status update in Q1 2026. In its open-label study, 65 participants have received at least one dose, with directional improvements across clinical outcomes and FXN levels; 7 anaphylaxis events occurred early in dosing and the firm is implementing a modified starting regimen agreed with FDA. Shares outstanding were 85,590,392 as of November 3, 2025.

Larimar Therapeutics, Inc. filed an 8-K announcing it furnished a press release with financial results and operational highlights for the third quarter ended September 30, 2025. The press release is attached as Exhibit 99.1.

The information disclosed under Item 2.02, including Exhibit 99.1, is being furnished and is not deemed filed under the Exchange Act.

Larimar Therapeutics (LRMR) reported that it posted an updated corporate slide presentation on its website. The presentation, dated October 14, 2025, is attached as Exhibit 99.1 and incorporated by reference.

Company representatives plan to use the materials in meetings with investors, analysts, and other parties from time to time. This is an informational update with no transaction terms or financial results disclosed in the notice.

Larimar Therapeutics, Inc. (LRMR) filed an 8-K to report a material event: a press release and conference presentation dated September 29, 2025 announcing positive clinical data from its ongoing long‑term open‑label study of nomlabofusp in participants with Friedreich's ataxia. The filing cites positive results at the 25 mg and 50 mg daily subcutaneous dose levels given either by self‑administration or by a caregiver. The press release and presentation are attached as Exhibit 99.1. The filing text is brief and does not disclose detailed efficacy endpoints, participant counts, statistical results, safety findings, or next regulatory steps.

Opaleye entities and individual James Silverman report a passive Schedule 13G showing shared beneficial ownership of 4,110,000 shares of Larimar Therapeutics common stock, representing 4.80% of the class. The filing states the shares are held by Opaleye, L.P., with Opaleye Management, Inc. acting as adviser and Mr. Silverman exercising control over the adviser. Voting and dispositive power are reported as shared for all 4,110,000 shares and no sole voting or dispositive power is claimed. The filing is voluntary and certifies the stake is not intended to influence control of the issuer.

Larimar Therapeutics (LRMR) is advancing nomlabofusp through clinical development with multiple recent regulatory and clinical milestones. The company increased open-label dosing to 50 mg daily and has active participants receiving that dose. In March 2025 the Safety Monitoring Team deemed anaphylaxis a likely adverse drug reaction and the protocol was amended to add antihistamine premedication for the first month. Adolescent PK run-in dosing (ages 12–17) completed dosing of 14 participants in March 2025 and some adolescents are transitioning into the open-label study.

Regulatory interactions include FDA acceptance of a lyophilized formulation for clinical use and FDA feedback under the START pilot that it is open to considering skin FXN concentration as a reasonably likely surrogate endpoint, subject to review in a future marketing application. FDA recommended safety database targets for an accelerated BLA: at least 30 participants with six months continuous exposure and a subset of at least 10 with one year. Larimar plans a BLA submission in Q2 2026. A July 2025 publication reported supporting nonclinical data. The company raised net proceeds of approximately $65.1 million in July 2025, which management expects to fund operations into Q4 2026.

Janus Henderson Group plc filed Amendment No. 5 to a Schedule 13G reporting its position in Larimar Therapeutics, Inc. (CUSIP 517125100). The filing states that Janus Henderson and certain indirect subsidiaries beneficially own 0 shares of Larimar common stock, representing 0.0% of the class. The report lists Janus Henderson as Type IA, HC with a principal address at 201 Bishopsgate, EC2M 3AE, United Kingdom, and shows 0 sole and shared voting and dispositive powers. The filing names JHIUS, JHIUKL and JHIAIFML as indirect subsidiaries providing investment advice to Managed Portfolios and includes a power of attorney dated December 9, 2022. The statement is signed by Kristin Mariani on 08/14/2025.

Larimar Therapeutics, Inc. announced its financial results and operational highlights for the second quarter ended June 30, 2025, via a press release furnished on August 14, 2025. The Current Report does not include the numerical results in-line but references that the press release is provided as Exhibit 99.1.

The company also posted an updated corporate slide presentation on its website, furnished as Exhibit 99.2, which company representatives will use in investor and analyst meetings. The filing states the furnished materials are intended to be "furnished" and not "filed" under the Exchange Act.